Novel Variance-Component TWAS method for studying complex human diseases with applications to Alzheimer’s dementia
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Title
Novel Variance-Component TWAS method for studying complex human diseases with applications to Alzheimer’s dementia
Authors
Keywords
Genome-wide association studies, Alzheimer's disease, Medical risk factors, Gene expression, Transcriptome analysis, Genetics, Phenotypes, Single nucleotide polymorphisms
Journal
PLoS Genetics
Volume 17, Issue 4, Pages e1009482
Publisher
Public Library of Science (PLoS)
Online
2021-04-03
DOI
10.1371/journal.pgen.1009482
References
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Note: Only part of the references are listed.- Multi-trait transcriptome-wide association studies with probabilistic Mendelian randomization
- (2021) Lu Liu et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Aryl Hydrocarbon Receptor in Post-Mortem Hippocampus and in Serum from Young, Elder, and Alzheimer’s Patients
- (2020) Nicte Alaide Ramos-García et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Testing and controlling for horizontal pleiotropy with probabilistic Mendelian randomization in transcriptome-wide association studies
- (2020) Zhongshang Yuan et al. Nature Communications
- Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer’s Dementia
- (2020) Andrew R. Ouellette et al. Cell Reports
- Tauopathy: A common mechanism for neurodegeneration and Brain Aging
- (2019) Pampa Saha et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk
- (2019) Iris E. Jansen et al. NATURE GENETICS
- Prioritizing Parkinson’s disease genes using population-scale transcriptomic data
- (2019) Yang I. Li et al. Nature Communications
- Population-based genome-wide association study of cognitive decline in older adults free of dementia: Identification of a novel locus for the attention domain
- (2019) M. Ilyas Kamboh et al. NEUROBIOLOGY OF AGING
- TIGAR: An Improved Bayesian Tool for Transcriptomic Data Imputation Enhances Gene Mapping of Complex Traits
- (2019) Sini Nagpal et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Genetically regulated gene expression underlies lipid traits in Hispanic cohorts
- (2019) Angela Andaleon et al. PLoS One
- CoMM-S2: a collaborative mixed model using summary statistics in transcriptome-wide association studies
- (2019) Yi Yang et al. BIOINFORMATICS
- Driving Progress in Posttraumatic Stress Disorder Biomarkers
- (2019) Andreas Jeromin et al. BIOLOGICAL PSYCHIATRY
- The effects of the TOMM40 poly-T alleles on Alzheimer's disease phenotypes
- (2018) Ornit Chiba-Falek et al. Alzheimers & Dementia
- Religious Orders Study and Rush Memory and Aging Project
- (2018) David A. Bennett et al. JOURNAL OF ALZHEIMERS DISEASE
- A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer
- (2018) Lang Wu et al. NATURE GENETICS
- Causal associations between risk factors and common diseases inferred from GWAS summary data
- (2018) Zhihong Zhu et al. Nature Communications
- Genetic architecture of gene expression traits across diverse populations
- (2018) Lauren S. Mogil et al. PLoS Genetics
- Deciphering the Emerging Complexities of Molecular Mechanisms at GWAS Loci
- (2018) Maren E. Cannon et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Altered Slc25 family gene expression as markers of mitochondrial dysfunction in brain regions under experimental mixed anxiety/depression-like disorder
- (2018) Vladimir N. Babenko et al. BMC NEUROSCIENCE
- Genetic effects on gene expression across human tissues
- (2017) François Aguet et al. NATURE
- An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome
- (2017) Bernard Ng et al. NATURE NEUROSCIENCE
- Identification and functional characterization of a novel MTFMT mutation associated with selective vulnerability of the visual pathway and a mild neurological phenotype
- (2017) Roberta La Piana et al. NEUROGENETICS
- MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity
- (2017) María-José Sandí et al. Science Signaling
- Non-parametric genetic prediction of complex traits with latent Dirichlet process regression models
- (2017) Ping Zeng et al. Nature Communications
- MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity
- (2017) María-José Sandí et al. Science Signaling
- Control for Population Structure and Relatedness for Binary Traits in Genetic Association Studies via Logistic Mixed Models
- (2016) Han Chen et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Next-generation genotype imputation service and methods
- (2016) Sayantan Das et al. NATURE GENETICS
- Integrative approaches for large-scale transcriptome-wide association studies
- (2016) Alexander Gusev et al. NATURE GENETICS
- Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease
- (2016) Jennifer S. Yokoyama et al. JAMA Neurology
- At the interface of sensory and motor dysfunctions and Alzheimer's disease
- (2015) Mark W. Albers et al. Alzheimers & Dementia
- A gene-based association method for mapping traits using reference transcriptome data
- (2015) Eric R Gamazon et al. NATURE GENETICS
- RAREMETAL: fast and powerful meta-analysis for rare variants
- (2014) S. Feng et al. BIOINFORMATICS
- Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci
- (2014) Philip L De Jager et al. NATURE NEUROSCIENCE
- Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias
- (2014) Gary W. Beecham et al. PLoS Genetics
- Genome-wide association study of the rate of cognitive decline in Alzheimer's disease
- (2013) Richard Sherva et al. Alzheimers & Dementia
- Sherlock: Detecting Gene-Disease Associations by Matching Patterns of Expression QTL and GWAS
- (2013) Xin He et al. AMERICAN JOURNAL OF HUMAN GENETICS
- General Framework for Meta-analysis of Rare Variants in Sequencing Association Studies
- (2013) Seunggeun Lee et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Sequence Kernel Association Tests for the Combined Effect of Rare and Common Variants
- (2013) Iuliana Ionita-Laza et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Overview and Findings from the Religious Orders Study
- (2013) David A. Bennett et al. Current Alzheimer Research
- Overview and Findings from the Rush Memory and Aging Project
- (2013) David A. Bennett et al. Current Alzheimer Research
- Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
- (2013) Jean-Charles Lambert et al. NATURE GENETICS
- Gene Ontology annotation of sequence-specific DNA binding transcription factors: setting the stage for a large-scale curation effort
- (2013) S. Tripathi et al. Database-The Journal of Biological Databases and Curation
- A comparison of cataloged variation between International HapMap Consortium and 1000 Genomes Project data
- (2012) Carrie C Buchanan et al. JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
- Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits
- (2012) Jian Yang et al. NATURE GENETICS
- Genome-wide association study identifies multiple loci influencing human serum metabolite levels
- (2012) Johannes Kettunen et al. NATURE GENETICS
- Brain Expression Genome-Wide Association Study (eGWAS) Identifies Human Disease-Associated Variants
- (2012) Fanggeng Zou et al. PLoS Genetics
- Rare-Variant Association Testing for Sequencing Data with the Sequence Kernel Association Test
- (2011) Michael C. Wu et al. AMERICAN JOURNAL OF HUMAN GENETICS
- A genome-wide scan for common variants affecting the rate of age-related cognitive decline
- (2011) Philip L. De Jager et al. NEUROBIOLOGY OF AGING
- Genetic Influences on Alzheimer’s Disease: Evidence of Interactions Between the Genes APOE, APOC1 and ACE in a Sample Population from the South of Brazil
- (2011) Juliana Fagion Lucatelli et al. NEUROCHEMICAL RESEARCH
- Genome-wide association study identifies multiple novel loci associated with disease progression in subjects with mild cognitive impairment
- (2011) X Hu et al. Translational Psychiatry
- Powerful SNP-Set Analysis for Case-Control Genome-wide Association Studies
- (2010) Michael C. Wu et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Chemotherapeutic drug susceptibility associated SNPs are enriched in expression quantitative trait loci
- (2010) E. R. Gamazon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Trait-Associated SNPs Are More Likely to Be eQTLs: Annotation to Enhance Discovery from GWAS
- (2010) Dan L. Nicolae et al. PLoS Genetics
- Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease
- (2009) Minerva M Carrasquillo et al. NATURE GENETICS
- A Powerful and Flexible Multilocus Association Test for Quantitative Traits
- (2008) Lydia Coulter Kwee et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Estimation and testing for the effect of a genetic pathway on a disease outcome using logistic kernel machine regression via logistic mixed models
- (2008) Dawei Liu et al. BMC BIOINFORMATICS
- Genome-wide association studies for complex traits: consensus, uncertainty and challenges
- (2008) Mark I. McCarthy et al. NATURE REVIEWS GENETICS
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