A two-hit adversity model in developing rats reveals sex-specific impacts on prefrontal cortex structure and behavior

Prefrontal parvalbumin interneurons require juvenile social experience to establish adult social behavior

(2020) Lucy K. Bicks et al.   Nature Communications

Altered corticolimbic connectivity reveals sex-specific adolescent outcomes in a rat model of early life adversity

(2020) Jennifer A Honeycutt et al.   eLife

Downregulation of parvalbumin expression in the prefrontal cortex during adolescence causes enduring prefrontal disinhibition in adulthood

(2020) Adriana Caballero et al.   NEUROPSYCHOPHARMACOLOGY

Systematic review and meta-analysis: effects of maternal separation on anxiety-like behavior in rodents

(2020) Daniel Wang et al.   Translational Psychiatry

Region-specific effects of maternal separation on oxidative stress accumulation in parvalbumin neurons of male and female rats

(2020) Alexa R. Soares et al.   BEHAVIOURAL BRAIN RESEARCH

Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity

(2020) Phi T. Nguyen et al.   CELL

Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain

(2020) Joshua D. Crapser et al.   EBioMedicine

Influences of age and pubertal status on number and intensity of perineuronal nets in the rat medial prefrontal cortex

(2020) Carly M. Drzewiecki et al.   Brain Structure & Function

Postweaning Isolation Rearing Alters the Adult Social, Sexual Preference and Mating Behaviors of Male CD-1 Mice

(2019) Zi-Wei Liu et al.   Frontiers in Behavioral Neuroscience

Multi-hit early life adversity affects gut microbiota, brain and behavior in a sex-dependent manner

(2019) Marion Rincel et al.   BRAIN BEHAVIOR AND IMMUNITY

Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity

(2019) Sahana Murthy et al.   BIOLOGICAL PSYCHIATRY

Cumulative multiple early life hits- a potent threat leading to neurological disorders

(2019) Tiyasha Sarkar et al.   BRAIN RESEARCH BULLETIN

Sex and Estrous Cycle Effects on Anxiety- and Depression-Related Phenotypes in a Two-Hit Developmental Stress Model

(2019) Ivana Jaric et al.   Frontiers in Molecular Neuroscience

The behavioral phenotype of early life adversity: A 3-level meta-analysis of rodent studies

(2019) V. Bonapersona et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Perineuronal Nets: Plasticity, Protection, and Therapeutic Potential

(2019) Amy C. Reichelt et al.   TRENDS IN NEUROSCIENCES

Alterations of perineuronal nets in the dorsolateral prefrontal cortex of neuropsychiatric patients

(2019) Julia Alcaide et al.   International Journal of Bipolar Disorders

Microglial depletion prevents extracellular matrix changes and striatal volume reduction in a model of Huntington's disease

(2019) Joshua D Crapser et al.   BRAIN

Region-specific Effects of Maternal Separation on Perineuronal Net and Parvalbumin-expressing Interneuron Formation in Male and Female Rats

(2019) Kelsea R. Gildawie et al.   NEUROSCIENCE

Stress begets stress: the association of adverse childhood experiences with psychological distress in the presence of adult life stress

(2018) Mercy Manyema et al.   BMC PUBLIC HEALTH

Neuroinflammatory priming to stress is differentially regulated in male and female rats

(2018) Laura K. Fonken et al.   BRAIN BEHAVIOR AND IMMUNITY

Adolescent Stress Disrupts the Maturation of Anxiety-related Behaviors and Alters the Developmental Trajectory of the Prefrontal Cortex in a Sex- and Age-specific Manner

(2018) Chloe E. Page et al.   NEUROSCIENCE

Adolescent Isolation Interacts With DISC1 Point Mutation to Impair Adult Social Memory and Synaptic Functions in the Hippocampus

(2018) Nan Li et al.   Frontiers in Cellular Neuroscience

Parvalbumin neurons and perineuronal nets in the mouse prefrontal cortex

(2017) Hiroshi Ueno et al.   NEUROSCIENCE

Region-specific impairments in parvalbumin interneurons in social isolation-reared mice

(2017) Hiroshi Ueno et al.   NEUROSCIENCE

Hippocampal extracellular matrix alterations contribute to cognitive impairment associated with a chronic depressive-like state in rats

(2017) Danai Riga et al.   Science Translational Medicine

Reduced Labeling of Parvalbumin Neurons and Perineuronal Nets in the Dorsolateral Prefrontal Cortex of Subjects with Schizophrenia

(2016) John F Enwright et al.   NEUROPSYCHOPHARMACOLOGY

Cognitive impairment effects of early life stress in adolescents can be predicted with early biomarkers: Impacts of sex, experience, and cytokines

(2016) Rodrigo Grassi-Oliveira et al.   PSYCHONEUROENDOCRINOLOGY

GABAergic Function as a Limiting Factor for Prefrontal Maturation during Adolescence

(2016) Adriana Caballero et al.   TRENDS IN NEUROSCIENCES

The extracellular matrix molecule brevican is an integral component of the machinery mediating fast synaptic transmission at the calyx of Held

(2015) Maren Blosa et al.   JOURNAL OF PHYSIOLOGY-LONDON

Sex differences and stress across the lifespan

(2015) Tracy L Bale et al.   NATURE NEUROSCIENCE

Functional Uncoupling NMDAR NR2A Subunit from PSD-95 in the Prefrontal Cortex: Effects on Behavioral Dysfunction and Parvalbumin Loss after Early-Life Stress

(2015) Prabarna Ganguly et al.   NEUROPSYCHOPHARMACOLOGY

Adult cortical plasticity depends on an early postnatal critical period

(2015) S. D. Greenhill et al.   SCIENCE

Broken or maladaptive? Altered trajectories in neuroinflammation and behavior after early life adversity

(2015) Prabarna Ganguly et al.   Developmental Cognitive Neuroscience

Naturalistic rodent models of chronic early-life stress

(2014) Jenny Molet et al.   DEVELOPMENTAL PSYCHOBIOLOGY

Sex differences in behavior and pro-inflammatory cytokine mRNA expression following stressor exposure and re-exposure

(2014) S.P. Hudson et al.   NEUROSCIENCE

Early life stress disrupts social behavior and prefrontal cortex parvalbumin interneurons at an earlier time-point in females than in males

(2014) Freedom H. Holland et al.   NEUROSCIENCE LETTERS

Impact of maternal separation on neural cell adhesion molecules expression in dopaminergic brain regions of juvenile, adolescent and adult rats

(2014) Agnieszka Chocyk et al.   Pharmacological Reports

Developmental Pattern of Perineuronal Nets in the Human Prefrontal Cortex and Their Deficit in Schizophrenia

(2013) Sarah A. Mauney et al.   BIOLOGICAL PSYCHIATRY

Perineuronal nets protect fast-spiking interneurons against oxidative stress

(2013) J.-H. Cabungcal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combination of prenatal immune challenge and restraint stress affects prepulse inhibition and dopaminergic/GABAergic markers

(2013) Jessica Deslauriers et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Social isolation rearing induces mitochondrial, immunological, neurochemical and behavioural deficits in rats, and is reversed by clozapine or N-acetyl cysteine

(2012) Marisa Möller et al.   BRAIN BEHAVIOR AND IMMUNITY

The perineuronal net and the control of CNS plasticity

(2012) Difei Wang et al.   CELL AND TISSUE RESEARCH

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Post-weaning social isolation attenuates c-Fos expression in GABAergic interneurons in the basolateral amygdala of adult female rats

(2012) Jodi L. Lukkes et al.   PHYSIOLOGY & BEHAVIOR

Current research trends in early life stress and depression: Review of human studies on sensitive periods, gene–environment interactions, and epigenetics

(2011) Christine Heim et al.   EXPERIMENTAL NEUROLOGY

Validation of an automated system for measuring anxiety-related behaviours in the elevated plus maze

(2010) Michelle M. Sidor et al.   JOURNAL OF NEUROSCIENCE METHODS

Comparison of the elevated plus and elevated zero mazes in treated and untreated male Sprague–Dawley rats: Effects of anxiolytic and anxiogenic agents

(2010) Amanda A. Braun et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Early life stress paradigms in rodents: potential animal models of depression?

(2010) Mathias V. Schmidt et al.   PSYCHOPHARMACOLOGY

Effects of early life stress on cognitive and affective function: an integrated review of human literature

(2010) Pia Pechtel et al.   PSYCHOPHARMACOLOGY

Involvement of NOX2 in the Development of Behavioral and Pathologic Alterations in Isolated Rats

(2009) Stefania Schiavone et al.   BIOLOGICAL PSYCHIATRY

Childhood adversity, adult stressful life events, and risk of past-year psychiatric disorder: a test of the stress sensitization hypothesis in a population-based sample of adults

(2009) K. A. McLaughlin et al.   PSYCHOLOGICAL MEDICINE

Effect of childhood trauma on adult depression and neuroendocrine function: sex-specific moderation by CRH receptor 1 gene

(2009) Christine Heim   Frontiers in Behavioral Neuroscience

Cumulative effect of multiple trauma on symptoms of posttraumatic stress disorder, anxiety, and depression in adolescents

(2008) Sharain Suliman et al.   COMPREHENSIVE PSYCHIATRY

Early life programming of hemispheric lateralization and synchronization in the adult medial prefrontal cortex

(2008) C.W. Stevenson et al.   NEUROSCIENCE

Behavioural and neurochemical effects of post-weaning social isolation in rodents—Relevance to developmental neuropsychiatric disorders

(2008) Kevin C.F. Fone et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The link between childhood trauma and depression: Insights from HPA axis studies in humans

(2008) Christine Heim et al.   PSYCHONEUROENDOCRINOLOGY

The postweaning social isolation in C57BL/6 mice: preferential vulnerability in the male sex

(2008) Susanna Pietropaolo et al.   PSYCHOPHARMACOLOGY

Gender differences in depression and anxiety across the adult lifespan: the role of psychosocial mediators

(2008) Liana S. Leach et al.   SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY

Stress, sensitive periods and maturational events in adolescent depression

(2008) Susan L. Andersen et al.   TRENDS IN NEUROSCIENCES