Modeling cell-specific dynamics and regulation of the common gamma chain cytokines

Defining the Threshold IL-2 Signal Required for Induction of Selective Treg Cell Responses Using Engineered IL-2 Muteins

(2020) Aazam Ghelani et al.   Frontiers in Immunology

The Limited Information Capacity of Cross-Reactive Sensors Drives the Evolutionary Expansion of Signaling

(2019) Michał Komorowski et al.   Cell Systems

The γc Family of Cytokines: Basic Biology to Therapeutic Ramifications

(2019) Warren J. Leonard et al.   IMMUNITY

A First-in-Human Study and Biomarker Analysis of NKTR-214, a Novel IL2Rβγ-Biased Cytokine, in Patients with Advanced or Metastatic Solid Tumors

(2019) Salah-Eddine Bentebibel et al.   Cancer Discovery

IL-2 receptors preassemble and signal in the ER/Golgi causing resistance to antiproliferative anti–IL-2Rα therapies

(2019) Julianna Volkó et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mathematical modeling of the receptor-mediated endocytosis process of targeted therapeutic agents in drug delivery systems

(2019) Jong Hyuk Byun et al.   APPLIED MATHEMATICAL MODELLING

Morphogen gradient reconstitution reveals Hedgehog pathway design principles

(2018) Pulin Li et al.   SCIENCE

A molecular mechanism for Wnt ligand-specific signaling

(2018) Marie Eubelen et al.   SCIENCE

A hierarchy of affinities between cytokine receptors and the common gamma chain leads to pathway cross-talk

(2018) Pauline Gonnord et al.   Science Signaling

A hierarchy of affinities between cytokine receptors and the common gamma chain leads to pathway cross-talk

(2018) Pauline Gonnord et al.   Science Signaling

Dissecting FcγR Regulation through a Multivalent Binding Model

(2018) Ryan A. Robinett et al.   Cell Systems

A long-lived IL-2 mutein that selectively activates and expands regulatory T cells as a therapy for autoimmune disease

(2018) Laurence B. Peterson et al.   JOURNAL OF AUTOIMMUNITY

Common gamma chain cytokines in combinatorial immune strategies against cancer

(2016) Stephanie R. Pulliam et al.   IMMUNOLOGY LETTERS

Acetylation Modulates IL-2 Receptor Signaling in T Cells

(2016) Taku Kuwabara et al.   JOURNAL OF IMMUNOLOGY

Synergistic Innate and Adaptive Immune Response to Combination Immunotherapy with Anti-Tumor Antigen Antibodies and Extended Serum Half-Life IL-2

(2015) Eric F. Zhu et al.   CANCER CELL

Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms

(2015) Jamie B. Spangler et al.   IMMUNITY

Interleukin-2 Activity Can Be Fine Tuned with Engineered Receptor Signaling Clamps

(2015) Suman Mitra et al.   IMMUNITY

Sustained in vivo signaling by long-lived IL-2 induces prolonged increases of regulatory T cells

(2015) Charles J.M. Bell et al.   JOURNAL OF AUTOIMMUNITY

The AXL Receptor Is a Sensor of Ligand Spatial Heterogeneity

(2015) Aaron S. Meyer et al.   Cell Systems

Human IL2RA null mutation mediates immunodeficiency with lymphoproliferation and autoimmunity

(2013) Kevin Goudy et al.   CLINICAL IMMUNOLOGY

Engineering a Monomeric Fc Domain Modality byN-Glycosylation for the Half-life Extension of Biotherapeutics

(2013) Tetsuya Ishino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The signalling factor PI3K is a specific regulator of the clathrin-independent dynamin-dependent endocytosis of IL-2 receptors

(2013) C. Basquin et al.   JOURNAL OF CELL SCIENCE

Cell-to-Cell Variability Analysis Dissects the Plasticity of Signaling of Common   Chain Cytokines in T Cells

(2013) J. W. Cotari et al.   Science Signaling

Mathematical Models of the Impact of IL2 Modulation Therapies on T Cell Dynamics

(2013) Kalet León et al.   Frontiers in Immunology

Structural insights into the common γ-chain family of cytokines and receptors from the interleukin-7 pathway

(2012) Scott T. R. Walsh   IMMUNOLOGICAL REVIEWS

Role of the common   chain in cell cycle progression of human malignant cell lines

(2012) I. Vigliano et al.   INTERNATIONAL IMMUNOLOGY

Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’

(2012) Aron M. Levin et al.   NATURE

Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15

(2012) Aaron M Ring et al.   NATURE IMMUNOLOGY

Key role for IL-21 in experimental autoimmune uveitis

(2011) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Biosensor Study Indicating That Entropy, Electrostatics, and Receptor Glycosylation Drive the Binding Interaction between Interleukin-7 and Its Receptor

(2010) Scott T. R. Walsh   BIOCHEMISTRY

Single-cell quantification of IL-2 response by effector and regulatory T cells reveals critical plasticity in immune response

(2010) Ofer Feinerman et al.   Molecular Systems Biology

Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells

(2010) C. Krieg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Cellular Amount of the Common  -Chain Influences Spontaneous or Induced Cell Proliferation

(2009) S. Amorosi et al.   JOURNAL OF IMMUNOLOGY