Glycocalyx components affect platelet function, whole blood coagulation, and fibrinolysis: an in vitro study suggesting a link to trauma-induced coagulopathy

Versican—A Critical Extracellular Matrix Regulator of Immunity and Inflammation

(2020) Thomas N. Wight et al.   Frontiers in Immunology

Good Platelets Gone Bad

(2020) Alexander T. Fields et al.   SHOCK

Endothelial Dysfunction is Associated With Increased Incidence, Worsened Severity, and Prolonged Duration of Acute Kidney Injury After Severe Trauma

(2020) Gabrielle E. Hatton et al.   SHOCK

Platelets retain inducible alpha granule secretion by P‐selectin expression but exhibit mechanical dysfunction during trauma‐induced coagulopathy

(2019) Alexander E. St. John et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Platelet dysfunction during trauma involves diverse signaling pathways and an inhibitory activity in patient-derived plasma

(2018) Christopher C. Verni et al.   Journal of Trauma and Acute Care Surgery

The current understanding of trauma-induced coagulopathy (TIC): a focused review on pathophysiology

(2017) Stefano Giordano et al.   Internal and Emergency Medicine

Tranexamic acid is associated with increased mortality in patients with physiological fibrinolysis

(2017) Hunter B. Moore et al.   JOURNAL OF SURGICAL RESEARCH

Syndecan-1: A Quantitative Marker for the Endotheliopathy of Trauma

(2017) Erika Gonzalez Rodriguez et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Sympathoadrenal activation and endotheliopathy are drivers of hypocoagulability and hyperfibrinolysis in trauma

(2017) Sisse R. Ostrowski et al.   Journal of Trauma and Acute Care Surgery

Fibrinolysis shutdown is associated with a fivefold increase in mortality in trauma patients lacking hypersensitivity to tissue plasminogen activator

(2017) Hunter B. Moore et al.   Journal of Trauma and Acute Care Surgery

Platelet transfusions reduce fibrinolysis but do not restore platelet function during trauma hemorrhage

(2017) Paul Vulliamy et al.   Journal of Trauma and Acute Care Surgery

Thrombin Provokes Degranulation of Platelet α-Granules Leading to the Release of Active Plasminogen Activator Inhibitor-1 (PAI-1)

(2017) Benjamin R. Huebner et al.   SHOCK

Sympathoadrenal activation and endotheliopathy are drivers of hypocoagulability and hyperfibrinolysis in trauma

(2017) Sisse R. Ostrowski et al.   Journal of Trauma and Acute Care Surgery

Fibrinolysis shutdown is associated with a fivefold increase in mortality in trauma patients lacking hypersensitivity to tissue plasminogen activator

(2017) Hunter B. Moore et al.   Journal of Trauma and Acute Care Surgery

Platelet transfusions reduce fibrinolysis but do not restore platelet function during trauma hemorrhage

(2017) Paul Vulliamy et al.   Journal of Trauma and Acute Care Surgery

Role of Versican and ADAMTS-1 in Polycystic Ovary Syndrome

(2017) Sibel Özler et al.   Journal of Clinical Research in Pediatric Endocrinology

Targeted Coagulation Management in Severe Trauma

(2016) James Winearls et al.   ANESTHESIA AND ANALGESIA

Anticoagulant Effect of Sugammadex

(2016) Daniel Dirkmann et al.   ANESTHESIOLOGY

Acute traumatic coagulopathy: pathophysiology and resuscitation

(2016) J.W. Simmons et al.   BRITISH JOURNAL OF ANAESTHESIA

Acute Fibrinolysis Shutdown after Injury Occurs Frequently and Increases Mortality: A Multicenter Evaluation of 2,540 Severely Injured Patients

(2016) Hunter B. Moore et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Overwhelming tPA release, not PAI-1 degradation, is responsible for hyperfibrinolysis in severely injured trauma patients

(2016) Michael P. Chapman et al.   Journal of Trauma and Acute Care Surgery

Overwhelming tPA release, not PAI-1 degradation, is responsible for hyperfibrinolysis in severely injured trauma patients

(2016) Michael P. Chapman et al.   Journal of Trauma and Acute Care Surgery

Viscoelastic measurements of platelet function, not fibrinogen function, predicts sensitivity to tissue-type plasminogen activator in trauma patients

(2015) H. B. Moore et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Endothelial glycocalyx shedding and vascular permeability in severely injured trauma patients

(2015) Elaheh Rahbar et al.   Journal of Translational Medicine

Hemolysis Exacerbates Hyperfibrinolysis, Whereas Platelolysis Shuts Down Fibrinolysis

(2015) Hunter B. Moore et al.   SHOCK

Recombinant tissue-type plasminogen activator–evoked hyperfibrinolysis is enhanced by acidosis and inhibited by hypothermia but still can be blocked by tranexamic acid

(2013) Daniel Dirkmann et al.   Journal of Trauma and Acute Care Surgery

Injuries

(2013) Robyn Norton et al.   NEW ENGLAND JOURNAL OF MEDICINE

Endothelial glycocalyx degradation induces endogenous heparinization in patients with severe injury and early traumatic coagulopathy

(2012) Sisse R. Ostrowski et al.   Journal of Trauma and Acute Care Surgery

Characterization of platelet dysfunction after trauma

(2012) Matthew E. Kutcher et al.   Journal of Trauma and Acute Care Surgery

Factor XIII and Tranexamic Acid But Not Recombinant Factor VIIa Attenuate Tissue Plasminogen Activator–Induced Hyperfibrinolysis in Human Whole Blood

(2011) Daniel Dirkmann et al.   ANESTHESIA AND ANALGESIA

The GNB3 C825T polymorphism influences platelet aggregation in human whole blood

(2011) Fabian Dusse et al.   Pharmacogenetics and Genomics

Platelet function following trauma

(2011) Cristina Solomon et al.   THROMBOSIS AND HAEMOSTASIS

TRANSFUSION PRACTICE: Thrombin generation in trauma patients

(2009) Nancy M. Dunbar et al.   TRANSFUSION

Acute Coagulopathy of Trauma: Hypoperfusion Induces Systemic Anticoagulation and Hyperfibrinolysis

(2009) Karim Brohi et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE