Strategies to reduce sample sizes in Alzheimer’s disease primary and secondary prevention trials using longitudinal amyloid PET imaging

Donanemab in Early Alzheimer’s Disease

(2021) Mark A. Mintun et al.   NEW ENGLAND JOURNAL OF MEDICINE

Comparison of amyloid PET measured in Centiloid units with neuropathological findings in Alzheimer’s disease

(2020) Sanka Amadoru et al.   Alzheimers Research & Therapy

Quantitative amyloid PET in Alzheimer's disease: the AMYPAD prognostic and natural history study

(2020) Isadora Lopes Alves et al.   Alzheimers & Dementia

Simulating the effect of cerebral blood flow changes on regional quantification of [18F]flutemetamol and [18F]florbetaben studies

(2020) Fiona Heeman et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Influence of apolipoprotein-E genotype on brain amyloid load and longitudinal trajectories

(2020) Brian J. .Lopresti et al.   NEUROBIOLOGY OF AGING

Defining a Centiloid scale threshold predicting long-term progression to dementia in patients attending the memory clinic: an [18F] flutemetamol amyloid PET study

(2020) Bernard J. Hanseeuw et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Multi-tracer model for staging cortical amyloid deposition using PET imaging

(2020) Lyduine E. Collij et al.   NEUROLOGY

Optimized dual-time-window protocols for quantitative [18F]flutemetamol and [18F]florbetaben PET studies

(2019) Fiona Heeman et al.   EJNMMI Research

Longitudinal evaluation of surrogates of regional cerebral blood flow computed from dynamic amyloid PET imaging

(2019) Murat Bilgel et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Multi-sensory Gamma Stimulation Ameliorates Alzheimer’s-Associated Pathology and Improves Cognition

(2019) Anthony J. Martorell et al.   CELL

BACE1 inhibitors: Current status and future directions in treating Alzheimer's disease

(2019) Nour M. Moussa‐Pacha et al.   MEDICINAL RESEARCH REVIEWS

Subthreshold amyloid and its biological and clinical meaning

(2019) Gérard N. Bischof et al.   NEUROLOGY

Prevalence of Biologically vs Clinically Defined Alzheimer Spectrum Entities Using the National Institute on Aging–Alzheimer’s Association Research Framework

(2019) Clifford R. Jack et al.   JAMA Neurology

Staging β-Amyloid Pathology With Amyloid Positron Emission Tomography

(2019) Niklas Mattsson et al.   JAMA Neurology

18F-FDG PET, the early phases and the delivery rate of 18F-AV45 PET as proxies of cerebral blood flow in Alzheimer's disease: Validation against 15O-H2O PET

(2019) Julie Ottoy et al.   Alzheimers & Dementia

Test–retest repeatability of [18F]Flortaucipir PET in Alzheimer’s disease and cognitively normal individuals

(2019) Tessa Timmers et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Spatial-Temporal Ordering of Amyloid Pathology and Opportunities for PET Imaging

(2019) Enrico Fantoni et al.   JOURNAL OF NUCLEAR MEDICINE

Monotonic Gaussian Process for spatio-temporal disease progression modeling in brain imaging data

(2019) Clément Abi Nader et al.   NEUROIMAGE

Rate of β-amyloid accumulation varies with baseline amyloid burden: Implications for anti-amyloid drug trials

(2018) Tengfei Guo et al.   Alzheimers & Dementia

Longitudinal brain imaging in preclinical Alzheimer disease: impact of APOE ε4 genotype

(2018) Shruti Mishra et al.   BRAIN

Randomized Trial of Verubecestat for Mild-to-Moderate Alzheimer’s Disease

(2018) Michael F. Egan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Trial of Solanezumab for Mild Dementia Due to Alzheimer’s Disease

(2018) Lawrence S. Honig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Utilizing the Centiloid scale in cross-sectional and longitudinal PiB PET studies

(2018) Yi Su et al.   NeuroImage-Clinical

Amyloid Load – a more sensitive biomarker for amyloid imaging

(2018) Alex Whittington et al.   JOURNAL OF NUCLEAR MEDICINE

Multisite study of the relationships between antemortem [11C]PIB-PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology

(2018) Renaud La Joie et al.   Alzheimers & Dementia

Assessing Amyloid Pathology in Cognitively Normal Subjects using [18F]Flutemetamol PET: Comparing Visual Reads and Quantitative Methods

(2018) Lyduine Collij et al.   JOURNAL OF NUCLEAR MEDICINE

Regional amyloid accumulation and cognitive decline in initially amyloid-negative adults

(2018) Michelle E. Farrell et al.   NEUROLOGY

Forward to the Past: The Case for Quantitative PET Imaging

(2017) Adriaan A. Lammertsma   JOURNAL OF NUCLEAR MEDICINE

APOE genotype and early β-amyloid accumulation in older adults without dementia

(2017) Yen Ying Lim et al.   NEUROLOGY

In vivo staging of regional amyloid deposition

(2017) Michel J. Grothe et al.   NEUROLOGY

Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity

(2017) Sebastian Palmqvist et al.   Nature Communications

Pittsburgh compound B imaging and cerebrospinal fluid amyloid-β in a multicentre European memory clinic study

(2016) Antoine Leuzy et al.   BRAIN

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers

(2016) Clifford R. Jack et al.   NEUROLOGY

Bapineuzumab for mild to moderate Alzheimer’s disease in two global, randomized, phase 3 trials

(2016) Rik Vandenberghe et al.   Alzheimers Research & Therapy

Is ApoE ɛ 4 a good biomarker for amyloid pathology in late onset Alzheimer’s disease?

(2016) Maowen Ba et al.   Translational Neurodegeneration

[ 18 F]flutemetamol amyloid positron emission tomography in preclinical and symptomatic Alzheimer's disease: Specific detection of advanced phases of amyloid-β pathology

(2015) Dietmar Rudolf Thal et al.   Alzheimers & Dementia

Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia

(2015) Willemijn J. Jansen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Quantification of [11C]PIB PET for Imaging Myelin in the Human Brain: A Test—Retest Reproducibility Study in High-Resolution Research Tomography

(2015) Mattia Veronese et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Improved Power for Characterizing Longitudinal Amyloid-  PET Changes and Evaluating Amyloid-Modifying Treatments with a Cerebral White Matter Reference Region

(2015) K. Chen et al.   JOURNAL OF NUCLEAR MEDICINE

Partial volume correction in quantitative amyloid imaging

(2015) Yi Su et al.   NEUROIMAGE

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

The A4 Study: Stopping AD Before Symptoms Begin?

(2014) R. A. Sperling et al.   Science Translational Medicine

Longitudinal Amyloid Imaging Using 11C-PiB: Methodologic Considerations

(2013) B. N. M. van Berckel et al.   JOURNAL OF NUCLEAR MEDICINE

Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study

(2013) Victor L Villemagne et al.   LANCET NEUROLOGY

Quantitative Analysis of PiB-PET with FreeSurfer ROIs

(2013) Yi Su et al.   PLoS One

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

(2012) Bradley T. Hyman et al.   Alzheimers & Dementia

Test-retest variability of quantitative [11C]PIB studies in Alzheimer’s disease

(2009) Nelleke Tolboom et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Consideration of Optimal Time Window for Pittsburgh Compound B PET Summed Uptake Measurements

(2009) R. L. McNamee et al.   JOURNAL OF NUCLEAR MEDICINE

Reducing between scanner differences in multi-center PET studies

(2009) Aniket Joshi et al.   NEUROIMAGE

Simplified parametric methods for [11C]PIB studies

(2008) Maqsood Yaqub et al.   NEUROIMAGE