Article
Rheumatology
Yuying Zhang, Zhifeng Chen, Yali Long, Bing Zhang, Qiao He, Kejing Tang, Xiangsong Zhang
Summary: F-18-FDG PET/CT is useful for assessing disease activity in patients with IIM-ILD. The combination of PET score, HRCT score, and anti-MDAS antibody can be used to identify patients at increased risk of RP-ILD and with poor prognoses.
CLINICAL RHEUMATOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lijuan Feng, Xu Yang, Xia Lu, Ying Kan, Chao Wang, Dehui Sun, Hui Zhang, Wei Wang, Jigang Yang
Summary: This study developed and validated a radiomics nomogram based on F-18-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for non-invasive prediction of bone marrow involvement (BMI) in pediatric neuroblastoma. The radiomics nomogram incorporated radiomics signature and independent clinical risk factors, and showed good predictive performance in predicting BMI.
INSIGHTS INTO IMAGING
(2022)
Article
Clinical Neurology
Antonio Canosa, Alessio Martino, Alessandro Giuliani, Cristina Moglia, Rosario Vasta, Maurizio Grassano, Francesca Palumbo, Sara Cabras, Francesca Di Pede, Filippo De Mattei, Enrico Matteoni, Giulia Polverari, Umberto Manera, Andrea Calvo, Marco Pagani, Adriano Chio
Summary: This study aimed to evaluate the ability of brain 2-[F-18]FDG-PET to reveal the metabolic features characterizing patients with pure bulbar or spinal motor impairment. The results showed that ALS patients with bulbar onset exhibited relative hypometabolism in the bilateral precentral gyrus, and the SVM classifier performed the best.
JOURNAL OF NEUROLOGY
(2023)
Article
Respiratory System
Hee-Young Yoon, Suk Hyun Lee, Sejin Ha, Jin-Sook Ryu, Jin Woo Song
Summary: The study found that F-18-FDG PET/CT may be useful in predicting postoperative AE in IPF patients, with SUVRTF being the best parameter for predicting postoperative AE in IPF patients.
BMC PULMONARY MEDICINE
(2021)
Article
Multidisciplinary Sciences
Ou Yamaguchi, Kyoichi Kaira, Ichiro Naruse, Yukihiro Umeda, Takeshi Honda, Satoshi Watanabe, Kosuke Ichikawa, Kazunari Tateishi, Norimitsu Kasahara, Tetsuya Higuchi, Kosuke Hashimoto, Shun Shinomiya, Yu Miura, Ayako Shiono, Atsuto Mouri, Hisao Imai, Kunihiko Iizuka, Tamotsu Ishizuka, Koichi Minato, Satoshi Suda, Hiroshi Kagamu, Keita Mori, Ichiei Kuji, Nobuhiko Seki
Summary: This study aimed to investigate the clinical relevance of F-18-FDG PET/CT compared to CT in predicting the response to PD-1 blockade in the early phase. The results showed that metabolic assessment by MTV or TLG was superior to morphological changes on CT for predicting the therapeutic response and survival.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Robert K. Doot, Anthony J. Young, Ilya M. Nasrallah, Reagan R. Wetherill, Andrew Siderowf, Robert H. Mach, Jacob G. Dubroff
Summary: Neuroinflammation is an important factor in neurodegenerative diseases and is mediated by microglia. This study used [F-18]NOS PET imaging to measure neuroinflammation in idiopathic Parkinson's disease patients and found increased oxidative stress as a marker of inflammation in early-stage disease.
Article
Biochemistry & Molecular Biology
Sebastien Bergeret, Cristina Birzu, Pierre Meneret, Alain Giron, Sophie Demeret, Clemence Marois, Louis Cousyn, Laura Rozenblum, Alice Laurenge, Agusti Alentorn, Vincent Navarro, Dimitri Psimaras, Aurelie Kas
Summary: This study retrospectively analyzed FDG PET results of patients diagnosed with autoimmune encephalitis (AE) between 2015 and 2020. The study found that 98% of patients showed abnormal PET results, displaying higher sensitivity compared to MRI (53%). The most frequent abnormalities were medial temporal lobe and/or striatum hypermetabolism, cortical hypometabolism, and cerebellum abnormalities. LGI1 AE showed more frequent medial temporal lobe hypermetabolism, while NMDAR AE showed widespread cortical hypometabolism. GAD AE showed fewer abnormalities. Striatum hypermetabolism was more frequent in patients treated for less than 1 month, suggesting a relation to disease activity.
Article
Radiology, Nuclear Medicine & Medical Imaging
Lijuan Feng, Xu Yang, Xia Lu, Ying Kan, Chao Wang, Hui Zhang, Wei Wang, Jigang Yang
Summary: This study developed and validated a radiomics nomogram based on 18F-FDG PET/CT for the diagnosis of bone marrow involvement in pediatric neuroblastoma. The nomogram showed good diagnostic performance and could improve the diagnostic accuracy without additional medical costs and radiation exposure.
ACADEMIC RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kun Guo, Jingjuan Wang, Bixiao Cui, Yihe Wang, Yaqin Hou, Guoguang Zhao, Jie Lu
Summary: The combination of [F-18]FDG PET/MRI and MEG in localizing the EZ in TLE patients showed higher concordance with surgical resection compared to PET/MRI or MEG alone. Lobar localization was clearly defined in majority of patients by [F-18]FDG PET/MRI/MEG. The results of PET/MRI/MEG in concordance with surgical outcome were found to be superior to PET/MRI or MEG alone.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gaetan Van Simaeys, Gilles Doumont, Coraline De Maeseneire, Nicolas Passon, Simon Lacroix, Cedric Lentz, Arnaud Horion, Corentin Warnier, David Torres, Corentin Martens, Irina Vierasu, Dominique Egrise, Serge Goldman
Summary: This preclinical study evaluated the changes in PSMA expression in CRPC tumors following standard treatment using [F-18]JK-PSMA-7 PET/CT. The results showed that PSMA expression decreased in tumor cells after successive ADT and chemotherapy, leading to a reduction in [F-18]JK-PSMA-7 PET uptake. Caution should be exercised when using PSMA-based imaging for therapy monitoring in CRPC patients.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stephan P. M. Souza, Fernanda C. Frasson, Maria Emilia S. Takahashi, Gislaine B. O. Duarte, Vania P. Castro, Fernando V. Pericole, Licio A. Velloso, Carmino A. De Souza, Irene Lorand-Metze, Allan O. Santos, Celso D. Ramos
Summary: The aim of this study was to compare [F-18]FDG and [Ga-68]Ga-PSMA-11 PET/CT image findings in patients with multiple myeloma (MM). The study found that both methods can detect most lesions, but half of the lesions can only be identified by one tracer, suggesting their possible complementary role in MM.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Benjamin Koa, Austin J. Borja, Mahmoud Aly, Sayuri Padmanabhan, Joseph Tran, Vincent Zhang, Chaitanya Rojulpote, Sheila K. Pierson, Mark-Avery Tamakloe, Johnson S. Khor, Thomas J. Werner, David C. Fajgenbaum, Abass Alavi, Mona-Elisabeth Revheim
Summary: Castleman disease is a rare hematologic condition involving lymphadenopathy and clinical abnormalities, classified into UCD and MCD; MCD is further divided based on etiological driver; FDG-PET/CT plays an important role in differential diagnosis and monitoring treatment responses.
INSIGHTS INTO IMAGING
(2021)
Article
Medicine, Research & Experimental
Marius E. Mayerhoefer, Markus Raderer, Wolfgang Lamm, Verena Pichler, Sarah Pfaff, Michael Weber, Barbara Kiesewetter, Markus Hacker, Lukas Kazianka, Philipp B. Staber, Hans-Juergen Wester, Johannes Rohrbeck, Ingrid Simonitsch-Klupp, Alexander Haug
Summary: In this prospective study, [Ga-68]Pentixafor-PET showed higher sensitivity and detection rates compared to [F-18]FDG-PET in patients with mantle cell lymphoma (MCL), indicating that it may be a potential alternative for imaging in these patients. The study also found that SUVs and TBRs were significantly higher for [Ga-68]Pentixafor-PET, with the most notable difference observed in mean TBRblood values.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sangwon Han, Yong-il Kim, Jungsu S. Oh, Seung Yeon Seo, Min-Jae Park, Geun Dong Lee, Sehoon Choi, Hyeong Ryul Kim, Yong-Hee Kim, Dong Kwan Kim, Seung-Il Park, Jin-Sook Ryu
Summary: The study evaluated the diagnostic and prognostic value of pretreatment 2-[F-18]FDG PET/CT in TETs patients. The results showed that SUVmax was excellent in distinguishing thymic carcinoma from other subtypes (low-risk thymoma, high-risk thymoma) and had significant prognostic value for predicting TC.
EUROPEAN RADIOLOGY
(2022)
Article
Veterinary Sciences
Dohee Lee, Taesik Yun, Yoonhoi Koo, Yeon Chae, Dongwoo Chang, Mhan-Pyo Yang, Byeong-Teck Kang, Hakhyun Kim
Summary: This is the first case report of using 18F-FDG PET/CT to diagnose suspected adrenal cortical carcinoma in a dog, providing valuable information for its diagnosis.
BMC VETERINARY RESEARCH
(2022)
Article
Respiratory System
Fatma Kort, Anoosha Habibi, Francois Lionnet, Marie-France Carette, Antoine Parrot, Laurent Savale, Hilario Nunes, Bernard Maitre, Frederic Schlemmer, Jean-Marc Naccache
Summary: Chronic interstitial lung abnormalities have been reported in patients with sickle cell disease, possibly due to a bronchiolar mechanism rather than more acute chest syndrome.
Article
Critical Care Medicine
Jean-Marc Naccache, Stephane Jouneau, Morgane Didier, Raphael Borie, Marine Cachanado, Arnaud Bourdin, Martine Reynaud-Gaubert, Philippe Bonniaud, Dominique Israel-Biet, Gregoire Prevot, Sandrine Hirschi, Francois Lebargy, Sylvain Marchand-Adam, Nathalie Bautin, Julie Traclet, Emmanuel Gomez, Sylvie Leroy, Frederic Gagnadoux, Frederic Riviere, Emmanuel Bergot, Anne Gondouin, Elodie Blanchard, Antoine Parrot, Francois-Xavier Blanc, Alexandre Chabrol, Stephane Dominique, Aude Gibelin, Abdellatif Tazi, Laurence Berard, Pierre Yves Brillet, Marie-Pierre Debray, Alexandra Rousseau, Mallorie Kerjouan, Olivia Freynet, Marie-Christine Dombret, Anne-Sophie Gamez, Ana Nieves, Guillaume Beltramo, Jean Pastre, Aurelie Le Borgne-Krams, Tristan Degot, Claire Launois, Laurent Plantier, Lidwine Wemeau-Stervinou, Jacques Cadranel, Cecile Chenivesse, Dominique Valeyre, Bruno Crestani, Vincent Cottin, Tabassome Simon, Hilario Nunes
Summary: The efficacy of cyclophosphamide in patients with acute exacerbation of idiopathic pulmonary fibrosis (IPF) is uncertain. The study suggests that adding cyclophosphamide to glucocorticoids increases the 3-month mortality rate in these patients.
LANCET RESPIRATORY MEDICINE
(2022)
Article
Medicine, Research & Experimental
Vincent Cottin, Sonia Gueguen, Hilario Nunes, Stephane Jouneau, Bruno Crestani, Philippe Bonniaud, Lidwine Wemeau, Dominique Israel-Biet, Martine Reynaud-Gaubert, Anne Gondouin, Jacques Cadranel, Sylvain Marchand-Adam, Marie Chevereau, Isabelle Dufaure-Gare, Serge Amselem, Annick Clement
Summary: This study in France on IPF patients using pirfenidone capsules and tablets showed good acceptability of the tablet formulation among patients, suggesting possible advantages over the capsules. The study highlighted no new adverse events and lower discontinuation rates in the tablet and substitution subgroups compared to the capsules-only subgroup.
ADVANCES IN THERAPY
(2022)
Article
Respiratory System
Nadia Nathan, Marie-Emeline Montagne, Odile Macchi, Paul-Andre Rosental, Simon Chauveau, Florence Jeny, Lucile Sese, Rola Abou Taam, Manon Brocvielle, Jacques Brouard, Mickael Catinon, Catherine Chapelon-Abric, Fleur Cohen-Aubart, Christophe Delacourt, Celine Delestrain, Antoine Deschildre, Antoine Dossier, Ralph Epaud, Julien Haroche, Veronique Houdouin, Dominique Israel-Biet, Karine Juvin, Sylvain Le Jeune, Francois Lionnet, Ulrich Meinzer, Marie Mittaine, Hilario Nunes, Sarah Mattioni, Jean-Marc Naccache, Marie-Helene Odievre, Michel Vincent, Annick Clement, Dominique Valeyre, Catherine Cavalin
Summary: The study found that pediatric sarcoidosis is associated with patients' indirect exposure to inorganic particles, their family members' occupations, and heating sources, especially factors like construction and metal dust which may increase the risk of the disease.
Article
Cardiac & Cardiovascular Systems
Marc A. Judson, Recai Yucel, Sara Preston, Edward S. Chen, Daniel A. Culver, Nabeel Hamzeh, Elyse E. Lower, Nadera J. Sweiss, Dominique Valeyre, Marcel Veltkamp, David E. Victorson, Jennifer L. Beaumont, Noopur Singh, Tricha Shivas, Rachel Vancavage, Robert P. Baughman
Summary: The study aimed to evaluate the predictive ability of different measures for outcomes of interest to sarcoidosis patients. Based on baseline measurements, most indicators were able to distinguish patients with different outcomes over the following 6 months. Among all the indicators, the patients' global assessment of their health status was the most accurate measurement.
RESPIRATORY MEDICINE
(2022)
Editorial Material
Respiratory System
V. Cottin, P. Bonniaud, J. Cadranel, S. Jouneau, S. Marchand-Adam, H. Nunes, L. Wemeau-Stervinou, B. Crestani
REVUE DES MALADIES RESPIRATOIRES
(2022)
Article
Respiratory System
V Cottin, P. Bonniaud, J. Cadranel, B. Crestani, S. Jouneau, S. Marchand-Adam, H. Nunes, L. Wemeau-Stervinou, E. Bergot, E. Blanchard, R. Borie, A. Bourdin, C. Chenivesse, A. Clement, E. Gomez, A. Gondouin, S. Hirschi, F. Lebargy, C-H Marquette, D. Montani, G. Prevot, S. Quetant, M. Reynaud-Gaubert, M. Salaun, O. Sanchez, B. Trumbic, K. Berkani, P-Y Brillet, M. Campana, L. Chalabreysse, G. Chatte, D. Debieuvre, G. Ferretti, J-M Fourrier, N. Just, M. Kambouchner, B. Legrand, F. Le Guillou, J-P Lhuillier, A. Mehdaoui, J-M Naccache, C. Paganon, M. Remy-Jardin, S. Si-Mohamed, P. Terrioux
Summary: This article presents the revision and content of the treatment guidelines for idiopathic pulmonary fibrosis in France, which were developed based on the clinical practice guidelines framework of the French health authority and the collaboration of multiple professional teams.
REVUE DES MALADIES RESPIRATOIRES
(2022)
Article
Surgery
Amelie Riviere, Clement Picard, Cristina Berastegui, Victor Manuel Mora, Vincent Bunel, Laurent Godinas, Elena Salvaterra, Valeria Rossetti, Laurent Savale, Dominique Israel-Biet, Xavier Demant, Julien Bermudez, Federica Meloni, Peter Jaksch, Jesper Magnusson, Laurence Beaumont, Michael Perch, Jean-Francois Mornex, Christiane Knoop, John-David Aubert, Baptiste Hervier, Hilario Nunes, Marc Humbert, Jens Gottlieb, Yurdagul Uzunhan, Jerome Le Pavec
Summary: This study aimed to evaluate the survival rate and prognostic factors in lung transplant recipients with interstitial lung disease complicating idiopathic inflammatory myopathy (IIM-ILD). The study found that the post-transplant survival rate in IIM-ILD was similar to that in international all-cause transplantation registries and worse in patients with classical IIM. Muscle involvement was identified as the main factor associated with worse survival.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Dana Radu, Olivia Freynet, Marianne Kambouchner, Marouane Boubaya, Hilario Nunes, Yurdagul Uzunhan, Pierre-Yves Brillet, Patrice Guiraudet, Mohammad Zaahid Noorah, Dominique Israel-Biet, Francoise Le Pimpec-Barthes, Karine Juvin, Anne Charpentier, Laure Gibault, Jalal Assouad, Jean-Marc Naccache, Martine Antoine, Sebastian Tavolaro, Marco Alifano, Isabelle Honore, Jean Pierre L'Huillier, Denis Debrosse, Clairelyne Dupin, Pauline Pradere, Marie-Pierre Debray, Aurelie Cazes, Pierre Mordant, Yves Castier, Sadek Beloucif, Bruno Crestani, Vincent Levy, Emmanuel Martinod, Dominique Valeyre
Summary: This study prospectively assessed the yield of diagnosis and safety of video-assisted thoracoscopic surgical lung biopsy (VATS-LB) for ILD diagnosis in 103 patients. The results showed that VATS-LB dramatically changed preoperative hypothetical diagnoses and treatment in ILD of unknown cause.
ANNALS OF THORACIC SURGERY
(2022)
Article
Rheumatology
Paul Breillat, Kuberaka Mariampillai, Paul Legendre, Pauline Martins, Bertrand Dunogue, Jean Luc Charuel, Makoto Miyara, Claire Goulvestre, Romain Paule, Helene Vanquaethem, Felix Ackermann, Olivier Benveniste, Hilario Nunes, Luc Mouthon, Yves Allenbach, Yurdagul Uzunhan
Summary: This study identified three distinct clinical phenotypes and outcomes among patients with anti-PM-Scl-scleroderma antibodies positive autoimmune diseases. Skin thickening and non-specific interstitial pneumonia were crucial predictors in differentiating these subgroups.
Article
Respiratory System
Alan K. Y. Teoh, Anne E. Holland, Julie Morisset, Kevin R. Flaherty, Athol U. Wells, Simon L. F. Walsh, Ian Glaspole, Wim A. Wuyts, Tamera J. Corte
Summary: This study achieved consensus among international ILD experts on the essential and desirable features of an ILD MDM through the use of a Delphi methodology. The findings provide important data for potential collaborative research on the standardization of ILD MDMs in the future.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hila Tal Tamir, Dana Stav, Yitzhac Hadad, Rivka Kessner
Summary: This study aimed to characterize thyroid nodules seen on Spectral Detector computed tomography (SDCT) and compare them with their Thyroid Imaging Reporting and Data System (TI-RADS) category on Ultrasound (US). The results showed that the spectral results of SDCT can assist in differentiating thyroid nodules of different risk levels.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Volha Nizhnikava, Ursula Reiter, Gabor Kovacs, Clemens Reiter, Corina Kraeuter, Horst Olschewski, Michael Fuchsjaeger, Gert Reiter
Summary: The purpose of this study was to investigate the associations between cardiac magnetic resonance feature-tracking-derived myocardial strain parameters and volumetric function and hemodynamic parameters in patients with pulmonary hypertension. The results showed that impairment of myocardial strains was more strongly associated with alterations in ventricular function parameters than elevated pulmonary arterial pressure, limiting the diagnostic information of myocardial strain parameters in pulmonary hypertension.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu-ling Qian, Rui-lin Quan, Xiao-xi Chen, Yang-yi Lin, Xiao-li Jing, Qing Gu, Chang-ming Xiong, Jian-guo He, Ai-hua Zhi
Summary: The purpose of this study was to investigate the imaging characteristics and prognostic factors for the long-term survival of Behcet's disease (BD) with arterial involvement. The results showed that arterial lesions associated with BD usually involve multiple arteries and manifest differently in different types of arteries. Cardiac involvement and pulmonary artery aneurysm/dilation were independent prognostic factors for the survival of BD patients with arterial involvement.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Yong Xie, Jian Wang, Yinghua Zou
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daria Kifjak, Maximilian Hochmair, Daniel Sobotka, Alexander R. Haug, Raphael Ambros, Florian Prayer, Benedikt H. Heidinger, Sebastian Roehrich, Ruxandra-Iulia Milos, Wolfgang Wadsak, Thorsten Fuereder, Dagmar Krenbek, Andreas Fazekas, Michael Meilinger, Marius E. Mayerhoefer, Georg Langs, Christian Herold, Helmut Prosch, Lucian Beer
Summary: The ability of pretreatment PET parameters and peripheral blood biomarkers to predict PFS and OS in NSCLC patients treated with ICIT was assessed. The study found that MTV and the number of SOI were independent risk factors for progression and overall survival, and the combination of these factors improved risk stratification.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Theresa Sophie Patzer, Jan-Peter Grunz, Henner Huflage, Jan-Lucca Hennes, Pauline Pannenbecker, Philipp Gruschwitz, Saif Afat, Judith Herrmann, Thorsten Alexander Bley, Andreas Steven Kunz
Summary: This study investigated the potential of tin prefiltration and virtual monoenergetic imaging (VMI) in suppressing metal artifacts in high-resolution CT images of the lower extremities. The results showed that VMI reconstructions had better artifact reduction compared to T3D. VMI110keV had the least image noise. In terms of image quality, interpretability of bone-metal interface, and overall image quality, VMI110keV performed the best.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yue Li, Huan Zhang, Lei Yue, Caixia Fu, Robert Grimm, Wenhua Li, Weijian Guo, Tong Tong
Summary: This study evaluated and compared the diagnostic value of diffusion-related texture analysis parameters from different magnetic resonance diffusion models in predicting the clinical response to chemotherapy in patients with colorectal liver metastases. Among the models, DKI-derived parameters showed the best performance for early prediction, followed by IVIM-derived parameters and DWI baseline features.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lu Wang, ShiXiong Zhang, Jun Xin
Summary: This study aimed to determine if sex differences in abdominal visceral fat composition and metabolism can help predict the prognosis of DLBCL patients. The results showed that females with certain fat composition and metabolism characteristics had worse progression-free survival, while no significant differences were found in males with DLBCL.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu-ping Wu, Lan Wu, Jing Ou, Jin-ming Cao, Mao-yong Fu, Tian-wu Chen, Erika Ouchi, Jiani Hu
Summary: This study aimed to develop CT radiomics models to preoperatively identify lymph node (LN) status in resectable esophageal squamous cell carcinoma (ESCC) patients. The results showed that the combined model, integrating ESCC and LN radiomics features with clinical features, had the highest predictive ability among the three models. The combined model's predictive ability was validated in both the test and external validation cohorts.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
