Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal/melanosomal TPC2
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal/melanosomal TPC2
Authors
Keywords
-
Journal
Scientific Reports
Volume 11, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-04-19
DOI
10.1038/s41598-021-88196-6
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Cancer statistics, 2020
- (2020) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function
- (2020) Susanne Gerndt et al. eLife
- Cost-of-illness of melanoma in Europe - a modelling approach
- (2019) M. Krensel et al. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
- TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKβ/VPS34 pathway
- (2019) A. Scotto Rosato et al. Nature Communications
- Flavonoids in Cancer and Apoptosis
- (2018) Mariam Abotaleb et al. Cancers
- Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes
- (2017) Cheng-Chang Chen et al. Nature Protocols
- TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms
- (2017) Yu-Kai Chao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Naringenin Impairs Two-Pore Channel 2 Activity And Inhibits VEGF-Induced Angiogenesis
- (2017) Irene Pafumi et al. Scientific Reports
- TPC2 controls pigmentation by regulating melanosome pH and size
- (2016) Andrea L. Ambrosio et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A melanosomal two-pore sodium channel regulates pigmentation
- (2016) Nicholas W. Bellono et al. Scientific Reports
- Calcium signals regulated by NAADP and two-pore channels - their role in development, differentiation and cancer
- (2015) John Parrington et al. INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
- Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation
- (2015) Wuyang Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells
- (2015) Diego Ploper et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment
- (2015) Yasuteru Sakurai et al. SCIENCE
- Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure
- (2015) S. Premi et al. SCIENCE
- Increased risk of developing cutaneous malignant melanoma is associated with variation in pigmentation genes and VDR, and may involve epistatic effects
- (2014) Agnieszka Kosiniak-Kamysz et al. MELANOMA RESEARCH
- TPC1 Has Two Variant Isoforms, and Their Removal Has Different Effects on Endo-Lysosomal Functions Compared to Loss of TPC2
- (2014) M. Ruas et al. MOLECULAR AND CELLULAR BIOLOGY
- VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling
- (2014) A. Favia et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- High susceptibility to fatty liver disease in two-pore channel 2-deficient mice
- (2014) Christian Grimm et al. Nature Communications
- Anti-cancer potential of flavonoids: recent trends and future perspectives
- (2013) Priya Batra et al. 3 Biotech
- 4-n-butylresorcinol, a highly effective tyrosinase inhibitor for the topical treatment of hyperpigmentation
- (2012) L. Kolbe et al. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
- Inhibition of Human Melanoma Cell Growth by the Dietary Flavonoid Fisetin Is Associated with Disruption of Wnt/β-Catenin Signaling and Decreased Mitf Levels
- (2011) Deeba N. Syed et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma
- (2011) Satoru Yokoyama et al. NATURE
- Flavonoids from the Heartwood of the Thai Medicinal PlantDalbergia parvifloraand Their Effects on Estrogenic-Responsive Human Breast Cancer Cells
- (2009) Kaoru Umehara et al. JOURNAL OF NATURAL PRODUCTS
- p-Coumaric acid, a constituent ofSasa quelpaertensisNakai, inhibits cellular melanogenesis stimulated by -melanocyte stimulating hormone
- (2008) S.M. An et al. BRITISH JOURNAL OF DERMATOLOGY
- Melanoma Genetics and Therapeutic Approaches in the 21st Century: Moving from the Benchside to the Bedside
- (2008) Thomas L. Hocker et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Two newly identified genetic determinants of pigmentation in Europeans
- (2008) Patrick Sulem et al. NATURE GENETICS
- Estrogenic constituents of the heartwood of Dalbergia parviflora
- (2007) Kaoru Umehara et al. PHYTOCHEMISTRY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started