Article
Nutrition & Dietetics
Gyu Seok Oh, Ju-Hak Lee, Kyunghee Byun, Dong-Il Kim, Ki Deok Park
Summary: The study confirmed that combining resistance exercise with leucine-rich protein supplements is more effective in preventing sarcopenia in the elderly than just performing resistance exercise alone.
Article
Nutrition & Dietetics
Anja M. Sedlmeier, Sebastian E. Baumeister, Andrea Weber, Beate Fischer, Barbara Thorand, Till Ittermann, Marcus Doerr, Stephan B. Felix, Henry Voelzke, Annette Peters, Michael F. Leitzmann
Summary: The study indicates that fat mass and fat-free mass show opposing associations with mortality risk. Excess fat mass is related to increased mortality risk, while fat-free mass is protective against mortality risk.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Endocrinology & Metabolism
Reshma Aziz Merchant, Santhosh Seetharaman, Lydia Au, Michael Wai Kit Wong, Beatrix Ling Ling Wong, Li Feng Tan, Matthew Zhixuan Chen, Shu Ee Ng, John Tshon Yit Soong, Richard Jor Yeong Hui, Sing Cheer Kwek, John E. Morley
Summary: This study found that higher FFMI and lower FM/FFM in the high BMI group were associated with better functional outcomes. The prevalence of low muscle mass was higher in the normal BMI group. Females had significantly higher FMI and FM/FFM, while males had significantly higher FFMI. Additionally, the highest FFMI tertile group had better physical function and lower prevalence of sarcopenic obesity and sarcopenia.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Surgery
Ali N. Gunesch, Thomas L. Sutton, Stephanie M. Krasnow, Christopher R. Deig, Brett C. Sheppard, Daniel L. Marks, Aaron J. Grossberg
Summary: This study validated an automated method for measuring muscle cross-sectional area in patients with pancreatic adenocarcinoma. The results showed a high correlation between the automated method and manual measurement, supporting the potential use of high-throughput sarcopenia analysis with abdominal CT scans for both clinical and research purposes.
AMERICAN JOURNAL OF SURGERY
(2022)
Article
Geriatrics & Gerontology
Jia-Xing Zhang, Juan Li, Chen Chen, Ting Yin, Qing-An Wang, Xiao-Xia Li, Fa-Xuan Wang, Jian-Hua Zhao, Yi Zhao, Yu-Hong Zhang
Summary: This study established reference values for skeletal muscle mass index, fat mass index, and fat-to-muscle ratio for healthy rural adults in western China. Results showed that men had higher skeletal muscle mass but lower fat mass and fat-to-muscle ratio than women, and there were age-related differences in body composition between men and women.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2021)
Article
Multidisciplinary Sciences
Shou-En Wu, Wei-Liang Chen
Summary: The study found that transitioning towards low muscle mass (states 3 and 4) leads to deterioration in metabolic indices, resulting in increased risks of metabolic syndrome, hypertension, and type II diabetes mellitus. On the other hand, transitioning from low muscle mass to normal state (state 2) decreases the risks of these diseases.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Multidisciplinary Sciences
Agustin Curiel-Regueros, Luca Paolo Ardigo, Alvaro Bustamante-Sanchez, Jose Francisco Tornero-Aguilera, Juan Pedro Fuentes-Garcia, Vicente Javier Clemente-Suarez
Summary: The purpose of this study was to analyze body composition symmetry in upper and lower body segments of aircraft pilots. The results showed that there is a tendency for imbalance in the upper and lower body segments of pilots, which could have detrimental effects on their flight maneuvers. It is recommended to design specific training protocols to improve this imbalance.
Review
Oncology
Lorenzo Bernardi, Raffaello Roesel, Filippo Vagelli, Pietro Majno-Hurst, Alessandra Cristaudi
Summary: Body composition profiling is gaining attention as a predictor for outcomes of patients undergoing liver surgery for oncologic indications, with current evidence focusing on CT-scans and the impact of factors such as sarcopenia on surgical outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Nutrition & Dietetics
Carla Manuela Crispim Nascimento, Juliana de Fatima Zacarin Cardoso, Isabela Thais Machado de Jesus, Fabiana de Souza Orlandi, Leticia Pimenta Costa-Guarisco, Grace Angelica de Oliveira Gomes, Ariene Angelini Dos Santos Orlandi, Fernando Augusto Vasilceac, Sofia Cristina Iost Pavarini, Karina Gramani-Say, Paula Costa Castro, Aline Cristina Martins Gratao, Marisa Silvana Zazzetta, Marcia Regina Cominetti, Henrique Pott-Junior
Summary: The study found that relative fat mass index is independently associated with sarcopenia, while loss of strength is associated with female sex, lower physical activity, worse nutrition and IL-10/TNF-a ratio. Female sex, insufficiently active lifestyle, and relative fat mass index are identified as key determinants of sarcopenia.
CLINICAL NUTRITION
(2021)
Editorial Material
Oncology
Mariam T. Nawas, Michael Scordo
Summary: Obesity and its associated pathophysiological changes are known to promote cancer development and affect anti-tumor immune responses, but little is known about their impact on outcomes after cellular immunotherapy. In this study, Rejeski and colleagues found that intrinsic host factors, including body composition and nutritional status, may predict response after chimeric antigen receptor T-cell therapy in patients with relapsed lymphomas. These findings highlight the clinical significance of these factors on treatment outcomes and may encourage further research on prehabilitation and nutritional optimization in these patients.
CANCER IMMUNOLOGY RESEARCH
(2023)
Article
Medicine, General & Internal
Hye-Ji An, Young-Gyun Seo
Summary: This study analyzed the impact of vitamin D levels and calcium intake on fat-free mass in adults, finding that high levels of VitD and Ca were associated with higher FFM.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Nutrition & Dietetics
Stefano Sbrignadello, Christian Goebl, Andrea Tura
Summary: Sarcopenia is a severe complication in type 2 diabetes, and nutritional aspects play a role in its development. Bioelectrical impedance analysis is an effective and cost-efficient method to assess body composition in T2DM patients with sarcopenia or at risk. However, more validation studies are needed in this specific population.
Article
Endocrinology & Metabolism
Lina Sun, Junling Fu, Zhijing Mu, Xiaoye Duan, Piu Chan, Shuangling Xiu
Summary: This study investigated the association between body fat (BF%) and sarcopenia in older adults with type 2 diabetes mellitus (T2DM), as well as the potential link with increased levels of inflammatory indicators and insulin resistance. The results showed that higher BF% was associated with an increased risk of sarcopenia in older adults with T2DM, highlighting the importance of assessing BF% in the management of sarcopenia.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Yi-Zhong Ge, Guo-Tian Ruan, Qi Zhang, Wen-Jun Dong, Xi Zhang, Meng-Meng Song, Xiao-Wei Zhang, Xiang-Rui Li, Kang-Ping Zhang, Meng Tang, Wei Li, Xian Shen, Han-Ping Shi
Summary: This study evaluated the relationship between body water and the prognosis of cancer patients with sarcopenia. The results showed that the ECW/TBW indicator had the best predictive accuracy for survival, and the combination of high ECW/TBW and high NLR further increased the risk of mortality.
NUTRITION & METABOLISM
(2022)
Article
Medicine, General & Internal
Shuai Liu, Yuru Yang, Jingye Song, Limin Ma, Yundan Wang, Qin Mei, Weijie Jiang
Summary: This study evaluated the predictive value of hydration of fat-free mass (FFM) on all-cause mortality in hemodialysis (HD) patients. The results showed that the TBW/FFM ratio was significantly associated with extracellular water (ECW)/TBW, phase angle (PhA), and sex. The TBW/FFM had better predictive potential compared to other parameters.
Review
Clinical Neurology
Francesca Di Giuliano, Eliseo Picchi, Massimo Muto, Antonello Calcagni, Valentina Ferrazzoli, Valerio Da Ros, Silvia Minosse, Agostino Chiaravalloti, Francesco Garaci, Roberto Floris, Mario Muto
Letter
Clinical Neurology
Mario Francesco Fraioli, Gianluca Scalia, Francesco Giuseppe Garaci, Chiara Fraioli, Pierpaolo Lunardi, Giuseppe Emmanuele Umana
WORLD NEUROSURGERY
(2020)
Review
Immunology
Harald Hampel, Filippo Caraci, A. Claudio Cuello, Giuseppe Caruso, Robert Nistico, Massimo Corbo, Filippo Baldacci, Nicola Toschi, Francesco Garaci, Patrizia A. Chiesa, Steven R. Verdooner, Leyla Akman-Anderson, Felix Hernandez, Jesus avila, Enzo Emanuele, Pedro L. Valenzuela, Alejandro Lucia, Mark Watling, Bruno P. Imbimbo, Andrea Vergallo, Simone Lista
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Hematology
Carmelo Gurnari, Massimo Breccia, Francesca Di Giuliano, Emilia Scalzulli, Mariadomenica Divona, Alfonso Piciocchi, Laura Cicconi, Eleonora De Bellis, Adriano Venditti, Maria Ilaria Del Principe, William Arcese, Francesco Lo-Coco, Francesco Garaci, Maria Teresa Voso
Summary: Patients with acute promyelocytic leukaemia (APL) who experience intracranial haemorrhage (ICH) are typically older and more likely to have high-risk APL. Positivity for the 'swirl' sign and hydrocephalus on neuroradiological imaging are predictors of a fatal outcome.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Armando Ugo Cavallo, Jacopo Troisi, Marco Forcina, Pier-Valerio Mari, Valerio Forte, Massimiliano Sperandio, Sergio Pagano, Pierpaolo Cavallo, Roberto Floris, Francesco Garaci
Summary: This study aimed to evaluate the diagnostic performance of texture analysis and machine learning models for Covid-19 interstitial pneumonia in Chest X-ray images. By ensembling six different models, it was found that the Covid-19 Ensemble Machine Learning Score showed high accuracy and sensitivity in diagnosing Covid-19 pneumonia.
CURRENT MEDICAL IMAGING
(2021)
Review
Biochemistry & Molecular Biology
Francesca Marciano, Giorgia Venutolo, Carminia Marina Ingenito, Antonella Verbeni, Concetta Terracciano, Elizabeth Plunk, Francesco Garaci, Armando Cavallo, Alessio Fasano
Summary: Autistic Spectrum Disorder (ASD) is a neurodevelopmental condition that affects approximately 1 in 70 children worldwide, characterized by cognitive delay, repetitive behaviors, and deficits in communication and social interaction. Artificial intelligence (AI) has been increasingly used to study ASD, aiming to improve diagnostic processes and early access to therapies. Machine learning (ML) approaches have shown promise in analyzing various aspects of ASD research, suggesting potential for enhancing screening, diagnostic, and therapeutic tools in the future.
CURRENT MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Susana Lopez-Ortiz, Jose Pinto-Fraga, Pedro L. Valenzuela, Juan Martin-Hernandez, Maria M. Seisdedos, Oscar Garcia-Lopez, Nicola Toschi, Francesca Di Giuliano, Francesco Garaci, Nicola Biagio Mercuri, Robert Nistico, Enzo Emanuele, Simone Lista, Alejandro Lucia, Alejandro Santos-Lozano
Summary: Regular physical exercise plays a protective role against Alzheimer's disease by inhibiting crucial pathophysiological molecular pathways related to the disease. Advanced neuroimaging technologies have become increasingly important in exploring the link between AD and physical exercise.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Silvia Minosse, Eliseo Picchi, Francesca Di Giuliano, Loredana Sarmati, Elisabetta Teti, Chiara Adriana Pistolese, Simona Lanzafame, Francesco Di Cio, Maria Guerrisi, Massimo Andreoni, Roberto Floris, Nicola Toschi, Francesco Garaci
Summary: Our study using rs-fMRI combined with advanced graph theoretical analysis and disruption indices revealed profound reorganization of brain function in HIV patients compared to healthy controls. The disruption index showed significant negative association with relative CD4 values, and a positive significant association between plasmatic HIV-RNA and local graph-theoretical metrics. Additionally, differential distribution of HIV clinical biomarkers and brain metrics was observed across different cART duration groups.
JOURNAL OF NEUROIMAGING
(2021)
Review
Cell Biology
Harald Hampel, Robert Nistico, Nicholas T. Seyfried, Allan I. Levey, Erica Modeste, Pablo Lemercier, Filippo Baldacci, Nicola Toschi, Francesco Garaci, George Perry, Enzo Emanuele, Pedro L. Valenzuela, Alejandro Lucia, Andrea Urbani, Giulia M. Sancesario, Mark Mapstone, Massimo Corbo, Andrea Vergallo, Simone Lista
Summary: Alzheimer's disease is characterized by complex pathophysiology with high heterogeneity, requiring a holistic approach to fully capture its multifaceted nature. Integrating omics sciences and systems biology network approaches can help detect and describe the biological changes occurring in the progression of AD.
AGEING RESEARCH REVIEWS
(2021)
Article
Cardiac & Cardiovascular Systems
Vincenzo De Stasio, Armando U. Cavallo, Luigi Spiritigliozzi, Luca Pugliese, Matteo Presicce, Carlo Di Donna, Federica Di Tosto, Monia Pasqualetto, Francesca D'Errico, Leonardo Benelli, Francesco P. Sbordone, Francesco Grimaldi, Cecilia Cerimele, Gianluca Vanni, Francesco Romeo, Roberto Floris, Francesco Garaci, Marcello Chiocchi
Summary: Pre-TAVI assessment of the angle between the membranous septum and the aortic annulus (SVA) may predict the onset of major arrhythmias requiring permanent pacemaker implantation, with high sensitivity (94%) and negative predictive value (96%).
JOURNAL OF CARDIOVASCULAR MEDICINE
(2021)
Review
Clinical Neurology
Eliseo Picchi, Valentina Ferrazzoli, Giulia Pizzicannella, Noemi Pucci, Francesca Pitocchi, Fabrizio Valente, Silvia Minosse, Francesca Izzi, Tommaso Schirinzi, Chiara Bonomi, Chiara Aiello, Roberto Floris, Francesco Garaci, Francesca Di Giuliano
Summary: Leukoencephalopathy with cerebral calcifications and cysts (LCC) is a neurological disorder characterized by white matter abnormalities, intracranial calcifications, and variable cystic lesions resulting from diffuse cerebral microangiopathy. Clinical manifestations include focal neurological deficits and seizures, severity depends on cyst size and location. Diffuse microangiopathy is a common histopathological finding, associated with pathogenic mutations in SNORD118 gene causing Labrune syndrome.
NEUROLOGICAL SCIENCES
(2021)
Article
Biophysics
Silvia Minosse, Francesco Garaci, Federica Martino, Roberta Di Mauro, Milena Melis, Francesca Di Giuliano, Eliseo Picchi, Maria Guerrisi, Roberto Floris, Stefano Di Girolamo, Nicola Toschi
Summary: Recent study used rs-fMRI, graph-theoretical analysis, and a functional disruption index to investigate whole-brain functional changes in patients with sudden sensorineural hearing loss (SSNHL). The findings demonstrated a brain-wide functional network reorganization in SSNHL patients, which correlated with clinical impairment.
NMR IN BIOMEDICINE
(2021)
Article
Sport Sciences
Giuseppe Coratella, Francesco Campa, Catarina N. Matias, Stefania Toselli, Josely C. Koury, Angela Andreoli, Lui-s B. Sardinha, Analiza M. Silva
Summary: The study aimed to validate the predictive equations for total body water and extracellular water in male and female athletes, finding that athlete-specific equations were more accurate than generalized equations. Most of the generalized predictive equations underestimated body fluid volumes, while the athlete-specific equations were more accurate.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2021)
Article
Biology
Francesco Campa, Diana Maria Thomas, Krista Watts, Nicholas Clark, Daniel Baller, Thomas Morin, Stefania Toselli, Josely Correa Koury, Giovanni Melchiorri, Angela Andreoli, Gabriele Mascherini, Cristian Petri, Luis Bettencourt Sardinha, Analiza Monica Silva
Summary: This study provides percentiles for phase angle in male and female athletes practicing different sports, which can track body composition and performance-related parameters in athletes.
Review
Radiology, Nuclear Medicine & Medical Imaging
Valerio Da Ros, Eliseo Picchi, Valentina Ferrazzoli, Tommaso Schirinzi, Federico Sabuzi, Piergiorgio Grillo, Massimo Muto, Francesco Garaci, Mario Muto, Francesca Di Giuliano
Summary: This article provides a comprehensive review on the radiological features of the most common vascular myelopathies, emphasizing the importance of understanding vascular spinal anatomy and the clinical aspects of different etiologies in promptly addressing diagnosis and radiological assessment.
EUROPEAN JOURNAL OF RADIOLOGY OPEN
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hila Tal Tamir, Dana Stav, Yitzhac Hadad, Rivka Kessner
Summary: This study aimed to characterize thyroid nodules seen on Spectral Detector computed tomography (SDCT) and compare them with their Thyroid Imaging Reporting and Data System (TI-RADS) category on Ultrasound (US). The results showed that the spectral results of SDCT can assist in differentiating thyroid nodules of different risk levels.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Volha Nizhnikava, Ursula Reiter, Gabor Kovacs, Clemens Reiter, Corina Kraeuter, Horst Olschewski, Michael Fuchsjaeger, Gert Reiter
Summary: The purpose of this study was to investigate the associations between cardiac magnetic resonance feature-tracking-derived myocardial strain parameters and volumetric function and hemodynamic parameters in patients with pulmonary hypertension. The results showed that impairment of myocardial strains was more strongly associated with alterations in ventricular function parameters than elevated pulmonary arterial pressure, limiting the diagnostic information of myocardial strain parameters in pulmonary hypertension.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu-ling Qian, Rui-lin Quan, Xiao-xi Chen, Yang-yi Lin, Xiao-li Jing, Qing Gu, Chang-ming Xiong, Jian-guo He, Ai-hua Zhi
Summary: The purpose of this study was to investigate the imaging characteristics and prognostic factors for the long-term survival of Behcet's disease (BD) with arterial involvement. The results showed that arterial lesions associated with BD usually involve multiple arteries and manifest differently in different types of arteries. Cardiac involvement and pulmonary artery aneurysm/dilation were independent prognostic factors for the survival of BD patients with arterial involvement.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Yong Xie, Jian Wang, Yinghua Zou
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daria Kifjak, Maximilian Hochmair, Daniel Sobotka, Alexander R. Haug, Raphael Ambros, Florian Prayer, Benedikt H. Heidinger, Sebastian Roehrich, Ruxandra-Iulia Milos, Wolfgang Wadsak, Thorsten Fuereder, Dagmar Krenbek, Andreas Fazekas, Michael Meilinger, Marius E. Mayerhoefer, Georg Langs, Christian Herold, Helmut Prosch, Lucian Beer
Summary: The ability of pretreatment PET parameters and peripheral blood biomarkers to predict PFS and OS in NSCLC patients treated with ICIT was assessed. The study found that MTV and the number of SOI were independent risk factors for progression and overall survival, and the combination of these factors improved risk stratification.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Theresa Sophie Patzer, Jan-Peter Grunz, Henner Huflage, Jan-Lucca Hennes, Pauline Pannenbecker, Philipp Gruschwitz, Saif Afat, Judith Herrmann, Thorsten Alexander Bley, Andreas Steven Kunz
Summary: This study investigated the potential of tin prefiltration and virtual monoenergetic imaging (VMI) in suppressing metal artifacts in high-resolution CT images of the lower extremities. The results showed that VMI reconstructions had better artifact reduction compared to T3D. VMI110keV had the least image noise. In terms of image quality, interpretability of bone-metal interface, and overall image quality, VMI110keV performed the best.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yue Li, Huan Zhang, Lei Yue, Caixia Fu, Robert Grimm, Wenhua Li, Weijian Guo, Tong Tong
Summary: This study evaluated and compared the diagnostic value of diffusion-related texture analysis parameters from different magnetic resonance diffusion models in predicting the clinical response to chemotherapy in patients with colorectal liver metastases. Among the models, DKI-derived parameters showed the best performance for early prediction, followed by IVIM-derived parameters and DWI baseline features.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lu Wang, ShiXiong Zhang, Jun Xin
Summary: This study aimed to determine if sex differences in abdominal visceral fat composition and metabolism can help predict the prognosis of DLBCL patients. The results showed that females with certain fat composition and metabolism characteristics had worse progression-free survival, while no significant differences were found in males with DLBCL.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu-ping Wu, Lan Wu, Jing Ou, Jin-ming Cao, Mao-yong Fu, Tian-wu Chen, Erika Ouchi, Jiani Hu
Summary: This study aimed to develop CT radiomics models to preoperatively identify lymph node (LN) status in resectable esophageal squamous cell carcinoma (ESCC) patients. The results showed that the combined model, integrating ESCC and LN radiomics features with clinical features, had the highest predictive ability among the three models. The combined model's predictive ability was validated in both the test and external validation cohorts.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
