The design of fluoroquinolone-based cholinesterase inhibitors: Synthesis, biological evaluation and in silico docking studies

The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease

(2018) V. Hepnarova et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pyrazole-based potent inhibitors of GGT1: Synthesis, biological evaluation, and molecular docking studies

(2016) Muhammad Mansha et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The first total synthesis of potent antitumoral (±)-mafaicheenamine A, unnatural 6-fluoromafaicheenamine A and expedient synthesis of clausine E

(2016) Yasir Abbas et al.   RSC Advances

Synthesis of quinoline-3-carboxylates by a Rh(II)-catalyzed cyclopropanation-ring expansion reaction of indoles with halodiazoacetates

(2015) Magnus Mortén et al.   Beilstein Journal of Organic Chemistry

Finding the perfect spot for fluorine: Improving potency up to 40-fold during a rational fluorine scan of a Bruton’s Tyrosine Kinase (BTK) inhibitor scaffold

(2015) Yan Lou et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Origins of the Quinolone Class of Antibacterials: An Expanded “Discovery Story”

(2015) Gregory S. Bisacchi   JOURNAL OF MEDICINAL CHEMISTRY

Applications of Fluorine in Medicinal Chemistry

(2015) Eric P. Gillis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice

(2015) Meaghan Morris et al.   NATURE NEUROSCIENCE

Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors

(2014) Xiaoyi Deng et al.   JOURNAL OF MEDICINAL CHEMISTRY

4-Quinolone Alkaloids from Melochia odorata

(2014) Raquel C. Jadulco et al.   JOURNAL OF NATURAL PRODUCTS

Design and Synthesis of New Dual Binding Site Cholinesterase Inhibitors: in vitro Inhibition Studies with in silico Docking

(2014) Muhammad Yar et al.   Letters in Drug Design & Discovery

The global prevalence of dementia: A systematic review and metaanalysis

(2013) Martin Prince et al.   Alzheimers & Dementia

A review on cholinesterase inhibitors for Alzheimer’s disease

(2013) Preet Anand et al.   ARCHIVES OF PHARMACAL RESEARCH

Vulnerable Neural Systems and the Borderland of Brain Aging and Neurodegeneration

(2013) William Jagust   NEURON

7-Oxo-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamides as Selective CB2 Cannabinoid Receptor Ligands: Structural Investigations around a Novel Class of Full Agonists

(2012) Pier Giovanni Baraldi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Structure–Activity Relationships of New Quinolone-Type Molecules against Trypanosoma brucei

(2012) Georg Hiltensperger et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structures of Human Acetylcholinesterase in Complex with Pharmacologically Important Ligands

(2012) Jonah Cheung et al.   JOURNAL OF MEDICINAL CHEMISTRY

4-Quinolones: Smart Phones of the Microbial World

(2010) Holly Huse et al.   CHEMICAL REVIEWS

Aryl- and heteroaryl-substituted aminobenzo[a]quinolizines as dipeptidyl peptidase IV inhibitors

(2009) Markus Boehringer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The 4-Quinolone-3-Carboxylic Acid Motif as a Multivalent Scaffold in Medicinal Chemistry

(2009) Claudia Mugnaini et al.   CURRENT MEDICINAL CHEMISTRY

Safety Profile of the Respiratory Fluoroquinolone Moxifloxacin

(2009) Françoise Van Bambeke et al.   DRUG SAFETY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation

(2009) L. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA