Challenges and Opportunities in Multicatalysis

Access to 1,3-Dinitriles by Enantioselective Auto-tandem Catalysis: Merging Allylic Cyanation with Asymmetric Hydrocyanation

(2020) Jinguo Long et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of rare sugar isomers through site-selective epimerization

(2020) Yong Wang et al.   NATURE

Enantioselective Iridium-Catalyzed α-Allylation with Aqueous Solutions of Acetaldehyde

(2020) Tobias Sandmeier et al.   ORGANIC LETTERS

Ternary Catalysis: A Stepping Stone toward Multicatalysis

(2020) Shashank P. Sancheti et al.   ACS Catalysis

Recent Developments in Enantioselective Multicatalyzed Tandem Reactions

(2020) Hélène Pellissier   ADVANCED SYNTHESIS & CATALYSIS

Stereodivergent Pd/Cu Catalysis for the Dynamic Kinetic Asymmetric Transformation of Racemic Unsymmetrical 1,3-Disubstituted Allyl Acetates

(2020) Rui He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cobalt-Catalyzed Enantioselective Hydroarylation of 1,6-Enynes

(2020) Andrew Whyte et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total synthesis of terpenes via palladium-catalysed cyclization strategy

(2020) Barry M. Trost et al.   Nature Chemistry

Photoinduced site-selective alkenylation of alkanes and aldehydes with aryl alkenes

(2020) Hui Cao et al.   Nature Communications

Synergistic Activation of Amides and Hydrocarbons for Direct C(sp 3 )–H Acylation Enabled by Metallaphotoredox Catalysis

(2020) Geun Seok Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iron‐based multi‐catalysis: eco‐compatible alternative for complex molecules synthesis

(2020) Adrien Quintard   CHEMISTRY-A EUROPEAN JOURNAL

Concentric liquid reactors for chemical synthesis and separation

(2020) Olgierd Cybulski et al.   NATURE

Static to inducibly dynamic stereocontrol: The convergent use of racemic β-substituted ketones

(2020) Jacob S. DeHovitz et al.   SCIENCE

Synergistic Dual Transition Metal Catalysis

(2020) U Bin Kim et al.   CHEMICAL REVIEWS

Stereodivergent Carbon–Carbon Bond Formation between Iminium and Enolate Intermediates by Synergistic Organocatalysis

(2020) Byungjun Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Multicatalytic Approach to the Hydroaminomethylation of α-Olefins

(2019) Steven Hanna et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dynamic Kinetic Resolution of Aldehydes by Hydroacylation

(2019) Zhiwei Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Delayed catalyst function enables direct enantioselective conversion of nitriles to NH2-amines

(2019) Shaochen Zhang et al.   SCIENCE

Multienzymatic Cascade Reactions via Enzyme Complex by Immobilization

(2019) Ee Taek Hwang et al.   ACS Catalysis

Stereodivergent Construction of Tertiary Fluorides in Vicinal Stereogenic Pairs by Allylic Substitution with Iridium and Copper Catalysts

(2019) Zhi-Tao He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Driving Recursive Dehydration by PIII/PV Catalysis: Annulation of Amines and Carboxylic Acids by Sequential C–N and C–C Bond Formation

(2019) Morgan Lecomte et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pd-Catalyzed Boroperfluoroalkylation of Alkynes Opens a Route to One-Pot Reductive Carboperfluoroalkylation of Alkynes with Perfluoroalkyl and Aryl Iodides

(2019) Sylwester Domański et al.   ORGANIC LETTERS

Direct arene C–H fluorination with 18F− via organic photoredox catalysis

(2019) Wei Chen et al.   SCIENCE

Synergetic iridium and amine catalysis enables asymmetric [4+2] cycloadditions of vinyl aminoalcohols with carbonyls

(2019) Mao-Mao Zhang et al.   Nature Communications

Enantioselective Oxidative Phenol-Indole [3 + 2] Coupling Enabled by Biomimetic Mn(III)/Brønsted Acid Relay Catalysis

(2019) Qile Yu et al.   ACS Catalysis

Stereodivergent Coupling of 1,3-Dienes with Aldimine Esters Enabled by Synergistic Pd and Cu Catalysis

(2019) Qinglong Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Regioselective Alkylative Cross-Coupling of Remote Unactivated C(sp3)–H Bonds

(2019) Scott M. Thullen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Different Strategies for Designing Dual-Catalytic Enantioselective Processes: From Fully Cooperative to Non-cooperative Systems

(2019) Filippo Romiti et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Light-driven deracemization enabled by excited-state electron transfer

(2019) Nick Y. Shin et al.   SCIENCE

Stereodivergent assembly of tetrahydro-γ-carbolines via synergistic catalytic asymmetric cascade reaction

(2019) Shi-Ming Xu et al.   Nature Communications

Zwitterionic 1,2,3-Triazolium Amidate as a Catalyst for Photoinduced Hydrogen-Atom Transfer Radical Alkylation

(2019) Kohsuke Ohmatsu et al.   ACS Catalysis

Diastereodivergent synthesis of enantioenriched α,β-disubstituted γ-butyrolactones via cooperative N-heterocyclic carbene and Ir catalysis

(2019) Santanu Singha et al.   Nature Catalysis

Enantioselective Synthesis of the Spirotropanyl Oxindole Scaffold through Bimetallic Relay Catalysis

(2018) Zhi-Jun Jia et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct Synthesis of Polysubstituted Aldehydes via Visible-Light Catalysis

(2018) Fengjin Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Advances in One-Pot Synthesis through Borrowing Hydrogen Catalysis

(2018) Avelino Corma et al.   CHEMICAL REVIEWS

Stereodivergent Synthesis of α,α-Disubstituted α-Amino Acids via Synergistic Cu/Ir Catalysis

(2018) Liang Wei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereodivergent Allylation of Azaaryl Acetamides and Acetates by Synergistic Iridium and Copper Catalysis

(2018) Xingyu Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ir/Cu Dual Catalysis: Enantio- and Diastereodivergent Access to α,α-Disubstituted α-Amino Acids Bearing Vicinal Stereocenters

(2018) Xiaohong Huo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Multienzyme Cascade Reactions—Status and Recent Advances

(2018) Josef M. Sperl et al.   ACS Catalysis

Sequential meta-/ortho-C–H Functionalizations by One-Pot Ruthenium(II/III) Catalysis

(2018) Korkit Korvorapun et al.   ACS Catalysis

α-Quaternary Chiral Aldehydes from Styrenes, Allylic Alcohols, and Syngas via Multi-catalyst Relay Catalysis

(2018) Jing Meng et al.   Chem

Diastereodivergent Reductive Cross Coupling of Alkynes through Tandem Catalysis: Z- and E-Selective Hydroarylation of Terminal Alkynes

(2018) Megan K. Armstrong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tandem Catalysis: Transforming Alcohols to Alkenes by Oxidative Dehydroxymethylation

(2018) Xuesong Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cooperative asymmetric reactions combining photocatalysis and enzymatic catalysis

(2018) Zachary C. Litman et al.   NATURE

Direct arylation of strong aliphatic C–H bonds

(2018) Ian B. Perry et al.   NATURE

Recent Developments in Enantioselective Metal-Catalyzed Domino Reactions

(2018) Hélène Pellissier   ADVANCED SYNTHESIS & CATALYSIS

Recent Advances in Alkyl Carbon-Carbon Bond Formation by Nickel/Photoredox Cross-Coupling

(2018) Gary Molander et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct Aldehyde C–H Arylation and Alkylation via the Combination of Nickel, Hydrogen Atom Transfer, and Photoredox Catalysis

(2017) Xiaheng Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective sp3 C–H alkylation via polarity-match-based cross-coupling

(2017) Chip Le et al.   NATURE

The merger of transition metal and photocatalysis

(2017) Jack Twilton et al.   Nature Reviews Chemistry

Thermodynamic Strategies for C–O Bond Formation and Cleavage via Tandem Catalysis

(2016) Tracy L. Lohr et al.   ACCOUNTS OF CHEMICAL RESEARCH

A General Approach to Catalytic Alkene Anti-Markovnikov Hydrofunctionalization Reactions via Acridinium Photoredox Catalysis

(2016) Kaila A. Margrey et al.   ACCOUNTS OF CHEMICAL RESEARCH

Recent Developments in Enantioselective Metal-Catalyzed Domino Reactions

(2016) Hélène Pellissier   ADVANCED SYNTHESIS & CATALYSIS

Genetic Optimization of Metalloenzymes: Enhancing Enzymes for Non-Natural Reactions

(2016) Todd K. Hyster et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

One-Pot Trimetallic Relay Catalysis: A Unified Approach for the Synthesis of β-Carbolines and Other [c]-Fused Pyridines

(2016) Seema Dhiman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nickel- and Photoredox-Catalyzed Cross-Coupling Reactions of Aryl Halides with 4-Alkyl-1,4-dihydropyridines as Formal Nucleophilic Alkylation Reagents

(2016) Kazunari Nakajima et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Combinations of Aminocatalysts and Metal Catalysts: A Powerful Cooperative Approach in Selective Organic Synthesis

(2016) Samson Afewerki et al.   CHEMICAL REVIEWS

Multicomponent and Multicatalytic Reactions - A Synthetic Strategy Inspired by Nature

(2016) Alicia Galván et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Auto-Tandem Catalysis: Activation of Multiple, Mechanistically Distinct Process by a Single Catalyst

(2016) Jason E. Camp   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Photoredox Catalysis in Organic Chemistry

(2016) Megan H. Shaw et al.   JOURNAL OF ORGANIC CHEMISTRY

Photochemical Nickel-Catalyzed C–H Arylation: Synthetic Scope and Mechanistic Investigations

(2016) Drew R. Heitz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct C(sp3)–H Cross Coupling Enabled by Catalytic Generation of Chlorine Radicals

(2016) Benjamin J. Shields et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Substrate channelling as an approach to cascade reactions

(2016) Ian Wheeldon et al.   Nature Chemistry

A New Multicomponent Multicatalyst Reaction (MC)2R: Chemoselective Cycloaddition and Latent Catalyst Activation for the Synthesis of Fully Substituted 1,2,3-Triazoles

(2016) Kosuke Yamamoto et al.   ORGANIC LETTERS

Immobilized multienzymatic systems for catalysis of cascade reactions

(2016) Qingzhi Ji et al.   PROCESS BIOCHEMISTRY

Native functionality in triple catalytic cross-coupling: sp3 C-H bonds as latent nucleophiles

(2016) M. H. Shaw et al.   SCIENCE

Pot economy and one-pot synthesis

(2016) Yujiro Hayashi   Chemical Science

Triple Iron/Copper/Iminium Activation for the Efficient Redox Neutral Catalytic Enantioselective Functionalization of Allylic Alcohols

(2016) Mylène Roudier et al.   ACS Catalysis

Stereodivergent Dual Catalytic α-Allylation of Protected α-Amino- and α-Hydroxyacetaldehydes

(2015) Tobias Sandmeier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cooperative Catalysis of Noncompatible Catalysts through Compartmentalization: Wacker Oxidation and Enzymatic Reduction in a One-Pot Process in Aqueous Media

(2015) Hirofumi Sato et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemoenzymatic Dynamic Kinetic Resolution: A Powerful Tool for the Preparation of Enantiomerically Pure Alcohols and Amines

(2015) Oscar Verho et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Compartmentalization of Incompatible Catalytic Transformations for Tandem Catalysis

(2015) Jie Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Base-Free Photoredox/Nickel Dual-Catalytic Cross-Coupling of Ammonium Alkylsilicates

(2015) Matthieu Jouffroy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Orthogonal tandem catalysis

(2015) Tracy L. Lohr et al.   Nature Chemistry

Enantioselective cooperative catalysis

(2015) Suleman M. Inamdar et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Amide and Amine Nucleophiles in Polar Radical Crossover Cycloadditions: Synthesis of γ-Lactams and Pyrrolidines

(2015) Nathan J. Gesmundo et al.   ORGANIC LETTERS

Synthesis of α-Benzyloxyamino-γ-butyrolactones via a Polar Radical Crossover Cycloaddition Reaction

(2015) Cortney L. Cavanaugh et al.   ORGANIC LETTERS

Site-selective arene C-H amination via photoredox catalysis

(2015) N. A. Romero et al.   SCIENCE

Development of a One-Pot Tandem Reaction Combining Ruthenium-Catalyzed Alkene Metathesis and Enantioselective Enzymatic Oxidation To Produce Aryl Epoxides

(2015) Carl A. Denard et al.   ACS Catalysis

Sequential Rhodium/Palladium Catalysis: Enantioselective Formation of Dihydroquinolinones in the Presence of Achiral and Chiral Ligands

(2014) Lei Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Triple Relay Catalysis: Enantioselective Synthesis of Spirocyclic Indolines through a One-Pot Process Featuring an Asymmetric 6π Electrocyclization

(2014) Xiao-Ping Yin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

anti-Markovnikov Hydroamination of Alkenes Catalyzed by a Two-Component Organic Photoredox System: Direct Access to Phenethylamine Derivatives

(2014) Tien M. Nguyen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dual Catalysis Sees the Light: Combining Photoredox with Organo-, Acid, and Transition-Metal Catalysis

(2014) Matthew N. Hopkinson et al.   CHEMISTRY-A EUROPEAN JOURNAL

Stereodivergent α-Allylation of Linear Aldehydes with Dual Iridium and Amine Catalysis

(2014) Simon Krautwald et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The direct anti-Markovnikov addition of mineral acids to styrenes

(2014) Dale J. Wilger et al.   Nature Chemistry

Butyrolactone Synthesis via Polar Radical Crossover Cycloaddition Reactions: Diastereoselective Syntheses of Methylenolactocin and Protolichesterinic Acid

(2014) Mary A. Zeller et al.   ORGANIC LETTERS

Single-electron transmetalation in organoboron cross-coupling by photoredox/nickel dual catalysis

(2014) J. C. Tellis et al.   SCIENCE

Merging photoredox with nickel catalysis: Coupling of  -carboxyl sp3-carbons with aryl halides

(2014) Z. Zuo et al.   SCIENCE

Tandem Catalytic Conversion of Glucose to 5-Hydroxymethylfurfural with an Immobilized Enzyme and a Solid Acid

(2014) Hua Huang et al.   ACS Catalysis

Rh/Pd Catalysis with Chiral and Achiral Ligands: Domino Synthesis of Aza-Dihydrodibenzoxepines

(2013) Adam A. Friedman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cooperative Tandem Catalysis by an Organometallic Complex and a Metalloenzyme

(2013) Carl A. Denard et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Iron/Amine-Catalyzed Cascade Process for the Enantioselective Functionalization of Allylic Alcohols

(2013) Adrien Quintard et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Auto-Tandem Catalysis with a Planar-Chiral Ruthenium Complex: Sequential Allylic Amidation and Atom-Transfer Radical Cyclization

(2013) Naoya Kanbayashi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Anti-Markovnikov Hydroamination of Alkenes Catalyzed by an Organic Photoredox System

(2013) Tien M. Nguyen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Catalytic Anti-Markovnikov Addition of Carboxylic Acids to Alkenes

(2013) Andrew J. Perkowski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Temporal separation of catalytic activities allows anti-Markovnikov reductive functionalization of terminal alkynes

(2013) Le Li et al.   Nature Chemistry

Enantio- and Diastereodivergent Dual Catalysis:  -Allylation of Branched Aldehydes

(2013) S. Krautwald et al.   SCIENCE

Photoredox Activation for the Direct  -Arylation of Ketones and Aldehydes

(2013) M. T. Pirnot et al.   SCIENCE

Selective Isomerization–Hydroformylation Sequence: A Strategy to Valuable α-Methyl-Branched Aldehydes from Terminal Olefins

(2013) Paweł Dydio et al.   ACS Catalysis

The Combination of Relay and Cooperative Catalysis with a Gold/Palladium/Brønsted Acid Ternary System for the Cascade Hydroamination/Allylic Alkylation Reaction

(2012) Hua Wu et al.   ADVANCED SYNTHESIS & CATALYSIS

Recent Developments in Enantioselective Metal-Catalyzed Domino Reactions

(2012) Hervé Clavier et al.   ADVANCED SYNTHESIS & CATALYSIS

Stereocontrolled Domino Reactions

(2012) Hélène Pellissier   CHEMICAL REVIEWS

Consecutive Intermolecular Reductive Hydroamination: Cooperative Transition-Metal and Chiral Brønsted Acid Catalysis

(2012) Steffen Fleischer et al.   CHEMISTRY-A EUROPEAN JOURNAL

Tandem Hydroformylation/Hydrogenation of Alkenes to Normal Alcohols Using Rh/Ru Dual Catalyst or Ru Single Component Catalyst

(2012) Kohei Takahashi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Catalytic Anti-Markovnikov Hydroetherification of Alkenols

(2012) David S. Hamilton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Etheric C–O Bond Hydrogenolysis Using a Tandem Lanthanide Triflate/Supported Palladium Nanoparticle Catalyst System

(2012) Abdurrahman C. Atesin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Engineering the third wave of biocatalysis

(2012) U. T. Bornscheuer et al.   NATURE

Synergistic catalysis: A powerful synthetic strategy for new reaction development

(2012) Anna E. Allen et al.   Chemical Science

Multi-Enzymatic Cascade Reactions: Overview and Perspectives

(2011) Emanuele Ricca et al.   ADVANCED SYNTHESIS & CATALYSIS

Domino Rhodium-Catalyzed Alkyne Arylation/Palladium-Catalyzed N Arylation: A Mechanistic Investigation

(2011) Jane Panteleev et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Heterocyclic Carbene Catalyzed Domino Reactions

(2011) André Grossmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cascade Catalysis for the Homogeneous Hydrogenation of CO2to Methanol

(2011) Chelsea A. Huff et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A one-pot catalysis: the strategic classification with some recent examples

(2011) Nitin T. Patil et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

High-Yielding Tandem Hydroformylation/Hydrogenation of a Terminal Olefin to Produce a Linear Alcohol Using a Rh/Ru Dual Catalyst System

(2010) Kohei Takahashi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multicatalysis: Advancing Synthetic Efficiency and Inspiring Discovery

(2010) Lisa M. Ambrosini et al.   ChemCatChem

Unifying Metal and Brønsted Acid Catalysis-Concepts, Mechanisms, and Classifications

(2010) Magnus Rueping et al.   CHEMISTRY-A EUROPEAN JOURNAL

Highly Enantioselective Relay Catalysis in the Three-Component Reaction for Direct Construction of Structurally Complex Heterocycles

(2010) Chao Wang et al.   ORGANIC LETTERS

Combining transition metal catalysis and organocatalysis: a broad new concept for catalysis

(2009) Zhihui Shao et al.   CHEMICAL SOCIETY REVIEWS

Auto-Tandem Catalysis: A Single Catalyst Activating Mechanistically Distinct Reactions in a Single Reactor

(2009) Naoya Shindoh et al.   CHEMISTRY-A EUROPEAN JOURNAL