Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart

Quantitative Fluxomics of Circulating Metabolites

(2020) Sheng Hui et al.   Cell Metabolism

Branched-chain amino acids in disease

(2019) Phillip J. White et al.   SCIENCE

Tissue-Specific Characterization of Mitochondrial Branched-Chain Keto Acid Oxidation Using a Multiplexed Assay Platform

(2019) Emma J Goldberg et al.   BIOCHEMICAL JOURNAL

BCAA catabolism in brown fat controls energy homeostasis through SLC25A44

(2019) Takeshi Yoneshiro et al.   NATURE

Propionate-induced changes in cardiac metabolism, notably CoA trapping, are not altered by L-carnitine

(2018) Yingxue Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase

(2018) Phillip J. White et al.   Cell Metabolism

UBE2N promotes melanoma growth via MEK/FRA1/SOX10 signaling

(2018) Anushka Dikshit et al.   CANCER RESEARCH

Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids

(2018) Michael D. Neinast et al.   Cell Metabolism

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Proteomic Analysis of Primary Human Airway Epithelial Cells Exposed to the Respiratory Toxicant Diacetyl

(2017) Matthew W. Foster et al.   JOURNAL OF PROTEOME RESEARCH

MSFragger: ultrafast and comprehensive peptide identification in mass spectrometry–based proteomics

(2017) Andy T Kong et al.   NATURE METHODS

Defective branched chain amino acid catabolism contributes to cardiac dysfunction and remodeling following myocardial infarction

(2016) Wei Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Catabolic Defect of Branched-Chain Amino Acids Promotes Heart FailureCLINICAL PERSPECTIVE

(2016) Haipeng Sun et al.   CIRCULATION

Prognostic Implications of Long-Chain Acylcarnitines in Heart Failure and Reversibility With Mechanical Circulatory Support

(2016) Tariq Ahmad et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance

(2016) Cholsoon Jang et al.   NATURE MEDICINE

Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation

(2016) Eoin McDonnell et al.   Cell Reports

Metabolomic Profiling Identifies Novel Circulating Biomarkers of Mitochondrial Dysfunction Differentially Elevated in Heart Failure With Preserved Versus Reduced Ejection Fraction: Evidence for Shared Metabolic Impairments in Clinical Heart Failure

(2016) Wynn G. Hunter et al.   Journal of the American Heart Association

Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export

(2016) Phillip J. White et al.   Molecular Metabolism

Differential effects of octanoate and heptanoate on myocardial metabolism during extracorporeal membrane oxygenation in an infant swine model

(2015) Masaki Kajimoto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Multiple Mass Isotopomer Tracing of Acetyl-CoA Metabolism in Langendorff-perfused Rat Hearts

(2015) Qingling Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Benzothiophene Carboxylate Derivatives as Novel Allosteric Inhibitors of Branched-chain α-Ketoacid Dehydrogenase Kinase

(2014) Shih-Chia Tso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

4-Hydroxy-2(E)-nonenal (HNE) catabolism and formation of HNE adducts are modulated by β oxidation of fatty acids in the isolated rat heart

(2013) Qingling Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

(2013) V. K. Ridaura et al.   SCIENCE

Branched-chain amino acid metabolism in heart disease: an epiphenomenon or a real culprit?

(2011) Y. Huang et al.   CARDIOVASCULAR RESEARCH

Metabolic flux analysis of CHO cells at growth and non-growth phases using isotopic tracers and mass spectrometry

(2011) Woo Suk Ahn et al.   METABOLIC ENGINEERING

Metabolite profiles and the risk of developing diabetes

(2011) Thomas J Wang et al.   NATURE MEDICINE

Robust cardiomyocyte-specific gene expression following systemic injection of AAV: in vivo gene delivery follows a Poisson distribution

(2010) K-M R Prasad et al.   GENE THERAPY

ERK1/2 Phosphorylate Raptor to Promote Ras-dependent Activation of mTOR Complex 1 (mTORC1)

(2010) Audrey Carriere et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

SUnSET, a nonradioactive method to monitor protein synthesis

(2009) Enrico K Schmidt et al.   NATURE METHODS

Apoptosis Signal-Regulating Kinase 1/p38 Signaling Pathway Negatively Regulates Physiological Hypertrophy

(2008) Masayuki Taniike et al.   CIRCULATION

Positive Regulation of A-RAF by Phosphorylation of Isoform-specific Hinge Segment and Identification of Novel Phosphorylation Sites

(2008) Angela Baljuls et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic Networks of Liver Metabolism Revealed by Integration of Metabolic and Transcriptional Profiling

(2008) Christine T. Ferrara et al.   PLoS Genetics