Article
Cell Biology
Mengna Zhang, Lingxian Zhang, Ajun Geng, Xiao Li, Yu Zhou, Liming Xu, Yi Arial Zeng, Jinpeng Li, Cheguo Cai
Summary: In this study, the researchers investigated the function of cyclin-dependent kinase 14 (CDK14) in mammary development and breast cancer progression. The results showed that CDK14 is expressed in mammary basal cells and elevated in triple negative breast cancer (TNBC). CDK14 knockdown or inhibition was found to suppress mammary regeneration and the progression of TNBC.
Article
Biochemistry & Molecular Biology
Duaa Alkaabi, Kholoud Arafat, Shahrazad Sulaiman, Aya Mudhafar Al-Azawi, Samir Attoub
Summary: Triple-negative breast cancer (TNBC) is a highly aggressive type of breast cancer with poor prognosis. This study investigated the role of programmed death-ligand 1 (PD-L1) in TNBC MDA-MB-231 cells independent of its binding to PD-1 receptors on T cells. The study found that knockout of PD-L1 inhibited cell proliferation, colony formation, migration, and invasion in vitro, as well as tumor growth in a chick embryo model in vivo. PD-L1 knockout also affected the expression of several downstream proteins involved in tumor progression. These findings suggest that targeting PD-L1 could be a potential therapeutic strategy for TNBC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Yao Li, Xue Meng, Yuqing Luo, Shuai Luo, Jin Li, Jiafei Zeng, Xiang Huang, Jinjing Wang
Summary: The study found that miR-429 is overexpressed in triple-negative breast cancer and promotes the development of breast cancer by degrading the tumor suppressor DLC1.
Article
Oncology
Sainan Liu, Bin Liu, Qian Zhao, Jikang Shi, Yulu Gu, Yanbo Guo, Yong Li, Yunkai Liu, Yi Cheng, Yichun Qiao, Yawen Liu
Summary: The study found that low FST expression is associated with poor prognosis of patients with TNBC, and FST exhibits heterogeneous roles in apoptosis in different subtypes of TNBC cells.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Seogho Son, Hyungjoo Kim, Hogeun Lim, Joo-hyung Lee, Kyung-min Lee, Incheol Shin
Summary: In this study, the overexpression of CCN3 in TNBC patients was found to be associated with unfavorable outcomes. CCN3 knockdown reduced cancer stem cell formation, metastasis, and tumor growth by inhibiting the EGFR/MAPK pathway. Furthermore, CCN3 was found to activate the Wnt signaling pathway, leading to increased expression of GPNMB.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Lianmei Zhang, Yang Zhao, Jing Yang, Yaning Zhu, Ting Li, Xiaoyan Liu, Pengfei Zhang, Jingliang Cheng, Suan Sun, Chunli Wei, Junjiang Fu
Summary: In this study, the expression of CTSL in TNBC tissues and adjacent tissues was monitored and analyzed for its correlation with clinicopathological characteristics. The results showed that CTSL levels were higher in TNBC and correlated with differentiation, TNM stage, tumor size, and lymph node metastasis. Moreover, in vitro experiments demonstrated that CTSL overexpression enhanced proliferation, migration, and invasion abilities in MCF-7 and MDA-MB-231 cell lines. Conversely, knockdown of CTSL decreased these characteristics in MDA-MB-231 cell line. The findings suggest that CTSL could serve as a potential therapeutic and prognostic target for TNBC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Samantha L. Payne, Priyanka Ram, Deepti H. Srinivasan, Thanh T. Le, Michael Levin, Madeleine J. Oudin
Summary: This study reveals that altering the resting membrane potential (RMP) of triple-negative breast cancer cells through manipulating potassium channel expression increases invasion and metastasis, accompanied by changes in gene expression related to cell adhesion. The study also identifies a new strategy to target metastatic breast cancer by repurposing an FDA-approved potassium channel blocker. These findings demonstrate that bioelectricity regulates cancer cell invasion and metastasis, potentially leading to new therapeutics for patients with metastatic disease.
Article
Oncology
Shunchao Yan, Parama Dey, Yvonne Ziegler, Xin Jiao, Sung Hoon Kim, John A. Katzenellenbogen, Benita S. Katzenellenbogen
Summary: The study revealed that ER beta 2/ER beta 5 and ER beta 1 exhibit contrasting activities in TNBC cells, suggesting that the absolute amounts and relative ratios of different ER beta isoforms may impact prognosis and treatment selection.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Review
Cell Biology
Krishan K. Thakur, Aviral Kumar, Kishore Banik, Elika Verma, Elina Khatoon, Choudhary Harsha, Gautam Sethi, Subash C. Gupta, Ajaikumar B. Kunnumakkara
Summary: Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, primarily affecting younger women. Long noncoding RNAs (lncRNAs) play a crucial role in TNBC treatment, serving as novel diagnostic and prognostic biomarkers. Extensive research is ongoing to uncover the mechanisms through which lncRNAs modulate TNBC progression and treatment.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Pathology
Dan Xie, Saiyang Li, Tianqi Wu, Xuehui Wang, Lin Fang
Summary: Breast cancer is the most common cancer in women worldwide, and triple negative breast cancer is a highly aggressive subtype of breast cancer. This study demonstrates that miR-181c inhibits the proliferation and migration of triple negative breast cancer cells, promotes apoptosis, and regulates the cell cycle. Importantly, miR-181c suppresses the tumor-promoting effect of MAP4K4 by targeting its expression.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Biotechnology & Applied Microbiology
Shaoxia Fan, Shen Yan, Yang Yang, Jian Shang, Min Hao
Summary: In this study, it was found that ACTL8 is upregulated in TNBC and is associated with poor prognosis. Silencing ACTL8 inhibited proliferation, migration, and invasion while promoting apoptosis in MDA-MB-231 and BT-549 cells. Additionally, silencing ACTL8 suppressed the activation of the PI3K/AKT/mTOR signaling pathway in these cells, indicating a potential mechanism of ACTL8 in TNBC progression.
ONCOTARGETS AND THERAPY
(2021)
Article
Cell Biology
Anli Yang, Fu Peng, Lewei Zhu, Xing Li, Shunling Ou, Zhongying Huang, Song Wu, Cheng Peng, Peng Liu, Yanan Kong
Summary: Melatonin treatment downregulated FUNDC1 and lnc049808 in TNBC cell lines, which inhibited cell proliferation, invasion, and metastasis. lnc049808 and FUNDC1 acted as competing endogenous RNAs binding to miR-101, indicating a potential therapeutic pathway for TNBC progression inhibition by melatonin.
CELL DEATH & DISEASE
(2021)
Article
Medicine, Research & Experimental
P. Carrillo, M. Bernal, C. Tellez-Quijona, A. D. Marrero, I. Vidal, L. Castilla, C. Caro, A. Dominguez, M. L. Garcia-Martin, A. R. Quesada, M. A. Medina, B. Martinez-Poveda
Summary: Stauprimide inhibits cell proliferation and migration in triple-negative breast cancer cells, both in vitro and in vivo. It exerts its effects by modulating ERK1/2, Akt, and p38 MAPK signaling pathways, and downregulating MYC. These findings suggest that stauprimide could be a promising therapeutic agent for triple-negative breast cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Juliana Haydee Enrique Steinberg, Fabiana Alejandra Rossi, Roberto Magliozzi, Laurensia Yuniati, Matteo Santucci, Mario Rossi, Daniele Guardavaccaro, Angela Lauriola
Summary: The research demonstrates that SHARP1 functions as a suppressor of metastasis in TNBC. It inhibits the invasive phenotype of TNBC by blocking hypoxia-inducible factors. Additionally, targeting the beta TrCP-dependent degradation of SHARP1 shows potential as a therapeutic strategy in TNBC.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Xuehui Wang, Hongming Song, Lin Fang, Tianqi Wu
Summary: In this study, it was found that circPRKCI, derived from the PRKCI gene, was highly expressed in TNBC and could promote the proliferation and migration of TNBC by regulating the WBP2 and PI3K/AKT signaling pathway, providing a new avenue for TNBC therapy.
CELL DEATH DISCOVERY
(2022)