Article
Biochemistry & Molecular Biology
Junyong Han, Shixin Ye, Jinyan Chen, Kun Wang, Jingjun Jin, Zhiyong Zeng, Shijie Xue
Summary: This study revealed that LSD1 promotes ESCC oncogenesis by upregulating DUSP4, which may serve as a potential therapeutic and diagnostic target in ESCC. Overexpression of DUSP4 enhanced proliferation, invasion, and migration of ESCC cells, while silencing DUSP4 had the opposite effect.
BIOCHEMISTRY-MOSCOW
(2021)
Article
Multidisciplinary Sciences
Hongxiao Wang, Zijun Song, Enjun Xie, Junyi Chen, Biyao Tang, Fudi Wang, Junxia Min
Summary: The combination of inhibiting LSD1 and G9a effectively suppresses cell growth in esophageal squamous cell carcinoma and reduces tumor growth. Clinical studies have shown that LSD1 and G9a are upregulated in cancer tissues and are significantly associated with poor prognosis. Inhibiting LSD1 and G9a induces cell death through S-phase arrest and apoptosis, and cotargeting ER stress pathways enhances this effect.
Article
Multidisciplinary Sciences
Xuejiao Liu, Simin Zhao, Keke Wang, Liting Zhou, Ming Jiang, Yunfeng Gao, Ran Yang, Shiwen Yan, Wen Zhang, Bingbing Lu, Feifei Liu, Ran Zhao, Wenting Liu, Zihan Zhang, Kangdong Liu, Xiang Li, Zigang Dong
Summary: Spatial transcriptomics analysis revealed expression changes in TAGLN2 and CRNN during the progression from esophageal squamous precancerous lesions (ESPL) to esophageal squamous cell carcinoma (ESCC). TAGLN2 expression significantly increased, while CRNN expression decreased along with ESCC progression. These findings suggest that TAGLN2 and CRNN can serve as candidate indicators for predicting the risk of ESCC at the ESPL stage.
NATURE COMMUNICATIONS
(2023)
Review
Integrative & Complementary Medicine
Li Zhong-Rui, Gu Meng-Zhen, Xu Xiao, Zhang Jing-Han, Zhang Hai-Li, Han Chao
Summary: This review highlights recent advances in natural LSD1 inhibitors, including their discovery and identification process, natural sources, chemical structures, anticancer effects, and structure-activity relationships. Natural products play an important role in drug discovery, particularly in cancer therapy.
CHINESE JOURNAL OF NATURAL MEDICINES
(2022)
Article
Pharmacology & Pharmacy
Lulu Guan, Yalan Yang, Yao Lu, Yu Chen, Xi Luo, Dao Xin, Xiangrui Meng, Zhengzheng Shan, Guozhong Jiang, Feng Wang
Summary: p53 mutations are common in human cancers, especially esophageal cancer. The mutant p53 protein promotes cancer progression and drug resistance. This study investigated the antitumor effects of PEITC in esophageal squamous cell carcinoma (ESCC) with p53 mutations and found that PEITC can restore p53 activity, inhibit the growth of ESCC, induce apoptosis, and arrest cell cycle progression. Mechanistic studies revealed that PEITC restores the wild-type conformation and transactivation function of p53. These findings suggest that PEITC has potential as a therapeutic strategy for p53-mutant ESCC.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Xu-Feng Shi, Zhan Zhang, Hai-Ying Wu, Yu Wang, Ai-Min Chang, Jun-Jun Gao, Kan Liu, Wan-Yu Song, Li Wang, Huan-Ping Wang
Summary: This study investigated the role of the KDM5C-BMP-7 signaling pathway in the pathogenesis of severe preeclampsia (sPE). The results showed increased expression of KDM5C and decreased expression of BMP-7 and BMPRII in sPE patients. The study also suggested that nuclear-cytoplasmic translocation of KDM5C may regulate sPE through the BMP-7 pathway.
Article
Medicine, Research & Experimental
Xu Qian, Zhong-Ming Bao, Dan Yao, Yang Shi
Summary: This study demonstrates that KDM5C plays a crucial role in the development of liver hepatocellular carcinoma (LIHC) by epigenetically reducing ITIH1 expression and activating the PI3K/AKT signaling pathway.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Lu Gao, Yun Ji, Lulu Wang, Meixia He, Xiaojing Yang, Yibing Qiu, Xu Sun, Zhenyu Ji, Guanrui Yang, Jianying Zhang, Shanshan Li, Liping Dai, Liguo Zhang
Summary: Piezo1 expression is upregulated in esophageal squamous cell carcinoma (ESCC) tissues and plays a role in promoting proliferation, migration, and invasion of ESCC cells, while downregulation of Piezo1 inhibits these processes and induces apoptosis. Further, Piezo1-p53-Bax-Caspase 3 axis is involved in mediating ESCC apoptosis, suggesting Piezo1 as a potential therapeutic target for ESCC.
Article
Biochemistry & Molecular Biology
Ying Deng, Yan Wang, Xiaokui Huo, Sa Deng, Lingling Jin, Houli Zhang, Zhenlong Yu, Jing Ning, Xiaochi Ma, Chao Wang
Summary: Microbial transformation of capsaicin produced diverse metabolites with various catalytic characteristics of human intestinal fungi. Some metabolites and capsaicin showed inhibitory effects on LSD1 activity, indicating potential application as LSD1 inhibitors against the invasion and migration of cancer cells.
Article
Clinical Neurology
Lea M. Stitzlein, Achintyan Gangadharan, Leslie M. Walsh, Deokhwa Nam, Alexsandra B. Espejo, Melissa M. Singh, Kareena H. Patel, Yue Lu, Xiaoping Su, Ravesanker Ezhilarasan, Joy Gumin, Sanjay Singh, Erik Sulman, Frederick F. Lang, Joya Chandra
Summary: In this study, the efficacy of LSD1 inhibitors in patient-derived glioblastoma stem cell (GSC) models was evaluated. The results showed that LSD1 inhibitors had selective cytotoxic effects, but tumor regrowth occurred. Genes that may predict resistance to LSD1 inhibitors were identified using RNA-seq, providing guidance for future combination therapies.
FRONTIERS IN NEUROLOGY
(2023)
Article
Immunology
Jingjing Wang, Zhikai Wu, Xingyi Zhu, Peixuan Li, Yiwu Fu, Xia Wang, Youpeng Sun, Ershun Zhou, Zhengtao Yang
Summary: The study demonstrates the important regulatory roles of LSD1 in LPS-induced mastitis and the inhibitory effects of GSK-LSD1 on LSD1 activity, leading to reduced inflammatory response and tissue damage. The inhibition of LSD1 results in increased histone H3K4me2 and H3K9me2 levels, and suppression of NF-kappa B signaling and cytokine production in mammary gland. These findings suggest LSD1 as a potential regulator of inflammation and provide insights into epigenetic control mechanisms in inflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Cathy J. Spangler, Aleksandra Skrajna, Caroline A. Foley, Anh Nguyen, Gabrielle R. Budziszewski, Dalal N. Azzam, Eyla C. Arteaga, Holly C. Simmons, Charlotte B. Smith, Nathaniel A. Wesley, Emily M. Wilkerson, Jeanne-Marie E. McPherson, Dmitri Kireev, Lindsey I. James, Stephen V. Frye, Dennis Goldfarb, Robert K. McGinty
Summary: The nucleosome acidic patch serves as a hub for chromatin interaction and allows enzymes, such as the H3K36 demethylase KDM2A, to bind to nucleosomes. However, the molecular mechanisms governing the substrate specificity of KDM2A and its related paralog, KDM2B, remain unclear. By using cryogenic electron microscopy, researchers discovered that the binding of KDM2A and KDM2B to nucleosomes is paralog-specific and facilitated by DNA unwrapping and histone charge shielding.
NATURE CHEMICAL BIOLOGY
(2023)
Article
Oncology
Yuanbo Cui, Chunyan Zhang, Shanshan Ma, Zhe Li, Wenjie Wang, Ya Li, Yingchao Ma, Jiarui Fang, Yaping Wang, Wei Cao, Fangxia Guan
Summary: This study reveals that m6A demethylation of LncRNA LINC00022 by fat mass and obesity-associated protein (FTO) promotes tumor growth of ESCC. Clinically, LINC00022 was up-regulated in primary ESCC samples and predicted poor clinical outcome for ESCC patients. Mechanistically, LINC00022 directly binds to p21 protein and promotes its ubiquitination-mediated degradation, facilitating cell-cycle progression and proliferation.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Peripheral Vascular Disease
Nao Kohata, Isao Kurihara, Kenichi Yokota, Sakiko Kobayashi, Ayano Murai-Takeda, Yuko Mitsuishi, Toshifumi Nakamura, Mitsuha Morisaki, Takahide Kozuma, Takuto Torimitsu, Miki Kawai, Hiroshi Itoh
Summary: Mineralocorticoid receptor (MR) and its ligand aldosterone control blood pressure by promoting sodium reabsorption. The study identified LSD1 as a newly discovered corepressor of MR and demonstrated its role in regulating target gene expression and development of hypertension in response to high-salt diet.
HYPERTENSION RESEARCH
(2022)
Article
Endocrinology & Metabolism
Wasita W. Parksook, Mahyar Heydarpour, Shadi K. Gholami, James M. Luther, Paul N. Hopkins, Luminita H. Pojoga, Jonathan S. Williams
Summary: There is a sex-by-age interaction with salt sensitivity of blood pressure (SSBP) and aldosterone regulation in individuals of African descent carrying the LSD1 risk allele. Female LSD1 risk allele carriers of African descent, particularly those with low estrogen levels (postmenopausal), have higher SSBP. A genotype-sex interaction was observed in the aldosterone response to angiotensin II stimulation in individuals aged 50 years or younger, with female carriers displaying decreased aldosterone responsiveness.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)