Article
Infectious Diseases
Nikola Puvaca, Dragana Ljubojevic Pelic, Milos Pelic, Vojislava Bursic, Vincenzo Tufarelli, Luca Piemontese, Gorica Vukovic
Summary: The aim of this study was to investigate the effects of biofilm on antibiotic resistance in fish meat bacteria and assess the risk of antibiotic residues on public health. Bacterial isolates such as Escherichia coli, Aeromonas hydrophila, Shewanella putrefaciens, Vibrio spp., and Staphylococcus spp. were observed in fish samples. The results showed that some isolates were sensitive to antibiotics while others were resistant. The presence of antibiotic residues in fish samples was also detected, with estimated daily intake values established for men and women.
Article
Environmental Sciences
April Hayes, Laura May Murray, Isobel Catherine Stanton, Lihong Zhang, Jason Snape, William Hugo Gaze, Aimee Kaye Murray
Summary: Antimicrobial resistance (AMR) is a threat to human and animal health, and the environment plays an important role in AMR evolution, dissemination, and transmission. Research in the UK shows that ciprofloxacin poses a high risk of selecting for AMR in wastewater, while macrolides have a lower risk. Further action is needed to prevent AMR selection in wastewater and environmental quality standards for antibiotics may be necessary.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Infectious Diseases
Katia Iskandar, Jayaseelan Murugaiyan, Dalal Hammoudi Halat, Said El Hage, Vindana Chibabhai, Saranya Adukkadukkam, Christine Roques, Laurent Molinier, Pascale Salameh, Maarten Van Dongen
Summary: The history and challenges of antibiotic discovery, as well as the need for diversity and innovation in tackling antimicrobial resistance (AMR), are described in this review. It emphasizes the public health concerns of acquired resistance caused by anthropogenic use of antibiotics and the global spread of AMR at an alarming rate. The lack of new leads in the current pipeline and the need to address resistance to old and novel antibiotics are also highlighted.
Article
Environmental Sciences
Sija Arun, Liu Xin, Omkar Gaonkar, B. Neppolian, Gan Zhang, Paromita Chakraborty
Summary: The study investigated the presence of 18 antibiotics in surface water, groundwater, and sewage treatment plants in Chennai city and the suburbs. The findings showed high concentrations of antibiotics in some locations, possibly due to direct sewer outfalls or open drains contaminating surface water bodies.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Biochemistry & Molecular Biology
Daria Nicolosi, Giulio Petronio Petronio, Stefano Russo, Maria Di Naro, Marco Alfio Cutuli, Claudio Russo, Roberto Di Marco
Summary: The overuse and misuse of antibiotics have led to the emergence and spread of multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria strains. To preserve the effectiveness of these drugs, it is crucial to use them appropriately. Innovative approaches are being investigated to improve drug treatments and reduce drug resistance. Global guidelines have been developed to optimize prescriptions and reduce the environmental spread of these life-saving molecules.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Adeoye John Kayode, Anthony Ifeanyi Okoh
Summary: Antimicrobial resistance poses a significant threat to the health sector and the management of microbial infections. This study analyzed the susceptibility of 194 Listeria monocytogenes isolates and investigated the risk of listeriosis associated with ready-to-eat foods and the empirical treatment of L. monocytogenes infections. The results showed high levels of antimicrobial resistance against prescribed and non-prescribed antimicrobials, indicating a potentially high risk of L. monocytogenes infection.
Review
Pharmacology & Pharmacy
Viktor Sebek, Pavel Anzenbacher, Dominik Rejman, Alena Spicakova, Milan Kolar
Summary: Lipophosphonoxins (LPPOs) are a new group of antibiotics that target bacterial cell membranes. They have bactericidal activity against both Gram-positive and Gram-negative bacteria, with better selectivity and less resistance compared to previous generations. LPPOs have shown potential therapeutic effects in bone cement infections and wound infections.
News Item
Biochemistry & Molecular Biology
Mike May
Summary: Researchers utilize AI and bioinformatics for finding novel antimicrobials, while governments experiment with financial incentives for pharmaceutical companies.
Article
Multidisciplinary Sciences
Gan Luo, Jue Zhang, HanBin Wang, YaQi Sun, BaoLi Cheng, ZhiPeng Xu, Yan Zhang, Hui Li, WuYuan Lu, Elizabeta Nemeth, Tomas Ganz, XiangMing Fang
Summary: A new class of peptidomimetic antibiotics designed based on the structure of human alpha-defensin 5 (HD5) showed promising activity against drug-resistant bacteria through multiple mechanisms of action.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Infectious Diseases
Moran Rubanenko, Sigalit Blumer, Kayan Maalof, Shlomo Elbahary, Lazar Katz, Johnny Kharouba
Summary: Both general dentists and pediatric dentists have poor knowledge levels on proper use of antibiotics, with a large percentage not knowing whether antibiotics are needed in specific dental cases. Pediatric dentists demonstrate relatively greater knowledge on correct use of antibiotics, especially in endodontics and trauma cases. Compliance with AAPD/EAPD guidelines is low, indicating a need for increased awareness and education among dentists regarding recommended antibiotic usage.
Review
Infectious Diseases
Hyunjin Shim
Summary: Antimicrobial resistance is a growing problem caused by the misuse of antibiotics. The emergence of resistance has outpaced the development of new antibiotics, leading to the end of the golden era of antibiotics. The current antibiotic market faces challenges such as lack of profitability and investment. To combat antimicrobial resistance, researchers are exploring next-generation antibiotics that offer specificity, evolvability, and non-immunogenicity. This review discusses the innovations and potential antimicrobial agents that may overcome the limitations of traditional antibiotics and highlights the need for addressing issues like infection diagnostics and regulatory frameworks.
Article
Infectious Diseases
Arthur Piraux, Ramy Hammoud, Jeremie Riou, Souhil Lebdai, Sebastien Faure
Summary: This study assesses compliance between prescriptions collected in community pharmacies and French cystitis guidelines. The results show an average compliance rate of 66%, but with disparities according to the type of cystitis. Cases at risk of complication had a lower compliance rate. The inclusion of a urine examination decreased the overall compliance rate for uncomplicated cystitis.
Article
Infectious Diseases
Oana Joean, Daniel Tahedl, Madita Flintrop, Thorben Winkler, Ruxandra Sabau, Tobias Welte, Markus A. Kuczyk, Ralf-Peter Vonberg, Jessica Rademacher
Summary: Antimicrobial stewardship programs can effectively reduce antibiotic use and resistance rates without increasing infection-related complications in urologic settings, highlighting their importance in this field.
Article
Infectious Diseases
Bindiya Bagga, Jeremy S. Stultz, Sandra Arnold, Kelley R. Lee
Summary: This study demonstrates that a pediatric ASP based on guideline development and prospective audit with feedback can improve antibiotic utilization and institutional bacterial susceptibilities without negatively affecting patient outcomes.
Article
Infectious Diseases
Iltaf Hussain, Nisa Yousaf, Sana Haider, Pervisha Jalil, Muhammad Usman Saleem, Imran Imran, Abdul Majeed, Anees Ur Rehman, Muhammad Uzair, Muhammad Fawad Rasool, Faleh Alqahtani, Hussain Alqhtani
Summary: The study found that the majority of university students have a good understanding of antimicrobial resistance (AMR) and antimicrobial stewardship (AMS), but there is still a need to further enhance knowledge and awareness of AMS and AMR. Incorporating dedicated modules on antibiotic use and AMS into undergraduate and postgraduate programs is recommended to improve student knowledge and perception.
Article
Chemistry, Analytical
Paola Grenni, Luisa Patrolecco, Jasmin Rauseo, Francesca Spataro, Martina Di Lenola, Giorgia Aimola, Massimo Zacchini, Fabrizio Pietrini, Daniela Di Baccio, Isobel C. Stanton, William H. Gaze, Anna Barra Caracciolo
MICROCHEMICAL JOURNAL
(2019)
Article
Engineering, Environmental
J. Rauseo, A. Barra Caracciolo, N. Ademollo, M. Cardoni, M. Di Lenola, W. Gaze, I Stanton, P. Grenni, T. Pescatore, F. Spataro, L. Patrolecco
JOURNAL OF HAZARDOUS MATERIALS
(2019)
Editorial Material
Microbiology
Aimee K. Murray
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Environmental Sciences
Isobel C. Stanton, Alison Bethel, Anne F. C. Leonard, William H. Gaze, Ruth Garside
ENVIRONMENTAL EVIDENCE
(2020)
Article
Environmental Sciences
Aimee K. Murray, Isobel C. Stanton, Jessica Wright, Lihong Zhang, Jason Snape, William H. Gaze
ENVIRONMENTAL HEALTH PERSPECTIVES
(2020)
Article
Biology
Isobel C. Stanton, Aimee K. Murray, Lihong Zhang, Jason Snape, William H. Gaze
COMMUNICATIONS BIOLOGY
(2020)
Article
Environmental Sciences
Isobel Catherine Stanton, Alison Bethel, Anne Frances Clare Leonard, William Hugo Gaze, Ruth Garside
Summary: This study created two systematic maps summarizing the global transmission of antibiotic resistance from the natural environment to humans and the state of antibiotic resistance in the UK environment. The results showed that consumption/ingestion was the most studied transmission route and E. coli was the most highly studied bacterium. The research focus was mainly on aquatic environments.
ENVIRONMENTAL EVIDENCE
(2022)
Article
Microbiology
Yue Wang, Zhigang Yu, Pengbo Ding, Ji Lu, Uli Kluemper, Aimee K. Murray, William H. Gaze, Jianhua Guo
Summary: Non-antibiotic pharmaceuticals can promote antibiotic resistance transfer in microbial communities, potentially increasing the risk of antibiotic resistance dissemination in the environment.
Article
Environmental Sciences
April Hayes, Laura May Murray, Isobel Catherine Stanton, Lihong Zhang, Jason Snape, William Hugo Gaze, Aimee Kaye Murray
Summary: Antimicrobial resistance (AMR) is a threat to human and animal health, and the environment plays an important role in AMR evolution, dissemination, and transmission. Research in the UK shows that ciprofloxacin poses a high risk of selecting for AMR in wastewater, while macrolides have a lower risk. Further action is needed to prevent AMR selection in wastewater and environmental quality standards for antibiotics may be necessary.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Environmental Sciences
Isobel C. Stanton, Holly J. Tipper, Kevin Chau, Uli Kluemper, Jessica Subirats, Aimee K. Murray
Summary: The environment plays a critical role in the development, dissemination, and transmission of antimicrobial resistance (AMR). Pharmaceuticals and personal care products (PPCPs) enter the environment through direct application and anthropogenic pollution. Although there is evidence on the role of antibiotics in AMR, limited evidence exists on non-antibiotic PPCPs. Research has focused on laboratory-based systems, but PPCP concentrations in wastewater, natural water, and soil environments are within the range shown to promote horizontal gene transfer. Increased selection and HGT of AMR by PPCPs will increase AMR abundance in the environment.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2022)
Article
Engineering, Environmental
Rong-Gui Zhu, Chang-Gui Pan, Feng-Jiao Peng, Chao-Yang Zhou, Jun-Jie Hu, Kefu Yu
Summary: This comprehensive survey investigated the occurrence, bioaccumulation, and trophic magnification of parabens and their metabolite 4-HB in a marine food web. Results showed that parabens were the predominant pollutants in marine organisms, with significant bioaccumulation from sediments. The estimated trophic magnification factor indicated biomagnification for MeP and trophic dilution for 4-HB. Overall, the risks for humans consuming marine organisms were found to be low.
Article
Engineering, Environmental
Andres F. Torres-Franco, Deborah Leroy-Freitas, Cristina Martinez-Fraile, Elisa Rodriguez, Pedro A. Garcia-Encina, Raul Munoz
Summary: Anaerobic and microalgae-based technologies have emerged as sustainable alternatives for municipal wastewater treatment. However, the presence of viruses in the treated wastewater is a major concern for reuse applications. This study assessed the ability of these technologies to reduce viruses during secondary wastewater treatment. The results showed that all technologies were effective in reducing the concentration of viruses, with microalgae-based treatment exhibiting the highest potential for reducing the disinfection requirements of treated wastewater.
Article
Engineering, Environmental
Young Gwang Kim, Sae Yun Kwon, Spencer J. Washburn, Scott C. Brooks, Ji Won Yoon, Lucien Besnard
Summary: The study uses Hg isotope ratios to identify the sources and exposure pathways of mercury in bivalves, finding that dissolved Hg phases in the water column are the primary source and exposure pathway to bivalves. This provides new insights into using bivalves as bioindicators for sediment quality monitoring.
Article
Engineering, Environmental
Hui Geng, Ying Xu, Rui Liu, Dianhai Yang, Xiaohu Dai
Summary: This study investigates the effect of cation exchange resin (CER) on the sequential recovery of hydrogen and methane from anaerobic digestion (AD) and the corresponding mechanisms. The results show that CER can simultaneously enhance the production of hydrogen and methane by promoting the solubilisation, hydrolysis, and acidification of organic matter. Additionally, CER facilitates effective contact between bacteria and organic particulates and reduces the energy barrier for mass transfer during methane production. The study also reveals changes in the microbial community structure and metagenomics during the AD process.
Article
Engineering, Environmental
Xiaojing Lin, Zhan Jin, Shunfeng Jiang, Zhiquan Wang, Suqing Wu, Ke Bei, Min Zhao, Xiangyong Zheng
Summary: Dehumidification combined with addition of absorbent resin supplement (ARS) was used to achieve rapid evaporation of non-pretreated urine, resulting in high water evaporation efficiency and nutrient recovery.
Article
Engineering, Environmental
Yangli Che, Chaoran Lin, Shen Li, Jiao Liu, Longhai Zhu, Shilei Yu, Nan Wang, Haoshuai Li, Mutai Bao, Yang Zhou, Tonghao Si, Rui Bao
Summary: Hydrodynamic processes play a crucial role in the transmission of sediments, microbial assembly, and organic carbon redistribution in the ocean. Through experiments and analysis, we found that hydrodynamics shape the assembly of microbial communities and control the redistribution of different sourced organic carbon, thereby influencing microbial-mediated biogeochemical transformation.
Article
Engineering, Environmental
Chao Chen, Yu Yang, Nigel J. D. Graham, Zhenyu Li, Xingtao Yang, Zhining Wang, Nadia Farhat, Johannes S. Vrouwenvelder, Li -an Hou
Summary: The fouling of seawater reverse osmosis membranes is a persistent challenge in desalination. This study monitored the operational performance of a desalination plant for 7 years and the fouling development in different areas of membrane modules. The findings showed that operational performance declined over time and fouling mainly occurred at the feed side of the modules, with the highest microbial diversity. Keystone species like Chloroflexi and Planctomycetes played an important role in maintaining community structure and biofilm maturation. Polysaccharides, soluble microbial products, marine humic acid-like substances, and inorganic substances contributed to fouling. Overall, biofouling had a significant impact on membrane fouling after 7 years of operation.
Article
Engineering, Environmental
Dan Li, Jieyi Sun, Yibo Fu, Wentao Hong, Heli Wang, Qian Yang, Junhong Wu, Sen Yang, Jianhui Xu, Yunfei Zhang, Yirong Deng, Yin Zhong, Ping'an Peng
Summary: Sulfidation-oxidation treatment of magnetite (Fe3O4) enhances the production of dark center dot OH, which can efficiently degrade dissolved organic matter (DOM) and accelerate carbon cycling.
Article
Engineering, Environmental
Cheng Yu, Kaijun Wang, Kaiyuan Zhang, Ruiyang Liu, Pingping Zheng
Summary: This study implemented a microaerobic-aerobic configuration in a full-scale municipal wastewater treatment facility and investigated the effects on sludge characteristics, pollutant removal, microbial community, and granulation mechanisms. The results showed successful transition from flocculent-activated sludge to well-defined AGS after two months of operation. The primary pathways for pollutant removal were simultaneous nitrification, denitrification, and phosphorus removal. Moreover, the incorporation of internal separators induced shifts in the flow pattern, which promoted granulation.
Article
Engineering, Environmental
Zhe Zhang, Shaoyang Hu, Guangrong Sun, Wei Wang
Summary: Halogenated aromatic disinfection byproducts (DBPs), such as halogenated phenols, have garnered widespread attention due to their high toxicity and prevalence. This study reports on the analysis, occurrence, and cytotoxicity of a group of emerging halogenated aromatic DBPs, known as halogenated polyhydroxyphenols (HPPs), in drinking water.
Article
Engineering, Environmental
Shengyue Chen, Jinliang Huang, Peng Wang, Xi Tang, Zhenyu Zhang
Summary: Accurate prediction of river water quality is crucial for sustainable water management. This study introduces wavelet analysis and transfer learning techniques to assist LSTM modeling, proposing a newly coupled modeling approach that improves short-term prediction of river water quality.
Article
Engineering, Environmental
Bang Du, Xinmin Zhan, Piet N. L. Lens, Yifeng Zhang, Guangxue Wu
Summary: Efficient anaerobic digestion relies on the cooperation of different microorganisms with different metabolic pathways. This study investigated the effects of different operational modes and the addition of powdered activated carbon (PAC) on ethanol metabolic pathways. The results showed that the SBR mode and the presence of CO2 facilitated ethanol metabolism towards propionate production, while the CFR mode with extended solids retention time enriched Geobacter. Adjusting operational modes and PAC addition can modulate anaerobic ethanol metabolism and enrich Geobacter.
Article
Engineering, Environmental
Wanfa Wang, Si-Liang Li, Jun Zhong, Yuanbi Yi, Fujun Yue, Zenglei Han, Qixin Wu, Ding He, Cong-Qiang Liu
Summary: This study compares the carbon biogeochemical processes in karst and non-karst regions within large thermal stratified river-reservoir systems. The results demonstrate that karst reservoirs have a reduced potential for carbon emissions and highlight the importance of considering geologic settings to improve accuracy in regional and global CO2 emission estimates.
Article
Engineering, Environmental
Chunxia Jiang, Zelong Zhao, Dong Zhu, Xiong Pan, Yuyi Yang
Summary: This study analyzed the occurrence and distribution of antibiotic resistance genes (ARGs) in different environmental media of the Yangtze River using metagenomics. Core resistome dominated by multidrug resistance genes was found in all samples, while rare resistome dominated by various resistance genes was more prevalent in plasmids. Specific bacteria were identified as hosts for both core and rare resistomes, with high clinical concern ARGs found in the rare resistome. Particle-associated environment provided the most ideal conditions for resistome hosts. This study provided insights into the genetic locations of ARGs and the community assembly mechanisms of ARG hosts in freshwater environments.
Article
Engineering, Environmental
Yu Zhang, Yongtao He, Linchun Jia, Lei Xu, Zheng Wang, Yueling He, Ling Xiong, Xumeng Lin, Hong Chen, Gang Xue
Summary: By synergizing organic carbon source, thiosulfate, and zero-valent iron, efficient mixotrophic denitrification of oligotrophic secondary effluent can be achieved. Thiosulfate plays a vital role in promoting TN removal efficiency, while corrosion of Fe0 releases OH- to neutralize H+ from thiosulfate-driven denitrification, creating a suitable environment for denitrification. The coordination of thiosulfate and Fe0 maintains the dominance of Thiobacillus for denitrification.