Durability of Immunity to SARS-CoV-2 and Other Respiratory Viruses

Evolution of antibody immunity to SARS-CoV-2

(2021) Christian Gaebler et al.   NATURE

Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults

(2021) Romina Libster et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection

(2021) Jennifer M. Dan et al.   SCIENCE

Neutralizing antibody titres in SARS-CoV-2 infections

(2021) Eric H. Y. Lau et al.   Nature Communications

Duration and key determinants of infectious virus shedding in hospitalized patients with coronavirus disease-2019 (COVID-19)

(2021) Jeroen J. A. van Kampen et al.   Nature Communications

SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques

(2021) Yashavanth Shaan Lakshmanappa et al.   Nature Communications

Early induction of functional SARS-CoV-2 specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients

(2021) Anthony T. Tan et al.   Cell Reports

Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection

(2021) Catherine J. Reynolds et al.   Science Immunology

Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection

(2021) Elizabeth M. Anderson et al.   CELL

Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7

(2021) Pengfei Wang et al.   NATURE

Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection

(2021) Jianmin Zuo et al.   NATURE IMMUNOLOGY

Risk of mortality in patients infected with SARS-CoV-2 variant of concern 202012/1: matched cohort study

(2021) Robert Challen et al.   BMJ-British Medical Journal

Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19

(2021) Ryan S Thwaites et al.   Science Immunology

Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody

(2020) Dora Pinto et al.   NATURE

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

(2020) Mingfeng Liao et al.   NATURE MEDICINE

Antibody responses to SARS-CoV-2 in patients with COVID-19

(2020) Quan-Xin Long et al.   NATURE MEDICINE

SARS-CoV-2 infection protects against rechallenge in rhesus macaques

(2020) Abishek Chandrashekar et al.   SCIENCE

Expansion of plasmablasts and loss of memory B cells in peripheral blood from COVID‐19 patients with pneumonia

(2020) Sara De Biasi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Analysis of a SARS-CoV-2-Infected Individual Reveals Development of Potent Neutralizing Antibodies with Limited Somatic Mutation

(2020) Emilie Seydoux et al.   IMMUNITY

Direct Observation of Repeated Infections With Endemic Coronaviruses

(2020) Marta Galanti et al.   JOURNAL OF INFECTIOUS DISEASES

SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls

(2020) Nina Le Bert et al.   NATURE

Convergent antibody responses to SARS-CoV-2 in convalescent individuals

(2020) Davide F. Robbiani et al.   NATURE

Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections

(2020) Quan-Xin Long et al.   NATURE MEDICINE

Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

(2020) Takuya Sekine et al.   CELL

Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19

(2020) Naoki Kaneko et al.   CELL

Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity

(2020) Carolyn Rydyznski Moderbacher et al.   CELL

Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology

(2020) Luca Piccoli et al.   CELL

Orthogonal SARS-CoV-2 Serological Assays Enable Surveillance of Low Prevalence Communities and Reveal Durable Humoral Immunity.

(2020) Tyler J. Ripperger et al.   IMMUNITY

Neutralizing Antibodies Correlate with Protection from SARS-CoV-2 in Humans during a Fishery Vessel Outbreak with a High Attack Rate

(2020) Amin Addetia et al.   JOURNAL OF CLINICAL MICROBIOLOGY

SARS-CoV-2 Antibody Avidity Responses in COVID-19 Patients and Convalescent Plasma Donors

(2020) Sarah E Benner et al.   JOURNAL OF INFECTIOUS DISEASES

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

(2020) Yanchun Peng et al.   NATURE IMMUNOLOGY

Seasonal coronavirus protective immunity is short-lasting

(2020) Arthur W. D. Edridge et al.   NATURE MEDICINE

Humoral Immune Response to SARS-CoV-2 in Iceland

(2020) Daniel F. Gudbjartsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Low genetic diversity may be an Achilles heel of SARS-CoV-2

(2020) Jason W. Rausch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophilic inflammation in the respiratory mucosa predisposes to RSV infection

(2020) Maximillian S. Habibi et al.   SCIENCE

REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters

(2020) Alina Baum et al.   SCIENCE

S Protein-Reactive IgG and Memory B Cell Production after Human SARS-CoV-2 Infection Includes Broad Reactivity to the S2 Subunit

(2020) Phuong Nguyen-Contant et al.   mBio

Tissue-Specific Immunopathology in Fatal COVID-19

(2020) David A. Dorward et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19

(2020) Lauren B. Rodda et al.   CELL

Quick COVID-19 Healers Sustain Anti-SARS-CoV-2 Antibody Production

(2020) Yuezhou Chen et al.   CELL

Correlates of protection against SARS-CoV-2 in rhesus macaques

(2020) Katherine McMahan et al.   NATURE

Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers

(2020) Sheila F. Lumley et al.   NEW ENGLAND JOURNAL OF MEDICINE

IgA dominates the early neutralizing antibody response to SARS-CoV-2

(2020) Delphine Sterlin et al.   Science Translational Medicine

Defining the features and duration of antibody responses to SARS-CoV-2 infection associated with disease severity and outcome

(2020) Katharina Röltgen et al.   Science Immunology

Mumps in a highly vaccinated Marshallese community in Arkansas, USA: an outbreak report

(2019) Virgie S Fields et al.   LANCET INFECTIOUS DISEASES

Systematic comparison of respiratory syncytial virus-induced memory B cell responses in two anatomical compartments

(2019) Laila Shehata et al.   Nature Communications

Factors That Influence the Immune Response to Vaccination

(2019) Petra Zimmermann et al.   CLINICAL MICROBIOLOGY REVIEWS

Influenza A Reinfection in Sequential Human Challenge: Implications for Protective Immunity and “Universal” Vaccine Development

(2019) Matthew J Memoli et al.   CLINICAL INFECTIOUS DISEASES

Role of Multivalency and Antigenic Threshold in Generating Protective Antibody Responses

(2019) Mark K. Slifka et al.   Frontiers in Immunology

Updates on immunologic correlates of vaccine-induced protection

(2019) Stanley A. Plotkin   VACCINE

Understanding Subset Diversity in T Cell Memory

(2018) Stephen C. Jameson et al.   IMMUNITY

Influenza-specific lung-resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles

(2018) Angela Pizzolla et al.   JOURNAL OF CLINICAL INVESTIGATION

Local proliferation maintains a stable pool of tissue-resident memory T cells after antiviral recall responses

(2018) Simone L. Park et al.   NATURE IMMUNOLOGY

Toll-like receptor 9 antagonizes antibody affinity maturation

(2018) Munir Akkaya et al.   NATURE IMMUNOLOGY

Memory B cells are reactivated in subcapsular proliferative foci of lymph nodes

(2018) Imogen Moran et al.   Nature Communications

Heterogeneity and longevity of antibody memory to viruses and vaccines

(2018) Alice Antia et al.   PLOS BIOLOGY

The establishment of resident memory B cells in the lung requires local antigen encounter

(2018) S. Rameeza Allie et al.   NATURE IMMUNOLOGY

Antibody-secreting plasma cells persist for decades in human intestine

(2017) Ole J.B. Landsverk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Plasma cell survival in the absence of B cell memory

(2017) Erika Hammarlund et al.   Nature Communications

Airway Memory CD4 + T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses

(2016) Jincun Zhao et al.   IMMUNITY

A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells

(2016) Florian J. Weisel et al.   IMMUNITY

Memory T cell responses targeting the SARS coronavirus persist up to 11 years post-infection

(2016) Oi-Wing Ng et al.   VACCINE

Impaired Antibody-mediated Protection and Defective IgA B-Cell Memory in Experimental Infection of Adults with Respiratory Syncytial Virus

(2015) Maximillian S. Habibi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Antiviral B cell and T cell immunity in the lungs

(2015) Christopher Chiu et al.   NATURE IMMUNOLOGY

RSV-specific airway resident memory CD8+ T cells and differential disease severity after experimental human infection

(2015) Agnieszka Jozwik et al.   Nature Communications

Challenges in developing a cross-serotype rhinovirus vaccine

(2015) Nicholas Glanville et al.   Current Opinion in Virology

Dynamics of Human Respiratory Virus-Specific CD8+ T Cell Responses in Blood and Airways during Episodes of Common Cold

(2014) J. Heidema et al.   JOURNAL OF IMMUNOLOGY

Virus-Specific Memory CD8 T Cells Provide Substantial Protection from Lethal Severe Acute Respiratory Syndrome Coronavirus Infection

(2014) R. Channappanavar et al.   JOURNAL OF VIROLOGY

First infection by all four non-severe acute respiratory syndrome human coronaviruses takes place during childhood

(2013) Weimin Zhou et al.   BMC INFECTIOUS DISEASES

Lung-resident memory CD8 T cells (TRM ) are indispensable for optimal cross-protection against pulmonary virus infection

(2013) Tao Wu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cellular immune correlates of protection against symptomatic pandemic influenza

(2013) Saranya Sridhar et al.   NATURE MEDICINE

Induction and maintenance of anti-influenza antigen-specific nasal secretory IgA levels and serum IgG levels after influenza infection in adults

(2012) Chisa Fujimoto et al.   Influenza and Other Respiratory Viruses

Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans

(2012) Tom M Wilkinson et al.   NATURE MEDICINE

Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells

(2012) G.-M. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection

(2011) Jens Wrammert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Memory B cells, but not long-lived plasma cells, possess antigen specificities for viral escape mutants

(2011) Whitney E. Purtha et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lack of Peripheral Memory B Cell Responses in Recovered Patients with Severe Acute Respiratory Syndrome: A Six-Year Follow-Up Study

(2011) F. Tang et al.   JOURNAL OF IMMUNOLOGY

Prevalence of Antibodies to Four Human Coronaviruses Is Lower in Nasal Secretions than in Serum

(2010) G. J. Gorse et al.   Clinical and Vaccine Immunology

Circulating Antibody‐Secreting Cells during Acute Respiratory Syncytial Virus Infection in Adults

(2010) F. Eun‐Hyung Lee et al.   JOURNAL OF INFECTIOUS DISEASES

Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic

(2009) Gavin J. D. Smith et al.   NATURE

The human spleen is a major reservoir for long-lived vaccinia virus-specific memory B cells

(2008) M. Mamani-Matsuda et al.   BLOOD

Young Infants Can Develop Protective Levels of Neutralizing Antibody after Infection with Respiratory Syncytial Virus

(2008) Joshua J. Shinoff et al.   JOURNAL OF INFECTIOUS DISEASES

Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors

(2008) Xiaocong Yu et al.   NATURE

SAP-controlled T–B cell interactions underlie germinal centre formation

(2008) Hai Qi et al.   NATURE