Rolling Circle Replication for Biosensing, Bioimaging, and Biomedicine

Hemin-Bridged MOF Interface with Double Amplification of G-Quadruplex Payload and DNAzyme Catalysis: Ultrasensitive Lasting Chemiluminescence MicroRNA Imaging

(2020) Lan Mi et al.   ACS Applied Materials & Interfaces

High-Fidelity Single Molecule Quantification in a Flow Cytometer Using Multiparametric Optical Analysis

(2020) Lucas D. Smith et al.   ACS Nano

DNA Structure Transition-Induced Affinity Switch for Biosensing Based on the Strong Electrochemiluminescence Platform from Organic Microcrystals

(2020) Ni Liao et al.   ANALYTICAL CHEMISTRY

Double Rolling Circle Amplification Generates Physically Cross-Linked DNA Network for Stem Cell Fishing

(2020) Chi Yao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Multifunctional DNA Polymer Assisted Upconversion Therapeutic Nanoplatform for Enhanced Photodynamic Therapy

(2020) Yi Jin et al.   ACS Applied Materials & Interfaces

Metal Ion-Mediated Potential-Resolved Ratiometric Electrochemiluminescence Bioassay for Efficient Determination of miR-133a in Early Diagnosis of Acute Myocardial Infarction

(2020) Jue Wang et al.   ANALYTICAL CHEMISTRY

RNA-primed Amplification for Noise-suppressed Visualization of Single-cell Splice Variants

(2020) Xiaowen Cao et al.   ANALYTICAL CHEMISTRY

In Situ Formation of Multifunctional DNA Nanospheres for a Sensitive and Accurate Dual-Mode Biosensor for Photoelectrochemical and Electrochemical Assay

(2020) Hanmei Deng et al.   ANALYTICAL CHEMISTRY

A Self-Assembled mRNA-Responsive DNA Nanosphere for Bioimaging and Cancer Therapy in Drug-Resistant Cells

(2020) Yifan Jiang et al.   ANALYTICAL CHEMISTRY

Ultrasensitive Detection of Attomolar Protein Concentrations by Dropcast Single Molecule Assays

(2020) Connie Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Sensitive MicroRNA Detection by Coupling Nicking-Enhanced Rolling Circle Amplification with MoS2 Quantum Dots

(2020) Jia Ge et al.   ANALYTICAL CHEMISTRY

Construction of a Ternary Complex Based DNA Logic Nanomachine for a Highly Accurate Imaging Analysis of Cancer Cells

(2020) Chang Feng et al.   ACS Sensors

Proteolysis-Responsive Rolling Circle Transcription Assay Enabling Femtomolar Sensitivity Detection of a Target Protease Biomarker

(2020) Xingyu Luo et al.   ANALYTICAL CHEMISTRY

Engineering of Bioinspired, Size-Controllable, Self-Degradable Cancer-Targeting DNA Nanoflowers via the Incorporation of an Artificial Sandwich Base

(2019) Lili Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Programmable DNA Ring/Hairpin-Constrained Structure Enables Ligation-Free Rolling Circle Amplification for Imaging mRNAs in Single Cells

(2019) Wenjiao Zhou et al.   ANALYTICAL CHEMISTRY

Bioinspired Fabrication of DNA–Inorganic Hybrid Composites Using Synthetic DNA

(2019) Eunjung Kim et al.   ACS Nano

Virus-Mimicking Cell Capture Using Heterovalency Magnetic DNA Nanoclaws

(2019) Zhiru Wang et al.   ACS Applied Materials & Interfaces

Nonviolent Self-Catabolic DNAzyme Nanosponges for Smart Anticancer Drug Delivery

(2019) Jing Wang et al.   ACS Nano

A Sensitive Aptasensor Based on a Hemin/G‐Quadruplex‐Assisted Signal Amplification Strategy for Electrochemical Detection of Gastric Cancer Exosomes

(2019) Rongrong Huang et al.   Small

Ultrasensitive Real-Time Rolling Circle Amplification Detection Enhanced by Nicking-Induced Tandem-Acting Polymerases

(2019) Bo Tian et al.   ANALYTICAL CHEMISTRY

Highly Stable and Multi-Emissive Silver Nanoclusters Synthesized in situ in DNA Hydrogel and Their Application for Hydroxyl Radical Sensing

(2018) Jing Li et al.   ACS Applied Materials & Interfaces

An Ultrasensitive Diagnostic Biochip Based on Biomimetic Periodic Nanostructure-Assisted Rolling Circle Amplification

(2018) Qian Yao et al.   ACS Nano

Effective and Selective Anti-Cancer Protein Delivery via All-Functions-in-One Nanocarriers Coupled with Visible Light-Responsive, Reversible Protein Engineering

(2018) Hua He et al.   ADVANCED FUNCTIONAL MATERIALS

In Situ Visualization of hERG Potassium Channel via Dual Signal Amplification

(2018) Xue-Jiao Yang et al.   ANALYTICAL CHEMISTRY

Ultrasensitive Fluorescent Assay Based on a Rolling-Circle-Amplification-Assisted Multisite-Strand-Displacement-Reaction Signal-Amplification Strategy

(2018) Xin Peng et al.   ANALYTICAL CHEMISTRY

Photoelectrochemical biosensing of disease marker on p-type Cu-doped Zn 0.3 Cd 0.7 S based on RCA and exonuclease III amplification

(2018) Kangyao Zhang et al.   BIOSENSORS & BIOELECTRONICS

Bio-bar-code-based photoelectrochemical immunoassay for sensitive detection of prostate-specific antigen using rolling circle amplification and enzymatic biocatalytic precipitation

(2018) Kangyao Zhang et al.   BIOSENSORS & BIOELECTRONICS

DNA nanoclew templated spherical nucleic acids for siRNA delivery

(2018) Weimin Ruan et al.   CHEMICAL COMMUNICATIONS

Integration of isothermal amplification with quantum dot-based fluorescence resonance energy transfer for simultaneous detection of multiple microRNAs

(2018) Juan Hu et al.   Chemical Science

SpliceRCA: in Situ Single-Cell Analysis of mRNA Splicing Variants

(2018) Xiaojun Ren et al.   ACS Central Science

Ligation-rolling circle amplification on quantum dot-encoded microbeads for detection of multiplex G-quadruplex-forming sequences

(2018) Xiaojun Qu et al.   ANALYTICAL CHEMISTRY

Recognition-Enhanced Metastably Shielded Aptamer for Digital Quantification of Small Molecules

(2018) Ruijie Deng et al.   ANALYTICAL CHEMISTRY

Single-cell study of the extracellular matrix effect on cell growth by in situ imaging of gene expression

(2017) Yupeng Sun et al.   Chemical Science

Highly specific imaging of mRNA in single cells by target RNA-initiated rolling circle amplification

(2017) Ruijie Deng et al.   Chemical Science

Intertwining DNA-RNA nanocapsules loaded with tumor neoantigens as synergistic nanovaccines for cancer immunotherapy

(2017) Guizhi Zhu et al.   Nature Communications

Biodegradable, multifunctional DNAzyme nanoflowers for enhanced cancer therapy

(2017) Yi Jin et al.   NPG Asia Materials

Bubbled RNA-Based Cargo for Boosting RNA Interference

(2017) Hyejin Kim et al.   Advanced Science

The Discovery of Rolling Circle Amplification and Rolling Circle Transcription

(2016) Michael G. Mohsen et al.   ACCOUNTS OF CHEMICAL RESEARCH

Cascade Signal Amplification Based on Copper Nanoparticle-Reported Rolling Circle Amplification for Ultrasensitive Electrochemical Detection of the Prostate Cancer Biomarker

(2016) Ye Zhu et al.   ACS Applied Materials & Interfaces

Acoustically Propelled Nanomotors for Intracellular siRNA Delivery

(2016) Berta Esteban-Fernández de Ávila et al.   ACS Nano

Inflammation-Triggered Cancer Immunotherapy by Programmed Delivery of CpG and Anti-PD1 Antibody

(2016) Chao Wang et al.   ADVANCED MATERIALS

Near-Infrared-Fluorescent Probes for Bioapplications Based on Silica-Coated Gold Nanobipyramids with Distance-Dependent Plasmon-Enhanced Fluorescence

(2016) Caixia Niu et al.   ANALYTICAL CHEMISTRY

In Situ Electrochemical Generation of Electrochemiluminescent Silver Naonoclusters on Target-Cycling Synchronized Rolling Circle Amplification Platform for MicroRNA Detection

(2016) Anyi Chen et al.   ANALYTICAL CHEMISTRY

Transformable DNA nanocarriers for plasma membrane targeted delivery of cytokine

(2016) Wujin Sun et al.   BIOMATERIALS

DNA–inorganic hybrid nanovaccine for cancer immunotherapy

(2016) Guizhi Zhu et al.   Nanoscale

NMR as a tool to investigate the structure, dynamics and function of membrane proteins

(2016) Binyong Liang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Applying DNA rolling circle amplification in fluorescence imaging of cell surface glycans labeled by a metabolic method

(2016) Xiaoru Zhang et al.   Chemical Science

Self-assembly of nucleic acid molecular aggregates catalyzed by a triple-helix probe for miRNA detection and single cell imaging

(2016) Zhen Zhang et al.   Chemical Science

DNA-mediated cell surface engineering for multiplexed glycan profiling using MALDI-TOF mass spectrometry

(2016) Ziyi He et al.   Chemical Science

NMR as a tool to investigate the structure, dynamics and function of membrane proteins

(2016) Binyong Liang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Bioanalytical applications of isothermal nucleic acid amplification techniques

(2015) Huimin Deng et al.   ANALYTICA CHIMICA ACTA

A Multi-RNAi Microsponge Platform for Simultaneous Controlled Delivery of Multiple Small Interfering RNAs

(2015) Young Hoon Roh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enzymatic Synthesis of Periodic DNA Nanoribbons for Intracellular pH Sensing and Gene Silencing

(2015) Gang Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Proximity Ligation Assay with Three-Way Junction-Induced Rolling Circle Amplification for Ultrasensitive Electronic Monitoring of Concanavalin A

(2014) Bingqian Liu et al.   ANALYTICAL CHEMISTRY

Tracking Surface Glycans on Live Cancer Cells with Single-Molecule Sensitivity

(2014) Hao Jiang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A rolling circle amplification-based DNA machine for miRNA screening coupling catalytic hairpin assembly with DNAzyme formation

(2014) Junyang Zhuang et al.   CHEMICAL COMMUNICATIONS

Rolling circle amplification: a versatile tool for chemical biology, materials science and medicine

(2014) M. Monsur Ali et al.   CHEMICAL SOCIETY REVIEWS

High Specific and Ultrasensitive Isothermal Detection of MicroRNA by Padlock Probe-Based Exponential Rolling Circle Amplification

(2013) Haiyun Liu et al.   ANALYTICAL CHEMISTRY

Noncanonical Self-Assembly of Multifunctional DNA Nanoflowers for Biomedical Applications

(2013) Guizhi Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Self-assembled RNA interference microsponges for efficient siRNA delivery

(2012) Jong Bum Lee et al.   NATURE MATERIALS

Fluorescent Probes for Live-Cell RNA Detection

(2009) Gang Bao et al.   Annual Review of Biomedical Engineering

Sensitive isothermal detection of nucleic-acid sequence by primer generation–rolling circle amplification

(2008) Taku Murakami et al.   NUCLEIC ACIDS RESEARCH