Strategies for optimizing acetyl-CoA formation from glucose in bacteria

Fine tuning the glycolytic flux ratio of EP-bifido pathway for mevalonate production by enhancing glucose-6-phosphate dehydrogenase (Zwf) and CRISPRi suppressing 6-phosphofructose kinase (PfkA) in Escherichia coli

(2021) Ying Li et al.   Microbial Cell Factories

Lycopene production from glucose, fatty acid and waste cooking oil by metabolically engineered Escherichia coli

(2020) Na Liu et al.   BIOCHEMICAL ENGINEERING JOURNAL

Metabolic engineering of Zymomonas mobilis for anaerobic isobutanol production

(2020) Mengyue Qiu et al.   Biotechnology for Biofuels

Multilevel optimisation of anaerobic ethyl acetate production in engineered Escherichia coli

(2020) Anna C. Bohnenkamp et al.   Biotechnology for Biofuels

Hydrogen peroxide-producing pyruvate oxidase from Lactobacillus delbrueckii is catalytically activated by phosphotidylethanolamine

(2020) Louis P. Cornacchione et al.   BMC MICROBIOLOGY

Novel Strategies and Platforms for Industrial Isoprenoid Engineering

(2020) Georgios Daletos et al.   TRENDS IN BIOTECHNOLOGY

Metabolic Engineering Design Strategies for Increasing Acetyl-CoA Flux

(2020) Jason T. Ku et al.   Metabolites

Adaptive laboratory evolution enhances methanol tolerance and conversion in engineered Corynebacterium glutamicum

(2020) Yu Wang et al.   Communications Biology

Construction of a carbon-conserving pathway for glycolate production by synergetic utilization of acetate and glucose in Escherichia coli

(2020) Yong Yu et al.   METABOLIC ENGINEERING

Awakening a latent carbon fixation cycle in Escherichia coli

(2020) Ari Satanowski et al.   Nature Communications

Constructing an ethanol utilization pathway in Escherichia coli to produce acetyl-CoA derived compounds

(2020) Hong Liang et al.   METABOLIC ENGINEERING

Perspectives for the biotechnological production of biofuels from CO2 and H2 using Ralstonia eutropha and other ‘Knallgas’ bacteria

(2019) Christopher Brigham   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Metabolic engineering of Escherichia coli carrying the hybrid acetone-biosynthesis pathway for efficient acetone biosynthesis from acetate

(2019) Hao Yang et al.   Microbial Cell Factories

Constructing a synthetic pathway for acetyl-coenzyme A from one-carbon through enzyme design

(2019) Xiaoyun Lu et al.   Nature Communications

Engineering Zymomonas mobilis for Robust Cellulosic Ethanol Production

(2019) Juan Xia et al.   TRENDS IN BIOTECHNOLOGY

Medium Chain Carboxylic Acids from Complex Organic Feedstocks by Mixed Culture Fermentation

(2019) Vicky De Groof et al.   MOLECULES

Heterologous phosphoketolase expression redirects flux towards acetate, perturbs sugar phosphate pools and increases respiratory demand in Saccharomyces cerevisiae

(2019) Alexandra Bergman et al.   Microbial Cell Factories

Increase ethyl acetate production in Saccharomyces cerevisiae by genetic engineering of ethyl acetate metabolic pathway

(2019) Jian Dong et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Medium chain carboxylic acids production from waste biomass: Current advances and perspectives

(2019) Qinglian Wu et al.   BIOTECHNOLOGY ADVANCES

Effects of lipopolysaccharide structure on lycopene production in Escherichia coli

(2019) Mao Cui et al.   ENZYME AND MICROBIAL TECHNOLOGY

Engineering an Artificial Membrane Vesicle Trafficking System (AMVTS) for the Excretion of β-Carotene in Escherichia coli

(2019) Tao Wu et al.   ACS Synthetic Biology

New Horizons in Acetogenic Conversion of One-Carbon Substrates and Biological Hydrogen Storage

(2019) Volker Müller   TRENDS IN BIOTECHNOLOGY

Systematic engineering for high-yield production of viridiflorol and amorphadiene in auxotrophic Escherichia coli

(2019) Sudha Shukal et al.   METABOLIC ENGINEERING

Metabolic engineering for efficient supply of acetyl-CoA from different carbon sources in Escherichia coli

(2019) Shasha Zhang et al.   Microbial Cell Factories

Engineering protein production by rationally choosing a carbon and nitrogen source using E. coli BL21 acetate metabolism knockout strains

(2019) Gema Lozano Terol et al.   Microbial Cell Factories

Growth-coupled evolution of phosphoketolase to improve l-glutamate production by Corynebacterium glutamicum

(2019) Taiwo Dele-Osibanjo et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

New AMP‐forming acid:CoA ligases from Streptomyces lividans , some of which are posttranslationally regulated by reversible lysine acetylation

(2019) Rachel M. Burckhardt et al.   MOLECULAR MICROBIOLOGY

Polyunsaturated fatty acid production by Yarrowia lipolytica employing designed myxobacterial PUFA synthases

(2019) Katja Gemperlein et al.   Nature Communications

Rewiring carbon metabolism in yeast for high level production of aromatic chemicals

(2019) Quanli Liu et al.   Nature Communications

An Efficient New Process for the Selective Production of Odd-Chain Carboxylic Acids by Simple Carbon Elongation Using Megasphaera hexanoica

(2019) Hyunjin Kim et al.   Scientific Reports

Kinetic modeling of butyric acid effects on butanol fermentation by Clostridium saccharoperbutylacetonicum

(2019) Quan Zhou et al.   New Biotechnology

Hyper-production of butyric acid from delignified rice straw by a novel consolidated bioprocess

(2018) Xue Chi et al.   BIORESOURCE TECHNOLOGY

Recent advances and strategies in process and strain engineering for the production of butyric acid by microbial fermentation

(2018) Hongzhen Luo et al.   BIORESOURCE TECHNOLOGY

Optimization of hexanoic acid production in recombinant Escherichia coli by precise flux rebalancing

(2018) Seong Gyeong Kim et al.   BIORESOURCE TECHNOLOGY

Characterizing the effect of expression of an acetyl-CoA synthetase insensitive to acetylation on co-utilization of glucose and acetate in batch and continuous cultures of E. coli W

(2018) Katharina Novak et al.   Microbial Cell Factories

Construction and evolution of anEscherichia colistrain relying on nonoxidative glycolysis for sugar catabolism

(2018) Paul P. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent trends in biobutanol production

(2018) Deepika Kushwaha et al.   REVIEWS IN CHEMICAL ENGINEERING

Augmenting the Calvin–Benson–Bassham cycle by a synthetic malyl-CoA-glycerate carbon fixation pathway

(2018) Hong Yu et al.   Nature Communications

News and views about carotenoids: Red-hot and true

(2018) Johannes von Lintig et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Expressing the Thermoanaerobacterium saccharolyticum pforA in engineered Clostridium thermocellum improves ethanol production

(2018) Shuen Hon et al.   Biotechnology for Biofuels

Altering the sensitivity of Escherichia coli pyruvate dehydrogenase complex to NADH inhibition by structure-guided design

(2018) Xiuwen Wang et al.   ENZYME AND MICROBIAL TECHNOLOGY

Engineering an in vivo EP-bifido pathway in Escherichia coli for high-yield acetyl-CoA generation with low CO 2 emission

(2018) Qian Wang et al.   METABOLIC ENGINEERING

Metabolic engineering of Escherichia coli for high-level astaxanthin production with high productivity

(2018) Seon Young Park et al.   METABOLIC ENGINEERING

Characterization of the Clostridium thermocellum AdhE, NfnAB, Ferredoxin and Pfor proteins for their ability to support high titer ethanol production in Thermoanaerobacterium saccharolyticum

(2018) Jingxuan Cui et al.   METABOLIC ENGINEERING

Artificial pathway emergence in central metabolism from three recursive phosphoketolase reactions

(2018) Jan L. Krüsemann et al.   FEBS Journal

Production of Caproic Acid from Mixed Organic Waste: An Environmental Life Cycle Perspective

(2017) Wei-Shan Chen et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Phosphoketolase overexpression increases biomass and lipid yield from methane in an obligate methanotrophic biocatalyst

(2017) Calvin A. Henard et al.   METABOLIC ENGINEERING

A systematically chromosomally engineered Escherichia coli efficiently produces butanol

(2017) Hongjun Dong et al.   METABOLIC ENGINEERING

Genetic engineering of Synechocystis sp. PCC6803 for poly-β-hydroxybutyrate overproduction

(2017) Roberta Carpine et al.   Algal Research-Biomass Biofuels and Bioproducts

Perturbation of formate pathway and NADH pathway acting on the biohydrogen production

(2017) Dong Liu et al.   Scientific Reports

n-Butanol production in Saccharomyces cerevisiae is limited by the availability of coenzyme A and cytosolic acetyl-CoA

(2016) Virginia Schadeweg et al.   Biotechnology for Biofuels

An engineered non-oxidative glycolysis pathway for acetone production in Escherichia coli

(2016) Xiaoyan Yang et al.   BIOTECHNOLOGY LETTERS

The potential of glycerol as a value-added commodity

(2016) M. Anitha et al.   CHEMICAL ENGINEERING JOURNAL

Developing fermentative terpenoid production for commercial usage

(2016) Michael D Leavell et al.   CURRENT OPINION IN BIOTECHNOLOGY

Formation of propionate and butyrate by the human colonic microbiota

(2016) Petra Louis et al.   ENVIRONMENTAL MICROBIOLOGY

Engineering cytosolic acetyl-coenzyme A supply in Saccharomyces cerevisiae : Pathway stoichiometry, free-energy conservation and redox-cofactor balancing

(2016) Harmen M. van Rossum et al.   METABOLIC ENGINEERING

Synergy between methylerythritol phosphate pathway and mevalonate pathway for isoprene production in Escherichia coli

(2016) Chen Yang et al.   METABOLIC ENGINEERING

Rewriting yeast central carbon metabolism for industrial isoprenoid production

(2016) Adam L. Meadows et al.   NATURE

A synthetic biochemistry module for production of bio-based chemicals from glucose

(2016) Paul H Opgenorth et al.   Nature Chemical Biology

EngineeringYarrowia lipolyticaas a platform for synthesis of drop-in transportation fuels and oleochemicals

(2016) Peng Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Waste Conversion into n-Caprylate and n-Caproate: Resource Recovery from Wine Lees Using Anaerobic Reactor Microbiomes and In-line Extraction

(2016) Leo A. Kucek et al.   Frontiers in Microbiology

Sustainable source of omega-3 eicosapentaenoic acid from metabolically engineered Yarrowia lipolytica: from fundamental research to commercial production

(2015) Dongming Xie et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Current status and prospects of industrial bio-production of n-butanol in China

(2015) Yu Jiang et al.   BIOTECHNOLOGY ADVANCES

Phosphoketolase pathway engineering for carbon-efficient biocatalysis

(2015) Calvin Andrew Henard et al.   CURRENT OPINION IN BIOTECHNOLOGY

Manipulating pyruvate to acetyl-CoA conversion in Escherichia coli for anaerobic succinate biosynthesis from glucose with the yield close to the stoichiometric maximum

(2015) Alexandra Yu. Skorokhodova et al.   JOURNAL OF BIOTECHNOLOGY

Microbial acetyl-CoA metabolism and metabolic engineering

(2015) Anastasia Krivoruchko et al.   METABOLIC ENGINEERING

Engineering the glycolytic pathway: A potential approach for improvement of biocatalyst performance

(2015) Toru Jojima et al.   Bioengineered

Phosphoketolases from Lactococcus lactis, Leuconostoc mesenteroides and Pseudomonas aeruginosa: dissimilar sequences, similar substrates but distinct enzymatic characteristics

(2014) Georgiana Petrareanu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The Pyruvate Dehydrogenase Complexes: Structure-based Function and Regulation

(2014) Mulchand S. Patel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A biosynthetic pathway for hexanoic acid production in Kluyveromyces marxianus

(2014) Yuna Cheon et al.   JOURNAL OF BIOTECHNOLOGY

Metabolic evolution of two reducing equivalent-conserving pathways for high-yield succinate production in Escherichia coli

(2014) Xinna Zhu et al.   METABOLIC ENGINEERING

Improved production of fatty acid ethyl esters in Saccharomyces cerevisiae through up-regulation of the ethanol degradation pathway and expression of the heterologous phosphoketolase pathway

(2014) Bouke Wim de Jong et al.   Microbial Cell Factories

Pyruvate Formate-lyase and Its Activation by Pyruvate Formate-lyase Activating Enzyme

(2013) Adam V. Crain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A reverse glyoxylate shunt to build a non-native route from C4 to C2 in Escherichia coli

(2013) Samuel E. Mainguet et al.   METABOLIC ENGINEERING

Replacement of the Saccharomyces cerevisiae acetyl-CoA synthetases by alternative pathways for cytosolic acetyl-CoA synthesis

(2013) Barbara U. Kozak et al.   METABOLIC ENGINEERING

Construction of an in vitro bypassed pyruvate decarboxylation pathway using thermostable enzyme modules and its application to N-acetylglutamate production

(2013) Borimas Krutsakorn et al.   Microbial Cell Factories

Synthetic non-oxidative glycolysis enables complete carbon conservation

(2013) Igor W. Bogorad et al.   NATURE

Production of omega-3 eicosapentaenoic acid by metabolic engineering of Yarrowia lipolytica

(2013) Zhixiong Xue et al.   NATURE BIOTECHNOLOGY

Physiological characterization of recombinant Saccharomyces cerevisiae expressing the Aspergillus nidulans phosphoketolase pathway: validation of activity through 13C-based metabolic flux analysis

(2012) Marta Papini et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Phosphoketolase Pathway for Xylose Catabolism in Clostridium acetobutylicum Revealed by 13C Metabolic Flux Analysis

(2012) L. Liu et al.   JOURNAL OF BACTERIOLOGY

A modified pathway for the production of acetone in Escherichia coli

(2012) Antje May et al.   METABOLIC ENGINEERING

A Synthetic Biology Approach to Engineer a Functional Reversal of the β-Oxidation Cycle

(2012) James M. Clomburg et al.   ACS Synthetic Biology

Driving Forces Enable High-Titer Anaerobic 1-Butanol Synthesis in Escherichia coli

(2011) Claire R. Shen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Enzyme mechanism as a kinetic control element for designing synthetic biofuel pathways

(2011) Brooks B Bond-Watts et al.   Nature Chemical Biology

Microbial production of bulk chemicals: development of anaerobic processes

(2011) Ruud A. Weusthuis et al.   TRENDS IN BIOTECHNOLOGY

Engineered Respiro-Fermentative Metabolism for the Production of Biofuels and Biochemicals from Fatty Acid-Rich Feedstocks

(2010) C. Dellomonaco et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Dihydrolipoamide Dehydrogenase Mutation Alters the NADH Sensitivity of Pyruvate Dehydrogenase Complex of Escherichia coli K-12

(2008) Y. Kim et al.   JOURNAL OF BACTERIOLOGY

Metabolic engineering of Escherichia coli for 1-butanol production

(2007) Shota Atsumi et al.   METABOLIC ENGINEERING

Characterization of the Acetate-Producing Pathways in Escherichia coli

(2005) Cheryl R. Dittrich et al.   BIOTECHNOLOGY PROGRESS