NLRP3 protects mice from radiation-induced colon and skin damage via attenuating cGAS-STING signaling

Ionizing radiation induces cutaneous lipid remolding and skin adipocytes confer protection against radiation-induced skin injury

(2020) Yuji Xiao et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Irradiation induces cancer lung metastasis through activation of the cGAS–STING–CCL5 pathway in mesenchymal stromal cells

(2020) Zhiyuan Zheng et al.   Cell Death & Disease

Improvement of magnesium isoglycyrrhizinate on DSS-induced acute and chronic colitis

(2020) Jian Cui et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Modulatory effect of a new benzopyran derivative via COX-2 blocking and down regulation of NF-κB against γ-radiation induced- intestinal inflammation

(2019) Omama E. Elshawi et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Management of Acute Radiation Dermatitis: A Review of the Literature and Proposal for Treatment Algorithm

(2019) Amanda Rosenthal et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Andrographolide triggers autophagy-mediated inflammation inhibition and attenuates chronic unpredictable mild stress (CUMS)-induced depressive-like behavior in mice

(2019) Ji Geng et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The role of NLRP3 inflammasome activation in radiation damage

(2019) Jinlong Wei et al.   BIOMEDICINE & PHARMACOTHERAPY

Efficacy of herbal medicine TJ-14 for acute radiation-induced enteritis: a multi-institutional prospective Phase II trial

(2019) Taro Murai et al.   JOURNAL OF RADIATION RESEARCH

Emerging Activators and Regulators of Inflammasomes and Pyroptosis

(2019) Yansong Xue et al.   TRENDS IN IMMUNOLOGY

5-Androstenediol prevents radiation injury in mice by promoting NF-κB signaling and inhibiting AIM2 inflammasome activation

(2019) Tiancong Wu et al.   BIOMEDICINE & PHARMACOTHERAPY

Radiation-induced intestinal damage: latest molecular and clinical developments

(2019) Lina Lu et al.   Future Oncology

Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis

(2019) Jian Gao et al.   Cell Death & Disease

Radiotherapy as a Backbone for Novel Concepts in Cancer Immunotherapy

(2019) Julijan Kabiljo et al.   Cancers

Lactobacillus rhamnosusGG protects the intestinal epithelium from radiation injury through release of lipoteichoic acid, macrophage activation and the migration of mesenchymal stem cells

(2018) Terrence E Riehl et al.   GUT

Protective Effects of Flagellin A N/C Against Radiation-Induced NLR Pyrin Domain Containing 3 Inflammasome-Dependent Pyroptosis in Intestinal Cells

(2018) Dongming Wu et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Targeting the NLRP3 inflammasome in inflammatory diseases

(2018) Matthew S. J. Mangan et al.   NATURE REVIEWS DRUG DISCOVERY

Synergistic actions of FGF2 and bone marrow transplantation mitigate radiation-induced intestinal injury

(2018) Byoung Hyuck Kim et al.   Cell Death & Disease

BCN057 induces intestinal stem cell repair and mitigates radiation-induced intestinal injury

(2018) Payel Bhanja et al.   Stem Cell Research & Therapy

Pravastatin Attenuates Acute Radiation-Induced Enteropathy and Improves Epithelial Cell Function

(2018) Hyosun Jang et al.   Frontiers in Pharmacology

ROS and the DNA damage response in cancer

(2018) Upadhyayula Sai Srinivas et al.   Redox Biology

Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection

(2017) Yutao Wang et al.   IMMUNITY

Remodelling of the gut microbiota by hyperactive NLRP3 induces regulatory T cells to maintain homeostasis

(2017) Xiaomin Yao et al.   Nature Communications

Radiation dermatitis: an overview

(2016) Fanni Hegedus et al.   INTERNATIONAL JOURNAL OF DERMATOLOGY

The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury

(2016) Bo Hu et al.   SCIENCE

Radiation takes its Toll

(2015) Josephine A. Ratikan et al.   CANCER LETTERS

The Nlrp3 Inflammasome Suppresses Colorectal Cancer Metastatic Growth in the Liver by Promoting Natural Killer Cell Tumoricidal Activity

(2015) Jeremy Dupaul-Chicoine et al.   IMMUNITY

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

(2014) Liufu Deng et al.   IMMUNITY

In Vivo Imaging of Reactive Oxygen and Nitrogen Species in Murine Colitis

(2014) M. Nadeem Asghar et al.   INFLAMMATORY BOWEL DISEASES

Radiation Exposure Induces Inflammasome Pathway Activation in Immune Cells

(2014) Veit M. Stoecklein et al.   JOURNAL OF IMMUNOLOGY

Biological Consequences of Radiation-induced DNA Damage: Relevance to Radiotherapy

(2013) M.E. Lomax et al.   CLINICAL ONCOLOGY

Selective Sequestration of STAT1 in the Cytoplasm via Phosphorylated SHP-2 Ameliorates Murine Experimental Colitis

(2012) X. Wu et al.   JOURNAL OF IMMUNOLOGY

STING manifests self DNA-dependent inflammatory disease

(2012) J. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

(2011) Greta Guarda et al.   IMMUNITY

Guidelines for reporting experiments involving animals: the ARRIVE guidelines

(2010) JC McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

(2010) C. Bauer et al.   GUT

The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental Colitis

(2010) Md. Hasan Zaki et al.   IMMUNITY

Radiation Dose–Volume Effects in the Stomach and Small Bowel

(2010) Brian D. Kavanagh et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Radiation Dose–Volume Effects in Radiation-Induced Rectal Injury

(2010) Jeff M. Michalski et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

(2009) Olaf Gross et al.   NATURE