Oral isoniazid causes oxidative stress, oocyte deterioration and infertility in mice

Metabolomics describes previously unknown toxicity mechanisms of isoniazid and rifampicin

(2020) Monique Combrink et al.   TOXICOLOGY LETTERS

Triclocarban exposure affects mouse oocyte in vitro maturation through inducing mitochondrial dysfunction and oxidative stress

(2020) Zhi-Ming Ding et al.   ENVIRONMENTAL POLLUTION

Melatonin supplementation during in vitro maturation of oocyte enhances subsequent development of bovine cloned embryos

(2019) Quanli An et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Plasticizer Bis(2-ethylhexyl) Phthalate Causes Meiosis Defects and Decreases Fertilization Ability of Mouse Oocytes in Vivo

(2019) Zhenzhen Lu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Eosinophil peroxidase oxidizes isoniazid to form the active metabolite against M. tuberculosis, isoniazid-NAD+

(2019) Dinesh Babu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Mechanism of isoniazid-induced hepatotoxicity in zebrafish larvae: Activation of ROS-mediated ERS, apoptosis and the Nrf2 pathway

(2019) Zhi-li Jia et al.   CHEMOSPHERE

Caspases in Cell Death, Inflammation, and Disease

(2019) Nina Van Opdenbosch et al.   IMMUNITY

Reproductive toxicity of acute Cd exposure in mouse: Resulting in oocyte defects and decreased female fertility

(2019) Yuyao Cheng et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Isoniazid Preventive Therapy in HIV-Infected Pregnant and Postpartum Women

(2019) Amita Gupta et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ochratoxin A exposure causes meiotic failure and oocyte deterioration in mice

(2019) Huiqun Jia et al.   THERIOGENOLOGY

Phosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization

(2019) Claudia M. Rival et al.   Nature Communications

Treatment of Latent Tuberculosis Infection—An Update

(2019) Moises A. Huaman et al.   CLINICS IN CHEST MEDICINE

Exposure to first line anti-tuberculosis drugs in prepubertal age reduces the quality and functional competence of spermatozoa and oocytes in Swiss albino mice

(2019) Arpitha Rao et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Mogroside V improves porcine oocyte in vitro maturation and subsequent embryonic development

(2019) Junyu Nie et al.   THERIOGENOLOGY

Actin cytoskeleton dynamics in mammalian oocyte meiosis

(2018) Xing Duan et al.   BIOLOGY OF REPRODUCTION

BaP exposure causes oocyte meiotic arrest and fertilization failure to weaken female fertility

(2018) Mianqun Zhang et al.   FASEB JOURNAL

Structure-based design of some isonicotinic acid hydrazide analogues as potential antitubercular agents

(2018) Amal Atta et al.   BIOORGANIC CHEMISTRY

Isoniazid derivatives and their anti-tubercular activity

(2017) Yuan-Qiang Hu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Bax, Bak and beyond - mitochondrial performance in apoptosis

(2017) Aida Peña-Blanco et al.   FEBS Journal

Oxidative stress-mediated developmental toxicity induced by isoniazide in zebrafish embryos and larvae

(2017) Yu Zou et al.   JOURNAL OF APPLIED TOXICOLOGY

Galactose and its Metabolites Deteriorate Metaphase II Mouse Oocyte Quality and Subsequent Embryo Development by Disrupting the Spindle Structure

(2017) Mili Thakur et al.   Scientific Reports

Oxidative Damage Induced by Arsenic in Mice or Rats: A Systematic Review and Meta-Analysis

(2016) Mengchuan Xu et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Ethambutol induces testicular damage and decreases the sperm functional competence in Swiss albino mice

(2016) Arpitha Rao et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Optimizing treatment outcome of first-line anti-tuberculosis drugs: the role of therapeutic drug monitoring

(2016) Roger K. Verbeeck et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Overview on mechanisms of isoniazid action and resistance in Mycobacterium tuberculosis

(2016) Ameeruddin Nusrath Unissa et al.   INFECTION GENETICS AND EVOLUTION

Oxidative stress and oocyte quality: ethiopathogenic mechanisms of minimal/mild endometriosis-related infertility

(2015) Michele Gomes Da Broi et al.   CELL AND TISSUE RESEARCH

Mitochondrial oxidative stress and dysfunction induced by isoniazid: study on isolated rat liver and brain mitochondria

(2015) Morteza Ahadpour et al.   DRUG AND CHEMICAL TOXICOLOGY

Molecular basis of the Keap1–Nrf2 system

(2015) Takafumi Suzuki et al.   FREE RADICAL BIOLOGY AND MEDICINE

Melatonin significantly improves the developmental competence of bovine somatic cell nuclear transfer embryos

(2015) Jianmin Su et al.   JOURNAL OF PINEAL RESEARCH

Induction of CYP2E1 in testes of isoniazid-treated rats as possible cause of testicular disorders

(2015) Ganna M. Shayakhmetova et al.   TOXICOLOGY LETTERS

Serum antioxidant enzymes activities and oxidative stress levels in patients with acute ischemic stroke: influence on neurological status and outcome

(2015) Aysel Milanlioglu et al.   WIENER KLINISCHE WOCHENSCHRIFT

Isoniazid prevents Nrf2 translocation by inhibiting ERK1 phosphorylation and induces oxidative stress and apoptosis

(2015) Ajeet Kumar Verma et al.   Redox Biology

Therapeutic potential of thymoquinone against anti-tuberculosis drugs induced liver damage

(2013) Amita Jaswal et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Antioxidant supplementation overcomes the deleterious effects of maternal restraint stress-induced oxidative stress on mouse oocytes

(2013) Hua-Yu Lian et al.   REPRODUCTION

Where Killers Meet--Permeabilization of the Outer Mitochondrial Membrane during Apoptosis

(2013) T. Bender et al.   Cold Spring Harbor Perspectives in Biology

MRI findings of isoniazid-induced central nervous system toxicity in a child

(2012) Z.I. Hasiloglu et al.   CLINICAL RADIOLOGY

Polar body emission

(2012) X. Johné Liu   Cytoskeleton

Effects of Sildenafil Citrate, Isoniazid, and Streptomycin on Testicular Tissue and Epididymal Semen Quality in Rats

(2012) Harun Alp et al.   UROLOGY

Cellular toxicity of isoniazid together with rifampicin and the metabolites of isoniazid on QSG-7701 hepatocytes

(2012) Zhi-Hua Zhang et al.   Asian Pacific Journal of Tropical Medicine

Bulk Cytoplasmic Actin and Its Functions in Meiosis and Mitosis

(2011) Christine M. Field et al.   CURRENT BIOLOGY

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE