Roles of ERK/Akt signals in mitochondria-dependent and endoplasmic reticulum stress-triggered neuronal cell apoptosis induced by 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene, a major active metabolite of bisphenol A

Protective effects of lycopene on hippocampal neurotoxicity and memory impairment induced by bisphenol A in rats

(2020) EM El Morsy et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Cr(VI) induces ROS-mediated mitochondrial-dependent apoptosis in neuronal cells via the activation of Akt/ERK/AMPK signaling pathway

(2020) Shih-Chang Fu et al.   TOXICOLOGY IN VITRO

Reaction to Endoplasmic Reticulum Stress via ATF6 in Amyotrophic Lateral Sclerosis Deteriorates With Aging

(2019) Tino Prell et al.   Frontiers in Aging Neuroscience

The Role of PI3K/Akt and ERK in Neurodegenerative Disorders

(2019) Sachchida Nand Rai et al.   NEUROTOXICITY RESEARCH

Mitochondrial dysfunction in neurodegenerative diseases and the potential countermeasure

(2019) Yan Wang et al.   CNS Neuroscience & Therapeutics

Neurotoxicity of BPA, BPS, and BPB for the hippocampal cell line (HT-22): An implication for the replacement of BPA in plastics

(2019) Qihua Pang et al.   CHEMOSPHERE

Bisphenol-A induces neurodegeneration through disturbance of intracellular calcium homeostasis in human embryonic stem cells-derived cortical neurons

(2019) Hongou Wang et al.   CHEMOSPHERE

Methylmercury exposure induces ROS/Akt inactivation-triggered endoplasmic reticulum stress-regulated neuronal cell apoptosis

(2019) Yao-Pang Chung et al.   TOXICOLOGY

Mitochondrial dysfunction in neurodegenerative diseases and drug targets via apoptotic signaling

(2019) Yuanbo Wu et al.   MITOCHONDRION

Silica nanoparticles induce caspase-dependent apoptosis through reactive oxygen species-activated endoplasmic reticulum stress pathway in neuronal cells

(2019) Kuan-I Lee et al.   TOXICOLOGY IN VITRO

Estrogenic Mechanisms and Cardiac Responses Following Early Life Exposure to Bisphenol A (BPA) and Its Metabolite 4-Methyl-2,4-bis(p-hydroxyphenyl)pent-1-ene (MBP) in Zebrafish

(2018) John Moreman et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Expression analysis of protein homeostasis pathways in the peripheral blood mononuclear cells of sporadic amyotrophic lateral sclerosis patients

(2018) Abhishek Vats et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Cardiovascular Effects and Molecular Mechanisms of Bisphenol A and Its Metabolite MBP in Zebrafish

(2018) A. Ross Brown et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Repeated exposure to 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP), an active metabolite of bisphenol A, aggressively stimulates breast cancer cell growth in an estrogen receptor β (ERβ)-dependent manner

(2018) Masayo Hirao-Suzuki et al.   MOLECULAR PHARMACOLOGY

Bisphenol A glucuronidation in patients with Parkinson’s disease

(2017) Annamaria Landolfi et al.   NEUROTOXICOLOGY

Involvement of Insulin Signaling Disturbances in Bisphenol A-Induced Alzheimer’s Disease-like Neurotoxicity

(2017) Tingwei Wang et al.   Scientific Reports

Estrogenic Endocrine Disrupting Chemicals Influencing NRF1 Regulated Gene Networks in the Development of Complex Human Brain Diseases

(2016) Mark Preciados et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The endoplasmic reticulum stress and the HIF-1 signalling pathways are involved in the neuronal damage caused by chemical hypoxia

(2015) Beatriz López-Hernández et al.   BRITISH JOURNAL OF PHARMACOLOGY

Agmatine Protects Against 6-OHDA-Induced Apoptosis, and ERK and Akt/GSK Disruption in SH-SY5Y Cells

(2015) Esmat Amiri et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Conditional inactivation of Akt three isoforms causes tau hyperphosphorylation in the brain

(2015) Long Wang et al.   Molecular Neurodegeneration

NLRP3 inflammasome activation by mitochondrial reactive oxygen species plays a key role in long-term cognitive impairment induced by paraquat exposure

(2015) Liuji Chen et al.   NEUROBIOLOGY OF AGING

Protective Effect of Paeoniflorin on Aβ25–35-Induced SH-SY5Y Cell Injury by Preventing Mitochondrial Dysfunction

(2013) Ke Wang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Arsenic induces reactive oxygen species-caused neuronal cell apoptosis through JNK/ERK-mediated mitochondria-dependent and GRP 78/CHOP-regulated pathways

(2013) Tien-Hui Lu et al.   TOXICOLOGY LETTERS

An ERcentric view of Parkinson's disease

(2013) Gabriela Mercado et al.   TRENDS IN MOLECULAR MEDICINE

Mitochondrial Trafficking in Neurons

(2013) T. L. Schwarz   Cold Spring Harbor Perspectives in Biology

Neurotoxin-induced ER stress in mouse dopaminergic neurons involves downregulation of TRPC1 and inhibition of AKT/mTOR signaling

(2012) Senthil Selvaraj et al.   JOURNAL OF CLINICAL INVESTIGATION

3D Models of MBP, a Biologically Active Metabolite of Bisphenol A, in Human Estrogen Receptor α and Estrogen Receptor β

(2012) Michael E. Baker et al.   PLoS One

Novel Pathway of Metabolic Activation of Bisphenol A-Related Compounds for Estrogenic Activity

(2011) K. Okuda et al.   DRUG METABOLISM AND DISPOSITION

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

(2011) Ying Liu et al.   JOURNAL OF PATHOLOGY

Neurotoxicity of Endocrine Disruptors: Possible Involvement in Brain Development and Neurodegeneration

(2011) Yoshinori Masuo et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Impact of Early-Life Bisphenol A Exposure on Behavior and Executive Function in Children

(2011) J. M. Braun et al.   PEDIATRICS

Involvement of oxidative stress-mediated ERK1/2 and p38 activation regulated mitochondria-dependent apoptotic signals in methylmercury-induced neuronal cell injury

(2011) Tien-Hui Lu et al.   TOXICOLOGY LETTERS

Manganese induces the overexpression of α-synuclein in PC12 cells via ERK activation

(2010) Tongjian Cai et al.   BRAIN RESEARCH

Urinary, Circulating, and Tissue Biomonitoring Studies Indicate Widespread Exposure to Bisphenol A

(2010) Laura N. Vandenberg et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

In vivo estrogenic potential of 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene, an active metabolite of bisphenol A, in uterus of ovariectomized rat

(2010) Katsuhiro Okuda et al.   TOXICOLOGY LETTERS

ERK and cell death: ERK1/2 in neuronal death

(2009) Srinivasa Subramaniam et al.   FEBS Journal

ERK and cell death: Mechanisms of ERK-induced cell death - apoptosis, autophagy and senescence

(2009) Sebastien Cagnol et al.   FEBS Journal

RTP801 Is Induced in Parkinson's Disease and Mediates Neuron Death by Inhibiting Akt Phosphorylation/Activation

(2009) C. Malagelada et al.   JOURNAL OF NEUROSCIENCE

Potential Risk of Bisphenol a Migration From Polycarbonate Containers After Heating, Boiling, and Microwaving

(2009) Duck Soo Lim et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Association of Urinary Bisphenol A Concentration With Medical Disorders and Laboratory Abnormalities in Adults

(2008) Iain A. Lang   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Signaling pathways of bisphenol A-induced apoptosis in hippocampal neuronal cells: Role of calcium-induced reactive oxygen species, mitogen-activated protein kinases, and nuclear factor-κB

(2008) Soyoung Lee et al.   JOURNAL OF NEUROSCIENCE RESEARCH