Review
Biochemistry & Molecular Biology
Besnik Muqaku, Patrick Oeckl
Summary: Mass spectrometry is an important technique for analyzing biomolecules, especially in the field of neurodegenerative diseases where peptidomics analysis of cerebrospinal fluid samples has played a crucial role.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Geriatrics & Gerontology
Bruno Santos-Lima, Enrica Caterina Pietronigro, Eleonora Terrabuio, Elena Zenaro, Gabriela Constantin
Summary: Neutrophil migration plays a crucial role in the development of neurological diseases with inflammatory components. These cells can damage the blood-brain barrier and the blood-cerebrospinal fluid barrier, leading to significant tissue damage.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Toxicology
Ekaterina Mostovenko, Matthew M. Dahm, Mary K. Schubauer-Berigan, Tracy Eye, Aaron Erdely, Tamara L. Young, Matthew J. Campen, Andrew K. Ottens
Summary: In this study, serum peptidome analysis among CNT/F workers identified 41 highly discriminatory peptides that were strongly correlated with CNT/F exposure. The findings suggest that CNT/F exposure may lead to cardiovascular pathology and a pro-thrombotic state among exposed workers.
PARTICLE AND FIBRE TOXICOLOGY
(2021)
Article
Immunology
Sarinnapha M. Vasunilashorn, Long H. Ngo, Simon T. Dillon, Tamara G. Fong, Becky C. Carlyle, Pia Kivisakk, Bianca A. Trombetta, Kamen V. Vlassakov, Lisa J. Kunze, Steven E. Arnold, Zhongcong Xie, Sharon K. Inouye, Towia A. Libermann, Edward R. Marcantonio
Summary: In a study of older adults undergoing hip or knee surgery, it was found that surgery did not compromise the blood-brain barrier integrity. After surgery, there was a higher correlation between plasma and CSF levels of CRP and IL-6, with an increase in all three inflammatory markers from preoperative to postoperative 1 month.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Pharmacology & Pharmacy
Wolfgang Loescher, Pavel Klein
Summary: The prevailing standard in drug discovery has shifted from designing highly selective compounds to multi-target and combinatorial drug therapies. Although drug combination therapy is effective for symptomatic treatment, identifying clinically effective disease-modifying treatments for complex brain diseases remains challenging.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Somayeh Mousavi, Haowen Qiu, Frazer I. Heinis, Eric C. Bredahl, Md Shadman Ridwan Abid, Ashley D. Clifton, Matthew T. Andrews, James W. Checco
Summary: This study investigated the effects of the commonly used anesthetics isoflurane and sodium pentobarbital on the peptide profile in the rodent hypothalamus and cerebral cortex. The results showed that acute anesthetic administration does not greatly affect the measured peptide profiles.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Immunology
Erik Hartman, Karl Wallblom, Mariena J. A. van der Plas, Jitka Petrlova, Jun Cai, Karim Saleh, Sven Kjellstrom, Artur Schmidtchen
Summary: The study investigates the peptidomes of wound fluids and reveals highly individualized profiles in patients, with differences based on wound type. Peptides from infected wounds may contribute to an antimicrobial environment. Validation of findings through literature compilation and cross checking against data confirms the presence of immunologically significant peptides in infected wounds. The use of sorting algorithms and open source software demonstrates the power to analyze and visualize peptidomic data.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Anesthesiology
Niccolo Terrando, Katerina Akassoglou
Summary: Systemic perturbations induce neurovascular, inflammatory, and cognitive changes. Dysfunction of the blood-brain barrier is a hallmark of aging and various neurological conditions.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Clinical Neurology
Matilde Bruno, Chiara Giuseppina Bonomi, Francesco Ricci, Martina Gaia Di Donna, Nicola Biagio Mercuri, Giacomo Koch, Alessandro Martorana, Caterina Motta
Summary: This study investigated the relationship between BBB permeability and neuroinflammation in AD patients. The findings suggest that different neuroinflammatory profiles can be associated with different levels of BBB permeability in AD.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kelly A. Dingess, Inge Gazi, Henk W. P. van den Toorn, Marko Mank, Bernd Stahl, Karli R. Reiding, Albert J. R. Heck
Summary: Human milk contains beta-casein, a protein that undergoes post-translational modifications such as phosphorylation and glycosylation. A study observed changes in phosphorylation and previously unexplored O-glycosylation of beta-casein in two donors over 16 weeks of lactation, indicating the importance of these modifications on antimicrobial peptides derived from beta-casein.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Natalia Czarniak, Joanna Kaminska, Joanna Matowicka-Karna, Olga Martyna Koper-Lenkiewicz
Summary: Cerebrospinal fluid plays a crucial role in protecting the central nervous system by providing support, absorbing shocks, and transporting nutrients and waste products. This review provides an overview of cerebrospinal fluid history, production, circulation, main components, and the roles of blood-brain barrier and blood-cerebrospinal fluid barrier in maintaining homeostasis. The utility of Albumin Quotient evaluation in the diagnosis of CNS diseases is discussed. The importance of research on cerebrospinal fluid for improving disease management and discovering new treatment options is highlighted.
Review
Biochemistry & Molecular Biology
Xin-Yu Ma, Ting-Ting Yang, Lian Liu, Xiao-Chun Peng, Feng Qian, Feng-Ru Tang
Summary: The loss of neurons caused by progressive damage to the nervous system is proposed as the main pathogenesis of neurodegenerative diseases. Ependyma, composed of ciliated ependymal cells, plays a role in the formation of the brain-cerebrospinal fluid barrier (BCB) and the circulation and material exchange of cerebrospinal fluid (CSF) and brain interstitial fluid. Radiation-induced brain injury (RIBI) leads to impairments of the blood-brain barrier (BBB). The vulnerability of ependyma to immune responses may disrupt the integrity of BCB, affecting CSF flow and material exchange, and contributing to the pathogenesis of neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Sieglinde Zelzer, Andreas Meinitzer, Markus Herrmann, Walter Goessler, Dietmar Enko
Summary: This study aimed to determine vitamin D metabolites in serum and cerebrospinal fluid (CSF) from individuals with varying brain-CSF-barrier (BCB) function. The findings revealed higher concentrations of vitamin D metabolites in CSF of patients with impaired BCB function, potentially due to passive diffusion across the BCB.
Article
Biochemistry & Molecular Biology
Tiago Giao, Tiago Teixeira, Maria Rosario Almeida, Isabel Cardoso
Summary: The choroid plexus is a monolayer of epithelial cells in the brain ventricles that forms a blood-cerebrospinal fluid barrier. It secretes cerebrospinal fluid and plays a role in immune surveillance and toxin removal. Impaired function of the choroid plexus is associated with diseases like Alzheimer's, and therapies to restore its function are being proposed.
Article
Biochemical Research Methods
Sam G. Galvin, Richard G. Kay, Rachel Foreman, Pierre Larraufie, Claire L. Meek, Emma Biggs, Peter Ravn, Lutz Jermutus, Frank Reimann, Fiona M. Gribble
Summary: The study utilized LC-MS to analyze extracts from human and mouse pancreatic islets as well as plasma samples, revealing changes in peptide content and hormone encoding. It showed noticeable alterations in specific peptide segments and hormone ratios in patients with type 2 diabetes.
JOURNAL OF PROTEOME RESEARCH
(2021)
Review
Biochemical Research Methods
Pavel N. Lizhnyak, Andrew K. Ottens
EXPERT REVIEW OF PROTEOMICS
(2015)
Article
Biochemistry & Molecular Biology
Christen L. Mumaw, Shannon Levesque, Constance McGraw, Sarah Robertson, Selita Lucas, Jillian E. Stafflinger, Matthew J. Campen, Pamela Hall, Jeffrey P. Norenberg, Tamara Anderson, Amie K. Lund, Jacob D. McDonald, Andrew K. Ottens, Michelle L. Block
Article
Toxicology
Mario Aragon, Aaron Erdely, Lindsey Bishop, Rebecca Salmen, John Weaver, Jim Liu, Pamela Hall, Tracy Eye, Vamsi Kodali, Patti Zeidler-Erdely, Jillian E. Stafflinger, Andrew K. Ottens, Matthew J. Campen
TOXICOLOGICAL SCIENCES
(2016)
Article
Multidisciplinary Sciences
Mario J. Aragon, Lauren Topper, Christina R. Tyler, Bethany Sanchez, Katherine Zychowski, Tamara Young, Guy Herbert, Pamela Hall, Aaron Erdely, Tracy Eye, Lindsey Bishop, Samantha A. Saunders, Pretal P. Muldoon, Andrew K. Ottens, Matthew J. Campen
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Biochemical Research Methods
Diego F. Cortes, Miranda K. Landis, Andrew K. Ottens
Article
Environmental Sciences
Brian F. Fuller, Diego F. Cortes, Miranda K. Landis, Hiyab Yohannes, Halley E. Griffin, Jillian E. Stafflinger, M. Scott Bowers, Mark H. Lewis, Michael A. Fox, Andrew K. Ottens
ENVIRONMENTAL HEALTH PERSPECTIVES
(2012)
Article
Immunology
Amandeep Kahlon, Nore Ojogun, Stephanie A. Ragland, David Seidman, Matthew J. Troese, Andrew K. Ottens, Juliana E. Mastronunzio, Hilary K. Truchan, Naomi J. Walker, Dori L. Borjesson, Erol Fikrig, Jason A. Carlyon
INFECTION AND IMMUNITY
(2013)
Article
Critical Care Medicine
Andrew K. Ottens, Jillian E. Stafflinger, Hailey E. Griffin, Richard D. Kunz, David X. Cifu, Janet P. Niemeier
JOURNAL OF NEUROTRAUMA
(2014)
Article
Biochemical Research Methods
Konstantinos Thalassinos, Johannes P. C. Vissers, Stefan Tenzer, Yishai Levin, J. Will Thompson, David Daniel, Darrin Mann, Mark R. DeLong, M. Arthur Moseley, Antoine H. America, Andrew K. Ottens, Greg S. Cavey, Georgios Efstathiou, James H. Scrivens, James I. Langridge, Scott J. Geromanos
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2012)
Article
Biochemical Research Methods
Liam S. C. Lewis, Pretal P. Muldoon, Pallavi P. Pilaka, Andrew K. Ottens
Article
Critical Care Medicine
Pavel N. Lizhnyak, Pretal P. Muldoon, Pallavi P. Pilaka, John T. Povlishock, Andrew K. Ottens
JOURNAL OF NEUROTRAUMA
(2019)
Article
Toxicology
Ekaterina Mostovenko, Tamara Young, Pretal P. Muldoon, Lindsey Bishop, Christopher G. Canal, Aleksandar Vucetic, Patti C. Zeidler-Erdely, Aaron Erdely, Matthew J. Campen, Andrew K. Ottens
PARTICLE AND FIBRE TOXICOLOGY
(2019)
Article
Toxicology
Ekaterina Mostovenko, Matthew M. Dahm, Mary K. Schubauer-Berigan, Tracy Eye, Aaron Erdely, Tamara L. Young, Matthew J. Campen, Andrew K. Ottens
Summary: In this study, serum peptidome analysis among CNT/F workers identified 41 highly discriminatory peptides that were strongly correlated with CNT/F exposure. The findings suggest that CNT/F exposure may lead to cardiovascular pathology and a pro-thrombotic state among exposed workers.
PARTICLE AND FIBRE TOXICOLOGY
(2021)
Article
Clinical Neurology
Parantap D. Patel, Jillian E. Stafflinger, Jennifer H. Marwitz, Janet P. Niemeier, Andrew K. Ottens
Summary: By analyzing TBI-responsive peptides secreted into urine, a predictive model of functional recovery during TBI rehabilitation was developed with high sensitivity and specificity.
NEUROREHABILITATION AND NEURAL REPAIR
(2021)