Review
Nutrition & Dietetics
Lucia Melguizo-Rodriguez, Victor J. Costela-Ruiz, Enrique Garcia-Recio, Elvira De Luna-Bertos, Concepcion Ruiz, Rebeca Illescas-Montes
Summary: The prevalence of hypovitaminosis D has been increasing in developed countries due to lifestyle changes and unhealthy habits. Scientific evidence shows an inverse relationship between vitamin D deficiency and metabolic syndrome (MetS), with supplementation helping improve outcomes in individuals with MetS. Maintaining optimal vitamin D concentrations is proposed as a preventive strategy against MetS.
Article
Medicine, General & Internal
Robert Krysiak, Karolina Kowalcze, Witold Szkrobka, Boguslaw Okopien
Summary: Metformin reduces FSH levels and tends to decrease LH levels in postmenopausal women, but only in those with normal vitamin D status or receiving vitamin D supplementation. Vitamin D status determines the impact of metformin on gonadotropin secretion. The drug does not affect the levels of other anterior pituitary hormones or vitamin D.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Namanjeet Ahluwalia, Ramkripa Raghavan, Guangyu Zhang, Sameera A. Talegawkar, Paul F. Jacques
Summary: This study found a significant association between low vitamin D levels and MetS, with varying strengths of association observed across different race and Hispanic origin groups.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Gabriele Brosolo, Andrea Da Porto, Luca Bulfone, Laura Scandolin, Antonio Vacca, Nicole Bertin, Cinzia Vivarelli, Leonardo A. Sechi, Cristiana Catena
Summary: Recent evidence suggests that mildly increased fasting and post-oral load blood glucose concentrations are associated with organ damage in nondiabetic patients with hypertension. This study aimed to examine the relationships between serum 25(OH)D levels and glucose tolerance and insulin sensitivity in hypertension.
Article
Public, Environmental & Occupational Health
Wei-Chen Shen, Zih-Jie Sun, Chieh-Ying Chou, Yu-Tsung Chou, Feng-Hwa Lu, Yi-Ching Yang, Chih-Jen Chang, Jin-Shang Wu
Summary: This study found that there is a higher risk of metabolic syndrome in individuals with simple renal cysts, particularly in those with larger (sizes ≥2cm) or plural (numbers ≥2) renal cysts.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Food Science & Technology
Yuting Xia, Yuandong Yu, Yi Zhao, Zhifen Deng, Lei Zhang, Guizhao Liang
Summary: The study reveals that vitamin D supplementation can significantly reduce triglyceride levels and improve insulin resistance in MetS. It identifies 14 core genes associated with MetS and highlights the potential of vitamin D to modulate the PPAR signaling pathway. The study emphasizes the need for further research to confirm these findings and explore genetic variability in response to vitamin D.
Review
Pharmacology & Pharmacy
Phiwayinkosi Dludla, Bongani B. Nkambule, Sithandiwe E. Mazibuko-Mbeje, Tawanda M. Nyambuya, Vuyolwethu Mxinwa, Kabelo Mokgalaboni, Khanyisani Ziqubu, Ilenia Cirilli, Fabio Marcheggiani, Johan Louw, Luca Tiano
Summary: Metformin is widely used for glucose-lowering, promoting weight loss, improving insulin resistance, and reducing levels of adiponectin and resistin, which leads to improvement in patients with metabolic syndrome.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Roisin Hambly, Niamh Kearney, Rosalind Hughes, Jean M. Fletcher, Brian Kirby
Summary: Hidradenitis suppurativa (HS) is an inflammatory disease that affects both the skin and the whole body, causing significant impact on mental health and quality of life. Metformin is commonly used for HS treatment and has shown effectiveness for certain patients, although its mechanism of action is not well understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Mohammad Rashidmayvan, Reza Sahebi, Majid Ghayour-Mobarhan
Summary: Long non-coding RNAs (lncRNAs) have emerged as important regulators of gene expression, influencing various biological processes such as cell growth, death, differentiation, and aging. Evidence suggests that imbalances in lncRNAs play a role in metabolic disorders including diabetes, obesity, and heart disease. This review focuses on the understanding of how lncRNAs control metabolism, particularly in diseases caused by chronic inflammation and metabolic syndrome. The potential of lncRNAs as diagnostic and therapeutic targets for improving metabolic homeostasis is also discussed.
MOLECULAR GENETICS AND GENOMICS
(2022)
Article
Nutrition & Dietetics
Joshua Garfein, Kerry Flannagan, Sheila Gahagan, Raquel Burrows, Betsy Lozoff, Eduardo Villamor
Summary: The study revealed a negative association between serum 25(OH)D at age 1 and childhood BMI, body fat percentage in adolescence, and metabolic syndrome score in adolescence.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Medicine, Research & Experimental
Maryam Farahmand, Maryam Rahmati, Fereidoun Azizi, Fahimeh Ramezani Tehrani
Summary: This study compared the effect of breastfeeding (BF) in women with and without gestational diabetes mellitus (GDM) on metabolic syndrome (MetS) incidence. The findings showed that BF, especially exclusive BF, has a protective effect on MetS incidence risk, and it is more effective in reducing the risk of MetS among women with a history of GDM.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Cell Biology
Haydar M. Al-kuraishy, Majid S. Jabir, Ali K. Albuhadily, Ali I. Al-Gareeb, Mayyadah F. Rafeeq
Summary: It has been shown that metabolic syndrome is associated with the neuropathology of Alzheimer's disease. The components of metabolic syndrome, including central obesity, hypertension, insulin resistance, and dyslipidemia, have negative effects on the pathogenesis of Alzheimer's disease through different mechanisms such as activation of the renin-angiotensin system, inflammatory signaling pathways, neuroinflammation, brain insulin resistance, mitochondrial dysfunction, and oxidative stress. Targeting these molecular pathways in metabolic syndrome could be a potential therapeutic strategy for managing Alzheimer's disease in high risk individuals, although the underlying mechanisms are not fully understood.
AGEING RESEARCH REVIEWS
(2023)
Review
Medicine, Research & Experimental
Yasmina Bourebaba, Malwina Mularczyk, Krzyzstof Marycz, Lynda Bourebaba
Summary: Metabolic Syndrome consists of obesity, lipodystrophy, diabetes, and hypertension, which can lead to cardiovascular disease development. Catestatin, a bioactive peptide, plays a significant role in regulating insulin and lipid levels, blood pressure, and cardiac function.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Grzegorz K. Jakubiak, Kamila Osadnik, Mateusz Lejawa, Tadeusz Osadnik, Marcin Golawski, Piotr Lewandowski, Natalia Pawlas
Summary: Metabolic syndrome is the coexistence of factors that increase the risk for type 2 diabetes and cardiovascular disease, and it is associated with oxidative stress. Among the components of metabolic syndrome, obesity and insulin resistance show the strongest association with oxidative stress.
Review
Health Care Sciences & Services
Haya Abuhijleh, Dana Alkhatib, Vijay Ganji
Summary: Metabolic syndrome is more prevalent in postmenopausal women, who also have a higher prevalence of hypovitaminosis D. Several cross-sectional studies have shown an inverse association between serum 25-hydroxyvitamin D concentrations and MetSyn. However, there is a lack of randomized controlled trials investigating the effect of vitamin D intake on biomarkers and prevalence of MetSyn.
Article
Ophthalmology
Amr S. Bessa, Ahmed M. Ragab, Rasha A. Nassra, David P. Pinero, Mohamed Shafik Shaheen
JOURNAL OF CATARACT AND REFRACTIVE SURGERY
(2018)
Article
Biochemistry & Molecular Biology
Gina N. Tageldin, Tamer M. Ibrahim, Salwa M. Fahmy, Hayam M. Ashour, Mounir A. Khalil, Rasha A. Nassra, Ibrahim M. Labouta
BIOORGANIC CHEMISTRY
(2019)
Article
Chemistry, Medicinal
Perihan A. Elzahhar, Rana Alaaeddine, Tamer M. Ibrahim, Rasha Nassra, Azza Ismail, Benjamin S. K. Chua, Rebecca L. Frkic, John B. Bruning, Nadja Wallner, Tilo Knape, Andreas von Knethen, Hala Labib, Ahmed F. El-Yazbi, Ahmed S. F. Belal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Nayera W. Hassan, Manal N. Saudi, Yasser S. Abdel-Ghany, Azza Ismail, Perihan A. Elzahhar, Dharmarajan Sriram, Rasha Nassra, Marwa M. Abdel-Aziz, Soad A. El-Hawash
BIOORGANIC CHEMISTRY
(2020)
Article
Clinical Neurology
Sahar A. Harby, Rasha A. Nassra, Jaidaa F. Mekky, Samia M. Ali, Cherine A. Ismail
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2020)
Article
Chemistry, Applied
Samah M. El Sohafy, Rasha A. Nassra, Gilda D'Urso, Sonia Piacente, Shaimaa M. Sallam
NATURAL PRODUCT RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Dalia K. Mostafa, Shaimaa Omar, Amani A. Abdellatif, Osama A. Sorour, Omnia A. Nayel, Marwa R. Abod Al Obaidi
Summary: The study aimed to evaluate the protective effects of resveratrol and co-enzyme-Q10 against UVA-induced skin aging, with results showing significant effects of both drugs on regulating autophagy, thereby alleviating skin damage caused by photoaging.
CURRENT MOLECULAR PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Dalia Kamal Mostafa, Mohamed Mostafa Khedr, Mervat Kamel Barakat, Amany Abdelbary Abdellatif, Amal Mohamed Elsharkawy
Summary: The study revealed that autophagy blockade by lansoprazole exacerbated diabetic nephropathy and counteracted the renal protective effects of metformin and enalapril. The use of PPIs in diabetes should be approached with caution.
Article
Biophysics
Heba M. K. Ebada, Maha M. A. Nasra, Yosra S. R. Elnaggar, Rasha A. Nassra, Amany A. Solaiman, Ossama Y. Abdallah
Summary: The novel RH-T-PHY transphytosome system demonstrates high flexibility and encapsulation efficacy, leading to significantly enhanced skin permeation compared to conventional phytosomes. Moreover, it shows great potential in maintaining chondroprotective activity in an OA rat model and is safe for vital organs based on histological examination.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Mostafa M. M. El-Miligy, Ahmed K. Al-Kubeisi, Saad R. El-Zemity, Rasha A. Nassra, Marwa M. Abu-Serie, Aly A. Hazzaa
Summary: The study aimed to combat CRC by synthesizing and evaluating new thymol - 4-thiazolidinone hybrids as multitarget anticancer agents that could inhibit the key COX-2, 5-LOX and PIM-1 kinase enzymes simultaneously. Compound 5g showed the most promising results, inhibiting three key targets leading to inhibition of human CRC cell proliferation both in vitro and in vivo.
BIOORGANIC CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Doaa M. Samy, Dalia Kamal Mostafa, Doaa A. Abdelmonsif, Cherine A. Ismail, Passainte S. Hassaan
Summary: The study reveals the complex role of chemerin in appetite regulation, with uncertainty surrounding its mechanism and relationship with histamine and AMPK. New findings suggest that neurobiochemical pathways play a crucial role in appetite and obesity regulation, highlighting the importance of further research on chemerin for clinical implications.
Article
Immunology
Dalia Kamal Mostafa, Omnia A. Nayel, Shaymaa Abdulmalek, Ahmed A. Abdelbary, Cherine A. Ismail
Summary: Long-term sun exposure is the most common cause of photoaging. This study found that metformin can improve photoaging by modulating autophagy, and its protective effect is enhanced by coenzyme Q10.
INFLAMMOPHARMACOLOGY
(2022)
Article
Neurosciences
Doaa M. Samy, Dalia Kamal Mostafa, Samar R. Saleh, Passainte S. Hassaan, Teshreen M. Zeitoun, Gamal A. G. Ammar, Nahed H. Elsokkary
Summary: The peri- and post-menopausal periods are considered a vulnerable stage for women to develop depressive symptoms. The underlying mechanisms of these symptoms are multifactorial and may make traditional antidepressants less effective. In this study, the perturbation of the Nrf2 signaling pathway was investigated as a potential mechanism for post-ovariectomy depression, and the benefits of carnosic acid (CA) were highlighted. The results showed that CA could alleviate depressive behavior, improve neurobiochemical markers, reduce oxidative stress and inflammation, and protect against histopathological changes. This suggests that CA may be a promising candidate for clinical evaluation as an antidepressant.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
C. A. Ismail, A. M. Baraka, R. M. Abdallah, O. G. El-Dien, D. K. Mostafa
Summary: This study evaluated the antihypertensive and diuretic effects of S. marina water and n-butanol extracts in hypertensive rats. The results showed that both extracts significantly reduced the blood pressure and the n-butanol fraction also exerted significant diuretic effects. The study suggests that S. marina could potentially be a novel antihypertensive agent with calcium channel blocking activity.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Medicine, Research & Experimental
Passainte S. Hassaan, Seham Zakaria Nassar, Yasmine Issa, Noha Zahran
ARCHIVES OF MEDICAL RESEARCH
(2019)