One-Pot Synthesis of Biheterocycles Based on Indole and Azole Scaffolds Using Tryptamines and 1,2-Diaza-1,3-dienes as Building Blocks

Organocatalyzed Formal [4+2] Cycloaddition ofin situGenerated Azoalkenes with Arylacetic Acids: An Efficient Approach to the Synthesis of 4,5-Dihydropyridazin-3(2H)-ones

(2015) Xuanyi Li et al.   ADVANCED SYNTHESIS & CATALYSIS

Inhibition of Testosterone Aromatization by the Indole-3-carbinol Derivative CTet in CYP19A1-overexpressing MCF-7 Breast Cancer Cells

(2015) Mauro Santi et al.   Anti-Cancer Agents in Medicinal Chemistry

The catalytic asymmetric synthesis of tetrahydropyridazines via inverse electron-demand aza-Diels–Alder reaction of enol ethers with azoalkenes

(2015) Liang Wei et al.   CHEMICAL COMMUNICATIONS

Visible-Light, Metal-Free α-Amino C(sp3)-H Activation through 1,5-Hydrogen Migration: A Concise Method for the Preparation of Bis(indolyl)alkanes

(2015) Saad Shaaban et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

A Nucleophilic Strategy for Enantioselective Intermolecular α-Amination: Access to Enantioenriched α-Arylamino Ketones

(2015) Dillon H. Miles et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Asymmetric Cascade Vinylogous Mukaiyama 1,6-Michael/Michael Addition of 2-Silyloxyfurans with Azoalkenes: Direct Approach to Fused Butyrolactones

(2015) Jun Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diastereoselective addition of Grignard reagents to α-epoxy N-sulfonyl hydrazones

(2015) Maulen M. Uteuliyev et al.   Nature Chemistry

[4 + 2] Cycloaddition of in Situ Generated 1,2-Diaza-1,3-dienes with Simple Olefins: Facile Approaches to Tetrahydropyridazines

(2015) Xingren Zhong et al.   ORGANIC LETTERS

Aerobic Oxidative Cycloaddition of α-Chlorotosylhydrazones with Arylamines: General Chemoselective Construction of 1,4-Disubstituted and 1,5-Disubstituted 1,2,3-Triazoles under Metal-Free and Azide-Free Conditions

(2015) Hui-Wen Bai et al.   ORGANIC LETTERS

I2–TBHP-Catalyzed Oxidative Cross-Coupling of N-Sulfonyl Hydrazones and Isocyanides to 5-Aminopyrazoles

(2015) Gopal Chandru Senadi et al.   ORGANIC LETTERS

Catalytic Asymmetric Synthesis of [2,3]-Fused Indoline Heterocycles through Inverse-Electron-Demand Aza-Diels-Alder Reaction of Indoles with Azoalkenes

(2014) Min-Chao Tong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthetic Approaches to 3-(2-Nitroalkyl) Indoles and Their Use to Access Tryptamines and Related Bioactive Compounds

(2014) Stefano Lancianesi et al.   CHEMICAL REVIEWS

Recent advances in the synthesis of pyrroles by multicomponent reactions

(2014) Verónica Estévez et al.   CHEMICAL SOCIETY REVIEWS

Brønsted Acid Catalyzed Bisindolization of α-Amido Acetals: Synthesis and Anticancer Activity of Bis(indolyl)ethanamino Derivatives

(2014) Michele Mari et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

(2014) Edon Vitaku et al.   JOURNAL OF MEDICINAL CHEMISTRY

Privileged Structures: Efficient Chemical “Navigators” toward Unexplored Biologically Relevant Chemical Spaces

(2014) Jonghoon Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-Heterocyclic Carbene Catalyzed Switchable Reactions of Enals with Azoalkenes: Formal [4 + 3] and [4 + 1] Annulations for the Synthesis of 1,2-Diazepines and Pyrazoles

(2014) Chang Guo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Mediated Synthesis of 1,2,3-Triazoles fromN-Tosylhydrazones and Anilines

(2013) Zhengkai Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design, synthesis and aromatase inhibitory activities of novel indole-imidazole derivatives

(2013) Rui Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

[4+3] Cycloaddition of in situ generated azoalkenes with C,N-cyclic azomethine imines: efficient synthesis of tetrazepine derivatives

(2013) Xiao-Qiang Hu et al.   CHEMICAL COMMUNICATIONS

Comprehensive Review in Current Developments of Imidazole-Based Medicinal Chemistry

(2013) Ling Zhang et al.   MEDICINAL RESEARCH REVIEWS

Biomedical Importance of Indoles

(2013) Nagendra Kaushik et al.   MOLECULES

Synthesis of indole alkaloids arsindoline A, arsindoline B and their analogues in low melting mixture

(2013) Rama Raju Jella et al.   TETRAHEDRON

Traceless Tosylhydrazone-Based Triazole Formation: A Metal-Free Alternative to Strain-Promoted Azide-Alkyne Cycloaddition

(2012) Sander S. van Berkel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Synthesis of Dihydropyrazoles by Formal [4+1] Cycloaddition of in Situ-Derived Azoalkenes and Sulfur Ylides

(2012) Jia-Rong Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Novel Assembly of Substituted Pyrroles by Acid-Catalyzed Sequential Three-Component Reaction of Amines, Alkynoates, and 1,2-Diaza-1,3-dienes

(2011) Orazio A. Attanasi et al.   ADVANCED SYNTHESIS & CATALYSIS

Marine Indole Alkaloids: Potential New Drug Leads for the Control of Depression and Anxiety

(2010) Anna J. Kochanowska-Karamyan et al.   CHEMICAL REVIEWS

One-Pot Synthesis of Imidazole-4-Carboxylates by Microwave-Assisted 1,5-Electrocyclization of Azavinyl Azomethine Ylides

(2010) Lisa Preti et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Solid-Phase Synthesis of Highly Diverse Purine-Hydroxyquinolinone Bisheterocycles

(2010) Barbora Vaňková et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

Catalytic Functionalization of Indoles in a New Dimension

(2009) Marco Bandini et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

3,3'-Diindolylmethane Enhances the Efficacy of Butyrate in Colon Cancer Prevention through Down-Regulation of Survivin

(2009) N. Bhatnagar et al.   Cancer Prevention Research

Cultivating the Passion to Build Heterocycles from 1,2-Diaza-1,3-dienes: the Force of Imagination

(2009) Orazio A. Attanasi et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Solid-Phase Synthesis of Bis-Heterocyclic Compounds with Skeletal Diversity from Resin-Bound 3-Propargylamino-2-seleno-ester

(2009) Jian Cao et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

Total Synthesis of the Antimitotic Bicyclic Peptide Celogentin C

(2009) Bing Ma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

From Nature to Drug Discovery: The Indole Scaffold as a ‘Privileged Structure’

(2009) Fernando de Sa Alves et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

α-Aminoester-Derived Imidazoles by 1,5-Electrocyclization of Azavinyl Azomethine Ylides

(2009) Orazio A. Attanasi et al.   ORGANIC LETTERS

Silencing of tryptamine biosynthesis for production of nonnatural alkaloids in plant culture

(2009) W. Runguphan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent Developments in Anti-Cancer Agents Targeting the Ras/Raf/ MEK/ERK Pathway

(2009) Kwong-Kwok Wong   Recent Patents on Anti-Cancer Drug Discovery

Design, synthesis and characterization of N9/N7-substituted 6-aminopurines as VEGF-R and EGF-R inhibitors

(2008) Christian Peifer et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Combinatorial Libraries of Bis-heterocyclic Compounds with Skeletal Diversity

(2008) Miroslav Soural et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

Lamellarins and Related Pyrrole-Derived Alkaloids from Marine Organisms

(2007) Hui Fan et al.   CHEMICAL REVIEWS