Selective autophagy of AKAP11 activates cAMP/PKA to fuel mitochondrial metabolism and tumor cell growth

Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells

(2020) Garry L. Coles et al.   CANCER CELL

Biological Functions of Autophagy Genes: A Disease Perspective

(2019) Beth Levine et al.   CELL

Intrinsically Disordered Protein TEX264 Mediates ER-phagy

(2019) Haruka Chino et al.   MOLECULAR CELL

ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway

(2019) Zhiqiang Deng et al.   Autophagy

Adenylyl cyclase 5–generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia

(2019) Arsalan U. Syed et al.   JOURNAL OF CLINICAL INVESTIGATION

Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1

(2019) Xiaocheng Zhao et al.   eLife

Mitochondrial elongation-mediated glucose metabolism reprogramming is essential for tumour cell survival during energy stress

(2017) J Li et al.   ONCOGENE

Metabolic regulation of mitochondrial dynamics

(2016) Prashant Mishra et al.   JOURNAL OF CELL BIOLOGY

Targeting cAMP/PKA pathway for glycemic control and type 2 diabetes therapy

(2016) Haihua Yang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins

(2016) Andrew D. Rouillard et al.   Database-The Journal of Biological Databases and Curation

Protein Kinase A Activation Promotes Cancer Cell Resistance to Glucose Starvation and Anoikis

(2016) Roberta Palorini et al.   PLoS Genetics

Feedback regulation between autophagy and PKA

(2015) Francisco Torres-Quiroz et al.   Autophagy

Intramitochondrial adenylyl cyclase controls the turnover of nuclear-encoded subunits and activity of mammalian complex I of the respiratory chain

(2015) Domenico De Rasmo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus

(2015) Keisuke Mochida et al.   NATURE

Signalling scaffolds and local organization of cellular behaviour

(2015) Lorene K. Langeberg et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dynamics-Driven Allostery in Protein Kinases

(2015) Alexandr P. Kornev et al.   TRENDS IN BIOCHEMICAL SCIENCES

Targeting Autophagy Addiction in Cancer

(2015) Joseph D. Mancias et al.   Oncotarget

Metabolic Control of Autophagy

(2014) Lorenzo Galluzzi et al.   CELL

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

(2014) Kıvanç Birsoy et al.   NATURE

Constitutive Activation of PKA Catalytic Subunit in Adrenal Cushing's Syndrome

(2014) Felix Beuschlein et al.   NEW ENGLAND JOURNAL OF MEDICINE

Activating hotspot L205R mutation in PRKACA and adrenal Cushing's syndrome

(2014) Y. Cao et al.   SCIENCE

Alternative fates of newly formed PrPSc upon prion conversion on the plasma membrane

(2013) R. Goold et al.   JOURNAL OF CELL SCIENCE

Mitochondrially localized PKA reverses mitochondrial pathology and dysfunction in a cellular model of Parkinson's disease

(2011) R K Dagda et al.   CELL DEATH AND DIFFERENTIATION

Protein Phosphorylation and Prevention of Cytochrome Oxidase Inhibition by ATP: Coupled Mechanisms of Energy Metabolism Regulation

(2011) Rebeca Acin-Perez et al.   Cell Metabolism

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

(2011) J. Y. Guo et al.   GENES & DEVELOPMENT

Isoform-specific targeting of PKA to multivesicular bodies

(2011) Michele E. Day et al.   JOURNAL OF CELL BIOLOGY

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

(2011) Ligia C. Gomes et al.   NATURE CELL BIOLOGY

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

cAMP dependent protein kinase regulates expression and post-translational processing of respiratory chain complex I in mammalian cells

(2010) Sergio Papa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Regulation of the autophagy protein LC3 by phosphorylation

(2010) Salvatore J. Cherra et al.   JOURNAL OF CELL BIOLOGY

Phosphorylation pattern of the NDUFS4 subunit of complex I of the mammalian respiratory chain

(2010) Domenico De Rasmo et al.   MITOCHONDRION

Visualization of PKA activity in plasma membrane microdomains

(2010) Charlene Depry et al.   Molecular BioSystems

Autophagy and Metabolism

(2010) J. D. Rabinowitz et al.   SCIENCE

The role of autophagy in tumour development and cancer therapy

(2009) Mathias T. Rosenfeldt et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Protein kinase A as a biological target in cancer therapy

(2008) Silvio Naviglio et al.   EXPERT OPINION ON THERAPEUTIC TARGETS