Protective effects of klotho on palmitate-induced podocyte injury in diabetic nephropathy

Angiotensin II-mediated MYH9 downregulation causes structural and functional podocyte injury in diabetic kidney disease

(2019) Jeong Suk Kang et al.   Scientific Reports

Diabetic nephropathy: Is there a role for oxidative stress?

(2018) Manpreet K. Sagoo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Soluble klotho as a marker of renal fibrosis and podocyte injuries in human kidneys

(2018) Nam-Jun Cho et al.   PLoS One

Klotho enhances FoxO3-mediated manganese superoxide dismutase expression by negatively regulating PI3K/AKT pathway during tacrolimus-induced oxidative stress

(2017) Sun Woo Lim et al.   Cell Death & Disease

Palmitate and oleate exert differential effects on insulin signalling and glucose uptake in human skeletal muscle cells

(2017) Selina Mäkinen et al.   Endocrine Connections

The anti-ageing hormone klotho induces Nrf2-mediated antioxidant defences in human aortic smooth muscle cells

(2016) Giuseppe Maltese et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Decreased plasma α-Klotho predict progression of nephropathy with type 2 diabetic patients

(2016) Sang Soo Kim et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Klotho May Ameliorate Proteinuria by Targeting TRPC6 Channels in Podocytes

(2016) Ji-Hee Kim et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The ASK1-Signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging

(2016) C-C Hsieh et al.   Aging-US

Palmitate promotes autophagy and apoptosis through ROS-dependent JNK and p38 MAPK

(2015) Jing Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phosphorylation of caveolin-1 on tyrosine-14 induced by ROS enhances palmitate-induced death of beta-pancreatic cells

(2015) Sergio Wehinger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Klotho Reduction in Alveolar Macrophages Contributes to Cigarette Smoke Extract-induced Inflammation in Chronic Obstructive Pulmonary Disease

(2015) Lingling Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Renal Production, Uptake, and Handling of Circulating  Klotho

(2015) M. C. Hu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Klotho gene delivery ameliorates renal hypertrophy and fibrosis in streptozotocin-induced diabetic rats by suppressing the Rho-associated coiled-coil kinase signaling pathway

(2015) MINGHONG DENG et al.   Molecular Medicine Reports

Palmitate induces ER calcium depletion and apoptosis in mouse podocytes subsequent to mitochondrial oxidative stress

(2015) S Xu et al.   Cell Death & Disease

Soluble Klotho Protects against Uremic Cardiomyopathy Independently of Fibroblast Growth Factor 23 and Phosphate

(2014) J. Xie et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Kidney Is the Principal Organ Mediating Klotho Effects

(2014) K. Lindberg et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Klotho Prevents NFκB Translocation and Protects Endothelial Cell From Senescence Induced by Uremia

(2014) Paula Buendía et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Klotho attenuates high glucose-induced fibronectin and cell hypertrophy via the ERK1/2-p38 kinase signaling pathway in renal interstitial fibroblasts

(2014) Jau-Shyang Huang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Soluble α-Klotho as a Novel Biomarker in the Early Stage of Nephropathy in Patients with Type 2 Diabetes

(2014) Eun Young Lee et al.   PLoS One

Prevalence and Determinants of Diabetic Nephropathy in Korea: Korea National Health and Nutrition Examination Survey

(2014) Jae Hee Ahn et al.   Diabetes & Metabolism Journal

Genetic Deficiency of Anti-Aging GeneKlothoExacerbates Early Nephropathy in STZ-Induced Diabetes in Male Mice

(2013) Yi Lin et al.   ENDOCRINOLOGY

Altered renal lipid metabolism and renal lipid accumulation in human diabetic nephropathy

(2013) Michal Herman-Edelstein et al.   JOURNAL OF LIPID RESEARCH

Endoplasmic Reticulum Stress and Type 2 Diabetes

(2012) Sung Hoon Back et al.   Annual Review of Biochemistry

Decreased renal α-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion

(2012) Osamu Asai et al.   KIDNEY INTERNATIONAL

Response of VEGF to activation of viral receptors and TNFα in human mesangial cells

(2012) Monika Merkle et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Bimodal regulation of FoxO3 by AKT and 14-3-3

(2011) Melissa Dobson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Klotho Depletion Contributes to Increased Inflammation in Kidney of the db/db Mouse Model of Diabetes via RelA (Serine)536 Phosphorylation

(2011) Y. Zhao et al.   DIABETES

Role of Fosinopril and Valsartan on Klotho Gene Expression Induced by Angiotensin II in Rat Renal Tubular Epithelial Cells

(2010) Q. Zhou et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Klotho deficiency is an early biomarker of renal ischemia–reperfusion injury and its replacement is protective

(2010) Ming-Chang Hu et al.   KIDNEY INTERNATIONAL

Lipid homeostasis, lipotoxicity and the metabolic syndrome

(2009) Roger H. Unger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Glucolipotoxicity of the pancreatic beta cell

(2009) Vincent Poitout et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Current understanding of klotho

(2008) Yuhong Wang et al.   AGEING RESEARCH REVIEWS