Article
Biochemistry & Molecular Biology
Njikem Asong-Fontem, Arnau Panisello-Rosello, Alexandre Lopez, Katsunori Imai, Franck Zal, Eric Delpy, Joan Rosello-Catafau, Rene Adam
Summary: The addition of HEMO2life(R) to the preservation solution has been shown to significantly protect steatotic livers during static cold storage, reducing reperfusion injury and improving graft function. This approach also decreases the generation of reactive oxygen species and reduces inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Kun-Ling Tsai, Pei-Ling Hsieh, Wan-Ching Chou, Hui-Ching Cheng, Yu-Ting Huang, Shih-Hung Chan
Summary: The study suggests that DAPA may alleviate oxidative stress and cardiac apoptosis induced by ischemia/reperfusion injury through modulation of AMPK, improving cardiac function. Additionally, DAPA may protect cardiac cells by influencing mitochondrial function.
CELL AND BIOSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Jing Gao, Hui-Xiang Su, Pang-Bo Li, Kai-Na Shi, Hui-Hua Li
Summary: The small molecule TCH-165 has been found to activate the 20S proteasome to prevent cardiac ischemia/reperfusion (I/R) damage. It improves heart function and reduces myocardial infarction, apoptosis, and superoxide levels.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Rongjun Zou, Wanting Shi, Junxiong Qiu, Na Zhou, Na Du, Hao Zhou, Xinxin Chen, Li Ma
Summary: Empagliflozin can protect microvasculature during myocardial ischemia reperfusion injury (I/R) by inhibiting the DNA-PKcs/Fis1/mitochondrial fission pathway.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Cell Biology
Ping Pang, Zhezhe Qu, Shuting Yu, Xiaochen Pang, Xin Li, Yuelin Gao, Kuiwu Liu, Qian Liu, Xiuzhu Wang, Yu Bian, Yingqi Liu, Yingqiong Jia, Zhiyong Sun, Hanif Khan, Zhongting Mei, Xiaoqian Bi, Changhao Wang, Xinda Yin, Zhimin Du, Weijie Du
Summary: The study demonstrates that Mettl14 attenuates cardiac I/R injury by activating Wnt/beta-catenin in an m6A-dependent manner, providing a novel therapeutic target for ischemic heart disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Chayodom Maneechote, Siripong Palee, Sasiwan Kerdphoo, Thidarat Jaiwongkam, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: Inhibiting mitochondrial fission and promoting mitochondrial fusion can reduce infarct size and improve left ventricular function in cardiac ischemia-reperfusion injury.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Cell Biology
Hanbyeol Moon, Jung-Won Choi, Byeong-Wook Song, Il-Kwon Kim, Soyeon Lim, Seahyoung Lee, Gyoonhee Han, Ki-Chul Hwang, Sang Woo Kim
Summary: This study found that high-thermogenic beige adipocytes (HBACs) secrete FGF21, which contributes to antioxidative and antiapoptotic effects mediated through NRF2 activation. Treatment with HBAC-conditioned medium (HBAC-CM) can attenuate ischemic rat heart tissue injury by activating NRF2. Therefore, HBAC-CM has the potential to be a promising therapeutic agent for myocardial infarction.
Review
Immunology
Soudeh Ghafouri-Fard, Hamed Shoorei, Yadollah Poornajaf, Bashdar Mahmud Hussen, Yasaman Hajiesmaeili, Atefe Abak, Mohammad Taheri, Ahmad Eghbali
Summary: NLRP3 is a protein expressed in immune cells that acts as a constituent of the inflammasome, recognizing pathogen-associated and damage-associated molecular patterns to activate inflammatory responses. Abnormal activation of NLRP3 is associated with inflammatory and metabolic diseases. Additionally, NLRP3 shows abnormal activity in ischemia/reperfusion injuries.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jian-Hong Lin, Kun-Ta Yang, Pei-Ching Ting, Yu-Po Luo, Ding-Jyun Lin, Yi-Shun Wang, Jui-Chih Chang
Summary: The study showed that Gossypol acetic acid (GAA) could attenuate ferroptosis induced by myocardial I/R by reducing malondialdehyde and reactive oxygen species production, chelating iron content, and downregulating mRNA levels of Ptgs2. GAA also prevented cell death and lipid peroxidation in cardiomyocytes induced by oxygen-glucose deprivation/reperfusion.
Article
Medicine, Research & Experimental
Chenliang Ge, Yang Cheng, Yihao Fan, Yan He
Summary: The study demonstrated that VCR attenuates cardiac fibrosis by directly suppressing the activation of the NLRP3 inflammasome, providing novel insights into the mechanism of action of VCR in alleviating cardiac fibrosis.
Article
Cell Biology
Dayin Lyu, Qing Tian, Huitao Qian, Chang He, Tianyu Shen, Jinxing Xi, Pingxi Xiao, Qiulun Lu
Summary: The study found that dioscin may potentially treat MI/R by suppressing ROS production and enhancing the expression of antioxidant enzymes. It suggests that dioscin could be a promising candidate for therapeutic interventions in MI/R injury.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Medicine, Research & Experimental
Wenyu Zhao, Mingxing Sui, Rui Chen, Hanlan Lu, Youhua Zhu, Lei Zhang, Li Zeng
Summary: The study revealed that SIRT3 protects against kidney damage from IRI by modulating the DRP1 pathway to induce mitochondrial autophagy.
Article
Pharmacology & Pharmacy
Lu Tang, Yun-peng Li, Juan Hu, Ai-hua Chen, Yingli Mo
Summary: Dexpramipexole (DPX) protects against myocardial injury induced by ischemia/reperfusion (I/R) by enhancing mitophagy through increased expression of PINK1 and Parkin.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tsendsuren Tungalag, Yeo-Jin Yoo, Hyun-Jin Tae, Dong Kwon Yang
Summary: Olanzapine-induced therapeutic hypothermia significantly increased survival rate and reduced renal tissue damage in rats after cardiac arrest and return of spontaneous circulation. Its protective effects were mediated through Sirt3-related signaling pathway, involving maintenance of mitochondrial function, suppression of oxidative stress, and activation of AMPK alpha and SOD2.
Article
Medicine, Research & Experimental
Tzu-Lin Lee, Tsai-Chun Lai, Shu-Rung Lin, Shu-Wha Lin, Yu-Chen Chen, Chi-Ming Pu, I-Ta Lee, Jaw-Shiun Tsai, Chiang-Wen Lee, Yuh-Lien Chen
Summary: The study demonstrates that ADSC-CM significantly reduces injury and fibrosis in I/R-treated hearts and H/R-treated cardiomyocytes, while decreasing expression of related proteins and promoting cell survival through the miR-221/222/p38/NF-kappa B pathway.
Article
Gastroenterology & Hepatology
Thomas Aparicio, Olivier Bouche, Pierre-Luc Etienne, Emilie Barbier, Laurent Mineur, Romain Desgrippes, Veronique Guerin-Meyer, Faycal Hocine, Jean Martin, Valerie Le Brun-Ly, Jacques Cretin, Jerome Desrame, Yves Rinaldi, Laurent Cany, Claire Falandry, Leila Bengrine Lefevre, Miguelle Marous, Eric Terrebonne, Laurent Mosser, Justine Turpin, Anthony Turpin, Lucille Bauguion, Cynthia Reichling, Marc Van den Eynde, Elisabeth Carola, Sandrine Hiret
Summary: In the preliminary tolerance analysis of the ADAGE-PRODIGE 34 trial, it was found that in patients over 70 years old, the group of patients treated with oxaliplatin and fluoropyrimidine had more grade 3-5 toxicities compared to the group treated with fluoropyrimidine alone in the fit patients.
DIGESTIVE AND LIVER DISEASE
(2023)
Editorial Material
Gastroenterology & Hepatology
Mariana Milashka-Brihay, Mariana Figueiredo, Miguel Pantaleon Sanchez, Clara Yzet, Sophie Collardeau-Frachon, Jerome Rivory, Mathieu Pioche
Article
Anesthesiology
Martin Ruste, Charlotte Chabanol, Jean-Luc Fellahi, Matthias Jacquet-Lagreze
Summary: Bioelectrical impedance analysis (BIA) is used to evaluate the body composition of critically-ill patients. This study aimed to assess the value of BIA as a fluid management monitoring tool. The results showed that BIA-derived hydration variables were significantly correlated with cumulative fluid balance, but there were limitations in the agreement between the measurements, indicating they cannot be used interchangeably.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2023)
Article
Pediatrics
Margaux Richou, Olivier L. Mantha, Noel Perettic, Beatrice Dubern, Emmanuel Mas, Regis Hankard, Arnaud De Luca, ePINUT Study Grp
Summary: In 2019, the French National Authority for Health (HAS) published guidelines on the diagnosis of undernutrition. This study aimed to assess the impact of switching from the 2012 guidelines of the Nutrition Committee of the French Paediatric Society (CNSFP) to the HAS guidelines on the frequency of hospital undernutrition in children. The results showed that the frequency of undernutrition increased almost twofold when using the HAS criteria compared to the CNSFP criteria. Malnourished children had longer hospital stays, gained more weight during hospitalization, and received nutritional support more frequently.
ARCHIVES DE PEDIATRIE
(2023)
Article
Cardiac & Cardiovascular Systems
Clemence Delhomme, Marina Urena, Oualid Zouaghi, Francisco Campelo-Parada, Patrick Ohlmann, Gilles Rioufol, Eric Van Belle, Frederic Pinaud, Nicolas Meneveau, Patrick Staat, Olivier Morel, Francois Derimay, Flavien Vincent, Frederic Rouleau, Eric Brochet, Caroline Chong-Nguyen, Dominique Himbert
Summary: This study evaluated the effectiveness of transcatheter aortic valve implantation using the SAPIEN 3 transcatheter heart valve in patients with pure aortic regurgitation. The results showed a device success rate of 94.6%, a 30-day all-cause mortality rate of 8.1%, and a one-year all-cause mortality rate of 16.2%. This method appears promising for treating high-risk patients with pure aortic regurgitation, but further research is needed.
ARCHIVES OF CARDIOVASCULAR DISEASES
(2023)
Review
Endocrinology & Metabolism
Anais Alves, Beatrice Morio
Summary: This review discusses the metabolic changes associated with obesity, including a decrease in plasma glycine concentration, which is closely related to insulin resistance and predicts the risk of developing chronic metabolic diseases. Recent studies have made progress in understanding the underlying causes of decreased glycine levels and in developing strategies to replenish glycine stores and improve insulin resistance in obesity.
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
(2023)
Article
Nutrition & Dietetics
Claire Bordat, Donato Vairo, Charlotte Cuerq, Charlotte Halimi, Franck Peiretti, Armelle Penhoat, Aurelie Vieille-Marchiset, Teresa Gonzalez, Marie-Caroline Michalski, Marion Nowicki, Noel Peretti, Emmanuelle Reboul
Summary: Abetalipoproteinemia (FHBL-SD1) and chylomicron retention disease (FHBL-SD3) are rare recessive disorders caused by mutations in the MTTP and SAR1B genes, respectively. These mutations lead to defective chylomicron formation and secretion, resulting in lipid and fat-soluble vitamin malabsorption and severe neuro-ophthalmic complications. Current treatment options are not fully effective in normalizing serum vitamin E levels and providing complete ophthalmic protection.
Review
Surgery
Robin Bayoux, Benoit Gignoux, Camille Barani, Jean-Yves Mabrut, Ali Mojallal
Summary: A training method for endoscopic treatment of diastasis rectus abdominis was developed and evaluated on fresh cadaver models. The results showed that laparoscopic surgery is an efficient and safe approach to correct diastasis of the rectus muscles.
ANNALES DE CHIRURGIE PLASTIQUE ESTHETIQUE
(2023)
Letter
Medical Laboratory Technology
Charles R. Lefevre, Elise Sacaze, Lena Damaj, Paul Rollier, Marie Lenski, Camille Le Stradic, Claude Bendavid, Pascal Reynier, Xavier Dieu, Delphine Prunier, Caroline Moreau, Chadi Homedan
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Nutrition & Dietetics
Laure Meiller, Valerie Sauvinet, Anne-Esther Breyton, Harimalala Ranaivo, Christelle Machon, Anne Mialon, Alexandra Meynier, Stephan C. Bischoff, Jens Walter, Audrey M. Neyrinck, Martine Laville, Nathalie M. Delzenne, Sophie Vinoy, Julie-Anne Nazare
Summary: This pilot study aimed to analyze the kinetics of C-13-labeled gut-derived metabolites from C-13-labeled wheat bran in breath, plasma, and stools. The study found differential fermentation profiles among subjects and identified distinct excretion patterns of gases in high-CH4 producers compared to low-CH4 producers. The study also revealed different kinetics of C-13-labelled short-chain fatty acids in plasma.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Geriatrics & Gerontology
Emilie Bres, Julia Bouvier, Aymeric Courtay, Leo Delaire, Joannes Humblot, Charlotte Cuerq, Stephanie Tripoz-Dit-Masson, Mathieu Fauvernier, Thomas Gilbert, Marc Bonnefoy
Summary: This study aimed to determine the correlation between serum fibroblast growth factor 19 (FGF19) levels and functional muscle tests and muscle ultrasound parameters. The results showed significant correlations between FGF19 levels and muscle ultrasound parameters, suggesting that FGF19 may promote the development of large muscle fibers. However, high FGF19 levels were unexpectedly associated with a low SPPB score. Further studies are needed to validate and further elucidate these exploratory findings.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Psychiatry
Leo Delaire, Aymeric Courtay, Benjamin Pageaux, Christele Gautier, Francoise Jay Rayon, France Mourey, Antoine Noel Racine, Joannes Humblot, Marc Bonnefoy
Summary: The implementation of exercise-focused strategies in preventing mobility disability in at-risk seniors is crucial for public health. These strategies should be practical, structured, and personalized, involving coordination of adapted physical exercise programs and incorporation of best practices. Clear guidelines should be established to ensure effective programs supported by evidence-based literature and consensus among multi-professional experts. These guidelines should address frequency, intensity, duration, type, volume, and individual progressiveness. Programs should also prioritize a personalized approach to educate and empower participants for long-term health-related behaviors, with supervision from trained professionals to ensure safety and effectiveness. These guidelines will support national policies for the prevention of loss of autonomy and mobility throughout the country.
GERIATRIE ET PSYCHOLOGIE NEUROPSYCHIATRIE DE VIEILLISSEMENT
(2023)
Article
Critical Care Medicine
Romain Arrestier, Anis Chaba, Asma Mabrouki, Clement Saccheri, Emmanuel Canet, Marc Pineton de Chambrun, Annabelle Stoclin, Muriel Picard, Florent Wallet, Francois Perier, Matthieu Turpin, Laurent Argaud, Maxens Decavele, Nahema Issa, Cyril Cadoz, Kada Klouche, Johana Cohen, Djamel Mokart, Julien Grouille, Tomas Urbina, Camille Hua, Olivier Chosidow, Armand Mekontso-Dessap, Elie Azoulay, Nicolas de Prost
Summary: This retrospective multicentre cohort study aimed to describe the characteristics and management of neutropenic patients with necrotizing soft tissue infections (NSTIs) in intensive care units (ICUs). The study found that compared to non-neutropenic patients, neutropenic patients had different clinical and microbiological characteristics and higher in-hospital mortality. The administration of granulocyte colony-stimulating factor (G-CSF) was associated with improved hospital survival.
ANNALS OF INTENSIVE CARE
(2023)
Article
Clinical Neurology
Anke Wouters, Lauranne Scheldeman, Hannelore Liessens, Patrick Dupont, Florent Boutitie, Bastian Cheng, Martin Ebinger, Matthias Endres, Jochen B. Fiebach, Christian Gerloff, Keith W. Muir, Norbert Nighoghossian, Salvador Pedraza, Claus Z. Simonsen, Vincent Thijs, Goetz Thomalla, Robin Lemmens
Summary: This study aimed to explore the differences between women and men in acute ischemic stroke. The results showed that although there were more men in the WAKE-UP trial, sex did not modify the treatment effect of alteplase.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Urology & Nephrology
Matthias Jacquet-Lagreze, Martin Ruste, William Fornier, Pierre-Louis Jacquemet, Remi Schweizer, Jean-Luc Fellahi
Summary: This study aimed to investigate the ability of plasma protein concentration variations to detect a decrease in cardiac index (CI) during mechanical fluid removal and to assess other predictive factors of CI change. The results showed that haemoconcentration and passive leg raising failed to accurately predict a decrease in CI.
JOURNAL OF NEPHROLOGY
(2023)