Article
Obstetrics & Gynecology
Stefania Greco, Alessandro Zannotti, Pamela Pellegrino, Federica Giantomassi, Giovanni Delli Carpini, Mattia D'Agostino, Gaia Goteri, Andrea Ciavattini, Chiara Donati, Caterina Bernacchioni, Felice Petraglia, Anna La Teana, Pasquapina Ciarmela
Summary: The hypusinated form of EIF5A was found in human myometrium, leiomyoma, and leiomyosarcoma, with increasing levels in neoplastic tissues. Inhibition of EIF5A hypusination reduced cell proliferation and fibronectin expression in myometrium, leiomyoma, and leiomyosarcoma cell lines. These findings suggest that EIF5A may play a role in the pathogenesis of myometrial benign and malignant pathologies.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Oncology
Jordi Gonzalez-Molina, Paula Hahn, Raul Maia Falcao, Okan Gultekin, Georgia Kokaraki, Valentina Zanfagnin, Tirzah Braz Petta, Kaisa Lehti, Joseph W. W. Carlson
Summary: This study explored the impact of fibrillar collagens on uterine leiomyosarcoma (uLMS) and found that uLMS tumors have low collagen density and increased expression of collagen-remodeling genes compared to uterine leiomyomas (LM)．The overexpression of matrix metalloproteinase-14 (MMP14) in uLMS was found to support uLMS cell proliferation, and uLMS cells were found to be less sensitive to changes in collagen substrate stiffness. Additionally, enhanced basal yes-associated protein 1 (YAP) activity was observed in uLMS cells, which sustains their growth in low-stiffness substrates. These findings suggest that matrix remodeling and YAP may be potential therapeutic targets for uLMS．
MOLECULAR ONCOLOGY
(2023)
Article
Oncology
Saya Tamura, Takuma Hayashi, Tomoyuki Ichimura, Nobuo Yaegashi, Kaoru Abiko, Ikuo Konishi
Summary: This study investigated the rare occurrence of primary uterine rhabdomyosarcoma during the follow-up of uterine leiomyoma. It was found that rhabdomyosarcoma is more common in children and has a higher response rate to treatment compared to adults. The study also identified potential biomarkers for the diagnosis of uterine rhabdomyosarcoma.
Article
Medicine, General & Internal
Jin Wang, Qiang Xu, Fei Xiao, Gang Chen
Summary: The study aimed to determine the dose-response of nitroglycerin in preventing pituitrin-induced hypertension. Prophylactic nitroglycerin administered immediately following injection of pituitrin effectively prevented hypertension, with the ED50 and ED95 of 54 μg and 136 μg, respectively.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Shoko Nishikawa, Takuma Hayashi, Yasuaki Amano, Nobuo Yaegashi, Kaoru Abiko, Ikuo Konishi
Summary: This study investigated the oncological properties of uterine lipoleiomyoma and hemangioma in adults through molecular pathological examination. A case of concurrent uterine hemangioma and lipoleiomyoma was reported, emphasizing the need to consider multiple types of mesenchymal tumors in the differential diagnosis of patients with abnormal vaginal bleeding.
Editorial Material
Obstetrics & Gynecology
Martha Duraes, Caroline Mandoul, Helene Perrochia, Gauthier Rathat
Summary: A 32-year-old nulliparous woman with a history of dysmenorrhea underwent fertility-sparing management for an atypical uterine myoma. Transcervical biopsy and minimally invasive myomectomy were performed successfully under ultrasound guidance, resulting in a confirmed diagnosis of benign leiomyoma and a successful recovery.
FERTILITY AND STERILITY
(2022)
Editorial Material
Obstetrics & Gynecology
Carlos M. Parra, Taraneh Shirazian
Summary: This study provided the first video demonstration of laparoscopic removal of bilateral uterine remnants in a patient with Mullerian agenesis. The surgery successfully alleviated the symptoms and highlighted the importance of laparoscopic surgery in the treatment of this condition.
FERTILITY AND STERILITY
(2022)
Article
Biochemistry & Molecular Biology
Takuma Hayashi, Kenji Sano, Nobuo Yaegashi, Kaoru Abiko, Ikuo Konishi
Summary: Uterine leiomyoma develops from smooth muscle tissue, while uterine sarcoma can develop from smooth muscle tissue or stroma. Uterine sarcoma is classified into three types: leiomyosarcoma, endometrial stromal sarcoma (ESS), and carcinosarcoma. Although both leiomyosarcoma and ESS are classified as uterine sarcoma, they differ in terms of their sites of occurrence, symptoms, and treatment methods.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Pathology
Johann Lok, Ka Yu Tse, Elaine Yuen Phin Lee, Richard Wing Cheuk Wong, Ivy Shui Ying Cheng, Alice Ngot Htain Chan, Charlotte Ka Lun Leung, Annie Nga Yin Cheung, Philip Pun Ching Ip
Summary: Frozen section diagnosis of uterine smooth muscle tumors has a high accuracy rate, with most cases examined due to abnormal tumor appearance and intraoperative discovery. Diagnostic errors typically result from stromal and cellular alterations.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Review
Oncology
Sabrina Croce, Frederic Chibon
Summary: From genomic complexity to treatment strategies, there are significant differences between uterine leiomyoma and leiomyosarcoma. The genomic index and CINSARC signature play crucial roles in prognosis, diagnosis, and treatment.
GENES CHROMOSOMES & CANCER
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hilal Sahin, Janette Smith, Jeries Paolo Zawaideh, Amreen Shakur, Luca Carmisciano, Iztok Caglic, Annemarie Bruining, Mercedes Jimenez-Linan, Sue Freeman, Helen Addley
Summary: The study demonstrates the potential utility of non-contrast MRI features in characterising LMS and differentiating it from atypical leiomyomas, which can influence the optimal management of these cases.
BRITISH JOURNAL OF RADIOLOGY
(2021)
Article
Dermatology
Eyal Taleb, Cristobal Saldias, Sergio Gonzalez, Carlos Misad, Ximena Wortsman
Summary: The study aimed to identify and characterize common sonographic features of LMT. Through a retrospective analysis of HFUS images in three different patients, shared ultrasound characteristics were found, and a new ultrasonographic sign in cutaneous leiomyomas called the pine tree sign was described.
DERMATOLOGY PRACTICAL & CONCEPTUAL
(2022)
Article
Pathology
Terhi Ahvenainen, Sara Khamaiseh, Amjad Alkodsi, Miika Mehine, Riikka Nevala, Anna Ayravainen, Ralf Buetzow, Pia Vahteristo
Summary: This article reports a case of a patient with uterine leiomyoma who developed pulmonary tumors years after hysterectomy. Molecular analysis revealed similar mutational profiles in all three tumors, suggesting the potential of metastasis and malignant transformation in uterine leiomyomas.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2022)
Article
Veterinary Sciences
M. C. M. Barozzi, C. F. Saba, K. P. Gendron
Summary: The study aimed to describe CT characteristics of uterine and vaginal mesenchymal tumors in dogs. Malignant tumors tended to be longer and occupy a larger portion of the pelvic canal compared to benign tumors, while there was overlap in their maximal diameter. Bone involvement was only observed in malignant tumors.
JOURNAL OF SMALL ANIMAL PRACTICE
(2021)
Article
Pathology
Brian Vadasz, Christopher Felicelli, Yue Feng, Ping Yin, Qing Zhang, Serdar Bulun, Jian-Jun Wei
Summary: Uterine leiomyosarcoma is a deadly disease that lacks specific biomarkers for diagnosis. Recent studies have shown a loss of dystrophin in uterine LMS, and the expression of dystrophin is significantly different between benign and malignant tumors. Patients with dystrophin-positive LMS have a better overall survival.
Article
Obstetrics & Gynecology
Mehmet R. Asoglu, Sarah Crimmins, Jerome N. Kopelman, Ozhan M. Turan, Katherine R. Goetzinger
Summary: The study aimed to assess the association between marginal placental cord insertion (PCI) and small for gestational age (SGA) as well as other adverse perinatal outcomes, and to determine if pregnancy-associated plasma protein A (PAPP-A) levels were altered in patients with marginal PCI. The results demonstrated that marginal PCI did not increase the incidence of adverse pregnancy outcomes, providing reassurance for patients with this sonographic finding.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Review
Reproductive Biology
Mariam Saadedine, Malak El Sabeh, Mostafa A. Borahay, Georges Daoud
Summary: COVID-19 infection may have an impact on reproductive health in women, primarily due to the cytokine storm and immune reaction, with less involvement of the COVID-19 receptor.
BIOLOGY OF REPRODUCTION
(2023)
Article
Medicine, Research & Experimental
Sadia Afrin, Malak El Sabeh, Mariko Miyashita-Ishiwata, Natasha Charewycz, Bhuchitra Singh, Mostafa A. Borahay
Summary: Simvastatin alters the caveolae and CAV1 in human leiomyomas, influencing ER-alpha signaling and plasma membrane trafficking, providing new insights for the treatment of uterine leiomyomas.
Review
Obstetrics & Gynecology
Kamran Hessami, Jennifer Welch, Anja Frost, Abdelrahman AlAshqar, Sara E. Arian, Ethan Gough, Mostafa A. Borahay
Summary: In this meta-analysis, we examined the quantity and dose of opioids dispensed during the perioperative period for benign hysterectomy, as well as the predictors of persistent opioid use after the procedure. A total of 8 studies involving 377,569 women were included. The findings showed that 83% of women were dispensed opioids during the perioperative period, and the rate of persistent opioid use after benign hysterectomy was 5%.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sadia Afrin, Malak El Sabah, Ahmed Manzoor, Mariko Miyashita-Ishiwata, Lauren Reschke, Mostafa A. Borahay
Summary: The aim of this study was to determine the cellular and molecular mechanisms by which adipocytes contribute to the initiation and promotion of uterine leiomyoma tumors. The results showed that adipocytes promote inflammation, fibrosis, and angiogenesis in leiomyoma cells by upregulating associated factors and transferring free fatty acids. Adipocyte-leiomyoma cell interaction increases the phosphorylation of NF-.B and enhances cell proliferation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Obstetrics & Gynecology
Jaden R. Kohn, Anja S. Frost, Anastasia Tambovtseva, Megan Hunt, Katharine Clark, Christina Wilson, Mostafa A. Borahay
Summary: This study aimed to identify the factors that drive total hospital charges for benign hysterectomy. A retrospective cohort study was conducted at five hospitals in Maryland. Patient, perioperative, and hospital characteristics were included as predictor variables in a multiple linear regression model. The results showed that perioperative and hospital factors significantly influenced the total hospital charges for benign hysterectomy.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Tara Brah, Abdelrahman AlAshqar, Mostafa A. Borahay
Summary: This retrospective cohort study aimed to evaluate the association between surgical start time and clinical and financial outcomes of hysterectomies for benign indications. The study found that an afternoon start time was associated with increased blood loss, longer length of stay, and decreased likelihood of same-day discharge. However, there was no significant difference in the rates of adverse perioperative events between the morning and afternoon groups. Interestingly, an afternoon start time was associated with decreased total hospital charges. Awareness of the relationship between surgical start time and outcomes can guide surgical scheduling and optimize same-day discharge.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2023)
Article
Nutrition & Dietetics
Sadia Afrin, Malini Ramaiyer, Umme Aoufa Mafruha Begum, Mostafa A. Borahay
Summary: This study investigated the effects of adipocyte coculture and leptin treatment on human myometrium and leiomyoma cells. The results showed that coculture and leptin treatment increased the expression of JAK2/STAT3, MAPK/ERK, and PI3k/AKT signaling pathways, as well as promoting the upregulation of tumor-related inflammatory, fibrotic, and angiogenic factors, and increasing leiomyoma cell growth. These findings suggest that adipocytes or their secreted hormones may contribute to leiomyoma development and growth by activating leptin receptor signaling pathways.
Article
Obstetrics & Gynecology
Mehmet Resit Asoglu, Mustafa Bahceci
Summary: This study investigated the association between endometrial thickness (EMT) and neonatal birth weight in singleton pregnancies following frozen-thawed blastocyst transfer (FET). The results showed that EMT was not found to be predictive of birth weight.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2023)
Article
Obstetrics & Gynecology
Chailee Moss, Carolyn Brookhart, Prerna Pandya, Mostafa A. Borahay, Melindia Mann, Victoria Handa, Anna Maya Powell
Summary: In this prospective cohort study, predictors of patient satisfaction with pain control, including opioid prescribing practices, were investigated. The analysis showed that patient satisfaction with pain control was primarily influenced by subjective assessment of shared decision-making with the gynecologist, rather than opioid prescription status. These findings suggest the need for a larger cohort to further explore the impact of opioid use on pain control satisfaction after minor gynecologic surgery.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Abdelrahman AlAshqar, Bethlehem Lulseged, Akailah Mason-Otey, Jinxiao Liang, Umme Aoufa Mafruha Begum, Sadia Afrin, Mostafa A. Borahay
Summary: In recent decades, our understanding of the complex pathobiology of uterine fibroid development has expanded. It is now known that uterine fibroids have different aspects of their genesis and oxidative stress plays an important role in their development. The influence of oxidative stress on fibroid development is mediated through genetic, epigenetic, and profibrotic mechanisms. This knowledge has led to clinical implications for diagnosis and treatment using biomarkers and antioxidants.
Review
Biology
Gregory W. Kirschen, Kamran Hessami, Abdelrahman AlAshqar, Sadia Afrin, Bethlehem Lulseged, Mostafa Borahay
Summary: RNA sequencing has advanced our understanding of the cellular complexity and dynamics underlying normal menstruation and gynecological disorders. Single-cell RNA sequencing has revealed novel endometrial cell subpopulations and their aberrant activity in pathological states, providing insights for developing novel therapeutic interventions.
Review
Obstetrics & Gynecology
Irem Kurt, Mehmet Kulhan, Abdelrahman AlAshqar, Mostafa A. Borahay
Summary: Collagen cross-linking is essential for maintaining the normal function and integrity of the uterus. Changes in cross-link density can lead to uterine disorders such as preterm birth and uterine fibroids. Studying the regulators of collagen cross-linking presents an opportunity for developing therapeutic targets in common uterine disorders.
REPRODUCTIVE SCIENCES
(2023)
Article
Genetics & Heredity
Sadia Afrin, Gregory W. Kirschen, Mostafa A. Borahay
Summary: This study aims to determine how adipocytes and adipocyte-secreted factors affect changes in myometrial stem cells (MSCs) in a manner that promotes the growth of uterine leiomyomas. The results showed that co-culture of MSCs with adipocytes increased proliferation and extracellular matrix (ECM) deposition, and adipocyte-secreted factors induced oxidative damage and DNA damage in MSCs. These findings suggest that obesity may mediate the initiation of tumorigenesis in MSCs, leading to the development of leiomyomas.
Meeting Abstract
Obstetrics & Gynecology
M. R. Asoglu, M. Bahceci
HUMAN REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
Tal Margaliot Kalifa, Hen Y. Sela, Jordanna Joseph, Sorina Grisaru-Granovsky, Fayez Khatib, Misgav Rottenstreich
Summary: Pregnancies following a second trimester uterine evacuation do not have an increased risk of preterm delivery or other adverse perinatal outcomes compared to pregnancies following a first trimester uterine evacuation.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Dominique A. Badr, Mieke M. Cannie, Caroline Kadji, Xin Kang, Andrew Carlin, Jacques C. Jani
Summary: The objective of this study was to assess the influence of the test-to-delivery interval on the performance of ultrasound and MRI in predicting birthweight. The results showed that MRI performed best in predicting birthweight greater than gestational age if delivery occurred within two weeks of the examination, with a slight decrease thereafter, while ultrasound performance decreased drastically over time.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Corina N. Schoen, Sami Backley, Lauren Orr, Amrita Roy, Tiffany Corlin, Alexander B. Knee
Summary: This retrospective cohort study aimed to evaluate whether induction of labor is associated with a lower risk of cesarean section in patients with isolated polyhydramnios. The study found that planned induction was associated with a lower rate of cesarean delivery compared to expectant management, but the difference was not statistically significant. Additionally, no differences were observed in maternal or fetal secondary outcomes.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Ohad Houri, Asaf Romano, Yossi Geron, Gil Zeevi, Eran Hadar, Shiri Barbash-Hazan, Shir Danieli-Gruber
Summary: Women with prior uterine rupture have good maternal and neonatal outcomes in subsequent pregnancies when managed at a tertiary medical center, with planned elective term cesarean delivery, or even earlier, at the onset of spontaneous preterm labor.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Correction
Obstetrics & Gynecology
Laura E. Janssen, Marjon A. de Boer, Eline C. E. von Konigslow, Elisa Dal, Martijn A. Oudijk, Danielle Robbers-Visser, Christianne J. M. de Groot
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Review
Obstetrics & Gynecology
Natalia Rzewuska, Jacek Kunicki, Katarzyna Pieniak, Paulina Laskus, Bernadeta Zabielska, Roman Smolarczyk, Michal Kunicki
Summary: This systematic review examined the comorbidity of idiopathic intracranial hypertension (IIH) and polycystic ovarian syndrome (PCOS) and their impact on metabolism, hormone levels, and reproduction. The findings showed a high prevalence of comorbidity between the two conditions, which may have significant clinical implications for patient management.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
