CDK8 maintains stemness and tumorigenicity of glioma stem cells by regulating the c-MYC pathway

CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci

(2020) Jonathan Martinez-Fabregas et al.   Cell Reports

A Novel Oral Anti-osteoporosis Drug with Osteogenesis-promoting Effects via Osteoblast Differentiation

(2019) Tatsuya Kitao et al.   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN

Mediator complex interaction partners organize the transcriptional network that defines neural stem cells

(2019) Marti Quevedo et al.   Nature Communications

BMP signaling mediates glioma stem cell quiescence and confers treatment resistance in glioblastoma

(2019) Rohit Sachdeva et al.   Scientific Reports

Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancer

(2018) Anne Serrao et al.   ONCOGENE

Ibrutinib inactivates BMX-STAT3 in glioma stem cells to impair malignant growth and radioresistance

(2018) Yu Shi et al.   Science Translational Medicine

NK Cell–Specific CDK8 Deletion Enhances Antitumor Responses

(2018) Agnieszka Witalisz-Siepracka et al.   Cancer Immunology Research

Primary brain and other central nervous system tumors in Appalachia: regional differences in incidence, mortality, and survival

(2018) Quinn T. Ostrom et al.   JOURNAL OF NEURO-ONCOLOGY

Ribociclib as First-Line Therapy for HR-Positive, Advanced Breast Cancer

(2018)   NEW ENGLAND JOURNAL OF MEDICINE

MONARCH 2: Abemaciclib in Combination With Fulvestrant in Women With HR+/HER2− Advanced Breast Cancer Who Had Progressed While Receiving Endocrine Therapy

(2017) George W. Sledge et al.   JOURNAL OF CLINICAL ONCOLOGY

CDK8/19 Mediator kinases potentiate induction of transcription by NFκB

(2017) Mengqian Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CDK4/6 Inhibition as a therapeutic strategy in breast cancer: palbociclib, ribociclib, and abemaciclib

(2017) Bahar Laderian et al.   SEMINARS IN ONCOLOGY

Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate Cancer

(2016) Johannes Brägelmann et al.   CLINICAL CANCER RESEARCH

Palbociclib and Letrozole in Advanced Breast Cancer

(2016) Richard S. Finn et al.   NEW ENGLAND JOURNAL OF MEDICINE

IKK/NF-κB signaling contributes to glioblastoma stem cell maintenance

(2016) Amanda L. Rinkenbaugh et al.   Oncotarget

Mutated K-ras activates CDK8 to stimulate the epithelial-to-mesenchymal transition in pancreatic cancer in part via the Wnt/β-catenin signaling pathway

(2015) Wei Xu et al.   CANCER LETTERS

Expression of CDK8 and CDK8-interacting Genes as Potential Biomarkers in Breast Cancer

(2015) Eugenia Broude et al.   CURRENT CANCER DRUG TARGETS

Cancer stem cells in glioblastoma

(2015) Justin D. Lathia et al.   GENES & DEVELOPMENT

Cdk8deletion in theApcMinmurine tumour model represses EZH2 activity and accelerates tumourigenesis

(2015) Mark L McCleland et al.   JOURNAL OF PATHOLOGY

Mediator kinase inhibition further activates super-enhancer-associated genes in AML

(2015) Henry E. Pelish et al.   NATURE

Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth

(2015) Wenchao Zhou et al.   NATURE CELL BIOLOGY

Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity

(2015) Mona Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dinaciclib, a novel CDK inhibitor, demonstrates encouraging single-agent activity in patients with relapsed multiple myeloma

(2014) S. K. Kumar et al.   BLOOD

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

Intercellular Cooperation and Competition in Brain Cancers: Lessons FromDrosophilaand Human Studies

(2014) Indrayani Waghmare et al.   Stem Cells Translational Medicine

Cyclin-dependent kinases

(2014) Marcos Malumbres   GENOME BIOLOGY

Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma

(2013) Krishna P.L. Bhat et al.   CANCER CELL

Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth

(2013) Lin Cheng et al.   CELL

HIF1A Employs CDK8-Mediator to Stimulate RNAPII Elongation in Response to Hypoxia

(2013) Matthew D. Galbraith et al.   CELL

Tumor-suppressive effects of CDK8 in endometrial cancer cells

(2013) Weiting Gu et al.   CELL CYCLE

Cdks, cyclins and CKIs: roles beyond cell cycle regulation

(2013) S. Lim et al.   DEVELOPMENT

CDK8 Kinase Phosphorylates Transcription Factor STAT1 to Selectively Regulate the Interferon Response

(2013) Joanna Bancerek et al.   IMMUNITY

CDK8-Mediated STAT1-S727 Phosphorylation Restrains NK Cell Cytotoxicity and Tumor Surveillance

(2013) Eva Maria Putz et al.   Cell Reports

CDK8 Maintains Tumor Dedifferentiation and Embryonic Stem Cell Pluripotency

(2012) A. S. Adler et al.   CANCER RESEARCH

FoxM1 Promotes β-Catenin Nuclear Localization and Controls Wnt Target-Gene Expression and Glioma Tumorigenesis

(2011) Nu Zhang et al.   CANCER CELL

Function and regulation of the Mediator complex

(2011) Ronald C Conaway et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Cancer stem cells in gliomas: Identifying and understanding the apex cell in cancer's hierarchy

(2011) Monica Venere et al.   GLIA

The histone variant macroH2A suppresses melanoma progression through regulation of CDK8

(2010) Avnish Kapoor et al.   NATURE

The human Mediator complex: a versatile, genome-wide regulator of transcription

(2010) Dylan J. Taatjes   TRENDS IN BIOCHEMICAL SCIENCES

Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways

(2009) Claudio Alarcón et al.   CELL

Autocrine TGF-β Signaling Maintains Tumorigenicity of Glioma-Initiating Cells through Sry-Related HMG-Box Factors

(2009) Hiroaki Ikushima et al.   Cell Stem Cell

MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities

(2009) C. V. Dang et al.   CLINICAL CANCER RESEARCH

Cyclin-dependent kinases: a family portrait

(2009) Marcos Malumbres et al.   NATURE CELL BIOLOGY

The Human CDK8 Subcomplex Is a Histone Kinase That Requires Med12 for Activity and Can Function Independently of Mediator

(2008) M. T. Knuesel et al.   MOLECULAR AND CELLULAR BIOLOGY

CDK8 is a colorectal cancer oncogene that regulates β-catenin activity

(2008) Ron Firestein et al.   NATURE

Malignant Gliomas in Adults

(2008) Patrick Y. Wen et al.   NEW ENGLAND JOURNAL OF MEDICINE