Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 75, Issue 1, Pages 161-168Publisher
WILEY
DOI: 10.1002/mrm.25590
Keywords
rotating frame; relaxation; brain; myelin; contrast imaging; fictitious field
Funding
- Academy of Finland
- Sigrid Juselius Foundation
- National Institutes of Health Biomedical Technology Resource Centers [P41-EB015894, P30-NS057091, R01-NS061866]
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [KL2TR000113, UL1TR000114] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [P41EB015894] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [P30NS057091, R01NS061866, P30NS076408] Funding Source: NIH RePORTER
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Purpose: Brain myelin plays an important role in normal brain function. Demyelination is involved in many degenerative brain diseases, thus quantitative imaging of myelin has been under active investigation. In previous work, we demonstrated the capability of the method known as Relaxation Along a Fictitious Field (RAFF) in the rotating frame of rank n (RAFFn) to provide image contrast between white and gray matter in human and rat brains. Here, we provide evidence pointing to myelin being the major source of this contrast. Methods: RAFFn relaxation time constant (T-RAFFn) was mapped in rat brain ex vivo. T-RAFFn was quantified in 12 different brain areas. T-RAFFn values were compared with multiple other MRI metrics (T-1, T-2, continuous wave T-1 rho, adiabatic T-1 rho and T-2 rho, magnetization transfer ratio), and with histologic measurements of cell density, myelin and iron content. Results: Highest contrast between white and grey matter was obtained with T-RAFFn in the rotating frames of ranks n = 4 and 5. T-RAFFn values correlated strongly with myelin content, whereas no associations between T-RAFFn and iron content or cell density were found. Conclusion: T-RAFFn with n = 4 or 5 provides a high sensitivity for selective myelin mapping in the rat brain. (C) 2015 Wiley Periodicals, Inc.
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