Altered perivascular fibroblast activity precedes ALS disease onset

Expression and Cellular Distribution of P-Glycoprotein and Breast Cancer Resistance Protein in Amyotrophic Lateral Sclerosis Patients

(2020) Erwin A van Vliet et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Cardiovascular disease, psychiatric diagnosis and sex differences in the multistep hypothesis of amyotrophic lateral sclerosis

(2020) F. C. Garton et al.   EUROPEAN JOURNAL OF NEUROLOGY

Genetic Convergence Brings Clarity to the Enigmatic Red Line in ALS

(2019) Casey Cook et al.   NEURON

Inflammatory markers in cerebrospinal fluid: independent prognostic biomarkers in amyotrophic lateral sclerosis?

(2019) Benjamin Gille et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Enlarged Perivascular Spaces and Dementia: A Systematic Review

(2019) David Smeijer et al.   JOURNAL OF ALZHEIMERS DISEASE

Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia

(2019) Oliver H. Tam et al.   Cell Reports

Understanding the role of the perivascular space in cerebral small vessel disease

(2018) Rosalind Brown et al.   CARDIOVASCULAR RESEARCH

Prognosis for patients with amyotrophic lateral sclerosis: development and validation of a personalised prediction model

(2018) Henk-Jan Westeneng et al.   LANCET NEUROLOGY

TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD

(2018) Matthew A. White et al.   NATURE NEUROSCIENCE

Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy

(2018) Krista J. Spiller et al.   NATURE NEUROSCIENCE

Molecular Architecture of the Mouse Nervous System

(2018) Amit Zeisel et al.   CELL

A molecular atlas of cell types and zonation in the brain vasculature

(2018) Michael Vanlandewijck et al.   NATURE

The Swedish motor neuron disease quality registry

(2018) Elisa Longinetti et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Neurofilament markers for ALS correlate with extent of upper and lower motor neuron disease

(2017) Koen Poesen et al.   NEUROLOGY

Amyotrophic Lateral Sclerosis

(2017) Robert H. Brown et al.   NEW ENGLAND JOURNAL OF MEDICINE

Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice

(2017) Qiaoli Ma et al.   Nature Communications

Large Perivascular Spaces Visible on Magnetic Resonance Imaging, Cerebral Small Vessel Disease Progression, and Risk of Dementia

(2017) Jie Ding et al.   JAMA Neurology

Axonal degeneration, distal collateral branching and neuromuscular junction architecture alterations occur prior to symptom onset in the SOD1G93A mouse model of amyotrophic lateral sclerosis

(2016) Jayden A. Clark et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system

(2016) S. Marques et al.   SCIENCE

Identification of Vulnerable Cell Types in Major Brain Disorders Using Single Cell Transcriptomes and Expression Weighted Cell Type Enrichment

(2016) Nathan G. Skene et al.   Frontiers in Neuroscience

Presymptomatic activation of the PDGF-CC pathway accelerates onset of ALS neurodegeneration

(2015) Sebastian A. Lewandowski et al.   ACTA NEUROPATHOLOGICA

Cerebrovascular injury as a risk factor for amyotrophic lateral sclerosis: Table 1

(2015) Martin R Turner et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS

(2015) Shuying Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

(2015) A. Zeisel et al.   SCIENCE

A revision of the El Escorial criteria - 2015

(2015) Albert Ludolph et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Osteopontin – A multi-modal marker and mediator in atherosclerotic vascular disease

(2014) Talya Wolak   ATHEROSCLEROSIS

Analysis of amyotrophic lateral sclerosis as a multistep process: a population-based modelling study

(2014) Ammar Al-Chalabi et al.   LANCET NEUROLOGY

Value of18Fluorodeoxyglucose–Positron-Emission Tomography in Amyotrophic Lateral Sclerosis

(2014) Koen Van Laere et al.   JAMA Neurology

Plasma profiling reveals three proteins associated to amyotrophic lateral sclerosis

(2014) Anna Häggmark et al.   Annals of Clinical and Translational Neurology

Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis

(2013) Shin H Kang et al.   NATURE NEUROSCIENCE

Amyotrophic lateral sclerosis—a model of corticofugal axonal spread

(2013) Heiko Braak et al.   Nature Reviews Neurology

A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model

(2013) Isaac M. Chiu et al.   Cell Reports

Widespread cerebral haemodynamics disturbances occur early in amyotrophic lateral sclerosis

(2012) Matthew J. Murphy et al.   Amyotrophic Lateral Sclerosis

Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis

(2012) Chi-Hong Wu et al.   NATURE

Deletion of galectin-3 exacerbates microglial activation and accelerates disease progression and demise in a SOD1G93Amouse model of amyotrophic lateral sclerosis

(2012) Bruce J. Lerman et al.   Brain and Behavior

Population based epidemiology of amyotrophic lateral sclerosis using capture-recapture methodology

(2011) M. H. B. Huisman et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Toll-like receptor signaling in amyotrophic lateral sclerosis spinal cord tissue

(2011) M. Casula et al.   NEUROSCIENCE

Gray matter perfusion correlates with disease severity in ALS

(2010) R. R. Rule et al.   NEUROLOGY

Sporadic ALS has compartment-specific aberrant exon splicing and altered cell–matrix adhesion biology

(2009) Stuart J. Rabin et al.   HUMAN MOLECULAR GENETICS

Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt

(2009) Steffen Durinck et al.   Nature Protocols

Cerebrospinal fluid outflow: An evolving perspective

(2008) Kapil G. Kapoor et al.   BRAIN RESEARCH BULLETIN

Antibody Suspension Bead Arrays within Serum Proteomics

(2008) Jochen M. Schwenk et al.   JOURNAL OF PROTEOME RESEARCH

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration

(2008) Zhihui Zhong et al.   NATURE NEUROSCIENCE

TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2008) J. Sreedharan et al.   SCIENCE