Expression and Cellular Distribution of P-Glycoprotein and Breast Cancer Resistance Protein in Amyotrophic Lateral Sclerosis Patients

Excess glutamate secreted from astrocytes drives upregulation of P-glycoprotein in endothelial cells in amyotrophic lateral sclerosis

(2019) Loqman A. Mohamed et al.   EXPERIMENTAL NEUROLOGY

Self-nanomicellizing solid dispersion of edaravone: part I – oral bioavailability improvement

(2018) Ankit Parikh et al.   Drug Design Development and Therapy

Obstacles to Brain Tumor Therapy: Key ABC Transporters

(2017) Juwina Wijaya et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial

(2017) Koji Abe et al.   LANCET NEUROLOGY

Selective induction of P-glycoprotein at the CNS barriers during symptomatic stage of an ALS animal model

(2017) Gary N.Y. Chan et al.   NEUROSCIENCE LETTERS

ALS Clinical Trials Review: 20 Years of Failure. Are We Any Closer to Registering a New Treatment?

(2017) Dmitry Petrov et al.   Frontiers in Aging Neuroscience

Network degeneration and dysfunction in presymptomatic C9ORF72 expansion carriers

(2017) Suzee E. Lee et al.   NeuroImage-Clinical

Glial influences on BBB functions and molecular players in immune cell trafficking

(2016) Marc-André Lécuyer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Astrocytes drive upregulation of the multidrug resistance transporter ABCB1 (P-Glycoprotein) in endothelial cells of the blood-brain barrier in mutant superoxide dismutase 1-linked amyotrophic lateral sclerosis

(2016) Hisham Qosa et al.   GLIA

Gene discovery in amyotrophic lateral sclerosis: implications for clinical management

(2016) Ammar Al-Chalabi et al.   Nature Reviews Neurology

¿Por qué degeneran las motoneuronas? Actualización en la patogenia de la esclerosis lateral amiotrófica

(2016) J. Riancho et al.   NEUROLOGIA

Pharmacological targeting of the PDGF-CC signaling pathway for blood–brain barrier restoration in neurological disorders

(2016) Sebastian A. Lewandowski et al.   PHARMACOLOGY & THERAPEUTICS

Impact of Membrane Drug Transporters on Resistance to Small-Molecule Tyrosine Kinase Inhibitors

(2016) Claudia Neul et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Impaired Autophagy and Defective Mitochondrial Function: Converging Paths on the Road to Motor Neuron Degeneration

(2016) Brittany M. Edens et al.   Frontiers in Cellular Neuroscience

ABC transporter-driven pharmacoresistance in Amyotrophic Lateral Sclerosis

(2015) Michael Jablonski et al.   BRAIN RESEARCH

Regulation of ABC efflux transporters at blood-brain barrier in health and neurological disorders

(2015) Hisham Qosa et al.   BRAIN RESEARCH

Neuropathology of Amyotrophic Lateral Sclerosis and Its Variants

(2015) Shahram Saberi et al.   NEUROLOGIC CLINICS

A revision of the El Escorial criteria - 2015

(2015) Albert Ludolph et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Inhibition of COX-2 in Colon Cancer Modulates Tumor Growth and MDR-1 Expression to Enhance Tumor Regression in Therapy-Refractory Cancers In Vivo

(2015) Mahbuba Rahman et al.   NEOPLASIA

Therapeutic Targeting of Epigenetic Components in Amyotrophic Lateral Sclerosis (ALS)

(2014) J. Lee et al.   CURRENT MEDICINAL CHEMISTRY

Neuroprotective effect of masitinib in rats with postischemic stroke

(2014) Ivan Kocic et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Blood-CNS Barrier Impairment in ALS patients versus an animal model

(2014) Svitlana Garbuzova-Davis et al.   Frontiers in Cellular Neuroscience

Inhibitory effects and mechanism of 5-fluorouracil combined with celecoxib on human gastric cancer xenografts in nude mice

(2014) XIAO-QIAN ZHANG et al.   Experimental and Therapeutic Medicine

Inhibiting drug efflux transporters improves efficacy of ALS therapeutics

(2014) Michael R. Jablonski et al.   Annals of Clinical and Translational Neurology

Protein aggregation in amyotrophic lateral sclerosis

(2013) Anna M. Blokhuis et al.   ACTA NEUROPATHOLOGICA

Impact of P-glycoprotein and breast cancer resistance protein on the brain distribution of antiepileptic drugs in knockout mouse models

(2013) Haruka Nakanishi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

Recent Advances in the Genetics of the ALS-FTLD Complex

(2012) Huw R. Morris et al.   Current Neurology and Neuroscience Reports

Breast Cancer Resistance Protein and P-Glycoprotein in Brain Cancer: Two Gatekeepers Team Up

(2012) Sagar Agarwal et al.   CURRENT PHARMACEUTICAL DESIGN

Pathophysiology of the Neurovascular Unit: Disease Cause or Consequence?

(2012) Danica B Stanimirovic et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Dual Cyclooxygenase/5-Lipoxygenase Inhibitor Licofelone Attenuates P-Glycoprotein-Mediated Drug Resistance in the Injured Spinal Cord

(2012) Jennifer N. Dulin et al.   JOURNAL OF NEUROTRAUMA

Selective increase of two ABC drug efflux transporters at the blood–spinal cord barrier suggests induced pharmacoresistance in ALS

(2012) Michael R. Jablonski et al.   NEUROBIOLOGY OF DISEASE

Cerebral expression of drug transporters in epilepsy

(2011) Eleonora Aronica et al.   ADVANCED DRUG DELIVERY REVIEWS

α-Tocopherol injections in rats up-regulate hepatic ABC transporters, but not cytochrome P450 enzymes

(2011) Maret G. Traber et al.   FREE RADICAL BIOLOGY AND MEDICINE

Amyotrophic lateral sclerosis

(2011) Matthew C Kiernan et al.   LANCET

Toll-like receptor signaling in amyotrophic lateral sclerosis spinal cord tissue

(2011) M. Casula et al.   NEUROSCIENCE

Adenosine triphosphate-binding cassette transporters mediate chemokine (C-C motif) ligand 2 secretion from reactive astrocytes: relevance to multiple sclerosis pathogenesis

(2010) Gijs Kooij et al.   BRAIN

Amyotrophic Lateral Sclerosis

(2010) Paul H. Gordon   CNS DRUGS

Restricted brain penetration of the tyrosine kinase inhibitor erlotinib due to the drug transporters P-gp and BCRP

(2010) Nienke A. de Vries et al.   INVESTIGATIONAL NEW DRUGS

P-glycoprotein expression and function are increased in an animal model of amyotrophic lateral sclerosis

(2010) Aline Milane et al.   NEUROSCIENCE LETTERS

Interactions between riluzole and ABCG2/BCRP transporter

(2009) Aline Milane et al.   NEUROSCIENCE LETTERS

Drug interactions at the blood-brain barrier: Fact or fantasy?☆

(2009) Sara Eyal et al.   PHARMACOLOGY & THERAPEUTICS

P-Glycoprotein Acts as an Immunomodulator during Neuroinflammation

(2009) Gijs Kooij et al.   PLoS One

TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

(2009) I. Wegorzewska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The complexities of antiretroviral drug–drug interactions: role of ABC and SLC transporters

(2009) Olena Kis et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The blood-brain barrier in brain homeostasis and neurological diseases

(2008) Nicolas Weiss et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Blood–brain barrier permeability considerations for CNS-targeted compound library design

(2008) Stephen A Hitchcock   CURRENT OPINION IN CHEMICAL BIOLOGY

Involvement of Multidrug Resistance-Associated Protein 2 (Abcc2) in Molecular Weight-Dependent Biliary Excretion of  -Lactam Antibiotics

(2008) Y. Kato et al.   DRUG METABOLISM AND DISPOSITION

Nordihydroguaiaretic acid increases glutamate uptake in vitro and in vivo: Therapeutic implications for amyotrophic lateral sclerosis

(2008) William Boston-Howes et al.   EXPERIMENTAL NEUROLOGY

The effect of P-gp (Mdr1a/1b), BCRP (Bcrp1) and P-gp/BCRP inhibitors on the in vivo absorption, distribution, metabolism and excretion of imatinib

(2008) Roos L. Oostendorp et al.   INVESTIGATIONAL NEW DRUGS

Decreased blood–brain barrier P-glycoprotein function in the progression of Parkinson’s disease, PSP and MSA

(2008) A. L. Bartels et al.   JOURNAL OF NEURAL TRANSMISSION

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON

Cellular localization of metabotropic glutamate receptors in cortical tubers and subependymal giant cell tumors of tuberous sclerosis complex

(2008) K. Boer et al.   NEUROSCIENCE

Interactions between antiparkinsonian drugs and ABCB1/P-glycoprotein at the blood–brain barrier in a rat brain endothelial cell model

(2008) Sarah Vautier et al.   NEUROSCIENCE LETTERS