Circularly permuted LOV2 as a modular photoswitch for optogenetic engineering

Safety and feasibility of anti-CD19 CAR T cells with fully human binding domains in patients with B-cell lymphoma

(2020) Jennifer N. Brudno et al.   NATURE MEDICINE

Engineering light-controllable CAR T cells for cancer immunotherapy

(2020) Ziliang Huang et al.   Science Advances

A yeast system for discovering optogenetic inhibitors of eukaryotic translation initiation

(2019) G. Andrew Woolley et al.   ACS Synthetic Biology

Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses

(2018) Jang Hwan Cho et al.   CELL

Blue-Light Receptors for Optogenetics

(2018) Aba Losi et al.   CHEMICAL REVIEWS

The market for chimeric antigen receptor T cell therapies

(2018) Amy Yip et al.   NATURE REVIEWS DRUG DISCOVERY

Chimeric Antigen Receptor Therapy

(2018) Carl H. June et al.   NEW ENGLAND JOURNAL OF MEDICINE

CAR T cell immunotherapy for human cancer

(2018) Carl H. June et al.   SCIENCE

Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency

(2018) Judith Feucht et al.   NATURE MEDICINE

Engineered anti-CRISPR proteins for optogenetic control of CRISPR–Cas9

(2018) Felix Bubeck et al.   NATURE METHODS

Inhibition Mechanism of an Anti-CRISPR Suppressor AcrIIA4 Targeting SpyCas9

(2017) Hui Yang et al.   MOLECULAR CELL

Structural basis of CRISPR–SpyCas9 inhibition by an anti-CRISPR protein

(2017) De Dong et al.   NATURE

Optogenetic Immunomodulation: Shedding Light on Antitumor Immunity

(2017) Peng Tan et al.   TRENDS IN BIOTECHNOLOGY

LOVTRAP: an optogenetic system for photoinduced protein dissociation

(2016) Hui Wang et al.   NATURE METHODS

Optogenetic control of nuclear protein export

(2016) Dominik Niopek et al.   Nature Communications

Antigen-Loaded Upconversion Nanoparticles for Dendritic Cell Stimulation, Tracking, and Vaccination in Dendritic Cell-Based Immunotherapy

(2015) Jian Xiang et al.   ACS Nano

A General Computational Approach for Repeat Protein Design

(2015) Fabio Parmeggiani et al.   JOURNAL OF MOLECULAR BIOLOGY

Appraising the suitability of succinimidyl and lipophilic fluorescent dyes to track proliferation in non-quiescent cells by dye dilution

(2015) Andrew Filby et al.   METHODS

CSI 3.0: a web server for identifying secondary and super-secondary structure in proteins using NMR chemical shifts

(2015) Noor E. Hafsa et al.   NUCLEIC ACIDS RESEARCH

Remote control of therapeutic T cells through a small molecule-gated chimeric receptor

(2015) C.-Y. Wu et al.   SCIENCE

Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation

(2015) Lian He et al.   eLife

Control of Protein Activity and Cell Fate Specification via Light-Mediated Nuclear Translocation

(2015) Hayretin Yumerefendi et al.   PLoS One

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Illuminating cell signalling with optogenetic tools

(2014) Doug Tischer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Factors That Control the Chemistry of the LOV Domain Photocycle

(2014) Josiah P. Zayner et al.   PLoS One

Engineering an improved light-induced dimer (iLID) for controlling the localization and activity of signaling proteins

(2014) Gurkan Guntas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

(2014) Yves Dondelinger et al.   Cell Reports

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Rationally improving LOV domain–based photoswitches

(2010) Devin Strickland et al.   NATURE METHODS

Circular permutation: a different way to engineer enzyme structure and function

(2010) Ying Yu et al.   TRENDS IN BIOTECHNOLOGY

A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels

(2009) Martin Muik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SOAR and the polybasic STIM1 domains gate and regulate Orai channels

(2009) Joseph P. Yuan et al.   NATURE CELL BIOLOGY

STIM1 gates the store-operated calcium channel ORAI1 in vitro

(2009) Yubin Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY