Article
Spectroscopy
Jun Wang, Jin-Ye Lu, Qiu-Yun Chen
Summary: Researchers have developed a water-soluble fluorescent sensor for rapid detection of mercaptans in materials and the environment. The sensor utilizes the coordination and steric effect of mercaptans to gold, allowing for differentiation of different types of mercaptans. By combining with mercaptans, the sensor exhibits enhanced fluorescence emission, enabling sensitive detection of mercaptans. The gold coordination competition between the sensor and mercaptans provides a strategy for the development of new fluorescence chemosensors.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Engineering, Biomedical
Ran Li, Junyi Ren, Dongxiang Zhang, Meiheng Lv, Zhan Wang, Huan Wang, Shan Zhang, Jianjun Du, Xin-Dong Jiang, Guiling Wang
Summary: In this study, di-tert-butyl substituted aza-BODIPYs were synthesized for the first time. The near-infrared dye SMe-tBuazaBDP demonstrated a significant Stokes shift and enhanced photothermal conversion efficiency, making it a potential candidate for photothermal therapy by inhibiting cancer cell proliferation and inducing apoptosis.
MATERIALS TODAY BIO
(2022)
Article
Chemistry, Analytical
Meng He, Miantai Ye, Bo Li, Tsunghsueh Wu, Chunfeng Lu, Pan Liu, Huiyue Li, Xingyu Zhou, Yanying Wang, Tao Liang, Haiyan Li, Chunya Li
Summary: In this study, a near-infrared fluorescent probe, TJM, was developed for selective and sensitive bioimaging of HClO. TJM exhibited excellent selectivity, high sensitivity, and low detection limit, making it suitable for imaging endogenous HClO in biological systems.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Organic
Zinaida M. Kaskova, Nadezhda S. Baleeva, Yulia V. Nelyubina, Anastasia A. Andrianova, Zinaida M. Kaskova, Aleksandra S. Tsarkova
Summary: A novel highly fluorescent benzothiophene-based dye with five fused rings was synthesized using a simple two-step method, showing a large Stokes shift in ethanol. The structural features of the compound allow for easy functionalization of the carbon core, potentially leading to the development of new classes of fluorescent dyes.
Article
Engineering, Biomedical
Liang Zhao, Han Zhu, You-Yang Duo, Dai-Wen Pang, Zhi-Gang Wang, Shu-Lin Liu
Summary: The integration of fluorescence diagnosis and photothermal therapy in NIR-II has become popular due to its high sensitivity, fast response, and noninvasiveness, which are essential for the early detection and effective treatment of cancer. This study focuses on designing a NIR-II hemicyanine with both better fluorescence and photothermal properties, using a positively charged pyridine salt, triphenylamine, and oxole. The synthesized compound, HCY-995, shows promise with its high quantum yield, photothermal conversion efficiency, and significant Stoke shift, making it suitable for tumor diagnosis and treatment. Rating: 8/10
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Physical
Rengel Cane E. Sia, Ruben Arturo Arellano-Reyes, Tia E. Keyes, Julien Guthmuller
Summary: The study investigates the radiative emission lifetime and excited state properties of a BODIPY dye using theoretical calculations, revealing that EOM-CCSD improves the emission energy compared to TDDFT. The state-specific solvation methods are more suitable for describing solvent effects on the dye, and vibronic effects increase the radiative lifetime. HT effects have minimal impact on spectra and lifetimes.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2021)
Article
Chemistry, Organic
Zhao Xiaolong, Guo Liangwu, Li Yuqing, Ran Qiyuan, Wu Huihui, Zhang Zhen, Su Yingpeng, Zhou Pengxin, Yan Na
Summary: Based on the main skeleton of fluoroboron dipyrrole (BODIPY), two near-infrared fluorescent probes Azo-BDP1 and Azo-BDP2 were designed and synthesized with large Stokes shift of 217 and 224 nm, respectively. As visualized probes for Na2S2O4, Azo-BDP1 and Azo-BDP2 showed high sensitivity and selectivity. The reaction-based recognition mechanism was confirmed by mass spectral analysis, and fluorescence imaging studies in zebrafish embryos and zebrafish demonstrated that Azo-BDP1 is suitable for the in vivo detection of Na2S2O4.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Zhou Hongmei, Tang Yonghe, Lu Huixu, Zhang Qian, Lin Weiying
Summary: Mitochondrial dysfunction is closely associated with serious diseases, and a new mitochondria targeted dye with excellent properties has been developed for cell imaging experiments.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Claudia Brito da Silva, Luana Silva, Natali Pires Debia, Otavio Augusto Chaves, Diogo Seibert Ludtke, Fabiano Severo Rodembusch
Summary: This study presents the synthesis of novel glycoconjugates with long wavelength emission and large Stokes shift using a copper-catalyzed 1,3-dipolar cycloaddition. These compounds show potential as chemical sensors for detecting Cu2+ ions and demonstrate strong interaction with proteins.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Spectroscopy
Hang Su, Jingpei Wang, Xiuxiu Yue, Benhua Wang, Xiangzhi Song
Summary: A ratiometric fluorescent probe MA-N2H4 was developed for simple and convenient detection of hydrazine (N2H4) in environmental and biological systems. The probe exhibited a significant blue-shifted emission and a rapid increase in fluorescent intensity ratio after treatment with N2H4, allowing for fast detection. Additionally, the probe was successfully used for tracking N2H4 in living cells and zebrafish.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Applied
Qingfei Hu, Haitao Zhang, Peng Ye, Shanghong Ma, Xiuzhong Zhu, Yang Bai
Summary: In this study, a novel fluorescent probe LD-H-Lyso was designed and synthesized to simultaneously label lipid droplets (LDs) and lysosomes in cells. The probe exhibited high specificity and could visualize the distribution of LDs and lysosomes with great precision. Furthermore, LD-H-Lyso showed significant potential as a monitoring tool in studying the interaction between LDs and lysosomes in various physiological and pathological processes.
Article
Nanoscience & Nanotechnology
Chang-Wei Yeh, Yu-Kai Wang, I-Hsuan Wu, Yi-Ching Yang, Pin-Ru Chen, Hsueh-Shih Chen
Summary: This study reports the synthesis of multicore/shell PbCdS quantum dots with an extraordinarily large Stokes shift. By using a specific preparation method, the QDs with a multidomain structure formed through PbS-CdS domain separation. These unique QDs exhibit unusual absorption and photoluminescence wavelengths, making them promising for applications such as solar harvesting.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Applied
Guifen Lu, Yongjie Gao, Xiaochun Wang, Dianqi Zhang, Suci Meng, Siyuan Yu, Yanfang Zhuang, Luyao Duan
Summary: In this study, a near-infrared fluorescent probe COR-DNBS based on corrole derivative was designed and synthesized for detection of hydrogen sulfide. The probe showed high selectivity and sensitivity, with a fast response and desirable properties for bioimaging applications.
Article
Chemistry, Analytical
Yuka Muraoka, Junya Muramoto, Yu Yasuhara, Mayuko Kawatake, Takashi Sakamoto
Summary: In this study, an NIR fluorescence switch-on probe for G4 imaging with higher selectivity and large Stokes shift was developed. This probe may contribute significantly to understanding the behaviors of G4 nucleic acids in cells and biological tissues.
ANALYTICAL CHEMISTRY
(2023)
Article
Spectroscopy
Fengxia Zou, Chun Wang, Wenwu Song, Lujie Shen, Runsheng Xu, Miao Wang, Minmin Wang, Tongming Sun, Jin Wang
Summary: The newly designed fluorescence probe L shows high selectivity and sensitivity to cysteine (Cys) with a specific cyclization for detection. Probe L also exhibits high biocompatibility and is capable of imaging Cys in living cells.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Biochemistry & Molecular Biology
Kseniya Kovaleva, Evgeniya Mamontova, Olga Yarovaya, Olga Zakharova, Alexandra Zakharenko, Olga Lavrik, Nariman Salakhutdinov
Summary: TDP1 is a DNA repair enzyme that could be a target for cancer treatment; its natural mutant causes neurodegenerative disease, inhibiting which may help control the progression of the disease; effective TDP1 inhibitors were found among the synthesized compounds.
MOLECULAR DIVERSITY
(2021)
Article
Biochemistry & Molecular Biology
Darya S. Novopashina, Mariya A. Vorobyeva, Alexander A. Lomzov, Vladimir N. Silnikov, Alya G. Venyaminova
Summary: This study synthesized novel oligonucleotide conjugates with closo-dodecaborate attached to different terminal positions of DNA, RNA, 2'-O-Me RNA, and 2'-F-Py RNA oligomers. The incorporation of boron clusters influenced the stability and double helix structure of the oligomers, with different effects observed for DNA and RNA sequences.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Oksana V. Salomatina, Irina I. Popadyuk, Alexandra L. Zakharenko, Olga D. Zakharova, Arina A. Chepanova, Nadezhda. S. Dyrkheeva, Nina I. Komarova, Johannes Reynisson, Rashid O. Anarbaev, Nariman F. Salakhutdinov, Olga I. Lavrik, Konstantin P. Volcho
Summary: Para-bromoanilides of deoxycholic acid were designed as potential tyrosyl-DNA phosphodiesterase 1 (Tdp1) inhibitors, with compound 3,12-dimethoxypara-bromoanilide 17 showing the highest activity. Evaluation in tumor cell lines revealed that derivative 17 exhibited excellent activity and low cytotoxicity.
Article
Biochemistry & Molecular Biology
Tatyana V. Popova, Inna A. Pyshnaya, Olga D. Zakharova, Andrey E. Akulov, Oleg B. Shevelev, Julia Poletaeva, Evgenii L. Zavjalov, Vladimir N. Silnikov, Elena I. Ryabchikova, Tatyana S. Godovikova
Summary: This study demonstrates the development of a theranostic system by conjugating anticancer nucleotides or boron-neutron capture therapy drugs to human serum albumin and reacting with gold nanoparticles. Despite a long circulation time, the accumulation of the therapeutic conjugates in the tumor was not significant.
Article
Agriculture, Dairy & Animal Science
Georgy A. Nevinsky, Ol'ga D. Zakharova, Ivan Yu Kompaneets, Anna M. Timofeeva, Pavel S. Dmitrenok, Natalia Menzorova
Summary: Antibodies with different catalytic activities (abzymes) in healthy women's milk were found, which are absent in other healthy people's sera. sIgA showed higher enzymatic activity and inhibition of tumor cell growth compared to IgG, suggesting a potential role of abzymes in sperm toxicity and cancer cell growth inhibition.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Transplantation
L. Antonova, E. O. Krivkina, V. N. Silnikov, V Gruzdeva, M. A. Rezvova, T. N. Akentieva, Tv Glushkova, V. O. Tkachenko, V. M. Sakharova, L. S. Barbarash
Summary: Surface modification of biodegradable vascular grafts with antithrombotic and antimicrobial drug coating significantly improved their biocompatibility and antimicrobial properties without compromising their physical-mechanical properties.
VESTNIK TRANSPLANTOLOGII I ISKUSSTVENNYH ORGANOV
(2021)
Article
Chemistry, Multidisciplinary
Vladimir Mironov, Irina A. Shchugoreva, Polina Artyushenko, Dmitry Morozov, Nicola Borbone, Giorgia Oliviero, Tatiana N. Zamay, Roman Moryachkov, Olga S. Kolovskaya, Kirill A. Lukyanenko, Yanling Song, Iuliia A. Merkuleva, Vladimir N. Zabluda, Georgy Peters, Lyudmila S. Koroleva, Dmitry V. Veprintsev, Yury E. Glazyrin, Ekaterina A. Volosnikova, Svetlana Belenkaya, Tatiana Esina, Anastasiya A. Isaeva, Valentina S. Nesmeyanova, Daniil Shanshin, Anna N. Berlina, Nadezhda S. Komova, Valery A. Svetlichnyi, Vladimir N. Silnikov, Dmitriy N. Shcherbakov, Galina S. Zamay, Sergey S. Zamay, Tatyana Smolyarova, Elena P. Tikhonova, Kelvin H-C Chen, U-Ser Jeng, Gerolama Condorelli, Vittorio Franciscis, Gerrit Groenhof, Chaoyong Yang, Alexander A. Moskovsky, Dmitri G. Fedorov, Felix N. Tomilin, Weihong Tan, Yuri Alexeev, Maxim Berezovski, Anna S. Kichkailo
Summary: This study developed a new approach for designing high-affinity aptamers, which can accelerate the development process. It can also be used to improve existing aptamers and provide a blueprint for designing targeting molecules against new pathogens.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Tatyana Popova, Maya A. Dymova, Ludmila S. Koroleva, Olga D. Zakharova, Vladimir A. Lisitskiy, Valeria Raskolupova, Tatiana Sycheva, Sergei Taskaev, Vladimir N. Silnikov, Tatyana S. Godovikova
Summary: Boron neutron capture therapy combines boron compounds with human serum albumin to accumulate in tumor cells and decrease tumor cell survival. The conjugation of thenoyltrifluoroacetone with albumin allows for the preparation of novel multimodal boronated albumin-based theranostic agents, showing potential for imaging-guided boron neutron capture therapy application.
Article
Biochemistry & Molecular Biology
Tatyana A. Kurgina, Stanislav I. Shram, Mikhail M. Kutuzov, Tatyana V. Abramova, Tatyana A. Shcherbakova, Ekaterina A. Maltseva, Vladimir V. Poroikov, Olga I. Lavrik, Vytas K. Svedas, Dmitry K. Nilov
Summary: This study found that 7-methylguanine (7mGua) and 8-hydroxy-7-methylguanine (8h7mGua) have inhibitory effects on PARP1 enzyme activity, with 8h7mGua showing stronger inhibition. Both compounds do not affect the activity of other DNA repair enzymes, indicating their selective inhibitory action.
BIOCHEMISTRY-MOSCOW
(2022)
Article
Microbiology
Alina E. Grigor'eva, Alevtina V. Bardasheva, Elena S. Ryabova, Anastasiya V. Tupitsyna, Danila A. Zadvornykh, Lyudmila S. Koroleva, Vladimir N. Silnikov, Nina V. Tikunova, Elena I. Ryabchikova
Summary: Understanding the relationship between the effects of antibacterial compounds and their chemical structure is crucial for the purposeful development of synthetic antibacterial compounds. In this study, we examined the ultrastructural changes in S. aureus cells caused by the polycationic amphiphile DL(4)12, ciprofloxacin, and their hybrid DL(5)Cip6. Our findings revealed that DL(4)12 damaged the bacterial cell wall and disrupted the cytoplasm, while ciprofloxacin altered the cell membrane and cytoplasm and inhibited bacterial division. The ultrastructural characteristics of S. aureus cells damaged by the hybrid differed from those under ciprofloxacin or DL(4)12 action. Furthermore, we observed clear differences in the effects of these compounds on the morphology of S. aureus biofilm.
Article
Chemistry, Organic
L. M. Gornostaev, D. S. Rudenko, T. A. Rukovets, O. I. Fominykh, Yu. G. Romashkova, Yu. V. Gatilov, V. N. Sil'nikov
Summary: Two types of compounds react with two different substrates to generate complex compounds with distinct structures.
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY
(2021)