MicroRNA governs bistable cell differentiation and lineage segregation via a noncanonical feedback

MicroRNAs organize intrinsic variation into stem cell states

(2020) Meenakshi Chakraborty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Dynamical Paradigm for Molecular Cell Biology

(2020) John J. Tyson et al.   TRENDS IN CELL BIOLOGY

An adhesion code ensures robust pattern formation during tissue morphogenesis

(2020) Tony Y.-C. Tsai et al.   SCIENCE

Structural Basis for Target-Directed MicroRNA Degradation

(2019) Jessica Sheu-Gruttadauria et al.   MOLECULAR CELL

Mir-17∼92 Confers Motor Neuron Subtype Differential Resistance to ALS-Associated Degeneration

(2019) Ying-Tsen Tung et al.   Cell Stem Cell

Global analyses of the dynamics of mammalian microRNA metabolism

(2019) Elena Kingston et al.   GENOME RESEARCH

Stochastic antagonism between two proteins governs a bacterial cell fate switch

(2019) Nathan D. Lord et al.   SCIENCE

Multifaceted roles of microRNAs: From motor neuron generation in embryos to degeneration in spinal muscular atrophy

(2019) Tai-Heng Chen et al.   eLife

Cell Identity Switching Regulated by Retinoic Acid Signaling Maintains Homogeneous Segments in the Hindbrain

(2018) Megan Addison et al.   DEVELOPMENTAL CELL

Dissipative structures in biological systems: bistability, oscillations, spatial patterns and waves

(2018) Albert Goldbeter   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Endogenous transcripts control miRNA levels and activity in mammalian cells by target-directed miRNA degradation

(2018) Francesco Ghini et al.   Nature Communications

Hysteresis control of epithelial-mesenchymal transition dynamics conveys a distinct program with enhanced metastatic ability

(2018) Toni Celià-Terrassa et al.   Nature Communications

Dlk1-Dio3 locus-derived lncRNAs perpetuate postmitotic motor neuron cell fate and subtype identity

(2018) Ya-Ping Yen et al.   eLife

Cell-cycle transitions: a common role for stoichiometric inhibitors

(2017) Michael Hopkins et al.   MOLECULAR BIOLOGY OF THE CELL

Decoding of position in the developing neural tube from antiparallel morphogen gradients

(2017) Marcin Zagorski et al.   SCIENCE

MicroRNA filters Hox temporal transcription noise to confer boundary formation in the spinal cord

(2017) Chung-Jung Li et al.   Nature Communications

Reciprocal regulation between mRNA and microRNA enables a bistable switch that directs cell fate decisions

(2016) Xiao-Jun Tian et al.   FEBS LETTERS

Hox Proteins Coordinate Motor Neuron Differentiation and Connectivity Programs through Ret/Gfrα Genes

(2016) Catarina Catela et al.   Cell Reports

Noise modulation in retinoic acid signaling sharpens segmental boundaries of gene expression in the embryonic zebrafish hindbrain

(2016) Julian Sosnik et al.   eLife

Hoxc8 initiates an ectopic mammary program by regulating Fgf10 and Tbx3 expression and Wnt/ -catenin signaling

(2015) L. S. Carroll et al.   DEVELOPMENT

Potent degradation of neuronal miRNAs induced by highly complementary targets

(2015) M. de la Mata et al.   EMBO REPORTS

Independent regulation of vertebral number and vertebral identity by microRNA-196 paralogs

(2015) Siew Fen Lisa Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mir-17∼92 Governs Motor Neuron Subtype Survival by Mediating Nuclear PTEN

(2015) Ying-Tsen Tung et al.   Cell Reports

An Ovol2-Zeb1 Mutual Inhibitory Circuit Governs Bidirectional and Multi-step Transition between Epithelial and Mesenchymal States

(2015) Tian Hong et al.   PLoS Computational Biology

Predicting effective microRNA target sites in mammalian mRNAs

(2015) Vikram Agarwal et al.   eLife

Statistical significance of variables driving systematic variation in high-dimensional data

(2014) Neo Christopher Chung et al.   BIOINFORMATICS

mRNA Destabilization Is the Dominant Effect of Mammalian MicroRNAs by the Time Substantial Repression Ensues

(2014) Stephen W. Eichhorn et al.   MOLECULAR CELL

TGF- -induced epithelial-to-mesenchymal transition proceeds through stepwise activation of multiple feedback loops

(2014) J. Zhang et al.   Science Signaling

Ultrasensitivity part II: multisite phosphorylation, stoichiometric inhibitors, and positive feedback

(2014) James E. Ferrell et al.   TRENDS IN BIOCHEMICAL SCIENCES

A Combination of Transcriptional and MicroRNA Regulation Improves the Stability of the Relative Concentrations of Target Genes

(2014) Andrea Riba et al.   PLoS Computational Biology

Coupled Reversible and Irreversible Bistable Switches Underlying TGFβ-induced Epithelial to Mesenchymal Transition

(2013) Xiao-Jun Tian et al.   BIOPHYSICAL JOURNAL

Tristability in Cancer-Associated MicroRNA-TF Chimera Toggle Switch

(2013) Mingyang Lu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Hox Genes: Choreographers in Neural Development, Architects of Circuit Organization

(2013) Polyxeni Philippidou et al.   NEURON

A systemic transcriptome analysis reveals the regulation of neural stem cell maintenance by an E2F1–miRNA feedback loop

(2013) Thomas Palm et al.   NUCLEIC ACIDS RESEARCH

miRNAs confer phenotypic robustness to gene networks by suppressing biological noise

(2013) Velia Siciliano et al.   Nature Communications

Roles for MicroRNAs in Conferring Robustness to Biological Processes

(2012) Margaret S. Ebert et al.   CELL

Gene Regulatory Logic for Reading the Sonic Hedgehog Signaling Gradient in the Vertebrate Neural Tube

(2012) Nikolaos Balaskas et al.   CELL

miRNA-Mediated Gene Silencing by Translational Repression Followed by mRNA Deadenylation and Decay

(2012) S. Djuranovic et al.   SCIENCE

Ribosome Profiling Shows That miR-430 Reduces Translation Before Causing mRNA Decay in Zebrafish

(2012) A. A. Bazzini et al.   SCIENCE

Kinetic Analysis Reveals the Fate of a MicroRNA following Target Regulation in Mammalian Cells

(2011) Alessia Baccarini et al.   CURRENT BIOLOGY

miRNA-mediated feedback inhibition of JAK/STAT morphogen signalling establishes a cell fate threshold

(2011) Wan Hee Yoon et al.   NATURE CELL BIOLOGY

MicroRNAs can generate thresholds in target gene expression

(2011) Shankar Mukherji et al.   NATURE GENETICS

Mir-17-3p Controls Spinal Neural Progenitor Patterning by Regulating Olig2/Irx3 Cross-Repressive Loop

(2011) Jun-An Chen et al.   NEURON

The Role of Incoherent MicroRNA-Mediated Feedforward Loops in Noise Buffering

(2011) Matteo Osella et al.   PLoS Computational Biology

Ratio of miR-196s to HOXC8 Messenger RNA Correlates with Breast Cancer Cell Migration and Metastasis

(2010) Y. Li et al.   CANCER RESEARCH

The gap gene network

(2010) Johannes Jaeger   CELLULAR AND MOLECULAR LIFE SCIENCES

An atlas of gene regulatory networks reveals multiple three-gene mechanisms for interpreting morphogen gradients

(2010) James Cotterell et al.   Molecular Systems Biology

Boundary formation and maintenance in tissue development

(2010) Christian Dahmann et al.   NATURE REVIEWS GENETICS

A MicroRNA Imparts Robustness against Environmental Fluctuation during Development

(2009) Xin Li et al.   CELL

Making a firm decision: multifaceted regulation of cell fate in the early mouse embryo

(2009) Magdalena Zernicka-Goetz et al.   NATURE REVIEWS GENETICS

Systems biology of stem cell fate and cellular reprogramming

(2009) Ben D. MacArthur et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A bistable Rb–E2F switch underlies the restriction point

(2008) Guang Yao et al.   NATURE CELL BIOLOGY