The application of biomarkers in clinical trials for motor neuron disease

Vgf is a novel biomarker associated with muscle weakness in amyotrophic lateral sclerosis (ALS), with a potential role in disease pathogenesis

(2012) Zhong Zhao et al.   International Journal of Medical Sciences

Diffusion Tensor Imaging in Sporadic and Familial (D90A SOD1) Forms of Amyotrophic Lateral Sclerosis

(2009) Biba R. Stanton et al.   ARCHIVES OF NEUROLOGY

Linear Longitudinal Decline in Fractional Anisotropy in Patients with Amyotrophic Lateral Sclerosis

(2009) Joshua P. Nickerson et al.   CLINICAL NEURORADIOLOGY

Biomarkers in Clinical Drug Development

(2009) JVS Gobburu   CLINICAL PHARMACOLOGY & THERAPEUTICS

Arterial spin-labeled perfusion MRI in basic and clinical neuroscience

(2009) John A Detre et al.   CURRENT OPINION IN NEUROLOGY

Increased levels of inflammatory chemokines in amyotrophic lateral sclerosis

(2009) J. Kuhle et al.   EUROPEAN JOURNAL OF NEUROLOGY

Stratifying disease stages with different progression rates determined by electrophysiological tests in patients with amyotrophic lateral sclerosis

(2009) Xiao-Xuan Liu et al.   MUSCLE & NERVE

Natural history and clinical features of the flail arm and flail leg ALS variants

(2009) L. C. Wijesekera et al.   NEUROLOGY

MRI and CSF biomarkers in normal, MCI, and AD subjects: Predicting future clinical change

(2009) P. Vemuri et al.   NEUROLOGY

Clinical features that distinguish PLS, upper motor neuron-dominant ALS, and typical ALS

(2009) P. H. Gordon et al.   NEUROLOGY

Amyotrophic lateral sclerosis

(2009) Lokesh C Wijesekera et al.   Orphanet Journal of Rare Diseases

Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

(2009) C. Vance et al.   SCIENCE

Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

(2009) T. J. Kwiatkowski et al.   SCIENCE

Accelerating Drug Development Using Biomarkers: A Case Study with Sitagliptin, A Novel DPP4 Inhibitor for Type 2 Diabetes

(2008) Rajesh Krishna et al.   AAPS Journal

Increased TDP-43 protein in cerebrospinal fluid of patients with amyotrophic lateral sclerosis

(2008) Takashi Kasai et al.   ACTA NEUROPATHOLOGICA

Magnetic Source Imaging of Cortical Dysfunction in Amyotrophic Lateral Sclerosis

(2008) Robert A. Boyajian et al.   AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION

Oxidative stress biomarkers in sporadic ALS

(2008) Hiroshi Mitsumoto et al.   Amyotrophic Lateral Sclerosis

Awaji diagnostic algorithm increases sensitivity of El Escorial criteria for ALS diagnosis

(2008) Mamede De Carvalho et al.   Amyotrophic Lateral Sclerosis

TDP-43 in Cerebrospinal Fluid of Patients With Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis

(2008) Petra Steinacker et al.   ARCHIVES OF NEUROLOGY

Development of a High-Throughput Microarray-Based Resequencing System for Neurological Disorders and Its Application to Molecular Genetics of Amyotrophic Lateral Sclerosis

(2008) Yuji Takahashi et al.   ARCHIVES OF NEUROLOGY

Cortical hyperexcitability may precede the onset of familial amyotrophic lateral sclerosis

(2008) Steve Vucic et al.   BRAIN

Electrodiagnostic criteria for diagnosis of ALS

(2008) Mamede de Carvalho et al.   CLINICAL NEUROPHYSIOLOGY

PET Imaging of the Peripheral Benzodiazepine Receptor: Monitoring Disease Progression and Therapy Response in Neurodegenerative Disorders

(2008) Janine Doorduin et al.   CURRENT PHARMACEUTICAL DESIGN

Lost in translation: Problems and pitfalls in translating laboratory observations to clinical utility

(2008) Richard Simon   EUROPEAN JOURNAL OF CANCER

Biomarkers in oncology drug development: rescuers or troublemakers?

(2008) Estelle Marrer et al.   Expert Opinion on Drug Metabolism & Toxicology

Protein biomarkers for amyotrophic lateral sclerosis

(2008) Henrik Ryberg et al.   Expert Review of Proteomics

Clinical heterogeneity in newly diagnosed Parkinson’s disease

(2008) B. Post et al.   JOURNAL OF NEUROLOGY

Biomarkers in amyotrophic lateral sclerosis

(2008) Martin R Turner et al.   LANCET NEUROLOGY

Magnetic resonance spectroscopy

(2008) Robert W. Prost   MEDICAL PHYSICS

Diffusion Tensor MR Imaging

(2008) Marco Rovaris et al.   NEUROIMAGING CLINICS OF NORTH AMERICA

Evaluation of corticospinal tracts in ALS with diffusion tensor MRI and brainstem stimulation

(2008) N. K. Iwata et al.   NEUROLOGY

Callosal dysfunction in amyotrophic lateral sclerosis correlates with diffusion tensor imaging of the central motor system

(2008) Claudia Bartels et al.   NEUROMUSCULAR DISORDERS

ALS drug development: Reflections from the past and a way forward

(2008) Swati Aggarwal et al.   Neurotherapeutics

TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2008) J. Sreedharan et al.   SCIENCE

Mapping the Structural Core of Human Cerebral Cortex

(2008) Patric Hagmann et al.   PLOS BIOLOGY