Cryptococcal meningoencephalitis: time for action

CSF early fungicidal activity as a surrogate endpoint for cryptococcal meningitis survival in clinical trials

(2020) Matthew F Pullen et al.   CLINICAL INFECTIOUS DISEASES

Time to embrace access programmes for medicines: Lessons from the South African flucytosine access programme

(2020) Amir Shroufi et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

AIDS-Related Mycoses: Updated Progress and Future Priorities

(2020) J. Claire Hoving et al.   TRENDS IN MICROBIOLOGY

Hope on the Horizon: Novel Fungal Treatments in Development

(2020) Adriana M Rauseo et al.   Open Forum Infectious Diseases

Evaluation of a Novel Semi-quantitative Cryptococcal Antigen Lateral Flow Assay in Patients with Advanced HIV Disease

(2020) Joseph N Jarvis et al.   JOURNAL OF CLINICAL MICROBIOLOGY

A pragmatic approach to managing antiretroviral therapy-experienced patients diagnosed with HIV-associated cryptococcal meningitis: impact of antiretroviral therapy adherence and duration

(2020) Melanie Alufandika et al.   AIDS

Tackling cryptococcal meningitis in Nigeria, one-step at a time; the impact of training

(2020) Rita O. Oladele et al.   PLoS One

Dynamic ploidy changes drive fluconazole resistance in human cryptococcal meningitis

(2019) Neil R.H. Stone et al.   JOURNAL OF CLINICAL INVESTIGATION

Cryptococcosis in Solid Organ Transplantation‐ Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice

(2019) J W Baddley et al.   CLINICAL TRANSPLANTATION

Addition of flucytosine to fluconazole for the treatment of cryptococcal meningitis in Africa: a multi-country cost-effectiveness analysis

(2019) Tinevimbo Shiri et al.   CLINICAL INFECTIOUS DISEASES

Reply to Rajasingham and Boulware

(2019) Joseph N Jarvis et al.   CLINICAL INFECTIOUS DISEASES

Efficacy of Oral Encochleated Amphotericin B in a Mouse Model of Cryptococcal Meningoencephalitis

(2019) R. Lu et al.   mBio

Cryptococcal-related Mortality Despite Fluconazole Preemptive Treatment in a Cryptococcal Antigen Screen-and-Treat Program

(2019) Rachel M Wake et al.   CLINICAL INFECTIOUS DISEASES

One-year Mortality Outcomes From the Advancing Cryptococcal Meningitis Treatment for Africa Trial of Cryptococcal Meningitis Treatment in Malawi

(2019) Cecilia Kanyama et al.   CLINICAL INFECTIOUS DISEASES

Mortality due to Cryptococcus neoformans and Cryptococcus gattii in low-income settings: an autopsy study

(2019) Juan Carlos Hurtado et al.   Scientific Reports

Adjunctive sertraline for HIV-associated cryptococcal meningitis: a randomised, placebo-controlled, double-blind phase 3 trial

(2019) Joshua Rhein et al.   LANCET INFECTIOUS DISEASES

Seizures in HIV-associated Cryptococcal Meningitis: Predictors and Outcomes

(2019) Katelyn A Pastick et al.   Open Forum Infectious Diseases

In vitro and in vivo Evaluation of APX001A/APX001 and other Gwt1 inhibitors against Cryptococcus

(2018) Karen Joy Shaw et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cost-effectiveness of Preventive Therapy for Tuberculosis With Isoniazid and Rifapentine Versus Isoniazid Alone in High-Burden Settings

(2018) Karl T Johnson et al.   CLINICAL INFECTIOUS DISEASES

The Continuing Burden of Advanced HIV Disease Over 10 Years of Increasing Antiretroviral Therapy Coverage in South Africa

(2018) Meg Osler et al.   CLINICAL INFECTIOUS DISEASES

Pharmacokinetics–pharmacodynamics of antifungal agents in the central nervous system

(2018) Katharine E Stott et al.   Expert Opinion on Drug Metabolism & Toxicology

OUP accepted manuscript

(2018)   JOURNAL OF INFECTIOUS DISEASES

Novel Treatment of Cryptococcal Meningitis via Neurapheresis Therapy

(2018) Gordon J Smilnak et al.   JOURNAL OF INFECTIOUS DISEASES

Understanding Causal Pathways in Cryptococcal Meningitis Immune Reconstitution Inflammatory Syndrome

(2018) Joseph N Jarvis et al.   JOURNAL OF INFECTIOUS DISEASES

Antifungal Combinations for Treatment of Cryptococcal Meningitis in Africa

(2018) Síle F. Molloy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Detrimental Outcomes of Unmasking Cryptococcal Meningitis with Recent ART Initiation

(2018) Joshua Rhein et al.   Open Forum Infectious Diseases

In Vivo Efficacy of VT-1129 against Experimental Cryptococcal Meningitis with the Use of a Loading Dose-Maintenance Dose Administration Strategy

(2018) Nathan P. Wiederhold et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Do intra-cerebral cytokine responses explain the harmful effects of dexamethasone in HIV-associated cryptococcal meningitis?

(2018) Justin Beardsley et al.   CLINICAL INFECTIOUS DISEASES

Reflexive laboratory-based cryptococcal antigen screening and preemptive fluconazole therapy for cryptococcal antigenemia in HIV-infected individuals with CD4

(2018) David B Meya et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Leave no one behind: response to new evidence and guidelines for the management of cryptococcal meningitis in low-income and middle-income countries

(2018) Angela Loyse et al.   LANCET INFECTIOUS DISEASES

AMBIsome Therapy Induction OptimisatioN (AMBITION): High Dose AmBisome for Cryptococcal Meningitis Induction Therapy in sub-Saharan Africa: Study Protocol for a Phase 3 Randomised Controlled Non-Inferiority Trial

(2018) David S. Lawrence et al.   Trials

High Mortality in HIV-Associated Cryptococcal Meningitis Patients Treated With Amphotericin B–Based Therapy Under Routine Care Conditions in Africa

(2018) Raju K K Patel et al.   Open Forum Infectious Diseases

Healthcare Costs and Life-years Gained From Treatments Within the Advancing Cryptococcal Meningitis Treatment for Africa (ACTA) Trial on Cryptococcal Meningitis: A Comparison of Antifungal Induction Strategies in Sub-Saharan Africa

(2018) Tao Chen et al.   CLINICAL INFECTIOUS DISEASES

Brief Report

(2017) Tom H. Boyles et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Corticosteroids for the management of severe intracranial hypertension in meningoencephalitis caused by Cryptococcus gattii : A case report and review

(2017) R.-A. Maciel et al.   JOURNAL DE MYCOLOGIE MEDICALE

Serum levels, safety and tolerability of new formulation SUBA-itraconazole prophylaxis in patients with haematological malignancy or undergoing allogeneic stem cell transplantation

(2017) Julian Lindsay et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Corticosteroids for shunted previously healthy patients with non-HIV cryptococcal meningoencephalitis

(2017) Gautam U Mehta et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis

(2017) Radha Rajasingham et al.   LANCET INFECTIOUS DISEASES

Cryptococcal meningitis: A neglected NTD?

(2017) Síle F. Molloy et al.   PLoS Neglected Tropical Diseases

First-in-Human Study to Assess Safety, Tolerability and Pharmacokinetics of APX001 Administered by Intravenous Infusion to Healthy Subjects

(2017) Michael R Hodges et al.   Open Forum Infectious Diseases

Cryptococcal Meningitis Treatment Strategies Affected by the Explosive Cost of Flucytosine in the United States: A Cost-effectiveness Analysis

(2016) Matthew Merry et al.   CLINICAL INFECTIOUS DISEASES

Global access to antifungal therapy and its variable cost

(2016) Matthew Kneale et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

A Glucuronoxylomannan-Associated Immune Signature, Characterized by Monocyte Deactivation and an Increased Interleukin 10 Level, Is a Predictor of Death in Cryptococcal Meningitis

(2016) James E. Scriven et al.   JOURNAL OF INFECTIOUS DISEASES

Adjunctive Dexamethasone in HIV-Associated Cryptococcal Meningitis

(2016) Justin Beardsley et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Epidemiology of Meningitis among Adults in a South African Province with a High HIV Prevalence, 2009-2012

(2016) Erika Britz et al.   PLoS One

Toxicity of Amphotericin B Deoxycholate-Based Induction Therapy in Patients with HIV-Associated Cryptococcal Meningitis

(2015) Tihana Bicanic et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Early ART After Cryptococcal Meningitis Is Associated With Cerebrospinal Fluid Pleocytosis and Macrophage Activation in a Multisite Randomized Trial

(2015) James E. Scriven et al.   JOURNAL OF INFECTIOUS DISEASES

Cryptococcal meningitis screening and community-based early adherence support in people with advanced HIV infection starting antiretroviral therapy in Tanzania and Zambia: an open-label, randomised controlled trial

(2015) Sayoki Mfinanga et al.   LANCET

Cryptococcus: from environmental saprophyte to global pathogen

(2015) Robin C. May et al.   NATURE REVIEWS MICROBIOLOGY

AMBITION-cm: intermittent high dose AmBisome on a high dose fluconazole backbone for cryptococcal meningitis induction therapy in sub-Saharan Africa: study protocol for a randomized controlled trial

(2015) Mooketsi Molefi et al.   Trials

Paradoxical Immune Responses in Non-HIV Cryptococcal Meningitis

(2015) Anil A. Panackal et al.   PLoS Pathogens

Cerebrospinal Fluid Cytokine Profiles Predict Risk of Early Mortality and Immune Reconstitution Inflammatory Syndrome in HIV-Associated Cryptococcal Meningitis

(2015) Joseph N. Jarvis et al.   PLoS Pathogens

Predictors of Immune Reconstitution Syndrome in Organ Transplant Recipients With Cryptococcosis: Implications for the Management of Immunosuppression

(2014) H.-Y. Sun et al.   CLINICAL INFECTIOUS DISEASES

The Effect of Therapeutic Lumbar Punctures on Acute Mortality From Cryptococcal Meningitis

(2014) Melissa A. Rolfes et al.   CLINICAL INFECTIOUS DISEASES

Cryptococcal Meningitis Management in Tanzania with Strict Schedule of Serial Lumber Punctures using Intravenous Tubing Sets

(2014) John Meda et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Predictors of neurocognitive outcomes on antiretroviral therapy after cryptococcal meningitis: a prospective cohort study

(2014) Renee Donahue Carlson et al.   METABOLIC BRAIN DISEASE

A Prospective Study of Mortality from Cryptococcal Meningitis following Treatment Induction with 1200mg Oral Fluconazole in Blantyre, Malawi

(2014) Katherine M. Gaskell et al.   PLoS One

Asymptomatic cryptococcal antigenemia is associated with mortality among HIV-positive patients in Indonesia

(2014) Ahmad Rizal Ganiem et al.   Journal of the International AIDS Society

Standardized Electrolyte Supplementation and Fluid Management Improves Survival During Amphotericin Therapy for Cryptococcal Meningitis in Resource-Limited Settings

(2014) Nathan C. Bahr et al.   Open Forum Infectious Diseases

Clinical and mycological predictors of cryptococcosis-associated immune reconstitution inflammatory syndrome

(2013) Christina C. Chang et al.   AIDS

Determinants of Mortality in a Combined Cohort of 501 Patients With HIV-Associated Cryptococcal Meningitis: Implications for Improving Outcomes

(2013) Joseph N. Jarvis et al.   CLINICAL INFECTIOUS DISEASES

Cryptococcus gattiiinfections: contemporary aspects of epidemiology, clinical manifestations and management of infection

(2013) Brendan Joseph McMullan et al.   Future Microbiology

Chemokine Levels and Chemokine Receptor Expression in the Blood and the Cerebrospinal Fluid of HIV-Infected Patients With Cryptococcal Meningitis and Cryptococcosis-Associated Immune Reconstitution Inflammatory Syndrome

(2013) Christina C. Chang et al.   JOURNAL OF INFECTIOUS DISEASES

The Phenotype of the Cryptococcus-Specific CD4+ Memory T-Cell Response Is Associated With Disease Severity and Outcome in HIV-Associated Cryptococcal Meningitis

(2013) Joseph N. Jarvis et al.   JOURNAL OF INFECTIOUS DISEASES

Cryptococcus neoformans Ex Vivo Capsule Size Is Associated With Intracranial Pressure and Host Immune Response in HIV-associated Cryptococcal Meningitis

(2013) Emma J. Robertson et al.   JOURNAL OF INFECTIOUS DISEASES

Combination Antifungal Therapy for Cryptococcal Meningitis

(2013) Jeremy N. Day et al.   NEW ENGLAND JOURNAL OF MEDICINE

Predictors of Mortality and Differences in Clinical Features among Patients with Cryptococcosis According to Immune Status

(2013) Kyle D. Brizendine et al.   PLoS One

Epidemiology of Cryptococcal Meningitis in the US: 1997–2009

(2013) Vasilios Pyrgos et al.   PLoS One

A Prospective Longitudinal Study of the Clinical Outcomes from Cryptococcal Meningitis following Treatment Induction with 800 mg Oral Fluconazole in Blantyre, Malawi

(2013) Camilla Rothe et al.   PLoS One

Adjunctive interferon-γ immunotherapy for the treatment of HIV-associated cryptococcal meningitis

(2012) Joseph N. Jarvis et al.   AIDS

Role of quantitative CSF microscopy to predict culture status and outcome in HIV-associated cryptococcal meningitis in a Brazilian cohort

(2012) José E. Vidal et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Different presentations and outcomes between HIV-infected and HIV-uninfected patients with Cryptococcal meningitis

(2012) Chia-Hung Liao et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Long Term 5-Year Survival of Persons with Cryptococcal Meningitis or Asymptomatic Subclinical Antigenemia in Uganda

(2012) Elissa K. Butler et al.   PLoS One

Predictors of outcome in routine care for Cryptococcal meningitis in Western Kenya: lessons for HIV outpatient care in resource-limited settings

(2012) Caroline Kendi et al.   POSTGRADUATE MEDICAL JOURNAL

Clinical, Epidemiological and Outcome Features of Patients with Cryptococcosis in Uberaba, Minas Gerais, Brazil

(2011) Delio José Mora et al.   MYCOPATHOLOGIA

Adult meningitis in a setting of high HIV and TB prevalence: findings from 4961 suspected cases

(2010) Joseph N Jarvis et al.   BMC INFECTIOUS DISEASES

Clinical Practice Guidelines for the Management of Cryptococcal Disease: 2010 Update by the Infectious Diseases Society of America

(2010) John R. Perfect et al.   CLINICAL INFECTIOUS DISEASES

Paucity of Initial Cerebrospinal Fluid Inflammation in Cryptococcal Meningitis Is Associated with Subsequent Immune Reconstitution Inflammatory Syndrome

(2010) David R. Boulware et al.   JOURNAL OF INFECTIOUS DISEASES

Immune reconstitution inflammatory syndrome in patients starting antiretroviral therapy for HIV infection: a systematic review and meta-analysis

(2010) Monika Müller et al.   LANCET INFECTIOUS DISEASES

Clinical Features and Serum Biomarkers in HIV Immune Reconstitution Inflammatory Syndrome after Cryptococcal Meningitis: A Prospective Cohort Study

(2010) David R. Boulware et al.   PLOS MEDICINE

Relationship of cerebrospinal fluid pressure, fungal burden and outcome in patients with cryptococcal meningitis undergoing serial lumbar punctures

(2009) Tihana Bicanic et al.   AIDS

Dexamethasone inCryptococcus gattiiCentral Nervous System Infection

(2009) Peter Phillips et al.   CLINICAL INFECTIOUS DISEASES

Independent Association between Rate of Clearance of Infection and Clinical Outcome of HIV‐Associated Cryptococcal Meningitis: Analysis of a Combined Cohort of 262 Patients

(2009) Tihana Bicanic et al.   CLINICAL INFECTIOUS DISEASES

Screening for Cryptococcal Antigenemia in Patients Accessing an Antiretroviral Treatment Program in South Africa

(2009) Joseph N. Jarvis et al.   CLINICAL INFECTIOUS DISEASES

Combination Flucytosine and High‐Dose Fluconazole Compared with Fluconazole Monotherapy for the Treatment of Cryptococcal Meningitis: A Randomized Trial in Malawi

(2009) Jesse C. Nussbaum et al.   CLINICAL INFECTIOUS DISEASES

Immune Reconstitution Inflammatory Syndrome in HIV-Associated Cryptococcal Meningitis: A Prospective Study

(2009) Tihana Bicanic et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

In Vitro and In Vivo Antifungal Activities of T-2307, a Novel Arylamidine

(2008) J. Mitsuyama et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

High‐Dose Amphotericin B with Flucytosine for the Treatment of Cryptococcal Meningitis in HIV‐Infected Patients: A Randomized Trial

(2008) Tihana Bicanic et al.   CLINICAL INFECTIOUS DISEASES

Histopathological Aspects of Neurocryptococcosis in HIV-Infected Patients: Autopsy Report of 45 Patients

(2008) Clóvis Klock et al.   INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY

Treatment of cryptococcal meningitis in Peruvian AIDS Patients using amphotericin B and fluconazole

(2008) P. Dammert et al.   JOURNAL OF INFECTION

Clinical and epidemiological features of 123 cases of cryptococcosis in Mato Grosso do Sul, Brazil

(2008) Andrea De Siqueira Campos Lindenberg et al.   REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO