Review
Orthopedics
F. Eckstein, W. Wirth, A. G. Culvenor
Summary: This article summarizes the articles published in the field of osteoarthritis imaging between January 2019 and April 2020, focusing on clinical models of early OA and imaging applications on structural modification of articular tissues. The research has shown that structural modification of articular cartilage is possible, and future studies should concentrate on translating these findings into clinical benefits.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Review
Orthopedics
G. Peat, M. J. Thomas
Summary: This review examines research themes and highlights in osteoarthritis studies from the past year, emphasizing the importance of epidemiological research and the continued commitment to improving research quality in this field. It highlights the burden of osteoarthritis in disadvantaged and marginalized communities, and showcases the ongoing elaboration of major drivers and interventions within a multi-level framework.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Review
Orthopedics
M. H. J. van den Bosch
Summary: This review summarizes important articles and research focuses on osteoarthritis biology published between 2019 and 2020, covering topics such as inflammatory changes, stem cell therapy, drug treatment, and microbiome. Overall, significant breakthroughs have been made in understanding the biology of osteoarthritis development over the past year, exploring new therapeutic possibilities.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Review
Orthopedics
J. L. Astephen Wilson, D. Kobsar
Summary: The mechanical environment of the joint during dynamic activity is crucial in osteoarthritis progression, with a focus on understanding how joint-specific loading features impact disease development and treatment response. Recent evidence highlights significant interest in using biomechanics to understand osteoarthritis structural and clinical progression, joint loading environment, and the role of muscle activation and forces. There is also growing interest in how gait biomechanics variability influences arthroplasty surgery outcomes, with a trend towards tailored treatment approaches and the application of translational biomechanics tools for improved clinical decision-making and outcomes assessment.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Review
Dermatology
Russell W. Jenkins, David E. Fisher
Summary: The melanoma field has made significant clinical advances in the past decade, with improved therapeutic efficacy for advanced or metastatic melanoma. Targeted approaches and immunotherapy have become the primary treatment strategies, with targeted approaches showing high predictability of efficacy and immunotherapy leading to higher rates of durable remissions. These advancements have not only transformed the standard of care for patients but also suggested novel strategies to further enhance effectiveness for more patients.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Review
Ophthalmology
Marcus Ang, Damien Gatinel, Dan Z. Reinstein, Erik Mertens, Jorge L. Alio del Barrio, Jorge L. Alio
Summary: Refractive surgery techniques are continuously evolving, including traditional laser surgery and new keratorefractive techniques; there are also more options for presbyopic treatment and lens exchange surgery; future developments involve the application of machine learning and artificial intelligence in refractive surgery as well as advancements in intraocular lens implants.
Review
Cell Biology
Alexandra Rayson, Maya Boudiffa, Maneeha Naveed, Jon Griffin, Enrico Dall'Ara, Ilaria Bellantuono
Summary: Osteoporosis and osteoarthritis are common age-related diseases of the musculoskeletal system. Mechanisms of ageing such as senescence, inflammation, and autophagy play a role in both diseases. Studies suggest that geroprotectors may be effective in preventing and reversing osteoporosis-like diseases but their effects on osteoarthritis-like diseases are still uncertain.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Oncology
Klaus Podar, Xavier Leleu
Summary: Collaborative translational studies have enhanced our knowledge of multiple myeloma pathophysiology over the past two decades, but it remains an incurable disease requiring ongoing research to improve patient outcomes. Exciting therapeutic progress, including new drug approvals and emerging treatments in 2020/2021, continues to advance in the field of multiple myeloma.
Review
Nutrition & Dietetics
Sofia Charneca, Ana Hernando, Patricia Costa-Reis, Catarina Sousa Guerreiro
Summary: Despite advances in understanding the biological mechanisms of rheumatic diseases (RDs), a significant proportion of patients still do not achieve remission with current pharmacological treatments. Therefore, patients are increasingly seeking complementary dietary interventions, including the use of herbs and spices. These natural ingredients, which have been widely used for culinary and medicinal purposes across different cultures, are now gaining interest for their bioactive molecules and potential benefits in immune-mediated diseases, including RDs. This paper aims to provide an updated review of the mechanisms through which herbs and spices may be beneficial in RDs, including modulation of gut microbiota, and summarize human studies investigating their effects in Rheumatoid Arthritis, Osteoarthritis, and Fibromyalgia.
Article
Chemistry, Multidisciplinary
Haesun Park, Andrew Otte, Kinam Park
Summary: The advancement in modern drug delivery technology over the past seven decades has revolutionized the field, providing innovative solutions to current and future unmet needs in disease treatment. These technological advancements are essential in overcoming challenges faced today and in developing more efficient formulations for long-term care.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Emergency Medicine
Danya Khoujah, Nicole Cimino-Fiallos
Summary: The healthcare considerations for the rapidly growing older adult patient population are gaining recognition, particularly in the field of Geriatric Emergency Medicine, especially in light of the pandemic. This review article examines various clinical topics like delirium, telehealth, end-of-life care, and elder abuse, while also addressing challenging topics like hip fractures and syncope.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Gulnur Zhakhina, Arnur Gusmanov, Yesbolat Sakko, Sauran Yerdessov, Yuliya Semenova, Dina Saginova, Arman Batpen, Abduzhappar Gaipov
Summary: A Global Burden of Disease study revealed that 9.6 million years lived with disability were lost due to hip and knee osteoarthritis in 2017. This study aims to investigate the epidemiology of knee osteoarthritis in Kazakhstan, utilizing data from 56,895 patients between 2014-2020. The findings highlight age and sex-based differences, as well as regional disparities in the incidence of knee osteoarthritis, providing valuable insights for the development of specific diagnostic approaches and personalized therapy protocols.
Article
Surgery
Lorena Gonzalez, Timothy M. Pawlik, Melina R. Kibbe, Brian Williams, Diego Vicente, Michael P. O'Leary, Catherine G. Velopulos, Luke M. Funk
Summary: 2020 was a significant year with the occurrence of the coronavirus pandemic and the public health crisis of racism. These crises affected healthcare, particularly surgical care and education. The spotlight on racism and health inequality during the pandemic highlighted the need for action in addressing gaps in surgical care and public health services. In addition, military surgeons can provide leadership guidance during times of crisis.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Orthopedics
Weiyi Sun, Peizhi Yuwen, Xuemei Yang, Wei Chen, Yingze Zhang
Summary: The study aimed to explore the changes in epidemiological and clinical characteristics of patients who underwent knee arthroplasty (KA) over a 10-year period in China. The medical records of patients with knee osteoarthritis (KOA) were retrospectively reviewed and analyzed. The results showed that there were significant differences in age, sex, BMI, K-L classification, comorbidities, surgical procedures, hospital stay, and hospitalization costs between the two periods. The study suggested that the epidemiological characteristics of patients undergoing KA treatment have changed over time, providing a scientific basis for the prevention and control of KOA.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Review
Food Science & Technology
Ledyane Taynara Marton, Sandra Maria Barbalho, Katia Portero Sloan, Lance Alan Sloan, Ricardo de Alvares Goulart, Adriano Cressoni Araujo, Marcelo Dib Bechara
Summary: Curcuma or curcumin can play a significant role in treating autoimmune and inflammatory diseases by improving symptoms, reducing disease progression, and showing effects equivalent to ibuprofen and diclofenac, but with fewer side effects.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
