PAD4 takes charge during neutrophil activation: Impact of PAD4 mediated NET formation on immune‐mediated disease

Autocitrullination of PAD4 does not alter its enzymatic activity: In vitro and in silico studies

(2021) Xiaosong Liu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study

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NETosis proceeds by cytoskeleton and endomembrane disassembly and PAD4-mediated chromatin decondensation and nuclear envelope rupture

(2020) Hawa Racine Thiam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil Extracellular Traps (NETs) Take the Central Stage in Driving Autoimmune Responses

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Preventing the development of severe CoVID 19 by modifying immunothrombosis

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Neutrophil Extracellular Traps in Arterial and Venous Thrombosis

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Insight into Neutrophil Extracellular Traps through Systematic Evaluation of Citrullination and Peptidylarginine Deiminases

(2019) Caitlyn L. Holmes et al.   Journal of Immunology Research

Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia

(2019) José Perdomo et al.   Nature Communications

PAD4-dependent NETs generation are indispensable for intestinal clearance of Citrobacter rodentium

(2019) Piu Saha et al.   Mucosal Immunology

Neutrophil Extracellular Traps

(2019) Charlotte Thålin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Plasma Peptidylarginine Deiminase IV Promotes VWF-Platelet String Formation and Accelerates Thrombosis after Vessel Injury

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The double-edged role of neutrophil extracellular traps in inflammation

(2019) Maximilien Euler et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Role of Peptidylarginine Deiminase 4 in Neutrophil Extracellular Trap Formation and Host Defense duringKlebsiella pneumoniae–Induced Pneumonia-Derived Sepsis

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Peptidylarginine deiminase 4 -104C/T polymorphism and risk of rheumatoid arthritis: A pooled analysis based on different populations

(2018) Jiong Hua et al.   PLoS One

Citrullination of RGG Motifs in FET Proteins by PAD4 Regulates Protein Aggregation and ALS Susceptibility

(2018) Chizu Tanikawa et al.   Cell Reports

Perspective on Protein Arginine Deiminase Activity—Bicarbonate Is a pH-Independent Regulator of Citrullination

(2018) Yebin Zhou et al.   Frontiers in Immunology

Physiological Stimuli Induce PAD4-Dependent, ROS-Independent NETosis, With Early and Late Events Controlled by Discrete Signaling Pathways

(2018) Olga Tatsiy et al.   Frontiers in Immunology

Reactive oxygen species inhibit catalytic activity of peptidylarginine deiminase

(2017) Dres Damgaard et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Probing the Roles of Calcium-Binding Sites during the Folding of Human Peptidylarginine Deiminase 4

(2017) Yi-Liang Liu et al.   Scientific Reports

Diverse stimuli engage different neutrophil extracellular trap pathways

(2017) Elaine F Kenny et al.   eLife

Decreased severity of experimental autoimmune arthritis in peptidylarginine deiminase type 4 knockout mice

(2016) Akari Suzuki et al.   BMC MUSCULOSKELETAL DISORDERS

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(2016) Aaron M. Wendelboe et al.   CIRCULATION RESEARCH

A Critical Reappraisal of Neutrophil Extracellular Traps and NETosis Mimics Based on Differential Requirements for Protein Citrullination

(2016) Maximilian F. Konig et al.   Frontiers in Immunology

The Emerging Role of NETs in Venous Thrombosis and Immunothrombosis

(2016) Andrew S. Kimball et al.   Frontiers in Immunology

Neutrophil Extracellular Trap-Related Extracellular Histones Cause Vascular Necrosis in Severe GN

(2015) S. V. R. Kumar et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

(2015) Huw D Lewis et al.   Nature Chemical Biology

Substrate tunnels in enzymes: Structure-function relationships and computational methodology

(2015) Laura J. Kingsley et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Extracellular histone H3 levels are inversely correlated with antithrombin levels and platelet counts and are associated with mortality in sepsis patients

(2015) Karin C.A.A. Wildhagen et al.   THROMBOSIS RESEARCH

Peptidylarginine deiminase type 4 deficiency reduced arthritis severity in a glucose-6-phosphate isomerase-induced arthritis model

(2015) Yu Seri et al.   Scientific Reports

Neutrophil Extracellular Traps Promote Thrombin Generation Through Platelet-Dependent and Platelet-Independent Mechanisms

(2014) Travis J. Gould et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

YASARA View—molecular graphics for all devices—from smartphones to workstations

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Neutrophils release extracellular DNA traps in response to exercise

(2014) Thomas Beiter et al.   JOURNAL OF APPLIED PHYSIOLOGY

Histone Deimination As a Response to Inflammatory Stimuli in Neutrophils

(2014) I. Neeli et al.   JOURNAL OF IMMUNOLOGY

Dysregulation of PAD4-mediated citrullination of nuclear GSK3  activates TGF-  signaling and induces epithelial-to-mesenchymal transition in breast cancer cells

(2013) S. C. Stadler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice

(2013) K. Martinod et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Erosive Rheumatoid Arthritis Is Associated with Antibodies That Activate PAD4 by Increasing Calcium Sensitivity

(2013) E. Darrah et al.   Science Translational Medicine

NET balancing: a problem in inflammatory lung diseases

(2013) Olivia Z. Cheng et al.   Frontiers in Immunology

Neutrophil Extracellular Traps That Are Not Degraded in Systemic Lupus Erythematosus Activate Complement Exacerbating the Disease

(2012) J. Leffler et al.   JOURNAL OF IMMUNOLOGY

T Lymphocyte Priming by Neutrophil Extracellular Traps Links Innate and Adaptive Immune Responses

(2012) K. Tillack et al.   JOURNAL OF IMMUNOLOGY

Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity

(2012) M. J. Kaplan et al.   JOURNAL OF IMMUNOLOGY

Inhibiting citrullination in rheumatoid arthritis: taking fuel from the fire

(2012) Benjamin AC Fisher et al.   ARTHRITIS RESEARCH & THERAPY

PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures

(2012) Marc Leshner et al.   Frontiers in Immunology

Activation of PAD4 in NET formation

(2012) Amanda S. Rohrbach et al.   Frontiers in Immunology

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics (5th edn)

(2012) E. Connell   ANNALS OF CLINICAL BIOCHEMISTRY

Autodeimination of Protein Arginine Deiminase 4 Alters Protein–Protein Interactions but Not Activity

(2011) Jessica L. Slack et al.   BIOCHEMISTRY

Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4

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Histones induce rapid and profound thrombocytopenia in mice

(2011) T. A. Fuchs et al.   BLOOD

Citrullination of Inhibitor of Growth 4 (ING4) by Peptidylarginine Deminase 4 (PAD4) Disrupts the Interaction between ING4 and p53

(2011) Qin Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of peptidylarginine deiminase-4 substrates by protein array: antagonistic citrullination and methylation of human ribosomal protein S2

(2011) Qin Guo et al.   Molecular BioSystems

Functional Role of Dimerization of Human Peptidylarginine Deiminase 4 (PAD4)

(2011) Yi-Liang Liu et al.   PLoS One

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

(2010) Pingxin Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

(2010) Steffen Massberg et al.   NATURE MEDICINE

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased levels of citrullinated antithrombin in plasma of patients with rheumatoid arthritis and colorectal adenocarcinoma determined by a newly developed ELISA using a specific monoclonal antibody

(2010) Adriana Ordóñez et al.   THROMBOSIS AND HAEMOSTASIS

Effect of citrullination on the function and conformation of antithrombin

(2009) A. Ordóñez et al.   FEBS Journal

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

(2009) Yanming Wang et al.   JOURNAL OF CELL BIOLOGY

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE