Review
Environmental Sciences
Wanitcha Gumtorntip, Nuntana Kasitanon, Worawit Louthrenoo, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: This review summarizes and discusses the association between air pollutants and the development or aggravation of rheumatoid arthritis (RA). The findings suggest that air pollutants can stimulate immunological processes and inflammatory mediators and autoantibodies productions. Furthermore, air pollutants can induce and aggravate RA disease activity. However, discrepancies in the results highlight the need for future studies to elucidate these mechanisms and identify reliable biomarkers for individual susceptibility and disease activity assessment.
ENVIRONMENTAL POLLUTION
(2023)
Article
Dentistry, Oral Surgery & Medicine
Yin Hui Lee, Nor Adinar Baharuddin, Siew Wui Chan, Mohammad Tariqur Rahman, P. Mark Bartold, Sargunan Sockalingam, Rathna Devi Vaithilingam
Summary: The study found that the number of cells containing citrullinated and carbamylated proteins in gingival tissues from patients with periodontitis, with or without rheumatoid arthritis, was significantly higher compared to healthy controls. The local accumulation of these proteins in inflamed gingival tissue may play a role in the pathogenesis of rheumatoid arthritis.
CLINICAL ORAL INVESTIGATIONS
(2021)
Review
Cell Biology
Brianna Hurysz, Nunzio Bottini
Summary: Rheumatoid arthritis (RA) is a common autoimmune disease associated with dysregulation of proteoglycans. Modulating the function and signaling of proteoglycans, as well as targeting citrullinated aggrecan with tolerizing agents, may provide a potential approach to improve current RA therapy.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Gabriel D. Roman-Melendez, Daniel R. Monaco, Janelle M. Montagne, Rachel S. Quizon, Maximilian F. Konig, Mekbib Astatke, Erika Darrah, H. Benjamin Larman
Summary: The study successfully utilized phage display technology to profile antibody reactivities in rheumatoid arthritis patients and quantify differences among patients, identifying specific antibody profiles. This provides a powerful tool for research on autoimmune diseases.
Review
Medicine, General & Internal
Jiaxi Liu, Jinfang Gao, Zewen Wu, Liangyu Mi, Na Li, Yajing Wang, Xinyue Peng, Ke Xu, Fengping Wu, Liyun Zhang
Summary: ACPAs are autoantibodies commonly found in patients with RA, with most of the mechanisms of formation and bone destruction well-understood. Despite advances in clinical applications and targeted therapies related to ACPAs, the presence of different subtypes poses a limitation.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Maria Isabel Trejo-Zambrano, Eduardo Gomez-Banuelos, Felipe Andrade
Summary: Antibodies to posttranslationally modified antigens play a pivotal role in rheumatoid arthritis (RA), especially those related to citrullination. Recent studies have found that ACPAs cross-react with carbamylated and acetylated peptides, challenging our understanding of the implications of such cross-reactivity.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Biochemical Research Methods
Carina Villacres, Victor Spicer, Oleg Krokhin
Summary: The study investigated the chromatographic behavior of peptides with citrulline and homocitrulline residues in LC-MS experiments, with the goal of differentiating between different modifications based on retention data. Various separation modes were tested, with SCX demonstrating the most differentiating power due to its ability to amplify the effect of charge loss upon citrullination. The study aimed to improve the confidence of MS-based identifications by understanding the chromatographic conditions for arginine citrullination and asparagine deamidation.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Immunology
Pureun Won, Youngkyun Kim, Hyerin Jung, Yeri Alice Rim, Dong Hyun Sohn, William H. Robinson, Su-Jin Moon, Ji Hyeon Ju
Summary: The study demonstrated that monoclonal antibody 12G1 can directly detect citrullinated proteins in rheumatoid arthritis (RA) target tissue and sera, indicating its potential in arthritis induction. 12G1 may be useful for diagnosing RA, including seronegative RA, and could help to understand the pathophysiological role of citrullination in RA.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Physiology
Gianluigi Pironti, Stefano Gastaldello, Dilson E. Rassier, Johanna T. Lanner, Mattias Carlstrom, Lars H. Lund, Hakan Westerblad, Takashi Yamada, Daniel C. Andersson
Summary: This study used a mouse model of rheumatoid arthritis (RA) to find evidence of impaired cardiac contractile function associated with reduced Ca2+ sensitivity, increased expression of PAD2, and citrullination of alpha-actin, which was triggered by TNF-alpha. This provides molecular and physiological evidence for acquired cardiomyopathy and a potential mechanism for RA-associated heart failure.
Review
Pharmacology & Pharmacy
Indhumathi Thirugnanasambandham, Arun Radhakrishnan, Gowthamarajan Kuppusamy, Sachin Kumar Singh, Kamal Dua
Summary: PAD4 is a crucial enzyme in the occurrence and development of rheumatoid arthritis, and research on its inhibitors is gaining attention. Targeted drug delivery systems that inhibit PAD4 at the inflamed site can improve therapeutic efficacy and reduce potential toxicity.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Immunology
Qiong Wang, Qinbin Ye, Xiaoyu Xi, Xiaoxue Cao, Xing Wang, Mengxiao Zhang, Yuan Xu, Tingting Deng, Xiaobing Deng, Guoqiang Zhang, Cheng Xiao
Summary: This study explored the association between RIPK1-dependent necroptosis and the pathogenesis of rheumatoid arthritis (RA), and identified a potential new treatment option. The plasma levels of RIPK1 and MLKL were found to be higher in RA patients and positively correlated with disease severity. Treatment with KW2449, a small molecule inhibitor targeting RIPK1, reduced joint inflammation and tissue damage in an animal model of RA. These findings suggest that RIPK1-dependent necroptosis could be a therapeutic target for RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Yu-Meng Zhang, Jian Shen, Jun-Ming Zhao, Jian Guan, Xin-Rui Wei, Dong-Yu Miao, Wei Li, Yi-Cheng Xie, Yu-Qing Zhao
Summary: Cedrol (CE) derived from ginger demonstrates efficacy in ameliorating rheumatoid arthritis through anti-inflammatory and immunological enhancement effects. The mechanism of CE involves inhibition of JAK3 protein phosphorylation, leading to reduced secretion of pro-inflammatory cytokines and inflammation mediators. Pharmacokinetic results show varying absolute bioavailability of CE at different dosages, indicating its potential for further application.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Biochemical Research Methods
Rui Vitorino, Sofia Guedes, Carla Vitorino, Rita Ferreira, Francisco Amado, Jennifer E. Van Eyk
Summary: This review discusses the key mechanisms of disease pathogenesis mediated by protein post-translational modification citrullination, with a focus on complex diseases such as rheumatoid arthritis, cancer, central nervous system disorders, and cardiovascular disease. The paper outlines novel methods for the detection of citrullination sites, which have the potential for greater specificity and sensitivity in diagnosing and treating the post-translational modification sites.
JOURNAL OF PROTEOME RESEARCH
(2021)
Review
Immunology
Anna Krutyholowa, Karolina Strzelec, Agata Dziedzic, Grzegorz P. P. Bereta, Katarzyna Lazarz-Bartyzel, Jan Potempa, Katarzyna Gawron
Summary: The study explores the relationship between periodontitis and rheumatoid arthritis, highlighting the genetic and environmental risk factors underlying the development of both diseases, with a special focus on bacteria implicated in the pathogenicity of periodontitis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Myriam Martin, Sara C. C. Nilsson, David Eikrem, Karin Fromell, Carsten Scavenius, Leonie M. M. Vogt, Ewa Bielecka, Jan Potempa, Jan J. J. Enghild, Bo Nilsson, Kristina N. N. Ekdahl, Meliha C. C. Kapetanovic, Anna M. M. Blom
Summary: This study found that citrullination induced by PAD2 and PAD4 impairs the ability of C1-INH to inhibit complement and contact systems, and increases its immunogenicity, potentially serving as an additional target of the autoantibody response observed in RA patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Rheumatology
Samira T. Miyamoto, Valeria Valim, Benjamin A. Fisher
Summary: HRQoL in SS patients is significantly reduced, similar to other chronic diseases, with no proven therapy to improve it. Although SS generally does not affect life expectancy, the associated costs and work disability are still concerning.
Article
Rheumatology
James Posada, Saba Valadkhan, Daniel Burge, Kristen Davies, Jessica Tarn, John Casement, Kerry Jobling, Peter Gallagher, Douglas Wilson, Francesca Barone, Benjamin A. Fisher, Wan-Fai Ng
Summary: In patients with primary SS, treatment with RSLV-132 led to clinically significant improvements in ESSPRI score, FACIT-F score, ProF score, and DSST, while placebo showed no changes in these measures. These improvements were correlated with increased expression of selected interferon-inducible genes.
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Rheumatology
Elizabeth Price, Alexander Allen, Saaeha Rauz, Anwar Tappuni, Nurhan Sutcliffe, Michele Bombardieri, Sara Carty, Coziana Ciurtin, Bridget Crampton, Lisa Duncalfe, Benjamin Fisher, Peter Glennon, Katie L. Hackett, Genevieve Larkin, Wan-Fai Ng, Athimalaipet Ramanan, Saad Rassam, Stephen B. Walsh, Simon Bowman
Summary: The guideline will be developed following the methods and processes outlined in Creating Clinical Guidelines: Our Protocol, and it has received accreditation from the National Institute for Health and Care Excellence (NICE) for producing guidance, advice, and recommendations for practice.
Letter
Rheumatology
Florian Kollert, Benjamin A. Fisher
Article
Geriatrics & Gerontology
Soledad Retamozo, Chiara Baldini, Hendrika Bootsma, Salvatore De Vita, Thomas Doerner, Benjamin A. Fisher, Jacques-Eric Gottenberg, Gabriela Hernandez-Molina, Agnes Kocher, Belchin Kostov, Aike A. Kruize, Thomas Mandl, Wan-Fai Ng, Raphaele Seror, Yehuda Shoenfeld, Antoni Siso-Almirall, Athanasios G. Tzioufas, Arjan Vissink, Claudio Vitali, Simon J. Bowman, Xavier Mariette, Manuel Ramos-Casals, Pilar Brito-Zeron
Summary: Primary Sjogren's syndrome is a systemic autoimmune disease commonly diagnosed in middle-aged women, with two-thirds of patients diagnosed between 30 and 60 years old. Older patients are more likely to have organ-related comorbidities and require caution when using various medications. A thorough evaluation of medical history is essential for older patients when prescribing drugs included in the EULAR guidelines, with specific attention to factors commonly associated with aging.
Letter
Rheumatology
James Posada, Benjamin A. Fisher, Wan-Fai Ng
ARTHRITIS & RHEUMATOLOGY
(2021)
Meeting Abstract
Rheumatology
T. Dorner, S. J. Bowman, R. Fox, X. Mariette, A. Papas, T. Grader-Beck, B. A. Fisher, F. Barcelos, S. De Vita, H. Schulze-Koops, R. J. Moots, G. Junge, J. Woznicki, M. Sopala, W. L. Luo, W. Hueber
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Critical Care Medicine
Benjamin A. Fisher, Tonny Veenith, Daniel Slade, Charlotte Gaskell, Matthew Rowland, Tony Whitehouse, James Scriven, Dhruv Parekh, Madhu S. Balasubramaniam, Graham Cooke, Nick Morley, Zoe Gabriel, Matthew P. Wise, Joanna Porter, Helen McShane, Ling-Pei Ho, Philip N. Newsome, Anna Rowe, Rowena Sharpe, David R. Thickett, Julian Bion, Simon Gates, Duncan Richards, Pamela Kearns
Summary: This study aimed to evaluate the efficacy of two drugs in hospitalized patients with COVID-19. The results showed that namilumab was able to reduce the inflammatory response, while infliximab did not show significant efficacy compared to usual care. Although there were some differences in adverse events and mortality rates, these differences were not significant.
LANCET RESPIRATORY MEDICINE
(2022)
Letter
Rheumatology
Florian Kollert, Valentina Pucino, Saba Nayar, Jason Turner, Saaeha Rauz, Andrea Richards, Jon Higham, Ana Poveda-Gallego, Rachel M. Brown, Timothy Bates, Simon J. Bowman, Francesca Barone, Benjamin A. Fisher
Article
Rheumatology
Valentina Pucino, Jason D. Turner, Saba Nayar, Florian Kollert, Saaeha Rauz, Andrea Richards, Jon Higham, Ana Poveda-Gallego, Simon J. Bowman, Francesca Barone, Benjamin A. Fisher
Summary: This study aimed to compare clinical and proteomic predictors of primary Sjogren's syndrome (SjS) and non-SjS sicca syndrome (sicca), and identify the key predictors of symptoms. The results showed that obesity-related metabolic factors may regulate symptoms in sicca, while further research is needed to explore the non-inflammatory drivers of high symptom burden in SjS.
Meeting Abstract
Rheumatology
Lisa Christ, Seraphina Kissling, Ruediger B. Mueller, Axel Finckh, Benjamin Fisher, Britta Maurer, Burkhard Moeller, Florian Kollert
ARTHRITIS & RHEUMATOLOGY
(2021)
Meeting Abstract
Rheumatology
Anu Desai, Lakshmi Priya Shadananan, Adam Croft, Lalit Pallan, Neil Steven, Benjamin Fisher
ARTHRITIS & RHEUMATOLOGY
(2021)
Meeting Abstract
Rheumatology
Thomas Doerner, Simon J. Bowman, Robert Fox, Xavier Mariette, Athena Papas, Thomas Grader-Beck, Ben A. Fisher, Filipe Barcelos, Salvatore De Vita, Hendrik Schulze-Koops, Robert Moots, Guido Junge, Janice Woznicki, Monika Sopala, Wen-Lin Luo, Wolfgang Hueber
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Medicine, General & Internal
Tonny Veenith, Benjamin A. Fisher, Daniel Slade, Anna Rowe, Rowena Sharpe, David R. Thickett, Tony Whitehouse, Matthew Rowland, James Scriven, Dhruv Parekh, Sarah J. Bowden, Joshua S. Savage, Duncan Richards, Julian Bion, Pamela Kearns, Simon Gates
Summary: The CATALYST trial aims to identify novel treatments for COVID-19 patients through immunomodulation to improve outcomes. The trial has been approved by the appropriate ethics committee and will disseminate results through national and international presentations and peer-reviewed publications.
Meeting Abstract
Rheumatology
M. H. Al-Mossawi, C. Worth, J. McDonald, P. M. Machado, B. Fisher, A. Chan, K. Gaffney, N. Gullick, J. Packham, R. Sengupta, T. Corn, J. Teh, P. C. Taylor, P. Bowness
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)