Pathogenic IL-23 signaling is required to initiate GM-CSF-driven autoimmune myocarditis in mice

NFATc1 deficiency in T cells protects mice from experimental autoimmune encephalomyelitis

(2015) Sarah Reppert et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Pouring fuel on the fire: Th17 cells, the environment, and autoimmunity

(2015) Patrick R. Burkett et al.   JOURNAL OF CLINICAL INVESTIGATION

Cardiac fibroblasts mediate IL-17A–driven inflammatory dilated cardiomyopathy

(2014) Lei Wu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

GM-CSF but Not IL-17 Is Critical for the Development of Severe Interstitial Lung Disease in SKG Mice

(2014) Aoi Shiomi et al.   JOURNAL OF IMMUNOLOGY

T-bet is essential for Th1-mediated, but not Th17-mediated, CNS autoimmune disease

(2013) Richard A. O'Connor et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Th17 cell development: from the cradle to the grave

(2013) Luis A. Zúñiga et al.   IMMUNOLOGICAL REVIEWS

Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1

(2013) Chuan Wu et al.   NATURE

Diagnosis, Treatment, and Outcome of Giant-Cell Myocarditis in the Era of Combined Immunosuppression

(2012) Riina Kandolin et al.   Circulation-Heart Failure

Update on Myocarditis

(2012) Ingrid Kindermann et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Induction and molecular signature of pathogenic TH17 cells

(2012) Youjin Lee et al.   NATURE IMMUNOLOGY

Ustekinumab Induction and Maintenance Therapy in Refractory Crohn's Disease

(2012) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Myocarditis

(2011) Sandeep Sagar et al.   LANCET

Fate mapping of IL-17-producing T cells in inflammatory responses

(2011) Keiji Hirota et al.   NATURE IMMUNOLOGY

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

(2011) Mohamed El-Behi et al.   NATURE IMMUNOLOGY

Interleukin-17A Is Dispensable for Myocarditis but Essential for the Progression to Dilated Cardiomyopathy

(2010) G. Christian Baldeviano et al.   CIRCULATION RESEARCH

Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells

(2010) Philip P. Ahern et al.   IMMUNITY

Synovial Fibroblasts Promote the Expression and Granule Accumulation of Tryptase via Interleukin-33 and Its Receptor ST-2 (IL1RL1)

(2010) Shinjiro Kaieda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Stressing the giant: A new approach to understanding dilated cardiomyopathy

(2009) Marion Lewis Greaser   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Myocarditis

(2009) Leslie T. Cooper   NEW ENGLAND JOURNAL OF MEDICINE

Usefulness of Immunosuppression for Giant Cell Myocarditis

(2008) Leslie T. Cooper et al.   AMERICAN JOURNAL OF CARDIOLOGY

Interleukin-13 Protects Against Experimental Autoimmune Myocarditis by Regulating Macrophage Differentiation

(2008) Daniela Cihakova et al.   AMERICAN JOURNAL OF PATHOLOGY

IL-23 and Autoimmunity: New Insights into the Pathogenesis of Inflammatory Bowel Disease

(2008) Clara Abraham et al.   Annual Review of Medicine

Interleukin-17 Promotes Autoimmunity by Triggering a Positive-Feedback Loop via Interleukin-6 Induction

(2008) Hideki Ogura et al.   IMMUNITY

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

(2008) Xuexian O. Yang et al.   IMMUNITY

Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)

(2008) Craig L Leonardi et al.   LANCET

Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study

(2008) Benjamin M Segal et al.   LANCET NEUROLOGY