Preliminary evidence for the phosphodiesterase type-4 inhibitor, roflumilast, in ameliorating cognitive flexibility deficits in patients with schizophrenia

The effects of roflumilast, a phosphodiesterase type-4 inhibitor, on EEG biomarkers in schizophrenia: A randomised controlled trial

(2020) James Gilleen et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Acute treatment with the PDE4 inhibitor roflumilast improves verbal word memory in healthy old individuals: a double-blind placebo-controlled study

(2019) Arjan Blokland et al.   NEUROBIOLOGY OF AGING

The Hyperfocusing Hypothesis: A New Account of Cognitive Dysfunction in Schizophrenia

(2019) Steven J Luck et al.   SCHIZOPHRENIA BULLETIN

Acute administration of roflumilast enhances immediate recall of verbal word memory in healthy young adults

(2018) M.A. Van Duinen et al.   NEUROPHARMACOLOGY

An experimental medicine study of the phosphodiesterase-4 inhibitor, roflumilast, on working memory-related brain activity and episodic memory in schizophrenia patients

(2018) James Gilleen et al.   PSYCHOPHARMACOLOGY

The neural underpinnings of cognitive flexibility and their disruption in psychotic illness

(2017) James A. Waltz   NEUROSCIENCE

Neurocognitive impairment in deficit and non-deficit schizophrenia: a meta-analysis

(2017) E. Bora et al.   PSYCHOLOGICAL MEDICINE

Acute administration of roflumilast enhances sensory gating in healthy young humans in a randomized trial

(2017) Pim R. A. Heckman et al.   PSYCHOPHARMACOLOGY

Psychometric characteristics of the MATRICS Consensus Cognitive Battery in a large pooled cohort of stable schizophrenia patients

(2017) Anastasia Georgiades et al.   SCHIZOPHRENIA RESEARCH

The PDE4 inhibitor roflumilast improves memory in rodents at non-emetic doses

(2016) Tim Vanmierlo et al.   BEHAVIOURAL BRAIN RESEARCH

Probabilistic Reversal Learning in Schizophrenia: Stability of Deficits and Potential Causal Mechanisms

(2016) Lena Felice Reddy et al.   SCHIZOPHRENIA BULLETIN

Impact of avolition and cognitive impairment on functional outcome in first-episode schizophrenia-spectrum disorder: a prospective one-year follow-up study

(2016) Wing Chung Chang et al.   SCHIZOPHRENIA RESEARCH

Treatment of Cognitive Impairment in Schizophrenia: Potential Value of Phosphodiesterase Inhibitors in Prefrontal Dysfunction

(2015) Marlies Duinen et al.   CURRENT PHARMACEUTICAL DESIGN

Effects of rolipram and roflumilast, phosphodiesterase-4 inhibitors, on hypertension-induced defects in memory function in rats

(2015) Sobhana George Sugin Lal Jabaris et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Impaired Activation in Cognitive Control Regions Predicts Reversal Learning in Schizophrenia

(2015) Adam J. Culbreth et al.   SCHIZOPHRENIA BULLETIN

Adjunctive sarcosine plus benzoate improved cognitive function in chronic schizophrenia patients with constant clinical symptoms: A randomised, double-blind, placebo-controlled trial

(2015) Chun-Yuan Lin et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Attentional Set-Shifting in Rodents: A Review of Behavioural Methods and Pharmacological Results

(2014) David Tait et al.   CURRENT PHARMACEUTICAL DESIGN

The Attentional Set-Shifting Test Paradigm in Rats for the Screening of Novel Pro-Cognitive Compounds with Relevance for Cognitive Deficits in Schizophrenia

(2014) Pascal Goetghebeur et al.   CURRENT PHARMACEUTICAL DESIGN

Meta-analysis of cognitive performance in drug-naïve patients with schizophrenia

(2014) Helena Fatouros-Bergman et al.   SCHIZOPHRENIA RESEARCH

ERK regulation of phosphodiesterase 4 enhances dopamine-stimulated AMPA receptor membrane insertion

(2013) R. S. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Add-on Treatment of Benzoate for Schizophrenia

(2013) Hsien-Yuan Lane et al.   JAMA Psychiatry

A role for synaptic plasticity in the adolescent development of executive function

(2013) L D Selemon   Translational Psychiatry

Dorsolateral prefrontal contributions to human working memory

(2012) Aron K. Barbey et al.   CORTEX

Inverted-U–Shaped Dopamine Actions on Human Working Memory and Cognitive Control

(2011) Roshan Cools et al.   BIOLOGICAL PSYCHIATRY

Selective phosphodiesterase inhibitors improve performance on the ED/ID cognitive task in rats

(2011) Joshua S. Rodefer et al.   NEUROPHARMACOLOGY

Putative cognitive enhancers in preclinical models related to schizophrenia: The search for an elusive target

(2011) Segev Barak et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Phosphodiesterase 4 inhibition enhances the dopamine D1 receptor/PKA/DARPP-32 signaling cascade in frontal cortex

(2011) Mahomi Kuroiwa et al.   PSYCHOPHARMACOLOGY

Sustained Attention and Planning Deficits but Intact Attentional Set-Shifting in Neuroleptic-Naïve First-Episode Schizophrenia Patients

(2009) Caroline C. Hilti et al.   NEUROPSYCHOBIOLOGY

Neurocognition in first-episode schizophrenia: A meta-analytic review.

(2009) Raquelle I. Mesholam-Gately et al.   NEUROPSYCHOLOGY

Attentional set-shifting ability in first-episode and established schizophrenia: Relationship to working memory

(2009) Christos Pantelis et al.   SCHIZOPHRENIA RESEARCH

Set-Shifting Ability and Schizophrenia: A Marker of Clinical Illness or an Intermediate Phenotype?

(2008) Alan E. Ceaser et al.   BIOLOGICAL PSYCHIATRY

Attentional control in Parkinson's disease is dependent on COMT val158met genotype

(2008) C. H. Williams-Gray et al.   BRAIN

Cell type–specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs

(2008) Helen S Bateup et al.   NATURE NEUROSCIENCE

Comparison of haloperidol, risperidone, sertindole, and modafinil to reverse an attentional set-shifting impairment following subchronic PCP administration in the rat—a back translational study

(2008) Pascal Goetghebeur et al.   PSYCHOPHARMACOLOGY

Reinforcement and Reversal Learning in First-Episode Psychosis

(2008) G. K. Murray et al.   SCHIZOPHRENIA BULLETIN

Orbitofrontal Dysfunction in Patients with Obsessive-Compulsive Disorder and Their Unaffected Relatives

(2008) S. R. Chamberlain et al.   SCIENCE