Tyrosine kinase 2 is not limiting human antiviral type III interferon responses

Immunofluorescence Analysis and Diagnosis of Primary Ciliary Dyskinesia with Radial Spoke Defects

(2015) Adrien Frommer et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

NK cells and interferons

(2015) Rossella Paolini et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Interferon-λ: Immune Functions at Barrier Surfaces and Beyond

(2015) Helen M. Lazear et al.   IMMUNITY

Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome

(2015) Alexandra Y. Kreins et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NK cells require IL-28R for optimal in vivo activity

(2015) Fernando Souza-Fonseca-Guimaraes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human IFNAR2 deficiency: Lessons for antiviral immunity

(2015) Christopher J. A. Duncan et al.   Science Translational Medicine

Leukocyte-Derived IFN-α/β and Epithelial IFN-λ Constitute a Compartmentalized Mucosal Defense System that Restricts Enteric Virus Infections

(2015) Tanel Mahlakõiv et al.   PLoS Pathogens

In vivotumor surveillance by NK cells requires TYK2 but not TYK2 kinase activity

(2015) Michaela Prchal-Murphy et al.   OncoImmunology

Eight-color immunophenotyping of T-, B-, and NK-cell subpopulations for characterization of chronic immunodeficiencies

(2014) Andreas Boldt et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line

(2014) Patrick Essletzbichler et al.   GENOME RESEARCH

Immunomodulatory Function of Interleukin 28B During Primary Infection With Cytomegalovirus

(2014) Adrian Egli et al.   JOURNAL OF INFECTIOUS DISEASES

A Restricted Role for TYK2 Catalytic Activity in Human Cytokine Responses Revealed by Novel TYK2-Selective Inhibitors

(2013) S. J. Sohn et al.   JOURNAL OF IMMUNOLOGY

DYX1C1 is required for axonemal dynein assembly and ciliary motility

(2013) Aarti Tarkar et al.   NATURE GENETICS

STAT2 deficiency and susceptibility to viral illness in humans

(2013) S. Hambleton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Systematic Analysis of Host Factors Reveals a Med23-Interferon-λ Regulatory Axis against Herpes Simplex Virus Type 1 Replication

(2013) Samantha J. Griffiths et al.   PLoS Pathogens

Inborn errors of human STAT1: allelic heterogeneity governs the diversity of immunological and infectious phenotypes

(2012) Stephanie Boisson-Dupuis et al.   CURRENT OPINION IN IMMUNOLOGY

IL28B polymorphisms predict interferon-related hepatitis B surface antigen seroclearance in genotype D hepatitis B e antigen-negative patients with chronic hepatitis B

(2012) Pietro Lampertico et al.   HEPATOLOGY

A Patient with Tyrosine Kinase 2 Deficiency without Hyper-IgE Syndrome

(2012) Sara S. Kilic et al.   JOURNAL OF PEDIATRICS

TYK2 Kinase Activity Is Required for Functional Type I Interferon Responses In Vivo

(2012) Michaela Prchal-Murphy et al.   PLoS One

Severe impairment of IFN-  and IFN-  responses in cells of a patient with a novel STAT1 splicing mutation

(2011) D. Vairo et al.   BLOOD

Tyrosine kinase 2 (TYK2) in cytokine signalling and host immunity

(2011) Birgit Strobl   Frontiers in Bioscience-Landmark

CD56brightCD16+ NK Cells: A Functional Intermediate Stage of NK Cell Differentiation

(2011) V. Beziat et al.   JOURNAL OF IMMUNOLOGY

Ebola virus entry requires the cholesterol transporter Niemann–Pick C1

(2011) Jan E. Carette et al.   NATURE

ORAI1-mediated calcium influx is required for human cytotoxic lymphocyte degranulation and target cell lysis

(2011) A. Maul-Pavicic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD62L expression identifies a unique subset of polyfunctional CD56dim NK cells

(2010) K. Juelke et al.   BLOOD

CD57 defines a functionally distinct population of mature NK cells in the human CD56dimCD16+ NK-cell subset

(2010) S. Lopez-Verges et al.   BLOOD

Despite IFN-λ receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines

(2009) K Witte et al.   GENES AND IMMUNITY

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

(2009) Dongliang Ge et al.   NATURE

Identification of an Indispensable Role for Tyrosine Kinase 2 in CTL-Mediated Tumor Surveillance

(2008) O. Simma et al.   CANCER RESEARCH