Unravelling the Structural Organization of Individual α-Synuclein Oligomers Grown in the Presence of Phospholipids

The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration

(2020) Anne-Laure Mahul-Mellier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Influence of Pathogenic Mutations in α-Synuclein on Biophysical and Structural Characteristics of Amyloid Fibrils

(2020) Francesco Simone Ruggeri et al.   ACS Nano

Structural Characterization of Individual α-Synuclein Oligomers Formed at Different Stages of Protein Aggregation by Atomic Force Microscopy-Infrared Spectroscopy

(2020) Lei Zhou et al.   ANALYTICAL CHEMISTRY

Structures of α-synuclein filaments from multiple system atrophy

(2020) Manuel Schweighauser et al.   NATURE

Single molecule secondary structure determination of proteins through infrared absorption nanospectroscopy

(2020) Francesco Simone Ruggeri et al.   Nature Communications

Cell-Type- and Brain-Region-Resolved Mouse Brain Lipidome

(2020) Dirk Fitzner et al.   Cell Reports

Nanoscale Structural Organization of Plant Epicuticular Wax Probed by Atomic Force Microscope Infrared Spectroscopy

(2019) Charles Farber et al.   ANALYTICAL CHEMISTRY

Nanometer scale infrared chemical imaging of organic matter in Ultracarbonaceous Antarctic micrometeorites (UCAMM)

(2019) J. Mathurin et al.   ASTRONOMY & ASTROPHYSICS

Extracellular aggregated alpha synuclein primarily triggers lysosomal dysfunction in neural cells prevented by trehalose

(2019) Anna-Carin Hoffmann et al.   Scientific Reports

Lipids at the Crossroad of α-Synuclein Function and Dysfunction: Biological and Pathological Implications

(2019) Natalia P. Alza et al.   Frontiers in Cellular Neuroscience

Nanoscale Structural Organization of Insulin Fibril Polymorphs Revealed By Atomic Force Microscope Infrared Spectroscopy (AFM‐IR)

(2019) Stanislav Rizevsky et al.   CHEMBIOCHEM

Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes

(2019) Sarah H. Shahmoradian et al.   NATURE NEUROSCIENCE

Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts

(2019) Timo Strohäker et al.   Nature Communications

Determination of Polypeptide Conformation with Nanoscale Resolution in Water

(2018) Georg Ramer et al.   ACS Nano

Multispectral Atomic Force Microscopy-Infrared Nano-Imaging of Malaria Infected Red Blood Cells

(2018) David Perez-Guaita et al.   ANALYTICAL CHEMISTRY

In vivo atomic force microscopy–infrared spectroscopy of bacteria

(2018) Kamila Kochan et al.   Journal of the Royal Society Interface

Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils

(2018) Francesco Simone Ruggeri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanoscale chemical imaging of individual chemotherapeutic cytarabine-loaded liposomal nanocarriers

(2018) Karin Wieland et al.   Nano Research

Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel

(2018) Binsen Li et al.   Nature Communications

The Cellular Environment Affects Monomeric α-Synuclein Structure

(2018) Amberley D. Stephens et al.   TRENDS IN BIOCHEMICAL SCIENCES

Selective neuronal vulnerability in Parkinson disease

(2017) D. James Surmeier et al.   NATURE REVIEWS NEUROSCIENCE

The Role of Lipids Interacting with α-Synuclein in the Pathogenesis of Parkinson’s Disease

(2017) Céline Galvagnion   Journal of Parkinsons Disease

CH 3 NH 3 PbI 3 perovskites: Ferroelasticity revealed

(2017) Evgheni Strelcov et al.   Science Advances

AFM-IR: Technology and Applications in Nanoscale Infrared Spectroscopy and Chemical Imaging

(2016) Alexandre Dazzi et al.   CHEMICAL REVIEWS

Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson’s disease

(2016) Mohamed-Bilal Fares et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein

(2016) Céline Galvagnion et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanoscale studies link amyloid maturity with polyglutamine diseases onset

(2016) F. S. Ruggeri et al.   Scientific Reports

Infrared Imaging and Spectroscopy Beyond the Diffraction Limit

(2015) Andrea Centrone   Annual Review of Analytical Chemistry

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation

(2015) Serene W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Infrared nanospectroscopy characterization of oligomeric and fibrillar aggregates during amyloid formation

(2015) F. S. Ruggeri et al.   Nature Communications

Tip-enhanced infrared nanospectroscopy via molecular expansion force detection

(2014) Feng Lu et al.   Nature Photonics

Analysis of bacterial polyhydroxybutyrate production by multimodal nanoimaging

(2012) Céline Mayet et al.   BIOTECHNOLOGY ADVANCES

Pathogenic Serum Amyloid A 1.1 Shows a Long Oligomer-rich Fibrillation Lag Phase Contrary to the Highly Amyloidogenic Non-pathogenic SAA2.2

(2012) Saipraveen Srinivasan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

100 years of Lewy pathology

(2012) Michel Goedert et al.   Nature Reviews Neurology

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of α-synuclein oligomers with distinct biochemical, morphological, and functional properties

(2010) Thomas Näsström et al.   FREE RADICAL BIOLOGY AND MEDICINE

ATR-FTIR studies of phospholipid vesicle interactions with α-FeOOH and α-Fe2O3 surfaces

(2009) Matteo Cagnasso et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Seeded growth of  -amyloid fibrils from Alzheimer's brain-derived fibrils produces a distinct fibril structure

(2009) A. K. Paravastu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fourier Transform Infrared (FTIR) Spectroscopy of Biological Tissues

(2008) Zanyar Movasaghi et al.   APPLIED SPECTROSCOPY REVIEWS

Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells

(2008) Tereza Vogiatzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The fold of  -synuclein fibrils

(2008) M. Vilar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical mapping of the distribution of viruses into infected bacteria with a photothermal method

(2007) A. Dazzi et al.   ULTRAMICROSCOPY