Diverse Native Ensembles Dictate the Differential Functional Responses of Nuclear Receptor Ligand-Binding Domains

Electrostatic Frustration Shapes Folding Mechanistic Differences in Paralogous Bacterial Stress Response Proteins

(2020) Abhishek Narayan et al.   JOURNAL OF MOLECULAR BIOLOGY

Dynamic allosteric communication pathway directing differential activation of the glucocorticoid receptor

(2020) C. Köhler et al.   Science Advances

Protein folding stability and binding interactions through the lens of evolution: a dynamical perspective

(2020) Tushar Modi et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Quantitative structural assessment of graded receptor agonism

(2019) Jinsai Shang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ

(2019) Zahra Heidari et al.   Nature Communications

Hydrogen-deuterium exchange mass spectrometry reveals folding and allostery in protein-protein interactions

(2018) Cesar A. Ramirez-Sarmiento et al.   METHODS

Ancient thioredoxins evolved to modern-day stability–function requirement by altering native state ensemble

(2018) Tushar Modi et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Defining a conformational ensemble that directs activation of PPARγ

(2018) Ian M. Chrisman et al.   Nature Communications

Quantifying the Intrinsic Conformation Energy Landscape Topography of Proteins with Large-Scale Open–Closed Transition

(2018) Wen-Ting Chu et al.   ACS Central Science

Single-molecule force spectroscopy reveals folding steps associated with hormone binding and activation of the glucocorticoid receptor

(2018) Thomas Suren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A structural mechanism for directing corepressor-selective inverse agonism of PPARγ

(2018) Richard Brust et al.   Nature Communications

A Universal Pattern in the Percolation and Dissipation of Protein Structural Perturbations

(2017) Nandakumar Rajasekaran et al.   Journal of Physical Chemistry Letters

Graded Structural Polymorphism in a Bacterial Thermosensor Protein

(2017) Abhishek Narayan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genetically tunable frustration controls allostery in an intrinsically disordered transcription factor

(2017) Jing Li et al.   eLife

On the link between conformational changes, ligand binding and heat capacity

(2016) S. Vega et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Limited cooperativity in protein folding

(2016) Victor Muñoz et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Quantifying Protein Disorder through Measures of Excess Conformational Entropy

(2016) Nandakumar Rajasekaran et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Historical overview of nuclear receptors

(2016) Jan-Ake Gustafsson   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Probing allosteric mechanisms using native mass spectrometry

(2015) Michal Sharon et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Glucocorticoid Receptor Function Regulated by Coordinated Action of the Hsp90 and Hsp70 Chaperone Cycles

(2014) Elaine Kirschke et al.   CELL

Evolution of Conformational Dynamics Determines the Conversion of a Promiscuous Generalist into a Specialist Enzyme

(2014) T. Zou et al.   MOLECULAR BIOLOGY AND EVOLUTION

Modulation of the Hsp90 Chaperone Cycle by a Stringent Client Protein

(2014) Oliver Robin Lorenz et al.   MOLECULAR CELL

Structural basis of the transactivation deficiency of the human PPARγ F360L mutant associated with familial partial lipodystrophy

(2014) Clorinda Lori et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Protein Conformational Populations and Functionally Relevant Substates

(2013) Arvind Ramanathan et al.   ACCOUNTS OF CHEMICAL RESEARCH

Understanding nuclear receptor form and function using structural biology

(2013) Fraydoon Rastinejad et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

A Rapid, Ensemble and Free Energy Based Method for Engineering Protein Stabilities

(2013) Athi N. Naganathan   JOURNAL OF PHYSICAL CHEMISTRY B

Native contacts determine protein folding mechanisms in atomistic simulations

(2013) R. B. Best et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural, energetic, and dynamic responses of the native state ensemble of staphylococcal nuclease to cavity-creating mutations

(2013) Julien Roche et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Interplay between allostery and intrinsic disorder in an ensemble

(2012) Hesam N. Motlagh et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Probing the diverse landscape of protein flexibility and binding

(2012) Joseph A Marsh et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Predictions from an Ising-like Statistical Mechanical Model on the Dynamic and Thermodynamic Effects of Protein Surface Electrostatics

(2012) Athi N. Naganathan   Journal of Chemical Theory and Computation

Exploration of Multi-State Conformational Dynamics and Underlying Global Functional Landscape of Maltose Binding Protein

(2012) Yong Wang et al.   PLoS Computational Biology

Statistical mechanics of protein allostery: Roles of backbone and side-chain structural fluctuations

(2011) Kazuhito Itoh et al.   JOURNAL OF CHEMICAL PHYSICS

Pre-existing soft modes of motion uniquely defined by native contact topology facilitate ligand binding to proteins

(2011) Lidio Meireles et al.   PROTEIN SCIENCE

Global Dynamics of Proteins: Bridging Between Structure and Function

(2010) Ivet Bahar et al.   Annual Review of Biophysics

Structural Overview of the Nuclear Receptor Superfamily: Insights into Physiology and Therapeutics

(2010) Pengxiang Huang et al.   Annual Review of Physiology

On the Denaturation Mechanisms of the Ligand Binding Domain of Thyroid Hormone Receptors

(2010) Leandro Martínez et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Folding and binding cascades: Dynamic landscapes and population shifts

(2010) Sandeep Kumar et al.   PROTEIN SCIENCE