CD33M inhibits microglial phagocytosis, migration and proliferation, but the Alzheimer’s disease‐protective variant CD33m stimulates phagocytosis and proliferation, and inhibits adhesion

Microglial Corpse Clearance: Lessons From Macrophages

(2020) Mar Márquez-Ropero et al.   Frontiers in Immunology

CCGG deletion (rs201074739) in CD33 results in premature termination codon and complete loss of CD33 expression: another key variant with potential impact on response to CD33-directed agents

(2019) Ioannis Papageorgiou et al.   LEUKEMIA & LYMPHOMA

Evaluation of CD33 as a genetic risk factor for Alzheimer’s disease

(2019) Steven Estus et al.   ACTA NEUROPATHOLOGICA

CD22 blockade restores homeostatic microglial phagocytosis in ageing brains

(2019) John V. Pluvinage et al.   NATURE

TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer’s Disease

(2019) Ana Griciuc et al.   NEURON

Activated microglia desialylate their surface, stimulating complement receptor 3‐mediated phagocytosis of neurons

(2019) David H. Allendorf et al.   GLIA

The human microglial HMC3 cell line: where do we stand? A systematic literature review

(2018) Cinzia Dello Russo et al.   Journal of Neuroinflammation

Neurophagy, the phagocytosis of live neurons and synapses by glia, contributes to brain development and disease

(2017) Anna Vilalta et al.   FEBS Journal

Activated Microglia Desialylate and Phagocytose Cells via Neuraminidase, Galectin-3, and Mer Tyrosine Kinase

(2017) Koji Nomura et al.   JOURNAL OF IMMUNOLOGY

Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology

(2016) Elizabeth E. Spangenberg et al.   BRAIN

Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

(2015) Nicole Maphis et al.   BRAIN

Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b  2-integrin-dependent signaling

(2013) S. J. McMillan et al.   BLOOD

CD33 Alzheimer's Risk-Altering Polymorphism, CD33 Expression, and Exon 2 Splicing

(2013) M. Malik et al.   JOURNAL OF NEUROSCIENCE

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology

(2013) Elizabeth M Bradshaw et al.   NATURE NEUROSCIENCE

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

(2013) Ana Griciuc et al.   NEURON

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Interstitial cell migration: integrin-dependent and alternative adhesion mechanisms

(2009) Samuel Schmidt et al.   CELL AND TISSUE RESEARCH

Debris clearance by microglia: an essential link between degeneration and regeneration

(2008) H. Neumann et al.   BRAIN