Molecular Mechanisms for Bacterial Potassium Homeostasis

The Microbiologist’s Guide to Membrane Potential Dynamics

(2020) Jonatan M. Benarroch et al.   TRENDS IN MICROBIOLOGY

TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential

(2020) Hanzhi Zhang et al.   Nature Communications

Structural basis of proton-coupled potassium transport in the KUP family

(2020) Igor Tascón et al.   Nature Communications

Two Ways To Convert a Low-Affinity Potassium Channel to High Affinity: Control of Bacillus subtilis KtrCD by Glutamate

(2020) Larissa Krüger et al.   JOURNAL OF BACTERIOLOGY

Ball-and-chain inactivation in a calcium-gated potassium channel

(2020) Chen Fan et al.   NATURE

Cyclic di-AMP Signaling in Bacteria

(2020) Jörg Stülke et al.   Annual Review of Microbiology

Membrane voltage dysregulation driven by metabolic dysfunction underlies bactericidal activity of aminoglycosides

(2020) Giancarlo Noe Bruni et al.   eLife

Serine phosphorylation regulates the P-type potassium pump KdpFABC

(2020) Marie E Sweet et al.   eLife

Unappreciated Roles for K+ Channels in Bacterial Physiology

(2020) Sarah D. Beagle et al.   TRENDS IN MICROBIOLOGY

Potassium response and homeostasis in Mycobacterium tuberculosis modulates environmental adaptation and is important for host colonization

(2019) Nathan J. MacGilvary et al.   PLoS Pathogens

Characterization of the molecular properties of KtrC, a second RCK domain that regulates a Ktr channel in Bacillus subtilis

(2019) Rita Rocha et al.   JOURNAL OF STRUCTURAL BIOLOGY

Onwards and [K+]upwards: a new potassium importer under the spell of cyclic-di-AMP

(2019) Huong Thi Pham et al.   JOURNAL OF BACTERIOLOGY

The KupA and KupB proteins of Lactococcus lactis IL1403 are novel c-di-AMP receptor proteins responsible for potassium uptake

(2019) Ingrid M. Quintana et al.   JOURNAL OF BACTERIOLOGY

Magnesium Flux Modulates Ribosomes to Increase Bacterial Survival

(2019) Dong-yeon D. Lee et al.   CELL

Sustained sensing in potassium homeostasis: Cyclic di-AMP controls potassium uptake by KimA at the levels of expression and activity

(2019) Jan Gundlach et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Electrically induced bacterial membrane-potential dynamics correspond to cellular proliferation capacity

(2019) James P. Stratford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How RCK domains regulate gating of K+ channels

(2019) Marina Schrecker et al.   BIOLOGICAL CHEMISTRY

The KdpFABC complex – K+ transport against all odds

(2019) Bjørn P. Pedersen et al.   MOLECULAR MEMBRANE BIOLOGY

Metabolic basis of brain-like electrical signalling in bacterial communities

(2019) Rosa Martinez-Corral et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The conduction pathway of potassium channels is water free under physiological conditions

(2019) Carl Öster et al.   Science Advances

c-di-AMP assists osmoadaptation by regulating the Listeria monocytogenes potassium transporters KimA and KtrCD

(2019) Johannes Gibhardt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A channel profile report of the unusual K+ channel KtrB

(2019) Vedrana Mikušević et al.   JOURNAL OF GENERAL PHYSIOLOGY

Activation of a nucleotide-dependent RCK domain requires binding of a cation cofactor to a conserved site

(2019) Celso M Teixeira-Duarte et al.   eLife

Direct knock-on of desolvated ions governs strict ion selectivity in K+ channels

(2018) Wojciech Kopec et al.   Nature Chemistry

Cryo-EM structures of KdpFABC suggest a K+ transport mechanism via two inter-subunit half-channels

(2018) C. Stock et al.   Nature Communications

Crystal structure of the potassium-importing KdpFABC membrane complex

(2017) Ching-Shin Huang et al.   NATURE

Voltage-gated calcium flux mediatesEscherichia colimechanosensation

(2017) Giancarlo N. Bruni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coupling between distant biofilms and emergence of nutrient time-sharing

(2017) Jintao Liu et al.   SCIENCE

Control of potassium homeostasis is an essential function of the second messenger cyclic di-AMP inBacillus subtilis

(2017) Jan Gundlach et al.   Science Signaling

Adaptation of Bacillus subtilis to Life at Extreme Potassium Limitation

(2017) Jan Gundlach et al.   mBio

Potassium is a key signal in host-microbiome dysbiosis in periodontitis

(2017) Susan Yost et al.   PLoS Pathogens

The gating cycle of a K+ channel at atomic resolution

(2017) Luis G Cuello et al.   eLife

Helical jackknives control the gates of the double-pore K+ uptake system KtrAB

(2017) Marina Diskowski et al.   eLife

Control of potassium homeostasis is an essential function of the second messenger cyclic di-AMP inBacillus subtilis

(2017) Jan Gundlach et al.   Science Signaling

Why Do Fast-Growing Bacteria Enter Overflow Metabolism? Testing the Membrane Real Estate Hypothesis

(2017) Mariola Szenk et al.   Cell Systems

Adaptation to Potassium-Limitation Is Essential forAcinetobacter baumanniiPneumonia Pathogenesis

(2016) Reham Samir et al.   JOURNAL OF INFECTIOUS DISEASES

A Dual-Sensing Receptor Confers Robust Cellular Homeostasis

(2016) Hannah Schramke et al.   Cell Reports

Dissecting the Molecular Mechanism of Nucleotide-Dependent Activation of the KtrAB K+ Transporter

(2016) Andras Szollosi et al.   PLOS BIOLOGY

Structural Insights into the Distinct Binding Mode of Cyclic Di-AMP with SaCpaA_RCK

(2015) Ko-Hsin Chin et al.   BIOCHEMISTRY

Structural Studies of Potassium Transport Protein KtrA Regulator of Conductance of K+(RCK) C Domain in Complex with Cyclic Diadenosine Monophosphate (c-di-AMP)

(2015) Henna Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cryo-electron microscopy structure of the Slo2.2 Na+-activated K+ channel

(2015) Richard K. Hite et al.   NATURE

Metabolic co-dependence gives rise to collective oscillations within biofilms

(2015) Jintao Liu et al.   NATURE

Ion channels enable electrical communication in bacterial communities

(2015) Arthur Prindle et al.   NATURE

Rapid label-free quantitative analysis of theE. coliBL21(DE3) inner membrane proteome

(2015) Malvina Papanastasiou et al.   PROTEOMICS

Recent progress on the structure and function of the TrkH/KtrB ion channel

(2014) Elena J Levin et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Defining membrane spanning domains and crucial membrane-localized acidic amino acid residues for K+ transport of a Kup/HAK/KT-type Escherichia coli potassium transporter

(2014) Yoko Sato et al.   JOURNAL OF BIOCHEMISTRY

Bacterial fluoride resistance, Fluc channels, and the weak acid accumulation effect

(2014) Chunhui Ji et al.   JOURNAL OF GENERAL PHYSIOLOGY

Multi-enzyme digestion FASP and the ‘Total Protein Approach’-based absolute quantification of the Escherichia coli proteome

(2014) Jacek R. Wiśniewski et al.   Journal of Proteomics

Expansion of the APC superfamily of secondary carriers

(2014) Ake Vastermark et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Ion permeation in K+ channels occurs by direct Coulomb knock-on

(2014) D. A. Kopfer et al.   SCIENCE

Mechanistic Analysis of the Pump Cycle of the KdpFABC P-Type ATPase

(2013) Bojana Damnjanovic et al.   BIOCHEMISTRY

Potassium transport of Salmonella is important for type III secretion and pathogenesis

(2013) Y. Liu et al.   MICROBIOLOGY-SGM

The sensor kinase KdpD ofEscherichia colisenses external K+

(2013) Vera Laermann et al.   MOLECULAR MICROBIOLOGY

The Ktr potassium transport system inStaphylococcus aureusand its role in cell physiology, antimicrobial resistance and pathogenesis

(2013) Casey M. Gries et al.   MOLECULAR MICROBIOLOGY

Methylglyoxal resistance inBacillus subtilis: contributions of bacillithiol-dependent and independent pathways

(2013) Pete Chandrangsu et al.   MOLECULAR MICROBIOLOGY

The structure of the KtrAB potassium transporter

(2013) Ricardo S. Vieira-Pires et al.   NATURE

Gating of the TrkH ion channel by its associated RCK protein TrkA

(2013) Yu Cao et al.   NATURE

Systematic identification of conserved bacterial c-di-AMP receptor proteins

(2013) R. M. Corrigan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional Profiling of Staphylococcus aureus During Growth in 2 M NaCl Leads to Clarification of Physiological Roles for Kdp and Ktr K+ Uptake Systems

(2013) A. Price-Whelan et al.   mBio

The KdpD/KdpE Two-Component System: Integrating K+ Homeostasis and Virulence

(2013) Zoë N. Freeman et al.   PLoS Pathogens

A family of fluoride-specific ion channels with dual-topology architecture

(2013) Randy B Stockbridge et al.   eLife

The ydaO motif is an ATP-sensing riboswitch in Bacillus subtilis

(2012) Peter Y Watson et al.   Nature Chemical Biology

Distinct gating mechanisms revealed by the structures of a multi-ligand gated K+ channel

(2012) Chunguang Kong et al.   eLife

Role of the KcsA Channel Cytoplasmic Domain in pH-Dependent Gating

(2011) Minako Hirano et al.   BIOPHYSICAL JOURNAL

KtrB, a member of the superfamily of K+ transporters

(2011) Inga Hänelt et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

The Staphylococcus aureus KdpDE Two-Component System Couples Extracellular K+Sensing and Agr Signaling to Infection Programming

(2011) Ting Xue et al.   INFECTION AND IMMUNITY

Crystal structure of a potassium ion transporter, TrkH

(2011) Yu Cao et al.   NATURE

Aerobic respiratory chain of Escherichia coli is not allowed to work in fully uncoupled mode

(2011) V. B. Borisov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Electrical Spiking in Escherichia coli Probed with a Fluorescent Voltage-Indicating Protein

(2011) Joel M. Kralj et al.   SCIENCE

Potassium and sodium transport in non-animal cells: the Trk/Ktr/HKT transporter family

(2010) C. Corratgé-Faillie et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Gain of Function Mutations in Membrane Region M2C2of KtrB Open a Gate Controlling K+Transport by the KtrAB System fromVibrio alginolyticus

(2010) Inga Hänelt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Region M2C2in Subunit KtrB of the K+Uptake System KtrAB fromVibrio alginolyticusForms a Flexible Gate Controlling K+Flux

(2010) Inga Hänelt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allosteric mechanism of Ca2+activation and H+-inhibited gating of the MthK K+channel

(2010) Victor P.T. Pau et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structural mechanism of C-type inactivation in K+ channels

(2010) Luis G. Cuello et al.   NATURE

Tuning the ion selectivity of tetrameric cation channels by changing the number of ion binding sites

(2010) M. G. Derebe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of ligand-gated potassium efflux in bacterial pathogens

(2010) T. P. Roosild et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potassium Transport in Corynebacterium glutamicum Is Facilitated by the Putative Channel Protein CglK, Which Is Essential for pH Homeostasis and Growth at Acidic pH

(2009) M. Follmann et al.   JOURNAL OF BACTERIOLOGY

NAD+ Activates KNa Channels in Dorsal Root Ganglion Neurons

(2009) T. J. Tamsett et al.   JOURNAL OF NEUROSCIENCE

The Potassium Transporter Trk and External Potassium Modulate Salmonella enterica Protein Secretion and Virulence

(2008) J. Su et al.   INFECTION AND IMMUNITY

Ion Channels in Microbes

(2008) Boris Martinac et al.   PHYSIOLOGICAL REVIEWS

The Desensitization Gating of the MthK K+ Channel Is Governed by Its Cytoplasmic Amino Terminus

(2008) Mario Meng-Chiang Kuo et al.   PLOS BIOLOGY