Cross-over Loop Cysteine C152 Acts as an Antioxidant to Maintain the Folding Stability and Deubiquitinase Activity of UCH-L1 Under Oxidative Stress

Untying a Protein Knot by Circular Permutation

(2019) Ya-Chu Chuang et al.   JOURNAL OF MOLECULAR BIOLOGY

Untying a Knotted SPOUT RNA Methyltransferase by Circular Permutation Results in a Domain-Swapped Dimer

(2019) Kuang-Ting Ko et al.   STRUCTURE

Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements

(2019) Vaishali Aggarwal et al.   Biomolecules

Protein knots provide mechano-resilience to an AAA+ protease-mediated proteolysis with profound ATP energy expenses

(2019) Manoj Kumar Sriramoju et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Comparative folding analyses of unknotted versus trefoil-knotted ornithine transcarbamylases suggest stabilizing effects of protein knots

(2018) Manoj Kumar Sriramoju et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Natively Monomeric Deubiquitinase UCH-L1 Forms Highly Dynamic but Defined Metastable Oligomeric Folding Intermediates

(2018) Yun-Tzai Cloud Lee et al.   Journal of Physical Chemistry Letters

Proteomic Analysis of Hippocampus in a Mouse Model of Depression Reveals Neuroprotective Function of Ubiquitin C-terminal Hydrolase L1 via Stress-induced Cysteine Oxidative Modifications

(2018) Jung-Eun Choi et al.   MOLECULAR & CELLULAR PROTEOMICS

Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) Promotes Hippocampus-Dependent Memory via Its Deubiquitinating Effect on TrkB

(2017) Yun-Yun Guo et al.   JOURNAL OF NEUROSCIENCE

Deciphering the Biophysical Effects of Oxidizing Sulfur-Containing Amino Acids in Interferon-beta-1a using MS and HDX-MS

(2017) Damian J. Houde et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress

(2017) Helmut Sies   Redox Biology

S-nitrosylation of UCHL1 induces its structural instability and promotes α-synuclein aggregation

(2017) Roshan Kumar et al.   Scientific Reports

Ubiquitin C-terminal hydrolase L1 (UCH-L1): structure, distribution and roles in brain function and dysfunction

(2016) P. Bishop et al.   BIOCHEMICAL JOURNAL

Regulation of DJ-1 by Glutaredoxin 1 in Vivo: Implications for Parkinson’s Disease

(2016) William M. Johnson et al.   BIOCHEMISTRY

The Knotted Protein UCH-L1 Exhibits Partially Unfolded Forms under Native Conditions that Share Common Structural Features with Its Kinetic Folding Intermediates

(2016) Shih-Chi Lou et al.   JOURNAL OF MOLECULAR BIOLOGY

Degradation of Redox-Sensitive Proteins including Peroxiredoxins and DJ-1 is Promoted by Oxidation-induced Conformational Changes and Ubiquitination

(2016) In-Kang Song et al.   Scientific Reports

Folding analysis of the most complex Stevedore’s protein knot

(2016) Iren Wang et al.   Scientific Reports

Protein knotting through concatenation significantly reduces folding stability

(2016) Shang-Te Danny Hsu   Scientific Reports

Unraveling the Folding Mechanism of the Smallest Knotted Protein, MJ0366

(2015) Iren Wang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) C Terminus Plays a Key Role in Protein Stability, but Its Farnesylation Is Not Required for Membrane Association in Primary Neurons

(2014) Paul Bishop et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endogenous neurotoxic dopamine derivative covalently binds to Parkinson's disease-associated ubiquitin C-terminal hydrolase L1 and alters its structure and function

(2014) Viorica Raluca Contu et al.   JOURNAL OF NEUROCHEMISTRY

Structure, function and inhibition of ent-kaurene synthase from Bradyrhizobium japonicum

(2014) Wenting Liu et al.   Scientific Reports

Glutathione metabolism and Parkinson's disease

(2013) Michelle Smeyne et al.   FREE RADICAL BIOLOGY AND MEDICINE

DUBs redox

(2013) Stéphane Larochelle   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Reversible inactivation of deubiquitinases by reactive oxygen species in vitro and in cells

(2013) Jin-Gu Lee et al.   Nature Communications

Deubiquitinases as a Signaling Target of Oxidative Stress

(2012) Xiomaris M. Cotto-Rios et al.   Cell Reports

Regulation of protein tyrosine phosphatases by reversible oxidation

(2011) Arne Östman et al.   JOURNAL OF BIOCHEMISTRY

Quantitative Mapping of Reversible Mitochondrial Complex I Cysteine Oxidation in a Parkinson Disease Mouse Model

(2011) Steven R. Danielson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cysteine residues exposed on protein surfaces are the dominant intramitochondrial thiol and may protect against oxidative damage

(2010) Raquel Requejo et al.   FEBS Journal

Cyclopentenone prostaglandin-induced unfolding and aggregation of the Parkinson disease-associated UCH-L1

(2010) L. M. I. Koharudin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation

(2010) D. A. Boudreaux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation and Cellular Roles of Ubiquitin-Specific Deubiquitinating Enzymes

(2009) Francisca E. Reyes-Turcu et al.   Annual Review of Biochemistry

Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

(2009) Bayani Uttara et al.   Current Neuropharmacology

DUBs at a glance

(2009) K. D. Wilkinson   JOURNAL OF CELL SCIENCE

Structure, Dynamics and Folding of an Immunoglobulin Domain of the Gelation Factor (ABP-120) from Dictyostelium discoideum

(2009) Shang-Te Danny Hsu et al.   JOURNAL OF MOLECULAR BIOLOGY

The Molecular Mechanism of the Catalase Reaction

(2009) Mercedes Alfonso-Prieto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reversal of long-term dendritic spine alterations in Alzheimer disease models

(2009) D. L. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UCHL1 (PGP 9.5): Neuronal biomarker and ubiquitin system protein

(2009) Ian N.M. Day et al.   PROGRESS IN NEUROBIOLOGY

Aberrant molecular properties shared by familial Parkinson’s disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1

(2008) Tomohiro Kabuta et al.   HUMAN MOLECULAR GENETICS

Effects of UCH-L1 on α-synuclein over-expression mouse model of Parkinson’s disease

(2008) Toru Yasuda et al.   JOURNAL OF NEUROCHEMISTRY

Glutathione: Overview of its protective roles, measurement, and biosynthesis

(2008) Henry Jay Forman et al.   MOLECULAR ASPECTS OF MEDICINE