Synthesis, characterization and pharmacological evaluation of quinoline derivatives and their complexes with copper(ΙΙ) in in vitro cell models of Alzheimer's disease

Development of the “hidden” multifunctional agents for Alzheimer's disease

(2019) Wenhai Huang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure-activity relationship studies of (E)-3,4-dihydroxystyryl alkyl sulfones as novel neuroprotective agents based on improved antioxidant, anti-inflammatory activities and BBB permeability

(2019) Ying Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, Characterization and Antimicrobial Properties of Mononuclear Copper(II) Compounds of N,N′-di(quinolin-8-yl)cyclohexane-1,2-diamine

(2019) Sarvesh S. Harmalkar et al.   INORGANICA CHIMICA ACTA

New 4-N-phenylaminoquinoline derivatives as antioxidant, metal chelating and cholinesterase inhibitors for Alzheimer’s disease

(2019) Rong Cai et al.   BIOORGANIC CHEMISTRY

Synthesis, biological evaluation and structure-activity relationship studies of hederacolchiside E and its derivatives as potential anti-Alzheimer agents

(2018) Hui-ning Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

(2018) C. Cheignon et al.   Redox Biology

In-vitro evaluation studies of 7-chloro-4-aminoquinoline Schiff bases and their copper complexes as cholinesterase inhibitors

(2018) Vanessa S. Zanon et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Apios americana Medik flowers extract protects PC12 cells against H2O2 induced neurotoxicity via regulating autophagy

(2018) Qiang Chu et al.   FOOD AND CHEMICAL TOXICOLOGY

Strategic Design of 2,2′-Bipyridine Derivatives to Modulate Metal–Amyloid-β Aggregation

(2017) Yonghwan Ji et al.   INORGANIC CHEMISTRY

Zinc Signal in Brain Diseases

(2017) Stuart Portbury et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biochemical profile and in vitro neuroprotective properties of Carpobrotus edulis L., a medicinal and edible halophyte native to the coast of South Africa

(2017) M.I. Rocha et al.   SOUTH AFRICAN JOURNAL OF BOTANY

Lignans from a wild vegetable (Patrinina villosa) able to combat Alzheimer’s disease

(2017) Ming Bai et al.   Journal of Functional Foods

Hydrogen peroxide modifies both activity and isoforms of acetylcholinesterase in human neuroblastoma SH-SY5Y cells

(2017) Alba Garcimartín et al.   Redox Biology

An In Vitro Model for Neuroscience: Differentiation of SH-SY5Y Cells into Cells with Morphological and Biochemical Characteristics of Mature Neurons

(2017) Lotta Agholme et al.   JOURNAL OF ALZHEIMERS DISEASE

Design, synthesis and biological evaluation of coumarin derivatives as novel acetylcholinesterase inhibitors that attenuate H2O2-induced apoptosis in SH-SY5Y cells

(2016) Dahong Yao et al.   BIOORGANIC CHEMISTRY

Metallothioneins in Prion- and Amyloid-Related Diseases

(2016) Pavlína Adam et al.   JOURNAL OF ALZHEIMERS DISEASE

Tacrine-(hydroxybenzoyl-pyridone) hybrids as potential multifunctional anti-Alzheimer's agents: AChE inhibition, antioxidant activity and metal chelating capacity

(2016) Karam Chand et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Regulation of Copper and Iron Homeostasis by Metal Chelators: A Possible Chemotherapy for Alzheimer’s Disease

(2015) Anne Robert et al.   ACCOUNTS OF CHEMICAL RESEARCH

Synthesis and biological evaluation of novel marine-derived indole-based 1,2,4-oxadiazoles derivatives as multifunctional neuroprotective agents

(2015) Cheng-Shi Jiang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Soluble Sugar-Based Quinoline Derivatives as New Antioxidant Modulators of Metal-Induced Amyloid Aggregation

(2015) Valentina Oliveri et al.   INORGANIC CHEMISTRY

What has fluorescent sensing told us about copper and brain malfunction?

(2015) Clara Shen et al.   Metallomics

Alzheimer's disease-related amyloid-β induces synaptotoxicity in human iPS cell-derived neurons

(2015) K Nieweg et al.   Cell Death & Disease

Design, Synthesis, and Evaluation of Multitarget-Directed Selenium-Containing Clioquinol Derivatives for the Treatment of Alzheimer’s Disease

(2014) Zhiren Wang et al.   ACS Chemical Neuroscience

Copper: toxicological relevance and mechanisms

(2014) Lisa M. Gaetke et al.   ARCHIVES OF TOXICOLOGY

Secreted Amyloid β-Proteins in a Cell Culture Model Include N-Terminally Extended Peptides That Impair Synaptic Plasticity

(2014) Alfred T. Welzel et al.   BIOCHEMISTRY

Exploring the Coordination Chemistry of 3,3′-Di(picolinamoyl)-2,2′-bipyridine: One Ligand, Multiple Nuclearities

(2014) Nicholas J. Hurley et al.   INORGANIC CHEMISTRY

8-Hydroxyquinoline Schiff-base compounds as antioxidants and modulators of copper-mediated Aβ peptide aggregation

(2014) Luiza M.F. Gomes et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Gamma-hydroxybutyrate, acting through an anti-apoptotic mechanism, protects native and amyloid-precursor-protein-transfected neuroblastoma cells against oxidative stress-induced death

(2014) G. Wendt et al.   NEUROSCIENCE

Bioinorganic Chemistry of Alzheimer’s Disease

(2012) Kasper P. Kepp   CHEMICAL REVIEWS

Liberation of Copper from Amyloid Plaques: Making a Risk Factor Useful for Alzheimer’s Disease Treatment

(2012) Jie Geng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Copper complexes of bis(thiosemicarbazones): from chemotherapeutics to diagnostic and therapeutic radiopharmaceuticals

(2011) Brett M. Paterson et al.   CHEMICAL SOCIETY REVIEWS

Stress Acts Cumulatively To Precipitate Alzheimer's Disease-Like Tau Pathology and Cognitive Deficits

(2011) I. Sotiropoulos et al.   JOURNAL OF NEUROSCIENCE

Copper complexes as therapeutic agents

(2011) Clare Duncan et al.   Metallomics

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

The history of the cholinergic hypothesis

(2010) Antonio Contestabile   BEHAVIOURAL BRAIN RESEARCH

Clioquinol: Review of its Mechanisms of Action and Clinical Uses in Neurodegenerative Disorders

(2010) Silvio R. Bareggi et al.   CNS Neuroscience & Therapeutics

Novel Tacrine−8-Hydroxyquinoline Hybrids as Multifunctional Agents for the Treatment of Alzheimer’s Disease, with Neuroprotective, Cholinergic, Antioxidant, and Copper-Complexing Properties

(2010) María Isabel Fernández-Bachiller et al.   JOURNAL OF MEDICINAL CHEMISTRY

Protective effects of TRH and its analogues against various cytotoxic agents in retinoic acid (RA)-differentiated human neuroblastoma SH-SY5Y cells

(2010) L. Jaworska-Feil et al.   NEUROPEPTIDES

Inhibition of H2O2-induced neuroblastoma cell cytotoxicity by a triazine derivative, AA3E2

(2009) Hamed Shaykhalishahi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY