Article
Food Science & Technology
Wen-Na Zhang, Yuan -Yuan Li, Jia-Jia Xu, Lu-Lu Shi, Lei Chen, Yong-Ming Lu, Qing-Xi Wu, Jian-Guang Luo, Yan Chen
Summary: Armillariella tabescens methanol extract (AME) has been found to have significant therapeutic effects on ulcerative colitis (UC), including reducing symptoms, increasing anti-inflammatory factors, and inhibiting inflammation signaling pathways. It also improves the expression of tight junction proteins. This study suggests that AME has the potential to be developed into a promising therapeutic agent for UC treatment.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Agriculture, Multidisciplinary
Yaping Li, Xiao Pan, Mingyuan Yin, Cuiping Li, Lirong Han
Summary: The study demonstrated the preventive effect of lycopene in dextran sulfate sodium-induced ulcerative colitis in mice by increasing anti-oxidant levels, reducing inflammation, and upregulating tight junction-related proteins through modulation of the TLR4/TRIF/NF-κB signaling pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Plant Sciences
Taoxiu Xiong, Xiang Zheng, Ke Zhang, Hansong Wu, Yingjie Dong, Fuchen Zhou, Bingbing Cheng, Linzi Li, Wanfeng Xu, Jie Su, Jiahui Huang, Zetian Jiang, Bo Li, Beibei Zhang, Guiyuan Lv, Suhong Chen
Summary: The study found that Ganluyin (GLY) exerts an anti-ulcerative colitis (UC) effect by improving the colonic mucosal barrier, inhibiting the enteric-origin lipopolysaccharide (LPS)/toll-like receptor (TLR)4/nuclear factor-kappa B (NF-κB) inflammatory pathway, and restoring the homeostasis of the intestinal flora in UC mice. These findings lay a strong foundation for GLY as a potential treatment for UC.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Food Science & Technology
Weidong Dou, Hao Xu, Shuo Feng, Tao Liu, Lin Xiao, Yingchao Wu, Shanwen Chen, Yisheng Pan, Xin Wang
Summary: This study investigates the protective effects of betaine on intestinal barrier function in a mouse model of ulcerative colitis and reveals its mechanism of action. The results show that betaine protects the intestinal barrier function of mice with ulcerative colitis by inhibiting the activation of the NF-kappa B-mediated signaling pathway.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Immunology
Yifan Qu, Xinyi Li, Fengying Xu, Shimin Zhao, Xuemei Wu, Yuzhen Wang, Jiming Xie
Summary: The study demonstrates that kaempferol has significant anti-inflammatory and antioxidant effects in DSS-induced colitis mice, alleviating UC symptoms by modulating the gut microbiota and TLR4-related signaling pathways.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Sameh Saber, Mahmoud E. Youssef, Hossam Sharaf, Noha A. Amin, Ruwyda El-Shedody, Farah H. Aboutouk, Yumna Abd El-Galeel, Amr El-Hefnawy, Dina Shabaka, Arwa Khalifa, Renad A. Saleh, Donya Osama, Ghada El-Zoghby, Naglaa A. Gobba
Summary: The study showed that the P2X7R blocker BBG and the selective NLRP3 inhibitor OLT1177, when used individually or in combination, effectively treated ulcerative colitis by reducing inflammation and repairing colonic damage. The combined administration of BBG and OLT1177 exhibited a stronger inhibitory effect on NLRP3 signaling.
Article
Biochemistry & Molecular Biology
Ping Zhou, Jia Lai, Yueyue Li, Junzhu Deng, Chunling Zhao, Qianqian Huang, Fei Yang, Shuo Yang, Yuesong Wu, Xiaoqin Tang, Feihong Huang, Long Wang, Xinwu Huang, Wenjun Zou, Jianming Wu
Summary: This study investigated the effects of methyl gallate (MG) on ulcerative colitis (UC) and found that MG can regulate macrophage polarization, alleviate inflammation, and inhibit the TLR4/NF-kappa B signaling pathway in UC treatment. Additionally, MG can alter the diversity and composition of the gut microbiota, contributing to the therapeutic effects on UC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Shiyan Chen, Yanan Li, Bingxin Chu, Lanxin Yuan, Ning Liu, Yaohong Zhu, Jiufeng Wang
Summary: The study demonstrated that Lactobacillus johnsonii L531 alleviated Salmonella Typhimurium induced damage to intestinal epithelial cells by inhibiting the activation of inflammatory signaling pathways and reducing the expression of pro-inflammatory cytokines.
Article
Pharmacology & Pharmacy
Ling Chen, Xiao-lin Zhong, Wen-yu Cao, Ming-li Mao, Dan-dan Liu, Wen-jia Liu, Xu-yu Zu, Jiang-hua Liu
Summary: In this study, the role and mechanism of IGF2 in ulcerative colitis were investigated using a mouse model. The results showed that IGF2 can alleviate colon injury and inflammation caused by ulcerative colitis by downregulating the cGAS-Sting pathway, thus maintaining colonic stemness and barrier integrity.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Plant Sciences
Zhenhua Bian, Yuwen Qin, Lin Li, Lianlin Su, Chenghao Fei, Yu Li, Minmin Hu, Xiaowei Chen, Wei Zhang, Chunqin Mao, Xiaohang Yuan, Tulin Lu, De Ji
Summary: This study investigated the protective effects and underlying action mechanisms of Schisandra chinensis extract (SCE) for ulcerative colitis (UC) treatment. The results showed that SCE can ameliorate UC symptoms, inhibit inflammatory response, and regulate gut microbiota balance.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Oncology
Sheng Yu, Haihua Qian
Summary: The study demonstrated that deoxyschizandrin (DSD) can alleviate symptoms of mice with DSS-induced ulcerative colitis by inhibiting body inflammation, improving oxidative stress, and reducing the apoptosis of colonic epithelial cells, possibly through inhibition of the TLR4/NF-kappa B signaling pathway.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Yongfu Wang, Jingjing Liu, Ziwei Huang, Yucui Li, Yuanyuan Liang, Chaodan Luo, Chen Ni, Jianhui Xie, Ziren Su, Jiannan Chen, Cailan Li
Summary: Coptisine has demonstrated therapeutic effects on ulcerative colitis by maintaining the integrity of the intestinal epithelial barrier, inhibiting apoptosis, and inflammatory response.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Junhong Tao, Zhihua Huang, Yudan Wang, Yaping Liu, Tianrui Zhao, Yifen Wang, Lei Tian, Guiguang Cheng
Summary: The research found that Pteris wallichiana J. Agardh extract can alleviate DSS-induced ulcerative colitis in mice through various mechanisms, including reducing the production of inflammatory factors, alleviating oxidative stress, improving intestinal barrier, and suppressing intestinal inflammation.
Review
Biochemistry & Molecular Biology
Zhenxiang Li, Hanyue Wang, Zhanjiang Wang, Yue Geng
Summary: Pine pollen polysaccharides and sulfated polysaccharides have a therapeutic effect on mice with ulcerative colitis by regulating the tight junctions of colonic epithelial cells and the RIPK3-dependent necroptosis pathways.
Article
Pharmacology & Pharmacy
Hanan S. Althagafy, Fares E. M. Ali, Emad H. M. Hassanein, Zuhair M. Mohammedsaleh, Mohamed I. Kotb El-Sayed, Ahmed M. Atwa, Ahmed M. Sayed, Ayman A. Soubh
Summary: This study demonstrates that canagliflozin can effectively attenuate ulcerative colitis by regulating multiple pathways and targets, reducing inflammation, alleviating oxidative stress, and restoring colonic function.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mosad A. Ghareeb, Mansour Sobeh, Walaa H. El-Maadawy, Hala Sh Mohammed, Heba Khalil, Sanaa Botros, Michael Wink
Article
Toxicology
W. H. El-Maadawy, O. A. Hammam, S. H. Seif el-Din, N. M. El-Lakkany
HUMAN & EXPERIMENTAL TOXICOLOGY
(2020)
Article
Nanoscience & Nanotechnology
Shaimaa Ali Ali Radwan, Walaa H. El-Maadawy, Carol Yousry, Aliaa Nabil ElMeshad, Raguia Aly Shoukri
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Article
Chemistry, Multidisciplinary
Shaimaa Ali Ali Radwan, Walaa H. El-Maadawy, Aliaa Nabil ElMeshad, Raguia Aly Shoukri, Carol Yousry
PHARMACEUTICAL RESEARCH
(2020)
Article
Plant Sciences
Heba M. A. Khalil, Hesham A. Eliwa, Riham A. El-Shiekh, Asmaa K. Al-Mokaddem, Marwa Hassan, Azza M. Tawfek, Walaa H. El-Maadawy
Summary: The study demonstrated that Ashwagandha root extract improved symptoms of thioacetamide-induced hepatic encephalopathy, including liver toxicity indices, ammonia levels, and brain histopathological changes. Ashwagandha also reduced levels of oxidative stress markers and modulated the expression of key proteins and genes.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Rabab M. Abdou, Walaa H. El-Maadawy, Marwa Hassan, Riham S. El-Dine, Tarek Aboushousha, Nebal D. El-Tanbouly, Aly M. El-Sayed
Summary: The study investigated the nephroprotective effects of Aframomum melegueta seed extracts (AMSE) against diclofenac (DIC)-induced acute kidney injury (AKI), and found that AMSE exhibited antioxidant, anti-inflammatory, and antiapoptotic activities. AMSE counteracted DIC-induced AKI by activating Nrf2/HO1 and AMPK/SIRT1, and inhibiting NF-κB/STAT3 signaling pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Environmental Sciences
Walaa H. El-Maadawy, Marwa Hassan, Rabab M. Abdou, Riham S. El-Dine, Tarek Aboushousha, Nebal D. El-Tanbouly, Aly M. El-Sayed
Summary: 6-Paradol (PDL) has protective effects against DIC-induced AKI by modulating autophagy and NLRP3 inflammasome pathways. It has anti-inflammatory, antioxidant and AMPK-activation properties. PDL restores renal structure and reduces inflammation markers.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Walaa H. El-Maadawy, Marwa Hassan, Ehab Hafiz, Mohamed H. Badawy, Samir Eldahshan, AbdulRahman AbuSeada, Maha A. M. El-Shazly, Mosad A. Ghareeb
Summary: This study investigated the therapeutic effects of esculin (ESC) and erythropoietin (EPO) against renal ischemia/reperfusion (RI/R) injury. ESC and EPO were found to reduce oxidative stress, inflammation, and apoptosis, and improve renal histopathological injury. ESC inhibited P2X7 receptor and NLRP3 inflammasome signaling, while EPO activated the PI3K/Akt pathway. The combination of ESC and EPO showed the best renoprotective effects.
SCIENTIFIC REPORTS
(2022)
Article
Instruments & Instrumentation
Heba M. A. Khalil, Islam A. Khalil, Asmaa K. Al-Mokaddem, Marwa Hassan, Riham A. El-Shiekh, Hesham A. Eliwa, Azza M. Tawfek, Walaa H. El-Maadawy
Summary: The encapsulation of ASH in chitosan-alginate bipolymeric nanocapsules (ASH-BPNCs) enhances its therapeutic effectiveness in the gastrointestinal tract, improving hepatoprotective and neuroprotective effects. The ASH-BPNCs also demonstrate promising biodistribution in the brain and hepatic tissues.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Walaa H. El-Maadawy, Ehab Hafiz, Hend Okasha, Noha A. Osman, Gamila H. Ali, Rehab Ali Hussein
Summary: This study investigated the therapeutic effectiveness of Phycocyanin (PC) against ulcerative colitis (UC) and found that PC acts as a CB2 receptor agonist, exerting anti-inflammatory effects and improving colon pathology as well as intestinal dysbiosis associated with UC.
Article
Medicine, Research & Experimental
Walaa H. El-Maadawy, Marwa Hassan, Mohamed H. Badawy, AbdulRahman AbuSeada, Ehab Hafiz
Summary: This study is the first to demonstrate the protective effect of probenecid (PBN) against renal ischemia/reperfusion injury (RI/RI). PBN inhibits the Panx1/P2X7R axis, reduces the activation of the NLRP3 inflammasome signaling pathway, and enhances the activity of regulatory T cells, leading to renal recovery.
Meeting Abstract
Surgery
E. Hafiz, W. H. El-Maadawy, M. Hassan, M. H. Badawy, S. Eldahshan, A. AbuSeada
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Correction
Chemistry, Multidisciplinary
Shaimaa Ali Ali Radwan, Walaa H. El-Maadawy, Aliaa Nabil ElMeshad, Raguia Aly Shoukri, Carol Yousry
PHARMACEUTICAL RESEARCH
(2020)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)