Article
Pharmacology & Pharmacy
Hetal P. Patel, Priyanka S. Chaudhari, Priyanshi A. Gandhi, Bhargavi Desai, Ditixa T. Desai, Praful P. Dedhiya, Bhavin A. Vyas, Furqan A. Maulvi
Summary: Clozapine nanosuspension prepared for intranasal delivery showed improved drug permeability and increased therapeutic concentration in brain tissue compared to conventional oral clozapine suspension, suggesting its potential for successful nose-to-brain drug delivery.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Sreeja C. Nair, Kollencheri Puthenveettil Vinayan, Sabitha Mangalathillam
Summary: The study demonstrates that nanosized phenytoin sodium loaded NLCs of < 50 nm can achieve direct and rapid nose to brain drug transport through the olfactory epithelium, offering promising potential for treating acute epileptic seizures.
Article
Nanoscience & Nanotechnology
Mustafa K. Shehata, Assem A. Ismail, Maher A. Kamel
Summary: This study aimed to prepare and evaluate AST-loaded nanostructured lipid carriers (NLCs) for nose-to-brain drug delivery in rat model of AD. The optimized AST-NLCs showed improved therapeutic properties and significantly reduced oxidative stress, amyloidogenic pathway, neuroinflammation, and apoptosis in AD-like rats.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Chemistry, Medicinal
Thi Mai Anh Pham, Dong Ho Lee, Young-Guk Na, Minki Jin, Minwoo Jung, Ha-Eun Kim, Hyelim Yoo, Jong-Hee Won, Jae-Young Lee, Jong-Suep Baek, Su-Cheol Han, Hong-Ki Lee, Cheong-Weon Cho
Summary: In this study, S(+)-zaltoprofen-loaded nanostructured lipid carriers (NLCs) were prepared to improve the oral bioavailability. The optimal NLC-SZPF exhibited high encapsulation efficiency, sustained-release profile, biocompatibility, and permeability across the intestinal tract. The relative bioavailability of NLC-SZPF was significantly enhanced compared to SZPF.
ARCHIVES OF PHARMACAL RESEARCH
(2022)
Article
Nanoscience & Nanotechnology
Sara Cunha, Ben Forbes, Jose Manuel Sousa Lobo, Ana Catarina Silva
Summary: Treatment for Alzheimer's disease focuses on slowing symptom progression and enhancing quality of life. Nasal delivery offers a potential alternative route to directly deliver drugs to the brain, but clearance mechanisms in the nasal cavity hinder drug delivery efficiency. Formulations of lipid-based nanosystems show promise in optimizing nose-to-brain drug delivery, minimizing side effects, and maximizing therapeutic benefits.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Medicine, Research & Experimental
Marina Raju, Shalvi Sinai Kunde, Sandip T. Auti, Yogesh A. Kulkarni, Sarika Wairkar
Summary: Berberine-loaded nanostructured lipid carriers were successfully developed with high entrapment efficiency and showed promising pharmacodynamic efficacy in an animal model of Alzheimer's disease. The optimized formulation exhibited significant improvements in behavioral parameters compared to pure berberine.
Article
Food Science & Technology
Ji Eun Hyun, Hye-Yoon Yi, Geun-Pyo Hong, Ji-Yeon Chun
Summary: This study encapsulated curcumin into nanostructured lipid carriers (NLCs) to improve its solubility, stability, and bioavailability. In vitro experiments showed that NLCs released approximately 31% of curcumin in the simulated saliva step, indicating their effectiveness as carriers in various fields.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
C. P. Costa, S. Cunha, J. N. Moreira, R. Silva, E. Gil-Martins, V. Silva, L. Azevedo, A. F. Peixoto, J. M. Sousa Lobo, A. C. Silva
Summary: Optimized diazepam-loaded NLC formulation with negative surface charge showed smaller particle size, higher encapsulation efficiency, and better biocompatibility for targeting the brain compared to the formulation with positive surface charge. The sustained drug release effect was observed in both formulations, with the negative surface charge formulation exhibiting greater cytotoxicity than the positive surface charge formulation.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Meghanath B. Shete, Ashwini S. Deshpande, Pravin Shende
Summary: In this study, silymarin (SME) was loaded in nanostructured lipid carriers (NLCs) and incorporated in mucoadhesive in-situ gel (SME-NLCs-Plx/CP-ISG) for localized treatment of oral cancer. The SME-loaded gel showed sustained release and enhanced inhibition against human KB oral cancer cells, making it a potential alternative to chemotherapy and surgery.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Claudia Pina Costa, Joao Nuno Moreira, Jose Manuel Sousa Lobo, Ana Catarina Silva
Summary: The management of CNS disorders is challenging due to the need for drugs to cross the BBB and reach the brain. Using the intranasal route combined with lipid-based nanocarriers has shown promising results in targeting drugs to the brain. Although the exact mechanism remains unclear, these systems are more effective than other routes and are expected to be approved by regulatory authorities in the future.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Pharmacology & Pharmacy
Shweta Agarwal, S. L. HariKumar, Poonam Negi, Navneet Upadhyay, Rajeev Garg
Summary: The study aimed to enhance the bioavailability of Quetiapine Fumarate by developing Nanostructured Lipid Carriers through Design of Experiment. The optimized formulation showed high Entrapment Efficiency and small Particle Size, leading to a significant enhancement in bioavailability. The results demonstrated the potential of Nanostructured Lipid Carriers as a promising delivery system for improving the oral bioavailability of Quetiapine Fumarate.
CURRENT DRUG DELIVERY
(2021)
Article
Pharmacology & Pharmacy
Nobuyuki Nomura, Kohei Kitagawa, Ryuhei So, Fuminari Misawa, Masafumi Kodama, Hiroyoshi Takeuchi, Robert Bies, Thomas Straubinger, Christopher Banker, Yuya Mizuno, Masaru Mimura, Hiroyuki Uchida
Summary: The study analyzed the relationship between clozapine concentrations and side effects, finding that different concentrations do not have a direct link with the severity of side effects. The results suggest that side effects associated with clozapine may occur at any dose or concentration.
THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Eman A. Bseiso, Sarah A. AbdEl-Aal, Maha Nasr, Omaima A. Sammour, Nabaweya A. Abd El Gawad
Summary: This study prepared and characterized lipidic nanocapsules loaded with melatonin and demonstrated their efficacy in treating ischemic stroke. The results showed that the nanocapsules had good stability and sustained release ability, and achieved efficient drug permeation across sheep nasal mucosa. The study also found that MEL-LNCs could reduce oxidative stress, decrease inflammatory response, and promote neuronal survival.
Article
Pharmacology & Pharmacy
Chandra Teja Uppuluri, Punna Rao Ravi, Avantika Dalvi
Summary: In this study, solid lipid nanoparticles (PBD-SLNs) were developed as a drug delivery system for the anti-Parkinson's drug, Piribedil (PBD), to improve its absorption efficiency and stability. By optimizing the particle size and morphology, the PBD-SLNs showed significantly increased drug uptake and stability. Loading the SLNs into thermoresponsive Methyl Cellulose in situ gel (PBD-SLN-ISG) led to improved drug delivery to the brain in rats, resulting in a four-fold increase in the area under the curve (AUC) and a 2.3-fold decrease in maximum plasma concentration (C-max) compared to plain intranasal suspension of PBD.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biophysics
Liu Miao, Liu Daozhou, Cheng Ying, Mei Qibing, Zhou Siyuan
Summary: Preparation of RES-loaded nanostructured lipid carrier gel (RES-NLC-gel) improved RES stability and accumulation in the epidermis. The gel effectively scavenged free radicals, protected skin cells from UV radiation, decreased expression of apoptotic proteins, and increased expression of survival proteins. Pretreatment with RES-NLC-gel reduced erythema, wrinkles, and scabs on mouse skin, decreased epidermal thickness, and increased antioxidant enzyme activities in skin tissue. RES-NLC-gel demonstrated significant anti-UV irradiation and antioxidant activity in vivo, showing great potential in skin protection.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Pharmacology & Pharmacy
Akshay R. Koli, Ketan M. Ranch, Hetal P. Patel, Rajesh K. Parikh, Dinesh O. Shah, Furqan A. Maulvi
Summary: Felodipine, a calcium channel blocker with low oral bioavailability, was studied using microemulsion to improve drug permeability in the intestine. Research showed that a stable microemulsion can significantly enhance the oral bioavailability of Felodipine through improved drug stability and permeability.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Ketan M. Ranch, Furqan A. Maulvi, Akshay R. Koli, Ditixa T. Desai, Rajesh K. Parikh, Dinesh O. Shah
Summary: The study successfully developed tailored doxycycline hyclate laden in situ gel for periodontitis treatment, which achieved sustained drug release above MIC, easy administration, and localization in the periodontal cavity. Optimization was conducted using Box-Behnken design with minimal polymers to meet the required characteristics for effective drug delivery.
Article
Pharmacology & Pharmacy
Hetal P. Patel, Priyanka S. Chaudhari, Priyanshi A. Gandhi, Bhargavi Desai, Ditixa T. Desai, Praful P. Dedhiya, Bhavin A. Vyas, Furqan A. Maulvi
Summary: Clozapine nanosuspension prepared for intranasal delivery showed improved drug permeability and increased therapeutic concentration in brain tissue compared to conventional oral clozapine suspension, suggesting its potential for successful nose-to-brain drug delivery.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biophysics
Furqan A. Maulvi, Parth D. Soni, Pooja J. Patel, Ankita R. Desai, Ditixa T. Desai, Manish R. Shukla, Shailesh A. Shah, Dinesh O. Shah, Mark D. P. Willcox
Summary: The research used graphene oxide (GO) to control the release of bimatoprost from contact lenses in order to improve drug uptake, lens swelling, and transmittance. Although GO did not enhance bimatoprost uptake, it improved the in vitro release profile of the drug.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Pharmacology & Pharmacy
Furqan A. Maulvi, Ditixa T. Desai, Kiran H. Shetty, Dinesh O. Shah, Mark D. P. Willcox
Summary: The delivery of drugs to ocular tissues can be challenging, and drug-laden contact lenses are being explored as a possible solution. However, there are several issues that need to be addressed before clinical application and commercialization, such as changes in contact lens properties during manufacture.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Pharmacology & Pharmacy
Furqan A. Maulvi, Kiran H. Shetty, Ditixa T. Desai, Dinesh O. Shah, Mark D. P. Willcox
Summary: The human eye is a complex organ with unique anatomy and physiology that restricts drug delivery. Recent advances in pharmacy, biotechnology and material science have led to the development of novel ophthalmic dosage forms, improving drug delivery, reducing dosing frequency and enhancing ocular bioavailability. Different routes of drug administration and their advancements and limitations have been discussed in ophthalmic preparations from 2016 to 2020.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Ditixa T. Desai, Furqan A. Maulvi, Ankita R. Desai, Manish R. Shukla, Bhargavi Desai, Avinash D. Khadela, Kiran H. Shetty, Dinesh O. Shah, Mark D. P. Willcox
Summary: In this study, drug-eluting contact lenses containing graphene oxide were developed to overcome the challenges associated with low drug uptake, altered swelling and optical properties. The incorporation of graphene oxide improved water holding capacity, optical properties, drug uptake and release kinetics. Furthermore, the safety and efficacy of the graphene oxide-contact lenses were demonstrated in ocular irritation, histopathological and in vivo drug release studies.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Furqan A. Maulvi, Prince A. Kanani, Harshani J. Jadav, Bhargavi Desai, Ditixa T. Desai, Hetal P. Patel, Kiran H. Shetty, Dinesh O. Shah, Mark D. P. Willcox
Summary: This study successfully improved the swelling and transmittance properties of contact lenses by incorporating graphene oxide (GO) during the fabrication process. Additionally, it achieved controlled release of timolol, a hydrophobic drug, through the use of GO-laden contact lenses.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xueliang Xiu, Shichao Ma, Zhiyong Li, Zhipeng Li, Xuemei Li, Yangtao Ruan, Dezhao Li, Jianwei Wang, Fengsen Ma
Summary: Liposomes are promising delivery vehicles for drugs and vaccines. The use of microfluidic chips for liposome preparation is an effective method. However, traditional liposome preparation technologies hinder their industrial production and clinical application. This study presents a novel three-dimensional integrated microfluidic device for continuous liposome preparation and purification, which shows potential for industrial production of nano-pharmaceutical applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2024)